Article
Dentistry, Oral Surgery & Medicine
Peungchaleoy Thammanichanon, Aunwaya Kaewpitak, Thunwa Binlateh, Prasit Pavasant, Chidchanok Leethanakul
Summary: The study found that continuous orthodontic force significantly increased pain behaviors at 1 and 3 days, while NF-kappa B levels significantly increased from 12 hours to 3 days. TRPV1 significantly elevated within 1 day, TRPA1 increased from 1 to 3 days, and CGRP expression increased from 12 hours to 3 days. The activation of TRPV1 and TRPA1 sensitizes trigeminal neurons, leading to CGRP release.
ARCHIVES OF ORAL BIOLOGY
(2021)
Article
Immunology
Darine Fakih, Adrian Guerrero-Moreno, Christophe Baudouin, Annabelle Reaux-Le Goazigo, Stephane Melik Parsadaniantz
Summary: The study evaluated the effectiveness of TRPV1 blockade in alleviating ocular pain, neuroinflammation, and anxiety-like behaviors associated with severe DED. Results showed that TRPV1 antagonist reduced corneal responsiveness to various stimuli and inhibited the upregulation of genes involved in neuropathic and inflammatory pain in the TG, leading to reduced ocular pain sensation and anxiety-like behaviors in severe DED.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Ophthalmology
Haihan Jiao, Jason J. Ivanusic, Paul G. McMenamin, Holly R. Chinnery
Summary: The study found that following corneal injury, TRPV1(+) nerves accounted for a higher proportion of corneal nerves. The close interactions of TRPV1(+) nerves with intraepithelial immune cells, and the expression of TRPV1 by stromal macrophages, provide important insights into neuroimmune interactions in the cornea.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Review
Medicine, Research & Experimental
Akhilesh, Ankit Uniyal, Anagha Gadepalli, Vineeta Tiwari, Meghana Allani, Deepak Chouhan, Obulapathi Ummadisetty, Nimisha Verma, Vinod Tiwari
Summary: Chemotherapy-induced neuropathic pain (CINP) is a common clinical complication associated with anti-cancer drugs, affecting nearly 68.1% of cancer patients undergoing chemotherapy. The involvement of TRPV1 in CINP signaling suggests that targeting this nociceptor with siRNA may provide effective therapeutic interventions for managing CINP.
Article
Pharmacology & Pharmacy
Rafael Gonzalez-Cano, Angeles Montilla-Garcia, Gloria Perazzoli, Jesus M. Torres, Francisco J. Canizares, Eduardo Fernandez-Segura, Michael Costigan, Jose M. Baeyens, Enrique J. Cobos
Summary: Both TRPA1 and purinergic P2X receptors are proposed as potential targets for the treatment of visceral pain. While a low dose of mustard oil induces visceral pain dependent on TRPA1, a higher dose results in pain mostly independent of TRPA1 but enhanced by ATP released from damaged tissues. Thus, TRPA1 inhibition may not be sufficient to decrease visceral pain significantly during tissue injury, and purinergic antagonism appears to be a more effective strategy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Hai Zhu, Yi Wang, Yibo He, Weifeng Yu
Summary: This study investigated the inflammation-mediated macrophage polarization and TRPV1/TRPA1 heteromers in endometriosis. The results showed that CD86 and CD206 positive macrophages accompanied TRPV1/TRPA1 heteromers in endometriosis tissues of patients with pain. Inflammatory factors in peritoneal lavage fluid and serum were correlated with TRPV1/TRPA1 expression in endometriosis tissues as well as macrophage polarization. Moreover, macrophage polarization induced ectopic endometrial cells migration with the increase in TRPV1/TRPA1 heteromers.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Neurosciences
Xin Luo, Ouyang Chen, Zilong Wang, Sangsu Bang, Jasmine Ji, Sang Hoon Lee, Yul Huh, Kenta Furutani, Qianru He, Xueshu Tao, Mei-Chuan Ko, Andrey Bortsov, Christopher R. Donnelly, Yong Chen, Andrea Nackley, Temugin Berta, Ru-Rong Ji
Summary: The IL-23/IL-17A/TRPV1 axis regulates female-specific mechanical pain, with IL-23 inducing pain in females but impaired in mice lacking IL-23 or IL-23r. IL-23-induced pain is promoted by estrogen and suppressed by androgen.
Review
Biochemistry & Molecular Biology
Mee-Ra Rhyu, Yiseul Kim, Vijay Lyall
Summary: Chemesthesis plays a central role in food consumption, with plant-derived molecules affecting taste qualities through TRPA1 and TRPV1 channels. Agonists of TRPA1 and TRPV1 can influence bitter, sour, and salt taste qualities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Chenyu Yang, Shanni Yamaki, Tyler Jung, Brian Kim, Ryan Huyhn, David D. McKemy
Summary: The detection of environmental temperatures is crucial for survival and inappropriate responses to thermal stimuli can negatively affect overall health. The physiological effect of cold is distinct and can be soothing and analgesic, but also agonizing in the context of tissue damage. Inflammatory mediators induce neurogenic inflammation that alters cold sensitivity through the activation of TRPV1 and TRPA1 ion channels.
JOURNAL OF NEUROSCIENCE
(2023)
Review
Allergy
Jean Bousquet, Wienczyslawa Czarlewski, Torsten Zuberbier, Joaquim Mullol, Hubert Blain, Jean-Paul Cristol, Rafael De la Torre, Nieves Pizarro Lozano, Vincent Le Moing, Anna Bedbrook, Ioana Agache, Cezmi A. Akdis, G. Walter Canonica, Alvaro A. Cruz, Alessandro Fiocchi, Joao A. Fonseca, Susana Fonseca, Bilun Gemicioglu, Tari Haahtela, Guido Iaccarino, Juan Carlos Ivancevich, Marek Jutel, Ludger Klimek, Helga Kraxner, Piotr Kuna, Desiree E. Larenas-Linnemann, Adrian Martineau, Erik Melen, Yoshitaka Okamoto, Nikolaos G. Papadopoulos, Oliver Pfaar, Frederico S. Regateiro, Jacques Reynes, Yves Rolland, Philip W. Rouadi, Boleslaw Samolinski, Aziz Sheikh, Sanna Toppila-Salmi, Arunas Valiulis, Hak-Jong Choi, Hyun Ju Kim, Josep M. Anto
Summary: This article suggests that differences in COVID-19 morbidity may be associated with TRPA1 and TRPV1 activation and desensitization, potentially leading to inflammation and various symptoms. Interactions between Nrf2-associated nutrients and TRPA1/TRPV1 may affect the severity of COVID-19 symptoms.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
S. Wang, X. Nie, Y. Siddiqui, X. Wang, V. Arora, X. Fan, V. Thumbigere-Math, M. K. Chung
Summary: Periodontitis is a chronic inflammatory disease that destroys the structures supporting teeth, causing tooth loss. The role of nociceptive nerves in periodontitis and bone destruction is controversial, but it has been found that TRPV1-expressing afferents can promote bone loss in patients with periodontitis.
JOURNAL OF DENTAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Michelle D. Bagood, R. Rivkah Isseroff
Summary: The study focuses on the role of TRPV1 in skin tissue and its potential value in treating non-healing wounds, providing important insights for future therapies to improve wound healing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Caryl Evans, Kathryn Howells, Rie Suzuki, Alastair J. H. Brown, Helen M. Cox
Summary: This study investigated the effects of capsaicin and allyl isothiocyanate on the gastrointestinal tract. It was found that they activate TRPV1 and TRPA1, leading to ion secretion and transport in the GI mucosa. The results also showed that TRPV1 signaling is regulated by submucosal neurons and epithelial NK1 receptor activation, while TRPA1 signaling is regulated by endogenous prostaglandins and EP4 receptor activation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Sabrina Qader Kudsi, Bruna Candia Piccoli, Daniel Ardisson-Araujo, Gabriela Trevisan
Summary: This article aims to analyze the baseline distribution of TRPA1, TRPV1, TRPV4, and TRPM8 channels in human systems at the transcriptional level. Using the RNA-seq dataset, the transcriptional levels of these channels were investigated and compared in 95 human subjects representing 33 different tissues, providing essential suggestions for further studies on these proteins.
Article
Cardiac & Cardiovascular Systems
Kimberley J. Holt, John Belcher, Jaclyn A. Smith
Summary: Through capsaicin cough challenges, the novel endpoints Emax and ED50 were found to effectively discriminate between healthy controls and refractory chronic cough patients, showing potential as a tool to identify patients with cough hyper-excitability.
RESPIRATORY MEDICINE
(2023)