期刊
AUTOPHAGY
卷 5, 期 7, 页码 1060-1061出版社
LANDES BIOSCIENCE
DOI: 10.4161/auto.5.7.9728
关键词
neuronal death; necrosis; apoptosis; autophagic cell death; neuroprotection; cerebral ischemia
类别
Cell death due to cerebral ischemia has been attributed to necrosis and apoptosis, but autophagic mechanisms have recently been implicated as well. Using rats exposed to neonatal focal cerebral ischemia, we have shown that lysosomal and autophagic activities are increased in ischemic neurons, and have obtained strong neuroprotection by post-ischemic inhibition of autophagy.
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