期刊
AUTOIMMUNITY REVIEWS
卷 7, 期 3, 页码 229-234出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.autrev.2007.11.013
关键词
neutrophil gelatinase-B associated lipocalin; NGAL; Lipocalin-2; systemic lupus erythematosus; lupus nephritis; biomarkers
类别
Lupus nephritis, a potentially devastating outcome of systemic lupus erythematosus (SLE), poses a real challenge in the management of SLE patients because of the difficulty in diagnosing its onset and identifying relapses before serious renal damage has ensued. Neutrophil gelatinase-B associated lipocalin (NGAL)/Lipocalin-2 has been implicated in the pathogenesis of several disease states in different organ systems, and especially in kidney diseases. Lipocalin-2 may play a protective role in the context of renal insults through the induction or prevention of apoptosis by an iron-transport dependent mechanism. Clinically, urinary Lipocalin-2 significantly correlates with measures of lupus nephritis disease activity, and may be an important and convenient marker for relapses. (C) 2007 Elsevier B.V. All rights reserved.
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