期刊
AUTOIMMUNITY
卷 42, 期 1, 页码 69-73出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/08916930802350789
关键词
Celiac disease; intestinal biopsy; Th17 response; Th1 response; interleukins
类别
资金
- Research Project [06/111030]
- Basque Department of Health [PI07/0796]
- Instituto de Salud Carlos III of the Spanish Ministry of Health
- Celiac Patient Association from Madrid
- Spanish Ministry of Education
- I3SNS Program of the Spanish Ministry of Health [CES05/036]
Celiac disease (CD) is an immunological disorder caused by intolerance to ingested gliadin and other cereal prolamins that has been included in the TH1-dominated group of diseases, where IL-12 induced IFN is the major proinflamatory signal. Recently, another linage of T cells has been described, namely TH17, characterized by production of IL-17, that differentiate in response to TGF and IL-6 and participate in the pathogenesis of several autoimmune diseases. Using RT-PCR analysis of gene expression, we analyzed the presence of TH1 (IL-12 and IFN) and TH17 (TGF, IL-6, IL-17A, IL-17F and IL-23) related cytokines in intestinal biopsies from CD patients with active disease compared to remission and from treated patients after acute, in vitro re-exposure to gliadin. Potent TH1 and TH17 responses were present in the active stage of the disease, whereas short incubation of normalized biopsies with gliadin did not increase the expression of the effector cytokines, although a tendency of upregulation for both TH1 and TH17 promoting factors was observed, suggestive of a reactivation of proinflammatory pathways. These results place CD into the group of autoimmune disorders in which TH17 cells also participate, although the relative importance of each T cell response and their role in the initial events of the disease need further investigation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据