期刊
AUTOIMMUNITY REVIEWS
卷 13, 期 4-5, 页码 451-458出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.autrev.2014.01.010
关键词
IgG4; IgG4-related disease; Autoimmune pancreatitis; Mikulicz disease; Regulatory T cell (Treg)
类别
资金
- Ministry of Culture and Science of Japan [23591017]
- Ministry of Health, Labor and Welfare of Japan
- Grants-in-Aid for Scientific Research [23591017] Funding Source: KAKEN
Recent studies suggested the existence of two subtypes of autoimmune pancreatitis (Alp): type I related with IgG4 as the pancreatic manifestation of IgG4-related disease (IgG4-RD), and type 2 related with a granulocytic epithelial lesion. Apart from type 2 AIP, the characteristic features of type 1 AIP are increased serum IgG4 levels, lymphoplasmacytic sclerosing pancreatitis (abundant infiltration of IgG4+ plasmacytes and lymphocytes, storiform fibrosis, and obliterative phlebitis), extra-pancreatic manifestations of IgG4-RD (e.g. sclerosing cholangitis, sclerosing sialadenitis, retroperitoneal fibrosis), and steroid responsiveness. Although the way how to diagnose IgG4-RD has not been established yet, the Comprehensive Diagnostic Criteria (CDC) for IgG4-RD for general use, and several organ specific criteria for AIP have been proposed; the International Consensus Diagnostic Criteria (ICDC) and the revised clinical diagnostic criteria in 2011 by Japan Pancreas Society (JPS-2011) for type1 AIP. In cases of probable or possible IgG4-RD diagnosed by the CDC, organ specific diagnostic criteria should be concurrently used according to an algorithm of diagnosis for IgG4-RD with reference to the specialist. (C) 2014 Elsevier B.V. All rights reserved.
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