期刊
AUTOPHAGY
卷 7, 期 12, 页码 1570-1572出版社
LANDES BIOSCIENCE
DOI: 10.4161/auto.7.12.18001
关键词
Atg9; autophagy; lysosome; phagophore assembly site; tubulovesicular clusters; SNARE; vacuole
类别
资金
- NIGMS NIH HHS [R01 GM053396] Funding Source: Medline
We recently showed that phagophore biogenesis requires SNAREs. Our data indicate that the exocytic SNAREs Sso1/2 and Sec9 are required far one of the earliest steps in autophagosome biogenesis, the homotypic fusion of Atg9-containing vesicles. We propose that this step precedes the formation of Atg9-containing tubulovesicular clusters (TVCs) that is a key step in perivacuolar, phagophore assembly. We also found that the endosomal Q/t-SNARE Tlg2 and the R/v-SNAREs Sec22 and Ykt6 interact with Sso1-Sec9, and are required for normal Atg9 trafficking. Thus, autophagosome biogenesis appears to involve multiple SNARE-mediated fusion events. These findings provide novel insights into the mechanism of autophagosome construction.
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