Review
Chemistry, Multidisciplinary
Abdusalom A. Suleymanov, Kay Severin
Summary: Recent developments have revealed that vinyl and alkynyl triazenes are highly interesting compounds with unique reactivity, enabled by the electron-donating properties of the triazenyl group. These compounds can be prepared in few steps from readily available starting materials, making them a promising area of study in synthetic organic and medicinal chemistry.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Organic
J. N. Abrams
Summary: An alternative mild method for synthesizing 1-aryl-3,3-dimethyl alkyl triazenes has been described, utilizing radical pathways initiated by homolysis of weak N-O bonds in diazo ether adducts. This method provides modest yields (ca. 20-40%) across a range of aryl diazonium salts. The use of DMF as both an electron donor and a source of dimethylamine radicals sets this approach apart from traditional methods.
Article
Chemistry, Multidisciplinary
Felix Stein, Simon Suhr, Arijit Singha Hazari, Robert Walter, Maite Noessler, Biprajit Sarkar
Summary: The synthesis and characterization of cationic azide-substituted 1,2,3-triazolium salts and their reactivity towards triphenylphosphine were reported. These salts were used as building blocks to develop unsymmetrical MIC-triazene-NHC/MIC' compounds which can be converted to radicals. The investigation of these radicals using various techniques sheds new light on the stabilization ability of MICs and their pi-accepting ability.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Organic
Nicolai Wippert, Martin Nieger, Claudine Herlan, Nicole Jung, Stefan Brase
Summary: This study describes the synthesis of 3,6-substituted-4,6-dihydro-3H-pyrazolo[3,4-d][1,2,3]triazines, nitrogen-rich heterocycles that were previously not accessible synthetically. The compounds were obtained in five steps, including key reaction steps of amidation and cyclative cleavage. Attempts to synthesize regioisomers were unsuccessful due to the higher stability of the triazene functionality in the precursors.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Jinchao Ma, Jagadish Das, Jiaheng Zhang, Jian Cheng, Saurav Sorcar, Brian A. Rosen, Pini Shekhter, Roman Dobrovetsky, Eli Flaxer, Yinon Yavor, Ruiqi Shen, Ilia Kaminker, Amir Goldbourt, Michael Gozin
Summary: A self-propagating combustion synthesis method was reported for the preparation of novel porous non-graphitic polymeric carbon nitrides (PCNs) using nitrogen-rich triazene-based precursors. The combustion behavior and morphology of the resulted PCNs were found to be highly dependent on the terminal functional groups in the precursors. The highly porous PCN5 exhibited excellent catalytic activity and was further evaluated for its potential application in solid composite propellant.
Article
Agricultural Engineering
Liu Xiaorui, Yuan Longji, Yang Xudong
Summary: The evolution of CHON functional groups during torrefaction of rice straw at 200-300 degrees C was investigated. Results showed that 300 degrees C was more suitable for rice straw torrefaction due to ideal fuel ratio and significantly improved HHV. The release of N-containing gases during torrefaction should be highly concerned for environmental perspective.
BIORESOURCE TECHNOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Dantong Shen, Luqian Dong, Guangxian Zhang, Fang Xu, Yunxuan Weng
Summary: A novel efficient flame retardant FR-AM was successfully synthesized and used to treat cotton fabrics, resulting in durable flame-retardant properties. The treated cotton fabrics showed increased LOI value, reduced heat release rate, and maintained good mechanical properties.
JOURNAL OF MATERIALS SCIENCE
(2022)
Article
Multidisciplinary Sciences
Xin Yu, Wencai Ren
Summary: Researchers report a versatile superionic conductor based on monolayer CdPS3 nanosheets, which exhibit high ion conductivities for various cations from -30 to 90°C, including both monovalent and multivalent ions, and the conductivity is one to two orders of magnitude higher than that of solid ionic conductors.
NATURE COMMUNICATIONS
(2023)
Article
Polymer Science
Xueting Wan, Jian Jiang, Yanyan Tu, Siyuan Xu, Jing Li, Huanjun Lu, Zhikai Li, Lianhu Xiong, Xiaohong Li, Youliang Zhao, Yingfeng Tu
Summary: The study presents a method for direct preparation of green copolyesters via cascade polycondensation-coupling ring-opening polymerization (PROP), which enables the introduction of multiple functional groups during synthesis, leading to the synthesis of biodegradable polyesters with high molecular weights.
Review
Chemistry, Multidisciplinary
Frederik Mueggenburg, Sabine Mueller
Summary: This review summarizes the synthetic methods of azide-modified nucleosides and their applications in RNA and DNA functionalization.
Article
Environmental Sciences
Xuefei Tan, Chaofan Zhang, Huangzhao Wei, Peng Shi, Haixing Chang, Shih-Hsin Ho
Summary: Biochar has been widely recognized as an efficient method for removing antibiotics, but it usually requires the addition of oxidants to obtain oxygen-containing functional groups. In this study, a environmentally friendly adsorbent called Chlamydomonas BC (CBC) was fabricated using a simple pyrolysis process, which contained carbon-oxygen functional groups that played a crucial role in sulfathiazole adsorption. The main mechanisms of sulfathiazole adsorption were identified as H-bonding, electron donor-acceptor interactions, and electrostatic attraction.
Article
Polymer Science
Keita Fuchise, Kazuhiko Sato, Masayasu Igarashi
Summary: In this study, linear polysiloxanes end-functionalized with disubstituted (Si-C CR) and monosubstituted alkynyl (Si-C CH) groups were successfully synthesized through controlled ring-opening polymerization using water or silanols as initiators, guanidines as catalysts, and alkynyl(amino)silanes as end-capping agents. Various alkynyl-terminated polysiloxanes were obtained, which showed compatibility with non-catalytic and catalytic Huisgen reactions with organoazide compounds. The versatility and orthogonality of the ethynyl groups and the allyl groups for independent modification reactions were demonstrated, providing potential for further functionalization of the polysiloxanes.
Article
Biochemistry & Molecular Biology
Alexey A. Voronin, Sofya P. Balabanova, Ivan Fedyanin, Aleksandr M. Churakov, Alla N. Pivkina, Yurii A. Strelenko, Michael S. Klenov, Vladimir A. Tartakovsky
Summary: In this study, a strategy for the synthesis of 5-((2-cyanoethyl)-X-amino)-[1,2,3]triazolo[4,5-c][1,2,5]oxadiazol-5-ium-4-ides (X = H; CH2CH2CN; NO2 (4a); CN (4b); CO2Et (4c)) starting from 3-amino-4-azido-1,2,5-oxadiazole was developed. The synthesized compounds were characterized and their thermal stability was investigated using various experimental techniques.
Article
Chemistry, Analytical
Guangchao Li, Yiming Ni, Huajun Guo, Xinhai Li, Zhixing Wang, Guochun Yan, Jiexi Wang, Wenjie Peng
Summary: A novel method of utilizing chelate metal-phosphorus interaction has been developed to achieve high capacity FeP anodes with fast ion transfer kinetics. This research provides a new way for metal phosphides and expands their potential application.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Organic
Enrique Gil de Montes, Matteo A. Tallarida, Ana T. Carmona, Claudio D. Navo, Inmaculada Robina, Pilar Elias-Rodriguez, Gonzalo Jimenez-Oses, Antonio J. Moreno-Vargas
Summary: This study highlights the regioselective rearrangement of aminyl radicals, leading to the formation of novel bicyclic diazabicyclic compounds. The research explores the impact of different bridgehead atoms and substituents on the rearrangement reaction, while providing a detailed mechanistic proposal supported by computational studies.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Crystallography
Ashraf A. Aly, Martin Nieger, Stefan Braese, Momtaz E. M. Bakheet
Summary: The X-ray structure analyses of four compounds were conducted, revealing strong intramolecular hydrogen bonds that play significant roles in their crystal packing.
JOURNAL OF CHEMICAL CRYSTALLOGRAPHY
(2023)
Article
Chemistry, Multidisciplinary
N. Maximilian Bojanowski, Aleksandra Vranic, Vincent Hahn, Pascal Rietz, Tobias Messer, Julian Brueckel, Christopher Barner-Kowollik, Eva Blasco, Stefan Braese, Martin Wegener
Summary: Recent studies have introduced a new generation of photoinitiators for 3D laser nanoprinting, replacing two-photon absorption with two-step absorption. This can now be achieved using inexpensive blue laser diodes instead of expensive femtosecond laser systems. Additionally, researchers are exploring alternative photoinitiators that can be excited by one-color two-step absorption and be de-excited by a different laser color.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Chun Li, Henrik Schopmans, Lukas Langer, Stefan Marschner, Abhinav Chandresh, Jochen Buerck, Youichi Tsuchiya, Adachi Chihaya, Wolfgang Wenzel, Stefan Braese, Mariana Kozlowska, Lars Heinke
Summary: Researchers have successfully prepared a crystalline film based on porphyrin with chiral properties and demonstrated excellent optoelectronic performance. By assembling in a metal-organic framework film, the porphyrin core becomes twisted and chiral. The close packing and crystalline order of the porphyrin cores in the film result in outstanding optoelectronic properties. Through exciting the Soret band of porphyrin, efficient photoconduction with a high On-Off ratio is achieved. Moreover, handedness-dependent circularly-polarized-light photoconduction is obtained. The combination of assembly-induced chirality with the rich porphyrin chemistry opens up possibilities for organic materials with exceptional chiral and optoelectronic properties.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Ashraf A. Aly, Mohammed B. Alshammari, Akil Ahmad, Hesham A. M. Gomaa, Bahaa G. M. Youssif, Stefan Braese, Mahmoud A. A. Ibrahim, Asmaa H. Mohamed
Summary: This article presents the synthesis and biological evaluation of a new series of thiazolylpyrimidine and thiazolidinylpyrimidine derivatives. The structures of the compounds were confirmed through various spectral techniques. The compounds showed no cytotoxic effects and exhibited promising antiproliferative activity against human cancer cell lines. Some of the compounds demonstrated dual inhibitory action against EGFR and BRAFV600E.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Physical
AbdElAziz A. Nayl, Ahmed I. Abd-Elhamid, Wael A. A. Arafa, Ismail M. Ahmed, Aref M. E. AbdEl-Rahman, Hesham M. A. Soliman, Mohamed A. Abdelgawad, Hazim M. Ali, Ashraf A. Aly, Stefan Braese
Summary: This study aimed to prepare a novel phosphate-embedded silica nanoparticles (P@SiO2) nanocomposite as an effective adsorbent. A mixed solution of sodium silicate and sodium phosphate was converted into hydrogen form using a strong acidic resin. The resultant solution was then hydrothermally treated to yield P@SiO2 nanocomposite.
Article
Chemistry, Multidisciplinary
Xujun Qiu, Julian Brueckel, Christoph Zippel, Martin Nieger, Frank Biedermann, Stefan Braese
Summary: In this article, a multifunctionalisable aryl azide, tris(4-azidophenyl)methanol, is reported. It can be used as a protecting group for thiols in peptoid synthesis and can be cleaved under mild reaction conditions via a Staudinger reduction. Additionally, the easily accessible aryl azide can be functionalised through copper-catalysed cycloaddition reactions, offering more possibilities for materials chemistry applications.
Article
Chemistry, Multidisciplinary
Aleksandra A. Vidyakina, Andrey A. Shtyrov, Mikhail N. Ryazantsev, Alexander F. Khlebnikov, Ilya E. Kolesnikov, Vladimir V. Sharoyko, Dar'ya Spiridonova, Irina A. Balova, Stefan Braese, Natalia A. Danilkina
Summary: Fluorescent isocoumarin-fused cycloalkynes have been developed, which react in SPAAC and give fluorescent triazoles regardless of the azide nature. The introduction of a pi-acceptor group at the C6 position of the isocoumarin ring converts the non-fluorescent cycloalkyne/triazole pair to its fluorescent counterpart. The design of the fluorescent cycloalkyne/triazole pairs is based on theoretical studies of the deactivation mechanism and electron density redistribution.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Organic
Helena Simek Tosino, Andre Jung, Olaf Fuhr, Claudia Muhle-Goll, Nicole Jung, Stefan Braese
Summary: A photochemical cyclization of F-tagged, o-alkynylated N-alkylamides to indoles catalyzed by a specific iridium complex is described. This reaction involves a rearrangement due to an electron withdrawing group, resulting in the formation of 3-acylindoles. A four-step reaction sequence including the photoreaction has been developed and optimized, leading to the synthesis of 16 derivatives with different modifications in good yields.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Frank Tristram, Nicole Jung, Patrick Hodapp, Rasmus R. Schroeder, Christof Woell, Stefan Braese
Summary: This article describes the latest methods of research data management (RDM) in academia, as well as the future prospects of digitalized molecular material workflows. The different elements of an integrated research data management strategy are described, and examples of automated processes are depicted. The use of electronic lab notebooks, data-integration and data-conversion strategies, and the establishment of two platforms for automated synthesis and analysis of materials are highlighted. Two examples of beneficial effects of successful RDM strategies are presented, including a sophisticated tool for data prediction based on machine learning and options for creating community-driven databases.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Essmat M. El-Sheref, Stefan Braese, Hendawy N. Tawfeek, Fatmah Ali Alasmary, Bahaa G. M. Youssif
Summary: The reaction between 4-azido-quinolin-2(1H)-ones and active methylene compounds was studied, leading to the synthesis of a series of 4-(1,2,3-triazol-1-yl)quinolin-2(1H)-ones. Compounds 3f-j showed potent antiproliferative activity and exhibited potential as multi-target inhibitors of EGFR, BRAF(V600E), and EGFR(T790M). Moreover, compounds 3g and 3h demonstrated caspase activation, down-regulation of antiapoptotic Bcl2, and promising antioxidant activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Ismail M. Ahmed, Ahmed I. Abd-Elhamid, Ashraf A. Aly, Stefan Braese, AbdElAziz A. Nayl
Summary: Ni2+/Fe3+ LDH, (Ni-Fe-CO3 LDH) with Ni/Fe molar ratio 3.0 was synthesized by co -precipitation for the remediation of chromium (VI) and Alizarine Red-S (ARS-dye). The effects of hydrogen ion concentration, shaking time, ARS-dye and/or Cr(VI) concentration, and adsorbents mass on the process were studied. The results showed that Ni-Fe-CO3 LDH fitted well with the pseudo-second-order model, and Langmuir isotherm had a better adsorption effect on ARS-dye and Cr(VI).
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2023)
Article
Materials Science, Multidisciplinary
Zhen Zhang, Peng Wu, Ke Wang, Hong Lin, Eduard Spuling, Rongrong Xia, Youjun Wu, Jin Cao, Jianhua Zhang, Bin Wei, Stefan Braese, Zixing Wang
Summary: White organic light-emitting diodes (WOLEDs) are important for energy conservation and reducing carbon emissions due to their excellent electro-optic conversion efficiency. However, the complexity of the structure and high fabrication costs limit the practicality of traditional WOLEDs. To address these issues, WOLEDs based on platinum (Pt) complexes with a single light-emitting layer show great potential.
ACS MATERIALS LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Steffen A. Otterbach, David Elsing, Alexander D. Schulz, Henrik Tappert, Wolfgang Wenzel, Mariana Kozlowska, Holger Roehm, Stefan Braese
Summary: In this study, eight different hole transport materials were synthesized via double CH activation. By varying the donor groups and pi-linkers, a wide range of ionization potentials (IPs) were achieved, demonstrating high customizability. One of the materials, DiPCP-2, showed good performance as a hole transport layer in PSCs, and its facile synthesis enables a cost reduction by two thirds.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Physical
Lena Pilz, Carsten Natzeck, Jonas Wohlgemuth, Nina Scheuermann, Simon Spiegel, Simon Osswald, Alexander Knebel, Stefan Braese, Christof Woell, Manuel Tsotsalas, Nicholaus Prasetya
Summary: This study presents a novel approach to enhance the properties of polymer membranes from MOFs through crosslinking of the organic linker molecules and subsequent metal-atom removal. The researchers automated the process and used machine learning optimization to ensure reproducibility and high quality of the resulting polymeric membranes. The SURMOF membranes showed improved gas selectivity after crosslinking, and the gas permeance could be restored to its initial condition after removing the metal centers. The resulting polymeric membrane outperforms commercially available polymer membranes for H2/CO2 gas separation.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Article
Oncology
Mengwu Pan, Valeria Solozobova, Nane C. Kuznik, Nicole Jung, Simone Grassle, Victor Gourain, Yvonne M. Heneka, Christina A. Cramer Von Clausbruch, Olaf Fuhr, Ravi S. N. Munuganti, Danilo Maddalo, Christine Blattner, Antje Neeb, Adam Sharp, Laura Cato, Carsten Weiss, Rinath M. Jeselsohn, Veronique Orian-Rousseau, Stefan Brase, Andrew C. B. Cato
Summary: A group of small molecules with imidazopyridine scaffolds have been identified as more potent inhibitors of breast cancer cell growth and activators of p53, resulting in cell cycle arrest and apoptosis.
CANCER RESEARCH COMMUNICATIONS
(2023)