Article
Biology
Helene De Bruyn, Nikky Corthout, Sebastian Munck, Wouter Everaerts, Thomas Voets
Summary: Understanding the lower urinary tract (LUT) is crucial for developing novel therapies for LUT disorders. We developed a videocystometry technique to accurately monitor the LUT in rodents, but it had limitations in awake and freely moving animals. To overcome this, we used machine learning to automatically analyze bladder filling and voiding cycles in behaving mice. Our findings revealed the effects of anesthesia on urethral relaxation and voiding duration, as well as the decreased bladder capacity after surgical implantation of a catheter. This approach provides a paradigm for noninvasive, in vivo monitoring of hollow organs in behaving animals and highlights the limitations of current standard techniques for studying the LUT in mice.
Article
Endocrinology & Metabolism
Kai Yu, Andreas Ladefoged Ebbehoj, Hiba Obeid, Anand Vaidya, Tobias Else, Heather Wachtel, Ailsa Maria Main, Esben Sondergaard, Louise Lehmann Christensen, C. Christofer Juhlin, Jan Calissendorff, Debbie L. Cohen, Bonita Bennett, Marianne Skovsager Andersen, Catharina Larsson, Madson Q. Almeida, Lauren Fishbein, Stephen A. Boorjian, William F. Young, Irina Bancos
Summary: This study characterized the presentation and outcomes of patients diagnosed with urinary bladder paraganglioma (UBPGL). Only a small number of patients were diagnosed before biopsy/surgery, indicating the need for better diagnostic strategies. Lifelong monitoring for recurrence and metastases is recommended for all UBPGL patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Multidisciplinary Sciences
Kurenai Kinno, Noritoshi Sekido, Yasuharu Takeuchi, Yoshitomo Sawada, Shoutarou Watanabe, Yasukuni Yoshimura
Summary: The study found that patients with OAB compared to those without OAB had higher body mass index, more severe pelvic floor muscle impairment, and more pronounced defects in support of the uterine cervix.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Stewart Christie, Vladimir Zagorodnyuk
Summary: Bladder afferents exhibit a significant time-of-day dependent variation in mechano-sensitivity and chemosensitivity, potentially influencing urine voiding patterns. Further studies on bladder afferent activity across a 24 h period are warranted to reveal potential circadian rhythm modulation.
SCIENTIFIC REPORTS
(2021)
Article
Physiology
Thomas J. Heppner, Grant W. Hennig, Mark T. Nelson, Gerald M. Herrera
Summary: The rate at which the bladder fills has a significant impact on voiding function, with faster filling rates increasing afferent nerve activity and leading to more frequent but smaller voids.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2022)
Article
Urology & Nephrology
Hans Veerman, Aletta P. Houwink, Peter F. E. Schutte, Jakko A. Nieuwenhuijzen, Ton A. Roeleveld, Esther Wit, Jan Willem Mazel, Tim M. van der Sluis, Andre N. Vis, Pim J. van Leeuwen, Henk G. van der Poel
Summary: The study compared different treatment regimens for catheter-related bladder discomfort in patients following robot-assisted radical prostatectomy. The results showed that perivesical and periurethral injections with ropivacaine significantly reduced the incidence of catheter-related bladder discomfort.
JOURNAL OF UROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Natalia Zeber-Lubecka, Maria Kulecka, Katarzyna Zaleska-Oracka, Michalina Dabrowska, Aneta Balabas, Ewa E. Hennig, Magdalena Szymanek-Szwed, Michal Mikula, Beata Jurkiewicz, Jerzy Ostrowski
Summary: The aim of this study is to determine the molecular differences between the bladder body and trigonal urothelia. The analysis of transcriptomes and microbiomes revealed functional differences between the two regions and significant differences in bacterial taxa in urine.
Article
Physiology
Yu Lu, Jie Li, Li Dong, Ping Luo, Guohua Zhang, Weifang Rong
Summary: This study investigates the role of peripheral serotonin and its receptors in bladder physiology and pathology. The results suggest that the 5-HT4R expressed on uroepithelial cells plays an inhibitory role in bladder mechanosensory transduction. Loss of 5-HT4R-mediated inhibition may enhance bladder afferent sensitivity and exacerbate bladder overactivity in pathological conditions. Therefore, 5-HT4R agonists might be potential treatment options for overactive and painful bladder symptoms.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cell Biology
Long Ma, Jing-Yuan Tang, Jin-Yong Zhou, Chen Zhu, Xin Zhang, Ping Zhou, Qiu Yu, Yan Wang, Xiao-Jian Gu
Summary: This study found that fluoxetine reduced residual urine in the bladder and decreased bladder pressure in mice with moderate spinal cord injury, but did not improve micturition function in severe spinal cord injury mice. Other serotonergic drugs had no effects on the micturition functions of spinal cord injury model mice.
NEURAL REGENERATION RESEARCH
(2021)
Article
Physiology
Gustavo B. Lamy, Eduardo M. Cafarchio, Barbara do Vale, Bruno B. Antonio, Daniel P. Venancio, Janaina S. de Souza, Rui M. Maciel, Gisele Giannocco, Artur F. Silva Neto, Lila M. Oyama, Patrik Aronsson, Monica A. Sato
Summary: This study found that Angiotensin-(1-7) has the ability to increase intravesical pressure in the urinary bladder, and the expression of related receptors and enzymes were detected in the bladder.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Urology & Nephrology
Logan C. Hubbard, Zhaoyue Shi, Ricardo R. Gonzalez, Khue Tran, Christof Karmonik, Yongchang Jang, Rose Khavari
Summary: This study investigates the brain activation patterns in men with BPH and BOO before and after outlet obstruction procedures, revealing important changes during the voiding process. The findings contribute to our understanding of neuroplasticity secondary to BPH and BOO.
Review
Biochemistry & Molecular Biology
Ozer Ural Cakici, Sibel Dincer
Summary: This paper reviews the physiological mechanisms involved in the cycle of filling, storing, and micturating in the human bladder, emphasizing the importance of muscle relaxation and bladder wall structure, as well as the synchronous functioning of the bladder outlet. The effects of amino acids on clinical conditions affecting the bladder are examined, with a focus on available therapeutic evidence and potential future roles of amino acids in treating bladder-related disorders.
Article
Chemistry, Medicinal
Wei-Yi Wu, Shih-Pin Lee, Bing-Juin Chiang, Wei-Yu Lin, Chiang-Ting Chien
Summary: The study confirmed that urothelial CaSR can regulate micturition function, with experiments demonstrating the effects of CaSR agonists and antagonists on bladder smooth muscle activity. Intravesical administration of AC inhibited micturition reflex, bladder nerve activities, and reversed bladder hyperactivity, indicating the chemosensory function of urothelial CaSR. Therefore, the study provided further evidence that urothelial CaSR could modulate micturition reflex and be a potential pharmacotherapeutic target for bladder disorders.
Article
Ophthalmology
Li Huang, Limei Sun, Xiaoyu Li, Songshan Li, Ting Zhang, Zhaotian Zhang, Xiaoyan Ding
Summary: Female carriers of NDP mutations exhibited clinical features of familial exudative vitreoretinopathy (FEVR), with 8.3% experiencing decreased visual acuity and 91.7% being asymptomatic. Fundus fluorescein angiography (FFA) revealed peripheral vascular changes in 75.0% of the carriers.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Andrology
Mina P. Ghatas, Linda S. Burkett, Gabrielle Grob, Peter T. Daniels, Lynn Stothers, Helen E. Query, Michael K. Shields, John E. Speich, Adam P. Klausner
Summary: This study used fNIRS to investigate cortical changes during bladder filling, providing a methodological template for further research and treatment of lower urinary tract symptoms, including OAB.
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2023)
Article
Neurosciences
Mattia Chini, Sabine Gretenkord, Johanna K. Kostka, Jastyn A. Popplau, Laura Cornelissen, Charles B. Berde, Ileana L. Hanganu-Opatz, Sebastian H. Bitzenhofer
FRONTIERS IN NEURAL CIRCUITS
(2019)
Article
Anesthesiology
Ioannis Pappas, Laura Cornelissen, David K. Menon, Charles B. Berde, Emmanuel A. Stamatakis
Editorial Material
Obstetrics & Gynecology
Omri David Soffer, Laura Cornelissen, Christy Cummings, Charles Berde
JOURNAL OF PERINATOLOGY
(2019)
Article
Medicine, General & Internal
J. Kim, C. Hu, C. Moufawad El Achkar, L. E. Black, J. Douville, A. Larson, M. K. Pendergast, S. F. Goldkind, E. A. Lee, A. Kuniholm, A. Soucy, J. Vaze, N. R. Belur, K. Fredriksen, I. Stojkovska, A. Tsytsykova, M. Armant, R. L. DiDonato, J. Choi, L. Cornelissen, L. M. Pereira, E. F. Augustine, C. A. Genetti, K. Dies, B. Barton, L. Williams, B. D. Goodlett, B. L. Riley, A. Pasternak, E. R. Berry, K. A. Pflock, S. Chu, C. Reed, K. Tyndall, P. B. Agrawal, A. H. Beggs, P. E. Grant, D. K. Urion, R. O. Snyder, S. E. Waisbren, A. Poduri, P. J. Park, A. Patterson, A. Biffi, J. R. Mazzulli, O. Bodamer, C. B. Berde, T. W. Yu
NEW ENGLAND JOURNAL OF MEDICINE
(2019)
Article
Multidisciplinary Sciences
Uday Agrawal, Charles B. Berde, Laura Cornelissen
Review
Anesthesiology
Steven P. Brandt, Elisa C. Walsh, Laura Cornelissen, Johanna M. Lee, Charles Berde, Erik S. Shank, Patrick L. Purdon
ANESTHESIA AND ANALGESIA
(2020)
Article
Pediatrics
Omri David Soffer, Angela Kim, Ellen Underwood, Anne Hansen, Laura Cornelissen, Charles Berde
FRONTIERS IN PEDIATRICS
(2020)
Article
Anesthesiology
Perri R. Tutelman, Christine T. Chambers, Laura Cornelissen, Conrad Fernandez, Annette Flanders, Julia MacLeod, Simon B. Sherry, Sherry H. Stewart, Robin Urquhart, Sitara de Gagne, Gregory M. T. Guilcher, Javeria Hashmi, Lauren C. Heathcote, Melanie Noel, Fiona S. M. Schulte, Jennifer N. Stinson, Maya Stern
Summary: Cancer and its treatment have long-term consequences on pain and sensory processing in survivors of childhood cancer. This study utilized a standardized quantitative sensory testing protocol to quantify the differences in pain and sensory processing in survivors compared to reference data. The results showed that survivors exhibited reduced sensitivity and a significant minority experienced pain sensitization. Several risk factors for changes in sensory processing were identified. Further research is needed to understand the long-term implications of altered somatosensation in this population.
Article
Clinical Neurology
Laura Cornelissen, Carolina Donado, Timothy W. Yu, Charles B. Berde
Summary: This article discusses the application of gene-targeting therapies, such as antisense oligonucleotides and viral vector-based gene therapy, in the treatment of neurological disorders. It introduces the use of quantitative sensory testing (QST) for detecting sensory dysfunction and presents individualized testing protocols. Through three case studies, the article highlights the limitations and challenges of QST in non-verbal subjects, and calls for collaborative efforts and data sharing in the field of pediatric neurology.
FRONTIERS IN NEUROLOGY
(2022)
Article
Anesthesiology
Adela Desowska, Charles B. Berde, Laura Cornelissen
Summary: This study reanalyzed EEG data from children undergoing sevoflurane general anesthesia and found that functional connectivity is reduced in anesthesia compared to wakefulness in delta band. Network density and node degree were lower in anesthesia, while modularity was higher. These effects decrease with age.
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Article
Clinical Neurology
Elena Madan, Sabrina Carri, Carolina Donado, Kimberly Lobo, Michelle Souris, Regina Laine, Elizabeth Beers, Laura Cornelissen, Basil T. Darras, Anjali Koka, Bobbie Riley, Pradeep Dinakar, Scellig Stone, Brian Snyder, Robert J. Graham, Horacio Padua, Navil Sethna, Charles Berde
Summary: This retrospective study aimed to evaluate the impact of spinal deformity and prior spinal fusion on lumbar puncture (LP) treatment for patients with spinal muscular atrophy (SMA), and propose a triage pathway for selective use of image guidance and nonstandard techniques. The study found that a stratified approach resulted in successful drug delivery and efficient resource allocation.
PEDIATRIC NEUROLOGY
(2022)
Article
Orthopedics
Nora O'Neill, Semhal Ghessese, Daniel Hedequist, Laura Lins, Craig Birch, M. Timothy Hresko, John Emans, Lawrence Karlin, Laura Cornelissen, Michael Glotzbecker
Summary: This study evaluated the presence, intensity, and duration of sensory changes in patients after posterior spinal fusion for adolescent idiopathic scoliosis. The results showed that sensory changes near the incision site can be detected within days after surgery, persisting at 1 month and improving at 6 months postoperatively. These sensory changes are likely transient.
JOURNAL OF PEDIATRIC ORTHOPAEDICS
(2023)
Article
Multidisciplinary Sciences
Laura Cornelissen, Ellen Underwood, Laurel J. Gabard-Durnam, Melissa Soto, Alice Tao, Kimberly Lobo, Takao K. Hensch, Charles B. Berde
Summary: This study aimed to investigate the tactile sensitivity and lower limb motor coordination in typically developing infants and develop feasible bedside sensory testing protocols. The results demonstrated that this brief sensory testing protocol can reliably measure tactile and nociceptive reactivity in infants, and age predicts nociceptive threshold. Prior hospital experience has a negligible global effect on sensory processing, indicating the resilience of the central nervous system in adverse environments.
Article
Anesthesiology
Luai Zakaria, Adela Desowska, Charles B. Berde, Laura Cornelissen
Summary: Sevoflurane-based anesthesia in pediatric patients is associated with specific delta-alpha phase-amplitude coupling, which is stronger during anesthesia than during emergence.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Anesthesiology
Ian Yuan, Jerry Y. Chao, C. Dean Kurth, Richard Missett, Laura Cornelissen
Summary: This review summarizes the literature on intraoperative electroencephalography (EEG) monitoring in pediatric anesthesia from 2017 to 2022. Recent findings include new developments in understanding EEG changes in the anesthetized and developing brain, emergence delirium, epileptiform activity, and EEG changes during spinal anesthesia. The review also covers the association between low voltage EEG and alpha frequency band changes, non-proprietary EEG to guide anesthetic dosing in young children, EEG-guided propofol anesthesia, and studies using EEG to improve clinical outcomes.
CURRENT ANESTHESIOLOGY REPORTS
(2023)