Article
Pharmacology & Pharmacy
Stewart Ramsay, Lauren Keightley, Simon Brookes, Vladimir Zagorodnyuk
Summary: The study aims to determine the efficacy of combination of TRPV1 and TRPM8 channel inhibition in reducing the pain associated with experimental cystitis. The results demonstrate that the combination of TRPV1 and TRPM8 antagonists can alleviate the pain caused by bladder hypersensitivity.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemical Research Methods
Alireza Poshtkohi, John Wade, Liam McDaid, Junxiu Liu, Mark Dallas, Angela Bithell
Summary: This research establishes a new mathematical model for investigating P2X-mediated calcium and sodium signaling in human microglial cells. The study reveals that the way P2X receptors regulate ion concentrations is crucial for microglial cell function, providing quantitative insights for future experimental research.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Claudia Garcia-Rodriguez, Ivan D. Bravo-Tobar, Yorley Duarte, Luis C. Barrio, Juan C. Saez
Summary: Overcoming refractory epilepsy's resistance to medication, reducing side effects, and preventing sudden unexpected death are crucial therapeutic goals. This review emphasizes the involvement of non-selective membrane channels and receptors in epilepsy, highlighting their activation and contribution to seizure intensity.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Stephanie Chadet, Jordan Allard, Lucie Brisson, Osbaldo Lopez-Charcas, Roxane Lemoine, Audrey Heraud, Stephanie Lerondel, Roseline Guibon, Gaelle Fromont, Alain Le Pape, Denis Angoulvant, Lin-Hua Jiang, Ruth Murrell-Lagnado, Sebastien Roger
Summary: The P2X4 purinergic receptor is upregulated in breast cancer patients and primarily localised in endolysosomes. It promotes breast cancer invasion, tumour growth, and metastasis by regulating lysosome acidity, promoting autophagy and cell survival. It is also associated with epithelial-to-mesenchymal transition and plays a more significant role under metabolic challenges.
Article
Biology
Danko Nikolic
Summary: The most important question in brain research is how the brain gives rise to the mind. The traditional connectionist paradigm suggests that knowledge and thinking skills are stored in connections, while the new paradigm proposes that they are stored in metabotropic receptors (MRs) and G protein-gated ion channels (GPGICs). Mental operations are executed by the functions of MRs and GPGICs, which temporarily re-route neural activity within the nervous system. This new paradigm argues that the mind emerges from the interplay of MRs and GPGICs, solving the intelligence scaling problem faced by the connectionist paradigm.
COMPUTATIONAL BIOLOGY AND CHEMISTRY
(2023)
Article
Physiology
Sadao Ohyama, Takehito Ouchi, Maki Kimura, Ryuya Kurashima, Keiko Yasumatsu, Daisuke Nishida, Suzuro Hitomi, Sobhan Ubaidus, Hidetaka Kuroda, Shinichirou Ito, Masayuki Takano, Kentaro Ono, Toshihide Mizoguchi, Akira Katakura, Yoshiyuki Shibukawa
Summary: Recent evidence suggests that dentinal pain or sensitivity is caused by dentinal fluid movement, which activates mechanosensitive TRP/Piezo channels in odontoblasts. The communication between odontoblasts and neurons mediated by the Piezo1/TRPA1-pannexin-1-P2X(3) receptor axis is crucial for the development of dentinal pain.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Physiology
Stewart Christie, Vladimir Zagorodnyuk
Summary: This study demonstrates the selective inhibitory effect of CB2 receptor agonists on capsaicin-sensitive mucosal bladder afferents, with no impact on muscular-mucosal afferents. This finding may have implications for understanding the role of endocannabinoids in modulating bladder function and sensation in health and diseases.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hyung-Il Kim, Jae-Chul Lee, Dae Won Kim, Myoung Cheol Shin, Jun Hwi Cho, Ji Hyeon Ahn, Soon-Sung Lim, Il Jun Kang, Joon Ha Park, Moo-Ho Won, Tae-Kyeong Lee
Summary: In this study, the neuroprotective effect of oxcarbazepine (OXC) against ischemic injury induced by transient forebrain ischemia was investigated in gerbils. The results showed that post-ischemic treatment with OXC significantly attenuated hyperactivity and cognitive impairment, as well as increased TRPV1 expression in the CA1 region of the hippocampus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Zili Xie, Jing Feng, Timothy J. Hibberd, Bao Nan Chen, Yonghui Zhao, Kaikai Zang, Xueming Hu, Xingliang Yang, Lvyi Chen, Simon J. Brookes, Nick J. Spencer, Hongzhen Hu
Summary: By ablating the sensory channels TRPV1 and Piezo2 from colon-innervating neurons, the visceromotor responses (VMR) induced by colorectal distention (CRD) are significantly reduced in mice. Selective ablation of Piezo2 channels in TRPV1 lineage neurons reduces mechanically evoked visceral afferent action potential firing and CRD-induced VMR under physiological conditions, as well as in mouse models of zymosan-induced IBS and partial colon obstruction (PCO). These findings demonstrate the important role of the mechanosensitive Piezo2 channels in TRPV1-lineage neurons in visceral mechanosensitivity and nociception under physiological conditions, as well as in visceral hypersensitivity under pathological conditions.
Review
Pharmacology & Pharmacy
Jianxiong Jiang, Ying Yu
Summary: Epilepsy is a prevalent and disabling brain disorder characterized by spontaneous seizures. The current medications for epilepsy are not effective for over 30% of patients and have significant adverse effects. Identifying novel drug targets, such as TRP channels, can lead to new therapies for epilepsy.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Chemistry, Medicinal
Hiroyuki Kai, Tohru Horiguchi, Takayuki Kameyama, Kentaro Asahi, Takeshi Endoh, Sae Jikihara, Tsuyoshi Hasegawa, Satoru Tanaka, Azusa Nozu, Chie Takeyama, Maki Tomari, Fumiyo Takahashi, Naomi Tamura, Shigenori Yagi, Tetsuji Itoh, Yasuyoshi Isou
Summary: The study identified a lead compound with moderate inhibitory effect on P2X(3) receptors through reevaluation of HTS evaluation compounds, leading to the development of a potent compound with strong analgesic effect against neuropathic pain.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Review
Anesthesiology
Brian M. Ilfeld, James C. Eisenach, Rodney A. Gabriel
Summary: The study demonstrates that overexpressing a nonconducting TRPC6 channel can partially ameliorate the imbalance of calcium and sodium in muscle caused by RYR1 variants, prolonging survival time during halothane exposure, but is not sufficient to prevent the lethal effects of exposure to volatile anesthetic malignant hyperthermia-triggering agents.
Review
Neurosciences
D. Fernandez-Fernandez, J. A. Lamas
Summary: Potassium channels play a crucial role in neuronal excitability by regulating the resting membrane potential and influencing both long-term potentiation and short-term plasticity. Metabotropic receptors link neurotransmitter actions to modulation of potassium channels, impacting synaptic plasticity induction and maintenance.
Review
Pharmacology & Pharmacy
Huilong Luo, Xavier Decleves, Salvatore Cisternino
Summary: The gliovascular unit consists of brain microvascular endothelial cells, mural cells, and astrocytes, whose features can be affected by various diseases disrupting brain homeostasis. Ca2+ dynamics play a significant role in determining BBB/GVU properties, with TRPV channels regulating calcium levels being important factors. Further studies are needed to understand the roles of TRPV channels in different cell types and the potential therapeutic benefits in treating brain diseases.
Review
Medicine, Research & Experimental
Fangyan Hu, Xiaohua Song, Dingxin Long
Summary: Calcium is a crucial signaling molecule in all cells, with TRPA1 being a potential target for treating sensory disorders such as pain and pruritus. TRPA1 is the only identified member of the ankyrin subfamily in mammals and has high permeability to calcium ions.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Neurosciences
Li Dong, Xizi Liang, Biying Sun, Xiaowei Ding, Hongxiu Han, Weifang Rong, Guohua Zhang
Article
Neurosciences
Katalin Rozmer, Po Gao, Michelle G. L. Araujo, Muhammad Tahir Khan, Juan Liu, Weifang Rong, Yong Tang, Heike Franke, Ute Kruegel, Maria Jose S. Fernandes, Peter Illes
Article
Neurosciences
Mei Yang, Juan Wang, Chunxue Yang, Hongxiu Han, Weifang Rong, Guohua Zhang
Article
Neurosciences
Po Gao, Xiaowei Ding, Tahir Muhammad Khan, Weifang Rong, Heike Franke, Peter Illes
Article
Multidisciplinary Sciences
Youqiang Meng, Li Dong, Biying Sun, Ping Luo, Guohua Zhang, Weifang Rong
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2017)
Correction
Multidisciplinary Sciences
Yan Wang, Yingwei Gao, Quan Tian, Qi Deng, Yangbo Wang, Tian Zhou, Qiang Liu, Kaidi Mei, Yingping Wang, Huiqing Liu, Ruining Ma, Yuqiang Ding, Weifang Rong, Jinke Cheng, Jing Yao, Tian-Le Xu, Michael X. Zhu, Yong Li
NATURE COMMUNICATIONS
(2018)
Article
Multidisciplinary Sciences
Yan Wang, Yingwei Gao, Quan Tian, Qi Deng, Yangbo Wang, Tian Zhou, Qiang Liu, Kaidi Mei, Yingping Wang, Huiqing Liu, Ruining Ma, Yuqiang Ding, Weifang Rong, Jinke Cheng, Jing Yao, Tian-Le Xu, Michael X. Zhu, Yong Li
NATURE COMMUNICATIONS
(2018)
Article
Biochemistry & Molecular Biology
Ping Luo, Jiayun Shao, Yingfu Jiao, Weifeng Yu, Weifang Rong
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2018)
Article
Neurosciences
Yingwei Wu, Yingping Wang, Juan Wang, Qi Fan, Jinyu Zhu, Liu Yang, Weifang Rong
Article
Biochemistry & Molecular Biology
Max W. G. Roberts, Guiping Sui, Rui Wu, Weifang Rong, Scott Wildman, Bruce Montgomery, Ahmed Ali, Steve Langley, Michael R. Ruggieri, Changhao Wu
Article
Neurosciences
Xiaowei Ding, Ting Gao, Po Gao, Youqiang Meng, Yi Zheng, Li Dong, Ping Luo, Guohua Zhang, Xueyin Shi, Weifang Rong
FRONTIERS IN NEUROSCIENCE
(2019)
Article
Neurosciences
Lijie Jia, Jianwei Wang, Huimin Cao, Xiaoyu Zhang, Weifang Rong, Zifeng Xu
Review
Neurosciences
Yanyuan Wu, Jun Qi, Changhao Wu, Weifang Rong
Summary: TRPV4 is a polymodal cation channel that plays a sensory role in the bladder and regulates bladder function. Altered TRPV4 expression in pathological bladder conditions suggests it may be a promising therapeutic target for bladder dysfunctions.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Neurosciences
Po Gao, Xiao-Wei Ding, Li Dong, Ping Luo, Guo-Hua Zhang, Wei-Fang Rong
CNS NEUROSCIENCE & THERAPEUTICS
(2017)
Article
Neurosciences
Hongxiu Han, Xizi Liang, Juan Wang, Qianqian Zhao, Mei Yang, Weifang Rong, Guohua Zhang