期刊
AUTOPHAGY
卷 5, 期 8, 页码 1224-+出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/auto.5.8.10219
关键词
autophagy; HCV; RNA; translation; infection; flaviviridae; autophagosome; ATG; virus
类别
Autophagy is a fundamental process for anti-viral defense. Not surprisingly, viruses have developed strategies to subvert or use autophagy for their own benefit. In cell culture, autophagy proteins are proviral factors that favor initiation of hepatitis C virus (HCV) infection. Autophagy proteins are required for translation of incoming viral RNA. We propose that autophagy factors might support the delivery of incoming RNA to the translation apparatus and/or the recruitment of cellular factors required to initiate HCV translation.
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