Article
Biochemistry & Molecular Biology
Foteini Malliou, Christina E. Andriopoulou, Aristeidis Kofinas, Allena Katsogridaki, George Leondaritis, Frank J. Gonzalez, Theologos M. Michaelidis, Marousa Darsinou, Leandros A. Skaltsounis, Maria Konstandi
Summary: Oleuropein (OLE), a main constituent of olives, has pleiotropic effects in health and disease, mainly based on its antioxidant and hypolipidemic properties, and its capacity to protect the myocardium during ischemia. This study investigated the effect of OLE on neural plasticity indices, focusing on the role of PPARff. The findings showed that OLE up-regulated BDNF and TrkB in the prefrontal cortex of mice, mediated by PPARff activation, and may improve cognitive functions.
Article
Pharmacology & Pharmacy
Kanishk Luhach, Giriraj T. Kulkarni, Vijay P. Singh, Bhupesh Sharma
Summary: The study showed that cilostazol could alleviate prenatal VPA exposure-related hyperlocomotion, social interaction deficits, repetitive behavior, and anxiety, while significantly increasing biochemical markers such as BDNF, pCREB, IL-10, and GSH in the assessed brain regions.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2021)
Review
Clinical Neurology
Lauren P. Giesler, Richelle Mychasiuk, Sandy R. Shultz, Stuart J. McDonald
Summary: Traumatic brain injury is a common health problem that affects millions of people every year. The Val66Met single-nucleotide polymorphism in BDNF has been studied for its impact on traumatic brain injury outcomes and its role in brain homeostasis. This review examines animal models and clinical studies investigating the effects of Val66Met on cognitive function, motor function, neuropsychiatric symptoms, and nociception in traumatic brain injury. It also reviews studies on the pathophysiology of traumatic brain injury and the use of circulating BDNF as a biomarker.
Article
Neurosciences
Md. Mominur Rahman, Md. Rezaul Islam, Fatema Akter Supti, Puja Sutro Dhar, Sheikh Shohag, Jannatul Ferdous, Shakil Khan Shuvo, Aklima Akter, Md. Sarowar Hossain, Rohit Sharma
Summary: Neurotrophins and neuropeptides play important roles in regulating peripheral nociceptive nerves and have potential therapeutic applications in neurodegenerative diseases. Neuropeptides have a neuroprotective impact, while neurotrophins target specific neurons affected by various neuropsychiatric conditions. Strategies for BDNF therapies include upregulating BDNF levels and boosting BDNF signals. This review discusses the mechanisms and potential applications of neurotrophins and neuropeptides in acute neural damage and neurodegenerative diseases.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Neurosciences
Umit Haluk Yesilkaya, Sakir Gica, Pelin Ozkara Menekseoglu, Busra Guney Tasdemir, Zeynep Cirakli, Nesrin Karamustafalioglu
Summary: Schizophrenia patients' siblings may share certain endophenotypes with the patients, which can help distinguish between trait and state markers. This study found that the balance of pro-BDNF/mature BDNF and its receptors p75NTR/TrkB may be an endophenotype of schizophrenia, and measuring the levels of related proteins can successfully differentiate patients and their siblings from healthy controls.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Nishtha Agnihotri, M. Hasan Mohajeri
Summary: This report systematically reviews preclinical rodent reports on the connection between the composition of the intestinal microbiota and neurogenesis and neurotrophins in the hippocampus. The findings suggest both positive and negative correlations between the microbiota composition and neurogenesis or BDNF expression. Age, SCFA, obesity, and chronic stress are identified as recurring factors in these studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Ophthalmology
Matthew M. Harper, Erin A. Boese, Randy H. Kardon, Johannes Ledolter, Markus H. Kuehn
Summary: There was no significant difference in the expression of BDNF and TrkB between glaucomatous and control retinas, but BDNF expression was associated with the use of prostaglandin analogs, while TrkB expression was correlated with factors such as intraocular pressure, drug usage, and treatment outcomes.
CURRENT EYE RESEARCH
(2021)
Article
Neurosciences
Basem H. Elesawy, Bassem M. Raafat, Aya Al Muqbali, Amr M. Abbas, Hussein F. Sakr
Summary: Intermittent fasting was found to significantly increase levels of neurotrophin 3 and brain-derived neurotrophic factor in both control and type 2 diabetes mellitus rats, while also elevating serotonin, dopamine, and glutamate levels in diabetic rats. Additionally, the study showed that IF modulated glucose homeostasis parameters and improved insulin resistance.
Article
Psychiatry
Umit Haluk Yesilkaya, Sakir Gica, Busra Guney Tasdemir, Pelin Ozkara Menekseoglu, Zeynep Cirakli, Nesrin Karamustafalioglu
Summary: The study suggests that an imbalance between pro-BDNF/mature BDNF and p75NTR/TrkB may contribute to the pathogenesis of synaptic pruning in psychotic disorders, with lower levels of mature BDNF, TrkB, and PAI-1, tPA, and higher levels of ACTH and cortisol observed in first-episode psychosis patients compared to healthy controls.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Kanishk Luhach, Giriraj T. Kulkarni, Vijay P. Singh, Bhupesh Sharma
Summary: This study investigated the effects of a PDE10A inhibitor, papaverine, on core phenotypes of ASD in a Pre-VPA model in rats. Papaverine administration improved social behavior, anxiety, locomotion, and nociception, while also impacting protein markers associated with neuronal function. The findings suggest that targeting PDE10A could be a potential strategy for further understanding ASD phenotypes.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Behavioral Sciences
Kanishk Luhach, Giriraj T. Kulkarni, Vijay P. Singh, Bhupesh Sharma
Summary: Vinpocetine, a PDE1 inhibitor, ameliorated ASD-associated symptoms in rats prenatally exposed to VPA, possibly by improving neuronal function, brain inflammation, and oxidative stress. This study suggests PDE1 as a potential new pharmacological target for ASD treatment.
Review
Physiology
I. Renteria, P. C. Garcia-Suarez, A. C. Fry, J. Moncada-Jimenez, J. P. Machado-Parra, B. M. Antunes, A. Jimenez-Maldonado
Summary: Brain-derived neurotrophic factor (BDNF) is a nerve growth factor mainly produced by the brain, playing important roles in synaptic modulation, neurogenesis, immune regulation, and other physiological processes. Recent studies have shown that BDNF is also synthesized in peripheral tissues, such as skeletal muscles, and it contributes to muscle function maintenance and plasticity. Additionally, during exercise, BDNF directly influences neuromuscular junctions, muscle regeneration, and metabolism in muscle tissues.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nan Xiao, Der Thor, Wei Ye Yu
Summary: Neurotrophic factors were found to promote migration of human DPSCs, accelerating wound healing and increasing the expression of phosphorylated-ERK.
BIOMEDICAL JOURNAL
(2021)
Article
Clinical Neurology
Antonino Giordano, Ferdinando Clarelli, Miryam Cannizzaro, Elisabetta Mascia, Silvia Santoro, Melissa Sorosina, Laura Ferre, Letizia Leocani, Federica Esposito
Summary: This study investigated the impact of genetic variants in the BDNF and NTRK2 genes on motor recovery after rehabilitation in progressive MS. The results showed that the BDNF Val66Met polymorphism was associated with improvements in walking function after rehabilitation, while the NTRK2 polymorphisms did not affect motor function recovery.
FRONTIERS IN NEUROLOGY
(2022)
Article
Pharmacology & Pharmacy
Kanishk Luhach, Giriraj T. Kulkarni, Vijay P. Singh, Bhupesh Sharma
Summary: The study found that papaverine can improve behavioral deficits related to autism spectrum disorder in rats with hyperserotonemia, and has significant effects on neuronal function, brain inflammation, and brain oxidative stress.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2021)
Article
Behavioral Sciences
Gayle C. Windham, Michelle Pearl, Meredith C. Anderson, Victor Poon, Darryl Eyles, Karen L. Jones, Kristen Lyall, Martin Kharrazi, Lisa A. Croen
Article
Behavioral Sciences
Jennifer L. Ames, Gayle C. Windham, Kristen Lyall, Michelle Pearl, Martin Kharrazi, Cathleen K. Yoshida, Judy Van de Water, Paul Ashwood, Lisa A. Croen
Article
Behavioral Sciences
Kristen Lyall, Lanxin Song, Kelly Botteron, Lisa A. Croen, Stephen R. Dager, M. Daniele Fallin, Heather C. Hazlett, Elizabeth Kauffman, Rebecca Landa, Christine Ladd-Acosta, Daniel S. Messinger, Sally Ozonoff, Juhi Pandey, Joseph Piven, Rebecca J. Schmidt, Robert T. Schultz, Wendy L. Stone, Craig J. Newschaffer, Heather E. Volk
Article
Behavioral Sciences
Emily E. Joyce, Jorge E. Chavarro, Juliette Rando, Ashley Y. Song, Lisa A. Croen, M. Daniele Fallin, Irva Hertz-Picciotto, Rebecca J. Schmidt, Heather Volk, Craig J. Newschaffer, Kristen Lyall
Summary: This study examined the relationship between pesticide exposure from residues in the diet during pregnancy and child autism-related traits. The findings suggest that pesticide residues in the diet were not related to child autism-related outcomes at age three. However, higher prenatal fruit and vegetable intake was associated with reductions in child autism-related traits.
Article
Behavioral Sciences
Irva Hertz-Picciotto, Susan A. Korrick, Christine Ladd-Acosta, Margaret R. Karagas, Kristen Lyall, Rebecca J. Schmidt, Anne L. Dunlop, Lisa A. Croen, Dana Dabelea, Julie L. Daniels, Cristiane S. Duarte, M. Daniele Fallin, Catherine J. Karr, Barry Lester, Leslie D. Leve, Yijun Li, Monica McGrath, Xuejuan Ning, Emily Oken, Sharon K. Sagiv, Sheela Sathyanaraya, Frances Tylavsky, Heather E. Volk, Lauren S. Wakschlag, Mingyu Zhang, T. Michael O'Shea, Rashelle J. Musci
Summary: This study examined the association between maternal prenatal smoking and autism spectrum disorder (ASD) in children. The findings suggest a modest association between maternal smoking and ASD diagnosis, as well as an increase in ASD-related traits. However, the study also acknowledges the heterogeneity of results and limitations in data collection and confounders.
Article
Biochemistry & Molecular Biology
Alexandra Ramirez-Celis, Lisa A. Croen, Cathleen K. Yoshida, Stacey E. Alexeeff, Joseph Schauer, Robert H. Yolken, Paul Ashwood, Judy van de Water
Summary: Maternal autoantibody-related ASD (MAR ASD) is a subtype of autism where maternal autoantibodies cross the placenta and affect the developing brain, leading to neurodevelopmental alterations and autism-associated behaviors in the offspring. This study validated previously identified MAR ASD patterns and their accuracy in predicting ASD risk.
MOLECULAR PSYCHIATRY
(2022)
Article
Behavioral Sciences
Ashley Y. Song, Kelly Bakulski, Jason Feinberg, Craig Newschaffer, Lisa A. Croen, Irva Hertz-Picciotto, Rebecca J. Schmidt, Homayoon Farzadegan, Kristen Lyall, M. Daniele Fallin, Heather E. Volk, Christine Ladd-Acosta
Summary: This study found that accelerated epigenetic aging in mothers was associated with lower cognitive ability and function in offspring at 12 months, while accelerated maternal epigenetic aging was marginally associated with increased odds of ASD in offspring at 36 months. On the other hand, father's accelerated aging was marginally associated with decreased ASD risk in their offspring. This suggests that epigenetic aging in parents may play a role in neurodevelopment and ASD risk.
Article
Behavioral Sciences
Frances L. Lynch, Joanna E. Bulkley, Alexandra Varga, Phillip Crawford, Lisa A. Croen, Yihe G. Daida, Eric Fombonne, Brigit Hatch, Maria Massolo, John F. Dickerson
Summary: Parents of children with autism spectrum disorder (ASD) and other chronic health conditions face challenges in maintaining employment. This study aimed to understand the specific impact of these health conditions on parent employment in order to provide support for families.
Article
Biochemistry & Molecular Biology
Jason I. I. Feinberg, Rose Schrott, Christine Ladd-Acosta, Craig J. J. Newschaffer, Irva Hertz-Picciotto, Lisa A. A. Croen, M. Daniele Fallin, Andrew P. P. Feinberg, Heather E. E. Volk
Summary: There is a need to consider the paternal contributions to autism spectrum disorder (ASD) and explore the association between paternal autistic traits, sperm epigenome, and autistic traits in children. This study analyzed the genetic and epigenetic data of fathers and children from the Early Autism Risk Longitudinal Investigation (EARLI) cohort. The results showed significant associations between differentially methylated regions (DMRs) in the sperm epigenome and autistic traits in 3-year-old offspring. These findings highlight the potential importance of sperm epigenetic mechanisms in the development of autism.
MOLECULAR PSYCHIATRY
(2023)
Article
Behavioral Sciences
Beth A. Malow, Yinge Qian, Jennifer L. Ames, Stacey Alexeeff, Lisa A. Croen
Summary: Compared to non-autistic adults, autistic adults have higher rates of medical and psychiatric conditions. This study examines the longitudinal trajectory of health conditions in autistic youth compared to non-autistic youth as they transition from adolescence to early adulthood in a large healthcare system. The study found that the prevalence of common medical and psychiatric conditions increased from age 14 to 22 in autistic youth, with higher rates compared to non-autistic youth. Obesity, neurological disorders, anxiety, and ADHD were the most prevalent conditions in autistic youth. The findings highlight the importance of screening and health education for autistic youth to prevent adverse health outcomes in adulthood.
Article
Psychology, Developmental
Jeroen Dewinter, Morenike Giwa Onaiwu, Maria L. Massolo, Reid Caplan, Els Van Beneden, Nikki Broermann, Eileen T. Crehan, Lisa A. Croen, Susan Faja, Dena L. Gassner, Laura Graham Holmes, Cat Hughes, Morrigan Hunter, Monique Huysamen, Paola Jelonche, Meng-Chuan Lai, Ilse Noens, Heta Pukki, Mark A. Stokes, John F. Strang, Anna I. R. Van der Miesen
Summary: This report presents recommendations to promote the health and well-being of autistic individuals in terms of their sexuality and gender diversity. The recommendations were developed based on the latest scientific knowledge and community involvement. A group of international experts in autism, sexuality, and gender diversity, along with autistic advocates, collaborated to develop the initial recommendations. These recommendations were then reviewed by the wider community through an online survey. Eight out of the original 11 recommendations received consensus support. The final recommendations focus on providing education and information, improving healthcare accessibility, and including the autism community in future research related to sexuality, relationships, and gender diversity.
Article
Neurosciences
Lisa A. Croen, Jennifer L. Ames, Yinge Qian, Stacey Alexeeff, Paul Ashwood, Erica P. Gunderson, Yvonne W. Wu, Andrew S. Boghossian, Robert Yolken, Judy Van de Water, Lauren A. Weiss
Summary: Inflammatory conditions during pregnancy, such as asthma and obesity, are associated with an increased risk of neurodevelopmental disorders, particularly autism spectrum disorder (ASD). However, there doesn't seem to be a shared genetic risk factor for these conditions and ASD. Children whose mothers have both asthma and obesity during pregnancy may benefit from earlier screening and intervention.
BIOLOGICAL PSYCHIATRY: GLOBAL OPEN SCIENCE
(2024)
Article
Environmental Sciences
Kimberly Berger, Patrick T. Bradshaw, Victor Poon, Marty Kharrazi, Darryl Eyles, Paul Ashwood, Kristen Lyall, Heather E. Volk, Jenn Ames, Lisa A. Croen, Gayle C. Windham, Michelle Pearl
Summary: Over two-thirds of pregnant women in the U.S. have insufficient Vitamin D concentrations, which may be associated with prenatal exposure to environmental chemical mixtures. Some pollutants are associated with decreased Vitamin D concentrations, while others are associated with increased concentrations. Overall mixture exposure is associated with lower Vitamin D concentrations.
ENVIRONMENTAL POLLUTION
(2024)
Article
Psychology, Developmental
Christina Nicolaidis, Kelly Y. Zhen, Junghee Lee, Dora M. Raymaker, Steven K. Kapp, Lisa A. Croen, Anna Urbanowicz, Joelle Maslak, Mirah Scharer
Summary: There is a pressing need for interventions to improve healthcare for autistic adults, but there is a lack of validated measures to evaluate such interventions. Through community-based participatory research, a set of patient- and proxy-reported instruments were created to measure healthcare outcomes and intervention targets in autistic adults, showing good psychometric characteristics. Future research should focus on assessing whether these interventions effectively improve healthcare outcomes in autistic adults.
Article
Behavioral Sciences
Gayle C. Windham, Michelle Pearl, Victor Poon, Kimberly Berger, Jasmine W. Soriano, Darryl Eyles, Kristen Lyall, Martin Kharrazi, Lisa A. Croen