期刊
AUTOPHAGY
卷 6, 期 1, 页码 158-159出版社
LANDES BIOSCIENCE
DOI: 10.4161/auto.6.1.10590
关键词
ClC-7; chloride transport; vesicular acidification; lysosomal storage; disease; autophagy
类别
Loss of the lysosomal chloride transport protein ClC-7 leads to complex phenotypes in mice and man, including osteopetrosis, accumulation of lysosomal storage material, and neurodegeneration. Using novel tissue-specific ClC-7 knockout mice, we have shown that upon loss of ClC-7, lysosomal degradation of endocytosed protein is slowed down and accumulation of autophagosomes occurs.
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