Review
Cell Biology
Gandhi F. Pavon-Romero, Nancy Haydee Serrano-Perez, Lizbeth Garcia-Sanchez, Fernando Ramirez-Jimenez, Luis M. Teran
Summary: Asthma is characterized by chronic inflammation of the lower airways, with neurotransmitters and neuropeptides playing a role in the disease, exerting different effects. Regulating these effects may represent a potential novel approach for asthma treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Cristian Scheau, Carmen Draghici, Mihaela Adriana Ilie, Mihai Lupu, Iulia Solomon, Mircea Tampa, Simona Roxana Georgescu, Ana Caruntu, Carolina Constantin, Monica Neagu, Constantin Caruntu
Summary: Melanoma is an aggressive and fatal malignant tumor, with early diagnosis being curable but advanced stages having high mortality rates. Studies have focused on neuroendocrine factors' role in melanoma development, but there are still unknown features to uncover. Investigating how neuroendocrine factors influence melanoma's clinical course may lead to new biomedical research areas and therapeutic approaches.
Review
Endocrinology & Metabolism
Brittany M. Katz, Lindsay R. Walton, Kaiulani M. Houston, Domenic H. Cerri, Yen-Yu Ian Shih
Summary: Functional magnetic resonance imaging (fMRI) is used to monitor brain-wide activity. The relationship between neuronal and hemodynamic activity is now believed to be influenced by heterogeneous cell types and neurochemical signaling. The impact of neurochemical influences on hemodynamics in largely GABAergic brain regions like the caudate putamen (CPu) is relatively unknown. Understanding CPu hemodynamics could have broad impacts on fMRI studies. This review discusses neurochemical contributions to hemodynamics in the CPu and their origins from various cell types and circuits.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Review
Anatomy & Morphology
Witold Zakowski, Piotr Zawistowski
Summary: This paper aims to review the distribution of various substances in the mammillary body (MB) of rats and describe their possible physiological roles, in order to enhance understanding of the MB functions and its complex relations with other structures of the extended hippocampal system.
BRAIN STRUCTURE & FUNCTION
(2023)
Review
Immunology
Emilia Diaz, Anthony Febres, Michelle Giammarresi, Adrian Silva, Oriana Vanegas, Carlos Gomes, Alicia Ponte-Sucre
Summary: Detection and transduction of environmental signals are crucial for successful parasite invasion, and Leishmania uses diverse molecules for inter-cellular signaling. While G protein-coupled receptors (GPCRs) and their related transduction mechanisms play an important role in this process, canonical GPCR-related signal transduction systems have not been found in Leishmania, although reduced versions have been identified in Trypanosomatidae. These inter-cellular communication systems are essential for the survival of multicellular and unicellular organisms.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Alexei Verkhratsky
Summary: Purines and pyrimidines are essential molecules for genetic code and bioenergetics. Through evolution, purines have been associated with damage-related extracellular signaling, while plants have developed a sophisticated purinergic signaling system. In vertebrates, the purinergic signaling system operates universally without anatomical or functional segregation.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Neurosciences
Yu WeiWei, Fei WenDi, Cui Mengru, Yang Tuo, Gang Chen
Summary: The rostral ventromedial medulla (RVM) plays a crucial role in chronic pain, but its specific role remains unclear, presenting challenges for drug development targeting this area.
REVIEWS IN THE NEUROSCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Lian Hollander-Cohen, Matan Golan, Berta Levavi-Sivan
Summary: The research findings demonstrate significant differences in the regulation of gonadotropin cells among different vertebrate classes, with fish and birds using a mono-hormonal strategy suggesting a potential convergent evolution. Through comparison of novel transcriptome data, unique GPCR signaling regulating metabolic and homeostatic hormones and shared genes among different species controlling gonadotropins were revealed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Shrouk Mohamed Ali, Eman Kolieb, Samar Imbaby, Abeer M. Hagras, Horeya Erfan Korayem Arafat, Eman Mohamed Kamel, Mohamed A. Abdelshakour, Maha Ismail Mohammed Ali
Summary: The study aims to determine the acute toxicity effects of MDMB-4en-PINACA compounds on behavior, neurochemistry, histopathology, and immunohistochemistry. The results showed impaired motor skills and coordination, decreased spatial learning and memory, and a dose-dependent decrease in neurotransmitter concentrations after injection of MDMB-4en-PINACA. Histopathological examination revealed degeneration of small pyramidal cells in the cerebral cortex and hippocampus. This study highlights the cognitive risk associated with synthetic cannabinoid abuse.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Review
Immunology
Ying Cao, Hongjie Chen, Jing Yang
Summary: Decades of research have demonstrated the presence of neural innervations in primary and secondary lymphoid organs, which release neurotransmitters and neuropeptides to directly modulate immune cells. Recent studies using advanced imaging techniques have clarified the neural distribution patterns in rodents and humans. It has been found that neural innervations in lymphoid organs are not static and undergo changes in pathophysiological conditions. This review aims to update the current knowledge on the neuroanatomy of lymphoid organs, focusing on anatomical features that can modulate immune responses, and identifies important questions for future research.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Behavioral Sciences
Yonatan M. Kupchik, Asheeta A. Prasad
Summary: The ventral pallidum plays a crucial role in drug seeking and relapse, with complex neurobiology involving neural anatomical subregions, cellular heterogeneity, circuitry, neurotransmitters, and peptides. Targeting the VP can reduce relapse rates and alleviate addiction symptoms.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Pharmacology & Pharmacy
Valentina Bordano, Gemma K. Kinsella, Stefania Cannito, Chiara Dianzani, Casimiro Luca Gigliotti, John C. Stephens, Chiara Monge, Claudia Bocca, Arianna C. Rosa, Gianluca Miglio, Umberto Dianzani, John B. C. Findlay, Elisa Benetti
Summary: This study evaluated the role of GPR21 in human macrophages, finding its involvement in cell migration and cytokine release, and the inhibition of its activity by the drug GRA2. GRA2 reduced the release of inflammatory cytokines from M1 macrophages and promoted the migration of M2 macrophages. Thus, pharmacological inhibition of GPR21 may be important in pathological conditions characterized by low-grade chronic inflammation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Neurosciences
Khushboo, Nikhat J. Siddiqi, Maria de Lourdes Pereira, Bechan Sharma
Summary: This review provides an overview of the structural changes in the brain during depression, different neurobiological theories and novel drug development, the strategy of augmentation with combinatorial therapy, receptors and targets of actions of antidepressants, and the involvement of key signaling factors in the regulation of depression, pharmacology, metabolism, and the underlying principles involved in displaying how the application of antidepressants modulates the structure and function of the brain.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Md Shadman Ridwan Abid, Somayeh Mousavi, James W. Checco
Summary: Identifying receptors for bioactive peptides is complex due to the dynamic biosynthetic pathways, interactions with multiple receptor protein families, and complex ligand-receptor interactions. Recent methodological advances have focused on transcript expression, high throughput screening, and direct ligand-receptor interaction using chemical probes to identify signaling partners for bioactive peptides.
ACS CHEMICAL BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Davia Prischich, Alexandre M. J. Gomila, Santiago Milla-Navarro, Gemma Sanguesa, Rebeca Diez-Alarcia, Beatrice Preda, Carlo Matera, Montserrat Batlle, Laura Ramirez, Ernest Giralt, Jordi Hernando, Eduard Guasch, J. Javier Meana, Pedro de la Villa, Pau Gorostiza
Summary: The paper introduces a first generation of photochromic ligands that can modulate physiological processes by manipulating adrenergic neurotransmission, demonstrating their control effects in zebrafish and mice.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Physiology
C. H. V. Hoyle, J. J. Pintor
Article
Endocrinology & Metabolism
Catharina Olsson, Joanna D. Holbrook, Giulia Bompadre, Elisabeth Jonsson, Charles H. V. Hoyle, Gareth J. Sanger, Susanne Hohngren, Paul L. R. Andrews
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2008)
Article
Gastroenterology & Hepatology
C. H. V. Hoyle, M. J. Saffrey
NEUROGASTROENTEROLOGY AND MOTILITY
(2012)
Article
Biochemistry & Molecular Biology
Fernando Huete, Ana Guzman-Aranguez, Javier Ortin, Charles H. V. Hoyle, Jesus Pintor
PURINERGIC SIGNALLING
(2011)
Article
Clinical Neurology
Ayrat U. Ziganshin, Adel E. Khairullin, Alexander Y. Teplov, Azat I. Gabdrakhmanov, Liliya E. Ziganshina, Charles H. V. Hoyle, Bulat A. Ziganshin, Sergey N. Grishin
Review
Biochemistry & Molecular Biology
Ayrat U. Ziganshin, Adel E. Khairullin, Charles H. Hoyle, Sergey N. Grishin
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Ophthalmology
Ana Guzman-Aranguez, Almudena Crooke, Assumpta Peral, Charles H. V. Hoyle, Jesus Pintor
PROGRESS IN RETINAL AND EYE RESEARCH
(2007)
Article
Pharmacology & Pharmacy
Charles H. V. Hoyle, Assumpta Peral, Jesus Pintor
EUROPEAN JOURNAL OF PHARMACOLOGY
(2006)
Article
Obstetrics & Gynecology
AU Ziganshin, JT Zefirova, TP Zefirova, LE Ziganshina, CHV Hoyle, G Burnstock
OBSTETRICS AND GYNECOLOGY
(2005)
Article
Neurosciences
CHV Hoyle
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
(2005)
Article
Pharmacology & Pharmacy
S Iram, CHV Hoyle
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2005)
Article
Endocrinology & Metabolism
CHV Hoyle, J Hill, GJ Sanger, PLR Andrews
REGULATORY PEPTIDES
(2003)
Article
Chemistry, Medicinal
J Pintor, A Peral, T Peláez, G Carracedo, A Bautista, CHV Hoyle
DRUG DEVELOPMENT RESEARCH
(2003)
Article
Pharmacology & Pharmacy
J Pintor, T Peláez, CHV Hoyle, A Peral
BRITISH JOURNAL OF PHARMACOLOGY
(2003)