期刊
AUTOIMMUNITY
卷 42, 期 4, 页码 286-288出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/08916930902828197
关键词
CRP; DNase I; nec; SLE
类别
资金
- DFG [HE 4490/3-1, GK592, SFB GK643]
- University Clinic of Erlangen [06.11.06.1]
- EU
CRP is an important inflammatory marker, however, CRP levels are relatively low in patients with SLE. In addition patients with SLE often display low activities and serum levels for DNase I and complement, respectively. Here we show that DNase I treatment of nec PBMC increased their binding of CRP. Consequently, reduced DNase I activity in patients with SLE may contribute to the impaired opsonisation by CRP of dead cells, exacerbating the clearance defect in SLE of apo and nec cells.
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