期刊
AUTOPHAGY
卷 7, 期 7, 页码 786-787出版社
LANDES BIOSCIENCE
DOI: 10.4161/auto.7.7.15595
关键词
Crohn disease; inflammatory bowel disease; AIEC; microRNA; genome wide association; synonymous polymorphism
类别
Susceptibility to Crohn disease (CD), an inflammatory bowel disease, is influenced by common variants at many loci like the exonic synonymous IRGM SNP (rs10065172, NM_001145805.1, c.313C>T). We recently showed that miR-196 is overexpressed in the inflammatory intestinal epithelia of individuals with CD and downregulates the IRGM protective (c.313C) but not the risk-associated (c.313T) allele. Eventually, loss of IRGM/miRNA regulation compromises xenophagy. These results highlight a critical menage a trois in risk susceptibility combining IRGM allele, miRNA and xenophagy.
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