Article
Biotechnology & Applied Microbiology
Junting Xiao, Baijie Tu, Xin Zhou, Xuejun Jiang, Ge Xu, Jun Zhang, Xia Qin, Golamaully Sumayyah, Jingchuan Fan, Bin Wang, Chengzhi Chen, Zhen Zou
Summary: CuONPs are widely used metal nanoparticles in industrial and commercial fields, and are associated with dose-dependent acute lung injury. The loss of lc3b may exacerbate lung injury induced by CuONPs, potentially due to the blockade of mitophagy and accumulation of aberrant mitochondria. Targeting autophagy may be a meaningful strategy against CuONPs-associated respiratory toxicity.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Cell Biology
Jung Yeon Hong, Mi Na Kim, Eun Gyul Kim, Jae Woo Lee, Hye Rin Kim, Soo Yeon Kim, Soon Min Lee, Yoon Hee Kim, Kyung Won Kim, Myung Hyun Sohn
Summary: Exposure to high oxygen concentrations leads to excessive generation of reactive oxygen species, causing cellular injury and multiple organ dysfunctions. Clusterin (CLU) expression is increased during prolonged hyperoxia-induced lung injury, and replenishment of CLU can alleviate hyperoxia-induced cell death.
Review
Immunology
Pamella Silva Lannes-Costa, Bruna Alves da Silva Pimentel, Prescilla Emy Nagao
Summary: This mini-review discusses the cellular pathogenesis and the role of Caveolin-1 (Cav-1) in sepsis. Cav-1 has been shown to play a significant role in sepsis through regulating membrane traffic and intracellular signaling pathways. Activation of apoptosis/autophagy is also considered relevant to the progression of sepsis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wenfang Xia, Zhou Pan, Huanming Zhang, Qingshan Zhou, Yu Liu
Summary: This study investigates the role of estrogen-related receptor alpha (ERRα) in sepsis-induced acute lung injury (ALI). The results show that overexpression of ERRα can ameliorate LPS-induced endothelial hyperpermeability, apoptosis, and inhibit autophagy, while knockdown of ERRα exacerbates these effects. Administration of an ERRα agonist can alleviate pathological damage, increase the levels of junctional proteins, and decrease apoptosis-related protein expression. Promoting ERRα expression enhances autophagy and reduces sepsis-induced ALI. ERRα is essential for maintaining the integrity of adherens junctions by regulating the balance between autophagy and apoptosis.
MOLECULAR MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Sahebgowda Sidramagowda Patil, Helena Hernandez-Cueryo, Jutaro Fukumoto, Sudarshan Krishnamurthy, Muling Lin, Matthew Alleyn, Mason Breitzig, Venkata Ramireddy Narala, Ramani Soundararajan, Richard F. Lockey, Narasaiah Kolliputi, Lakshmi Galam
Summary: Acute lung injury (ALI) is a leading cause of mortality in older adults, and oxygen therapy is a common treatment method. Alda-1 protects against oxidative stress by enhancing ALDH2 activity, and also shows protective effects against ischemic reperfusion injury, heart failure, and other conditions.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Meina Huang, Jinhui Wang, Meili Zhai, Jiqiang Liu, Yongjie Zhu, Yang Zhang, Jing Zhao, Huiquan Wang, Jinglai Sun, Hui Yu, Chong Liu
Summary: Perioperative hyperoxia therapy plays a significant role in saving the lives of patients, but the mechanisms and clinical prevention and treatment measures for hyperoxia-induced acute lung injury (HALI) are not well understood. In this experiment, a model with automatic regulation of oxygen concentration was used to explore the involvement of the Sig-1R-regulated ER stress signaling pathway in HALI. Dexmedetomidine was selected as a potential medication for HALI during the perioperative period. The results showed that Dex partially reversed the changes in the expression levels of proteins in the Sig-1R-regulated ER stress pathway, suggesting a potential protective role in HALI.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Medicine, Research & Experimental
Jiahua Zheng, Shaochai Wei, Tingting Xiao, Guanwu Li
Summary: This study demonstrates that resveratrol induces non-canonical autophagy and apoptosis activation simultaneously in A549 lung cancer cells, while mitophagy mediated by LC3B/p62 interaction protects tumor cells against apoptosis.
Article
Urology & Nephrology
Ruolin Wang, Siheng Shen, Luyong Jian, Shuhua Liu, Qi Yuan, Huahui Guo, Jiasheng Huang, Penghui Chen, Renfa Huang
Summary: This study investigated the role of autophagy in AKI-induced ALI and found that autophagy can effectively ameliorate the injury by suppressing inflammation and oxidative stress.
Article
Cell Biology
Jiayao Zhao, Qun Liang, Chenfei Fu, Didi Cong, Long Wang, Xiaoxin Xu
Summary: Sepsis-induced acute lung injury (ALI) is a severe syndrome with a heavy burden on family and society. Autophagy, as a key factor in cellular homeostasis, plays an important role in the pathophysiological process of sepsis-induced ALI. Regulating autophagy may be beneficial for this disease, although its role in the etiology and treatment is not well characterized.
CELLULAR SIGNALLING
(2023)
Article
Medicine, Research & Experimental
Fei Tong, Wenchao Shen, Jingjing Zhao, Yonghe Hu, Qi Zhao, Huizhi Lv, Feifan Liu, Zhipeng Meng, Jing Liu
Summary: This study aims to investigate the protective effects of SIRT1 on lipopolysaccharide (LPS)-induced acute lung injury (ALI) and reveal its underlying molecular mechanism. The results suggest that SIRT1 protects against LPS-induced ALI by counteracting inflammatory remission and activation of Cav-1 expression via suppressing STAT3. This study reveals the potential importance of SIRT1 in the treatment of ALI.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell Biology
Tianyu Han, Pengcheng Wang, Yanan Wang, Wenze Xun, Jiapeng Lei, Tao Wang, Zhuo Lu, Mingxi Gan, Wei Zhang, Bentong Yu, Jian-Bin Wang
Summary: The research uncovered that FAIM promotes tetramer formation of GAC and stabilizes GAC by modulating the MTOR pathway, leading to increased production of alpha-ketoglutarate. Furthermore, FAIM inhibits autophagy induction, thereby furthering the development of lung adenocarcinoma.
Review
Biochemistry & Molecular Biology
Yan Zhang, Jin Zhang, Zhiling Fu
Summary: This review discusses the potential therapeutic effects of molecular hydrogen on acute lung injury (ALI) and its underlying mechanisms, aiming to provide a theoretical basis for the clinical treatment of ALI and COVID-19.
MOLECULAR MEDICINE
(2022)
Article
Nutrition & Dietetics
Shi-Jye Chu, Shih-En Tang, Hsin-Ping Pao, Shu-Yu Wu, Wen- Liao
Summary: This study found that a high fiber diet and acetate supplementation can alter the gut microbiota and reduce the severity of hyperoxia-induced acute lung injury, demonstrating anti-inflammatory effects.
Article
Medicine, Research & Experimental
Liming Jia, Hongzhong Hao, Chunyu Wang, Jianfeng Wei
Summary: Etomidate within a certain dose range can reduce lung injury induced by high oxygen exposure in mice, enhance antioxidant and anti-inflammatory effects, and this protective mechanism may be associated with the upregulation of the Nrf2/HO-1 signaling pathway.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Multidisciplinary Sciences
Tian-jiao Song, Xiao-hong Lin, Ping-ting Huang, Yu-qing Chen, Li-min Chen
Summary: Lung cancer is a malignant tumor with high morbidity and mortality rates worldwide. The current chemotherapy for lung cancer is ineffective due to drug resistance. Tripchlorolide (T4), a natural extract, has been found to have immunosuppressive and antitumor effects, making it a potential therapeutic agent for lung cancer. This study investigated the effect of T4 on reducing chemoresistance in lung cancer cells and explored the underlying mechanism. The results showed that T4 can increase the sensitivity of lung cancer cells to cisplatin, a chemotherapy drug, by reducing the expression of AEG-1 protein.
SCIENTIFIC REPORTS
(2022)