☆ 4.3 Article

MoMa from patients with systemic lupus erythematosus show altered adhesive activity

AUTOIMMUNITY (2009)

期刊

AUTOIMMUNITY

卷 42, 期 4, 页码 269-271

出版社

TAYLOR & FRANCIS LTD

DOI: 10.1080/08916930902827983

关键词

Adhesion; M Phi; SLE; phagocytosis

类别

Immunology

资金

Deutsche Forschungsgemeinschaft [SFB 643]
European Commissions [QLK3-CT-200202017-APOCLEAR]
High Level Scholarships for Latin America [E04D047956VE, E07D400430VE]

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摘要

The phagocytosis of apo cells in patients with systemic lupus erythematosus (SLE) has been shown to be impaired. Recognition and engulfment of dying cells are mediated by molecules and receptors that are also involved in cell adhesion. Therefore, we analysed the adhesion capabilities of MoMa from patients with SLE. We employed a colorimetric assay to quantify the adhesion of MoMa to various substrates. In addition, we evaluated the morphological characteristics of the M Phi adhesion cultures by phase contrast microscopy. We have observed various morphologic characteristics depending on the adhesive substrate. The typical spindle shaped MoMa adhered to plastic and a bigger and rounder formed MoMa adhered to immunoglobulin (Ig) coated surfaces. Quantitatively, adhesion to plastic was significantly decreased in some SLE patients. Those patients showing a defective adhesion to plastic simultaneously showed an enhanced adhesion to Ig coated surfaces. These findings suggest that there is an alteration in the integrin and/or Fc gamma R mediated stimulation of MoMa from SLE patients and this alteration may be associated with the impaired clearance of apo cells seen in this disease.

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Review Immunology

Receptor-Mediated NETosis on Neutrophils

Tao Chen, Yanhong Li, Rui Sun, Huifang Hu, Yi Liu, Martin Herrmann, Yi Zhao, Luis E. Munoz

Summary: Neutrophil extracellular traps (NETs) play a significant role in assisting neutrophils to capture and kill microorganisms during infection, but overproduction is linked to inflammation, autoimmune disorders, and other issues. Understanding neutrophil activation signals and NET formation is crucial for studying immune regulation.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Immunology

Low Dose Radiation Therapy Induces Long-Lasting Reduction of Pain and Immune Modulations in the Peripheral Blood - Interim Analysis of the IMMO-LDRT01 Trial

Anna-Jasmina Donaubauer, Ina Becker, Thomas Weissmann, Birgitta M. Froehlich, Luis E. Munoz, Thomas Gryc, Manuel Denzler, Oliver J. Ott, Rainer Fietkau, Udo S. Gaipl, Benjamin Frey

Summary: LDRT shows promise in treating chronic inflammatory and degenerative diseases, improving pain levels and inducing systemic immune modulations; LDRT leads to a slight reduction in certain immune cell populations and an increase in B cells; Monitoring immune biomarkers may help predict therapeutic success and symptom improvement in LDRT.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Immunology

Hypoxia Promotes Neutrophil Survival After Acute Myocardial Infarction

Maximilian Doelling, Markus Eckstein, Jeeshan Singh, Christine Schauer, Janina Schoen, Xiaomei Shan, Aline Bozec, Jasmin Knopf, Georg Schett, Luis E. Munoz, Martin Herrmann

Summary: The study found that in the cardiac tissue of patients with acute myocardial infarction, there was a significant increase in neutrophil infiltration but reduced formation of NETs. The hypoxic environment increased neutrophil survival, and nuclear HIF-1 alpha was associated with prolonged neutrophil survival and enhanced oxidative stress.

FRONTIERS IN IMMUNOLOGY (2022)

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Correction Immunology

Low Dose Radiation Therapy Induces Long-Lasting Reduction of Pain and Immune Modulations in the Peripheral Blood-Interim Analysis of the IMMO-LDRT01 Trial (vol 12, 740742, 2021)

Anna-Jasmina Donaubauer, Ina Becker, Thomas Weissmann, Birgitta M. Froehlich, Luis E. Munoz, Thomas Gryc, Manuel Denzler, Oliver J. Ott, Rainer Fietkau, Udo S. Gaipl, Benjamin Frey

FRONTIERS IN IMMUNOLOGY (2022)

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Article Multidisciplinary Sciences

Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Jeeshan Singh, Xiaomei Shan, Aparna Mahajan, Martin Herrmann, Christine Schauer, Jasmin Knopf, Luis E. Munoz

Summary: This article introduces a method for inducing ocular surface inflammation and meibomian gland dysfunction, as well as describes the procedures for collecting organs related to the ocular surface. These methods enable the assessment of inflammatory state and investigation of anti-inflammatory interventions.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2022)

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Article Immunology

Alpha-1 antitrypsin in autoimmune diseases: Roles and therapeutic prospects

Rui Sun, Zhiqiang Xu, Chenxi Zhu, Tao Chen, Luis E. Munoz, Lunzhi Dai, Yi Zhao

Summary: Alpha-1 antitrypsin (A1AT) is a protease inhibitor with multiple activities including anti-inflammatory, anti-apoptotic, anti-oxidative stress, anti-viral, and antibacterial effects. It shows therapeutic prospects in autoimmune diseases and is beneficial for patients and animal models.

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

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Article Biochemistry & Molecular Biology

A Pleomorphic Puzzle: Heterogeneous Pulmonary Vascular Occlusions in Patients with COVID-19

Jeeshan Singh, Irmgard Herrmann, Aparna Mahajan, Christine Schauer, Xiaomei Shan, Arndt Hartmann, Ralf J. Rieker, Katja Evert, Christina Falkeis, Elisabeth Naschberger, Saskia von Stillfried, Peter Boor, Luis E. Munoz, Georg Schett, Martin Herrmann, Jasmin Knopf

Summary: This study reports the occurrence of pleomorphic vascular occlusions in patients with COVID-19 and the detection of these occlusions using a label-free method called NEF. Lung specimens showed different types of occlusions, including those rich in DNA but poor in NE, those rich in NE but DNA poor, and those rich in both DNA and NE.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Editorial Material Cell Biology

Formation and Clearance of NETs in Health and Disease

Jasmin Knopf, Aparna Mahajan, Luis E. Munoz, Martin Herrmann

CELLS (2022)

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Article Biochemistry & Molecular Biology

Anti-DNA-IgM Favors the Detection of NET-Associated Extracellular DNA

Han Wang, Antonia Margarethe Stehr, Jeeshan Singh, Leticija Zlatar, Arndt Hartmann, Katja Evert, Elisabeth Naschberger, Saskia von Stillfried, Peter Boor, Luis E. E. Munoz, Jasmin Knopf, Michael Stuerzl, Martin Herrmann

Summary: During inflammatory responses, neutrophils utilize various defense mechanisms, such as phagocytosis, degranulation, recruitment of immune cells, secretion of anti-microbials, and release of neutrophil extracellular traps (NETs). Detection of NETs in tissue sections can be challenging due to the high fluorescence signals emitted from condensed nuclear DNA. However, using anti-DNA-IgM antibodies can effectively detect the extended DNA patches of NETs, providing a new perspective for studying neutrophil-associated immune reactions in diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Article Biochemistry & Molecular Biology

Anti-CD19 CAR T cell therapy for refractory systemic lupus erythematosus

Andreas Mackensen, Fabian Mueller, Dimitrios Mougiakakos, Sebastian Boeltz, Artur Wilhelm, Michael Aigner, Simon Voelkl, David Simon, Arnd Kleyer, Luis Munoz, Sascha Kretschmann, Soraya Kharboutli, Regina Gary, Hannah Reimann, Wolf Roesler, Stefan Uderhardt, Holger Bang, Martin Herrmann, Arif Buelent Ekici, Christian Buettner, Katharina Maria Habenicht, Thomas H. Winkler, Gerhard Kroenke, Georg Schett

Summary: A study of five patients with refractory systemic lupus erythematosus treated with anti-CD19 CAR T cell therapy showed remission of SLE disease in all patients after 3 months, and long-term drug-free remission was maintained during follow-up.

NATURE MEDICINE (2022)

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