Article
Biochemistry & Molecular Biology
Quaiser Saquib, Abdullah M. Al-Salem, Maqsood A. Siddiqui, Sabiha M. Ansari, Xiaowei Zhang, Abdulaziz A. Al-Khedhairy
Summary: This study found that Tris (2-ethylhexyl) phosphate (TEHP) has cytotoxic and genotoxic effects on HepG2 cells, possibly through inducing oxidative stress, causing mitochondrial dysfunction, and leading to DNA damage and cell death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Environmental
Peter R. Tentscher, Beate Escher, Rita Schlichting, Maria Koenig, Nadine Bramaz, Kristin Schirmer, Urs von Gunten
Summary: The study found that both para-benzoquinones and hydroquinones can induce oxidative stress response, and they can react rapidly with components of the incubation medium. However, they do not activate defense against genotoxicity or DNA repair activity.
Article
Biochemistry & Molecular Biology
Galina N. Chelomina, Sergey P. Kukla, Viktor P. Chelomin, Pham N. Doanh
Summary: Parasite infection can lead to DNA damage, potentially involving oxidative stress and cancer development; these research findings are important for understanding the pathogenesis mechanisms of parasitic diseases.
Article
Public, Environmental & Occupational Health
Martin Roursgaard, Monika Hezareh Rothmann, Juliane Schulte, Ioanna Karadimou, Elena Marinelli, Peter Moller
Summary: This study investigated the extraction of nanoplastic particles from food containers and found that these nanoparticles can cause genotoxicity in cell cultures, while their cytotoxic effects were limited.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Ying Chen, Yewei Wang, Georgia Charkoftaki, David J. Orlicky, Emily Davidson, Fengjie Wan, Gary Ginsberg, David C. Thompson, Vasilis Vasiliou
Summary: 1,4-Dioxane (DX) is a synthetic chemical widely contaminated in drinking water in the US. Despite lacking a Maximum Contaminant Level (MCL) for DX, various drinking water targets have been established by different authorities. The carcinogenic mechanism of DX remains unclear, but oxidative stress may play a role in its liver carcinogenicity.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Food Science & Technology
Robin Mesnage, Scarlett Ferguson, Inger Brandsma, Nynke Moelijker, Gaonan Zhang, Francesca Mazzacuva, Anna Caldwell, John Halket, Michael N. Antoniou
Summary: The co-formulant POE-15 tallow amine (POE-15) and the active ingredient glyphosate in herbicides have been found to be cytotoxic, causing cell necrosis and oxidative stress. The study highlights the importance of comprehensive testing of both co-formulants and active ingredients of commercial pesticides to ensure better regulation and protection of public health and the environment.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Review
Environmental Sciences
Ivana Durovcova, Stanislav Kyzek, Jana Fabova, Jana Makukova, Eliska Galova, Andrea Sevcovicova
Summary: This review aims to summarize the genotoxic effects of BPA on organisms across all taxa. BPA can induce DNA damage through multiple mechanisms and has adverse effects on organisms in various ecosystems.
ENVIRONMENTAL POLLUTION
(2022)
Article
Multidisciplinary Sciences
Emine Yalcin, Kultigin Cavusoglu
Summary: This study investigated the toxic effects of potassium bromate on Allium cepa L. and tested the reducing effects of grape seed extract (GSE). The results showed that potassium bromate exposure caused decreases in physiological parameters and abnormalities in cell genetic indicators, disrupting the antioxidant/oxidant balance. GSE administration reduced the toxic effects of potassium bromate and improved the examined parameters.
SCIENTIFIC REPORTS
(2022)
Review
Environmental Sciences
Rupa Rani, Abhidha Kela, Geeta Dhaniya, Kamini Arya, Amit K. Tripathi, Rajesh Ahirwar
Summary: Specific miRNAs have been identified as early warning biomarkers for health effects associated with exposure to PAHs in exposed populations, and they can serve as indicators of early health effects in response to chronic environmental exposure to PAHs.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Muhammed Atamanalp, Hasan Turkez, Asli cilingir Yeltekin, Fatma Betuel Ozgeris, Arzu Ucar, Ozge caglar, Veysel Parlak, Sena Oner, Gonca Alak
Summary: The compound acrylamide (AA) is widely used in industries such as paper, dyes, and plastics, but its water solubility suggests it could pose environmental problems. AA has been found to be neurotoxic, immunotoxic, reproductive toxic, and carcinogenic in animals. This study investigated the potential of boron compounds, such as borax (BX), to ameliorate AA-induced toxicities in rainbow trout. The results showed that AA exposure led to oxidative stress and DNA damage in both blood and liver tissues of the fish. However, co-exposure of BX with AA also elicited oxidative stress and cell death. Overall, BX was suggested as a useful and effective natural agent for preventing and treating AA toxicity in fish.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2022)
Article
Environmental Sciences
Jian Lu, Yun Yang, Lianhua Zhu, Meng Li, Wenping Xu, Cheng Zhang, Jiagao Cheng, Liming Tao, Zhong Li, Yang Zhang
Summary: Natural pyrethrins induce oxidative stress, DNA damage and liver toxicity in both human HepG2 cells and zebrafish. The observed chronic toxicity may lead to irreversible DNA damage and severe toxic effects on cells. In conclusion, hepatotoxicity of natural pyrethrins poses a risk to human health by causing liver degeneration and steatosis.
Article
Environmental Sciences
Silvana Arias, Veronica Estrada, Isabel C. Ortiz, Francisco J. Molina, John R. Agudelo
Summary: This study investigated the biological response of soluble organic fraction (SOF) and water-soluble fraction (WSF) extracted from particles emitted by an automotive diesel engine. The results showed that SOF had no cytotoxic activity, but different fuel blends had varying effects on genotoxicity and oxidative DNA damage. WSF did not show any ecotoxicity, but certain fuel blends increased the toxicity of polycyclic aromatic hydrocarbons.
ENVIRONMENTAL POLLUTION
(2022)
Article
Chemistry, Multidisciplinary
Zhangjian Chen, Jiaqi Shi, Yi Zhang, Shuo Han, Jiahe Zhang, Guang Jia
Summary: The genotoxic effects and underlying mechanisms of titanium dioxide nanoparticles (TiO2 NPs) on human bronchial epithelial cells (BEAS-2B) were investigated in this study. TiO2 NPs were found to induce cytotoxicity, oxidative stress, and DNA oxidative damage, with DNA oxidative damage being a more sensitive indicator for detecting the genotoxicity of TiO2 NPs.
Article
Nanoscience & Nanotechnology
Asmaa M. Shehata, Fatma M. S. Salem, Eiman M. El-Saied, Sahar S. Abd El-Rahman, Mohamed Y. Mahmoud, Peter A. Noshy
Summary: The study showed that exposure to Ag-NPs had adverse effects on the male reproductive system, affecting sperm motility, morphology, and concentration, inducing oxidative stress and lipid peroxidation in testicular tissue, and decreasing serum hormone levels. However, coadministration of Zn-NPs ameliorated most of the toxic effects of Ag-NPs through their antioxidative capacity.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Islam El-Garawani, Sobhy Hassab El-Nabi, Ahmed El Kattan, Azza Sallam, Sabha Elballat, Shaimaa Abou-Ghanima, Islam H. El Azab, Hesham R. El-Seedi, Shaden A. M. Khalifa, Sawsan El-Shamy
Summary: The study demonstrated that Arabic gum has a protective effect against oxidative stress and genotoxicity induced by a radiographic contrast medium. The active metabolites in Arabic gum were identified as key contributors to this protective role.