期刊
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
卷 145, 期 1-2, 页码 50-54出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.autneu.2008.11.004
关键词
Spleen; Rat; Athymic nude mice; Nerve; Human cancer; In vivo; Tumor inhibition
The spleen is an important organ for tumor immunity, and the splenic sympathetic nerve has a suppressive effect on splenic natural killer (NK) cytotoxicity. On the basis of this and reports that Lentinus edodes (Shiitake mushroom) has tumor-inhibitory effects, the authors hypothesized that an extract of a mycelial culture of L. edodes grown in a solid medium of sugar-cane bagasse and defatted rice bran-LE-M-might affect the sympathetic splenic sympathetic nerve activity (Splenic-SNA) and thus inhibit tumor proliferation. Thus, the effect of LE-M on Splenic-SNA and human cancer cell proliferation was examined. Splenic-SNA was found to be suppressed by an intraduodenal LE-M injection in urethane-anesthetized rats, which significantly inhibited increases in the tumor volume of human colon and breast cancer cells implanted in athymic nude mice. These findings suggest that LE-M has an inhibitory effect on tumor proliferation possibly via a reduction in NK cytotoxicity through the suppression of Splenic-SNA. (c) 2008 Elsevier B.V. All rights reserved.
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