Article
Endocrinology & Metabolism
Taylor M. Triolo, Laura Pyle, Hali Broncucia, Taylor Armstrong, Liping Yu, Peter A. Gottlieb, Andrea K. Steck
Summary: Objective Electrochemiluminescence (ECL) assays are high-affinity autoantibody tests used for risk screening and prediction of type 1 diabetes progression. This study analyzed the association of high-risk HLA haplotypes and genotypes with ECL positivity in relatives of individuals with type 1 diabetes, showing that ECL-GADA and ECL-IAA positivity are associated with HLA-DR3 and HLA-DR4 haplotypes, respectively.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Immunology
Erin Strachan, Xavier Clemente-Casares, Sue Tsai
Summary: Maternal influences on the immune health and development of an infant begin in utero and continue after birth, shaping and educating the child's immune system. Two important provisions from the mother include early microbial colonizers and the transfer of antibodies. These provisions help educate the developing neonatal immune system, connecting with the microbiota and influencing disease development.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Yan Chen, Yuting Xie, Ying Xia, Zhiguo Xie, Gan Huang, Li Fan, Zhiguang Zhou, Xia Li
Summary: Investigated the frequency, clinical characteristics, and HLA genotypes of idiopathic type 1 diabetes (T1D), finding that idiopathic T1D represents approximately 1/4 of newly diagnosed T1D cases and is associated with older age, higher body mass index, lower HbA1c, higher fasting and postprandial C-peptide levels, and a higher likelihood of having a family history of type 2 diabetes. Additionally, adult-onset and preserved beta-cell function patients with idiopathic T1D show lower HLA susceptibility.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Endocrinology & Metabolism
Stephane Besancon, Denira Govender, Assa Traore Sidibe, Janelle Annette Noble, Amagara Togo, Julie Ann Lane, Steven John Mack, Mark A. Atkinson, Clive Henry Wasserfall, Faizy Kakkat, Gregory G. N. Martin, Graham David Ogle
Summary: This study investigated the characteristics of new diabetes cases in children and adolescents in Mali, finding that the majority were diagnosed with type 1 diabetes, but some cases may have atypical type 1 diabetes, ketosis-prone type 2 diabetes, or youth-onset type 2 diabetes. This study is important for the assessment and individual management of diabetes cases in Mali.
PEDIATRIC DIABETES
(2022)
Article
Endocrinology & Metabolism
Charanya Muralidharan, Abass M. Conteh, Michelle R. Marasco, Justin J. Crowder, Jeroen Kuipers, Pascal de Boer, Amelia K. Linnemann
Summary: The study provides evidence of impaired islet macroautophagy/crinophagy in human type 1 diabetes, as well as accumulation of telolysosomes with peripheral nitrogen in beta cells of autoantibody-positive donors, indicating altered lysosome content associated with lysosome dysfunction before clinical hyperglycemia. Similar macroautophagy impairments are also present in the NOD mouse model of type 1 diabetes.
Article
Multidisciplinary Sciences
Bum Chul Kwon, Vibha Anand, Peter Achenbach, Jessica L. Dunne, William Hagopian, Jianying Hu, Eileen Koski, Ake Lernmark, Markus Lundgren, Kenney Ng, Jorma Toppari, Riitta Veijola, Brigitte Frohnert
Summary: The development of islet autoimmunity in children with type 1 diabetes can be predicted, but the presence of autoantibodies does not always result in noticeable symptoms. Through long-term sampling and analysis of clinical characteristics, it was found that disease progression follows three distinct trajectories, with the ability to further predict disease onset based on age, sex, and HLA-DR status.
NATURE COMMUNICATIONS
(2022)
Review
Public, Environmental & Occupational Health
Jean Claude Katte, Timothy J. McDonald, Eugene Sobngwi, Angus G. Jones
Summary: The phenotype of type 1 diabetes in Africa, especially sub-Saharan Africa, is poorly understood. Previous studies have suggested differences in phenotype from the classical form of the disease described in western literature. Accurate diagnosis is challenging due to atypical diabetes forms and limited resources. The age of onset seems to be later in sub-Saharan Africa.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Immunology
Yikai Liu, Zhiying Chen, Junlin Qiu, Hongzhi Chen, Zhiguang Zhou
Summary: Our study revealed altered Tim-1 and IL-10 expression in regulatory B cells in T1D patients. Tim-1, as shown by the study, is associated with islet function and blood glucose levels, indicating that Tim-1(+) Bregs and IL-10(+) Bregs are involved in the pathogenesis of T1D.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Endocrinology & Metabolism
Michelle So, Cate Speake, Andrea K. Steck, Markus Lundgren, Peter G. Colman, Jerry P. Palmer, Kevan C. Herold, Carla J. Greenbaum
Summary: Islet autoantibodies are key markers for diagnosing type 1 diabetes and identifying at-risk individuals pre-symptomatically. Prediction of disease progression based on autoantibody count has been shown to be effective, but heterogeneous. Characteristics such as molecular specifics and sequence-dependent risk profiles have emerged as predictive features. Studying these features can improve trial design aimed at predicting and preventing disease.
Article
Endocrinology & Metabolism
Luc Marchand, Meihang Li, Coralie Leblicq, Ibrar Rafique, Tugba Alarcon-Martinez, Claire Lange, Laura Rendon, Emily Tam, Ariane Courville-Le Bouyonnec, Constantin Polychronakos
Summary: It is hypothesized that about 1% of clinically diagnosed type 1 diabetes patients actually have non-autoimmune monogenic diabetes. By testing low genetic risk for type 1 diabetes, a significant percentage of patients with actionable monogenic variants can be identified, even in the absence of an affected parent. This approach could help in selecting patients for further screening studies and potentially change therapeutic strategies.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Genetics & Heredity
Jana Sticht, Miguel Alvaro-Benito, Stefan Konigorski
Summary: Type 1 diabetes is an autoimmune disease with increasing incidence in high-income countries. Genetic and environmental factors play important roles in its pathogenesis. A comprehensive genetic association analysis of the HLA region can provide deeper insights into the etiology of the disease.
FRONTIERS IN GENETICS
(2021)
Article
Chemistry, Analytical
Jihong Wang, Junqi Zhao, Yawen Liu, Zhen Meng, Xiaoxia Han, Baofeng Xu, Rui Liu, Chengyan He, Ziyi Cheng, Bing Zhao
Summary: A SERS-based immunoassay was developed for the detection of two autoantibodies, GADA and IAA, related to type 1 diabetes mellitus. The method showed potential for rapid, sensitive, and high-throughput screening of T1DM.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Medicine, General & Internal
Teresa Quattrin, Lucy D. Mastrandrea, Lucy S. K. Walker
Summary: Type 1 diabetes is a chronic disease caused by autoimmune destruction of pancreatic beta cells, and individuals with this disease rely on insulin for survival. Despite advancements, the burden of this disease remains high. Research shows that blocking the immune attack on beta cells holds promise in preserving endogenous insulin production.
Article
Endocrinology & Metabolism
Kenney Ng, Vibha Anand, Harry Stavropoulos, Riitta Veijola, Jorma Toppari, Marlena Maziarz, Markus Lundgren, Kathy Waugh, Brigitte Frohnert, Frank Martin, Olivia Lou, William Hagopian, Peter Achenbach
Summary: This study aimed to investigate the usefulness of islet autoantibody (IAb) levels in predicting type 1 diabetes in children positive for autoantibodies. The results showed that considering the quantitative patterns of IAb levels improved the predictive power for type 1 diabetes beyond the qualitative IAb positivity status in children positive for autoantibodies.
Article
Immunology
Giada Amodio, Alessandra Mandelli, Rosalia Curto, Paola M. Rancoita, Angela Stabilini, Riccardo Bonfanti, Maurizio de Pellegrin, Emanuele Bosi, Clelia Di Serio, Manuela Battaglia, Silvia Gregori
Summary: DC-10, a subset of human dendritic cells involved in IL-10-mediated tolerance and naturally expressing HLA-G, may serve as a potential marker for stratifying individuals at risk of developing Type 1 diabetes (T1D). The alteration in DC-10 number and phenotype during T1D development is associated with an increased risk of the disease, suggesting a possible use of CD83(+) DC-10 as a prognostic factor.
FRONTIERS IN IMMUNOLOGY
(2021)
