Article
Pharmacology & Pharmacy
Noemie Tanguay, Nadia Abdelouahab, Marie-Noelle Simard, Jean R. Seguin, Isabelle Marc, Catherine M. Herba, Andrea A. N. Macleod, Yohann Courtemanche, William D. Fraser, Gina Muckle
Summary: This study found a negative association between prenatal exposure to antidepressants and motor development in two-year-old children, but no association with cognitive and language development. This association was influenced by maternal prenatal distress, but the effect size was very small.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Anna Linda Leutritz, Lara van Braam, Katharina Preis, Andrea Gehrmann, Maike Scherf-Clavel, Katrin Fiedler, Stefan Unterecker, Sarah Kittel-Schneider
Summary: Limited knowledge exists regarding changes in blood concentrations of psychotropic drugs during pregnancy, transfer of drugs into breastmilk, and their effects on exposed children. This study examined the changes in medication concentrations during pregnancy and lactation in a sample of 60 mothers, and observed the development of exposed children in their first 12 months. The findings showed variations in drug concentrations in serum and breastmilk, but no significant differences in birth outcomes or developmental progress.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Psychiatry
Megan Galbally, Stuart J. Watson, Olav Spigset, Philip Boyce, Tim F. Oberlander, Andrew J. Lewis
Summary: This study examined the impact of exposure to antidepressants during pregnancy on child motor development. The findings suggest a mixed association between sensorimotor development and antidepressant use, with potential implications for visuospatial processing. Further exploration of these associations is warranted.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Clinical Neurology
Francesca Anns, Karen E. Waldie, Elizabeth R. Peterson, Caroline Walker, Susan M. B. Morton, Stephanie D'Souza
Summary: This study examined the associations between antenatal exposure to antidepressants, maternal depression, and child behavioral difficulties. The results showed that neither antenatal exposure to unmedicated depression nor antidepressants were associated with an increased risk of behavioral difficulties in children. However, maternal later life depression was found to be associated with behavioral difficulties at all three ages investigated.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Megan Galbally, Stuart J. Watson, Philip Boyce, Rebecca Anglin, Elizabeth McKinnon, Andrew J. Lewis
Summary: The study found that women with untreated depression during pregnancy had higher intake of unhealthy takeaway food throughout the postpartum period, while higher depressive symptoms in the postpartum were also associated with higher takeaway intake. However, there was no difference in fruit and vegetable intake among the three groups, and intake was highest for all women late in pregnancy and declined in the postpartum period.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Behavioral Sciences
Miriam T. Y. Leung, Kirstie H. Wong, Phoebe W. H. Ho, Patrick Ip, Li Wei, Ian C. K. Wong, Kenneth K. C. Man
Summary: The study examined the association between gestational exposure to antidepressants and the risk of seizures in offspring, finding a 2.3-fold increase in seizure incidence. While the causal relationship was inconclusive, further research is warranted for clinical aspects and fetal neurodevelopment monitoring during antidepressant use in pregnant women. Individualized decision-making is recommended, balancing the risks of untreated maternal depression with the potential consequences of abrupt withdrawal of antidepressants during pregnancy for cases at risk of seizures in offspring.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Clinical Neurology
Megan Galbally, Stuart J. Watson, Jeffrey A. Keelan, Olav Spigset, Andrew Lewis
Summary: This study examined the relationship between antidepressant use during the perinatal period and oxytocin levels. While concurrent oxytocin blood concentrations were not associated with antidepressant use, women taking antidepressants during pregnancy showed larger increases in oxytocin over the perinatal period compared to control women. Future research could investigate specific antidepressant agents and their impact on parenting.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Psychiatry
Jian-An Su, Chih-Cheng Chang, Yao-Hsu Yang, Chuan-pin Lee, Ko-Jung Chen, Chung-Ying Lin
Summary: In this study, the effects of antidepressant use and underlying depression on pregnancy and neonatal complications were evaluated separately, considering confounding factors. The results showed that mothers with depression but no antidepressant use had increased risks of intrauterine growth restriction and preterm delivery compared to those without depression. Antidepressant use during pregnancy increased the risks of gestational diabetes, malpresentation, preterm delivery, cardiovascular anomalies, anemia, low Apgar score, preterm delivery, and genitourinary defects. However, the use of antidepressants before and during pregnancy did not increase the risk of stillbirth. Therefore, physicians should consider the risks and benefits to both the mother and fetus when treating depression during pregnancy with antidepressants.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Medicine, General & Internal
Jaqueline Wendland, Xavier Benarous, Heloise Young, Takoua Brahim, Gisele Apter, Nicolas Bodeau, David Cohen, Priscille Gerardin
Summary: This study assessed how the timing of maternal perinatal depressive symptoms affects infants' socio-emotional characteristics, and found that infants of mothers who experienced both prenatal and postnatal depression had higher scores on the internalizing subscore. These findings emphasize the importance of screening for prenatal depression.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Psychiatry
Megan Galbally, Stuart J. Watson, Olav Spigset
Summary: This study found that pregnant women with depression or taking certain types of antidepressants are at a higher risk of developing hypertensive disorders of pregnancy. Close monitoring of their health and early treatment of depression, while considering the specific class of antidepressants, is recommended.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Review
Nutrition & Dietetics
Megan G. Bragg, Elizabeth L. Prado, Christine P. Stewart
Summary: Choline and DHA are important nutrients for child neurodevelopment and health, but may be lacking in the diets of pregnant and lactating women and young children in low- and middle-income countries. More research is needed to understand the specific, long-term effects of perinatal intake of these nutrients in different contexts.
Article
Pharmacology & Pharmacy
Hana Horackova, Rona Karahoda, Lukas Cerveny, Veronika Vachalova, Ronja Ebner, Cilia Abad, Frantisek Staud
Summary: Depression is common during pregnancy and many women are prescribed antidepressants. These drugs may disrupt serotonin homeostasis in the placenta or fetus, potentially leading to adverse effects of antidepressant use during pregnancy.
Article
Clinical Neurology
Yu-Wei Liu, Hui Liu, Kun Huang, Bei-Bei Zhu, Shuang-Qin Yan, Jia-Hu Hao, Peng Zhu, Fang-Biao Tao, Shan-Shan Shao
Summary: Pregnancy-related anxiety (PRA) is correlated with children's behavioral development, and parenting styles mediate this relationship while breastfeeding methods have no effect.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Pediatrics
Sara Fortin-Miller, Brendel Plonka, Heather Gibbs, Danielle Christifano, Holly Hull
Summary: Prenatal interventions such as diet, exercise, or combined approaches do not have a consistent lasting effect on child adiposity. Combined interventions initiated early in pregnancy may decrease offspring adiposity in the first year of life.
Article
Multidisciplinary Sciences
Mamothena Carol Mothupi, Jeroen De Man, Hanani Tabana, Lucia Knight
Summary: This study developed and tested a composite index to assess the continuum of care for maternal health in a province in South Africa, showing overall improvement in service delivery over time. The index was found to be robust and valid, identifying areas for improvement including social determinants of health and access to care.
Article
Psychology, Clinical
Megan Galbally, Stuart J. Watson, Elisabeth F. C. van Rossum, Wai Chen, Edo Ronald de Kloet, Andrew J. Lewis
Summary: The study found that preterm birth, antenatal depression, and maternal childhood trauma were associated with childhood anxiety disorders at the age of 4. Additionally, the study suggests that maternal factors before conception, during pregnancy, and in the postnatal period play a significant role in predicting CAD.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Psychiatry
Megan Galbally, Stuart J. Watson, Anne Tharner, Maartje Luijk, Gaynor Blankley, Kelli K. MacMillan, Josephine Power, Andrew J. Lewis
Summary: Understanding the relationship between attachment and mental health is crucial for managing perinatal mental disorders and promoting infant mental health. While previous research suggested that attachment experiences are transmitted across generations, findings from this study indicate that maternal depression and non-autonomous attachment may have a significant impact on infant-parent attachment. Maternal sensitivity was not found to mediate the relationship between parental and infant attachment security in this sample.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2022)
Article
Public, Environmental & Occupational Health
Gabriella Catanzariti, Stuart Watson, Raoul Oehmen, Kelli MacMillan, Megan Galbally
Summary: This study found that rural women diagnosed with depression were more likely to experience stressful life events compared to rural women without depression and metropolitan women. This highlights the need for targeted, preventative interventions for Australian rural women during the prenatal period.
AUSTRALIAN JOURNAL OF RURAL HEALTH
(2022)
Article
Psychiatry
Megan Galbally, Stuart J. Watson, Olav Spigset
Summary: This study found that pregnant women with depression or taking certain types of antidepressants are at a higher risk of developing hypertensive disorders of pregnancy. Close monitoring of their health and early treatment of depression, while considering the specific class of antidepressants, is recommended.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Megan Galbally, Katherine Eggleston, Korinne Northwood, Dan Siskind, Michael Berk, Shuichi Suetani, Neeraj Gill, Nick O'Connor, Samuel B. Harvey, Susanna Every-Palmer
Summary: Re-examining the position of women in academic psychiatry and addressing the barriers they face is crucial for the revival and gender equity of this field. By promoting gender equality, academic psychiatry can make significant progress and gain insights into mental disorders.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Article
Public, Environmental & Occupational Health
Megan Galbally, Stuart J. Watson, Mathew Coleman, Paul Worley, Leanda Verrier, Vineet Padmanabhan, Andrew J. Lewis
Summary: This study compares perinatal well-being between women living in metropolitan and rural regions. The results showed that there were no significant differences between urban and rural women in terms of depressive disorders, breastfeeding cessation, exercise, sleep, and partner support. However, rural women with depression reported higher parenting stress and lower access to parenting activities.
AUSTRALIAN JOURNAL OF RURAL HEALTH
(2023)
Article
Psychiatry
Melissa Mulcahy, Christian Long, Teagan Morrow, Megan Galbally, Clare Rees, Rebecca Anderson
Summary: The perinatal period is a vulnerable time for parents with obsessive-compulsive disorder (OCD), but existing guidelines do not address specific considerations for OCD in this period. This study used a survey to establish best practice recommendations for perinatal OCD. Experts and individuals with lived experience endorsed 102 statements, which inform practice across eight themes.
ARCHIVES OF WOMENS MENTAL HEALTH
(2023)
Article
Psychiatry
Akilew A. Adane, Carrington C. J. Shepherd, Roz Walker, Helen D. Bailey, Megan Galbally, Rhonda Marriott
Summary: This study examined the association between maternal mental disorders and adverse perinatal outcomes among Aboriginal births in Western Australia. The results showed that maternal mental disorders were associated with an increased risk of various adverse birth outcomes. The study highlights the importance of providing holistic perinatal care, treatment, and support for women with mental disorders.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Article
Family Studies
Yu Ying Low, Andrew J. Lewis, Irene G. Serfaty
Summary: The Parental Reflective Interview Procedure was developed as part of an initial assessment interview for an attachment-based intervention for child mental health conditions. This pilot randomised controlled trial compared the effects of the Parental Reflective Interview Procedure with a diagnostic interview on parental reflective functioning. Results showed that the Parental Reflective Interview Procedure led to improvements in parents' understanding of their children's mental states and maintenance in their reflections on intergenerational parent-child relationship patterns, while the diagnostic interview showed decreases in these dimensions. This suggests that the Parental Reflective Interview Procedure is a promising format for initial assessment when there are difficulties in the parent-child relationship.
JOURNAL OF CHILD AND FAMILY STUDIES
(2023)
Article
Psychiatry
Megan Galbally, Beth Kotze, Ryan Barber, Sue Mackersey
Summary: The objectives of this study were to present data on gender equity, describe the development of an action plan, and discuss its alignment with a commitment to inclusion and diversity. The methods included the formation of a working group, data snapshot and discussion, literature review, and consultation across the organization. The results showed clear gaps in leadership roles, academic activities, and awards, which led to the development of an action plan.
AUSTRALASIAN PSYCHIATRY
(2023)
Article
Psychiatry
Megan Galbally, Stuart J. Watson, Philip Boyce, Louise Howard, Helen Herrman
Summary: This study investigated 360 women and found that the Edinburgh Postnatal Depression Scale cannot accurately predict different types of postnatal depression and associated complications. However, the study provides guidance for researching the impact of personalized management on the prognosis of women with postnatal depression.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Article
Psychology, Clinical
Josephine Power, Stuart Watson, Wai Chen, Andrew Lewis, Marinus van IJzendoorn, Megan Galbally
Summary: This study finds that increasing maternal depressive symptoms during the perinatal period are associated with poorer executive function outcomes in children at the age of 4, independent of prenatal smoking, drinking, or antidepressant use. The chronicity, severity, and postpartum influences of depression may play crucial roles in determining childhood executive function outcomes.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Developmental
Megan Galbally, Stuart J. Watson, Thinh Nguyen, Philip Boyce
Summary: This longitudinal study investigates the impact of fetal exposure to selective serotonergic reuptake inhibitor antidepressants on infant sleep behaviors at six and 12 months of age. The study focuses on three commonly prescribed antidepressants during pregnancy. The results show that sertraline is associated with longer time to sleep for infants, but these antidepressants are not related to increased waking or time awake for infants.
INFANT BEHAVIOR & DEVELOPMENT
(2023)
Article
Psychiatry
Judy Hope, David Copolov, John Tiller, Megan Galbally, Malcolm Hopwood, Richard Newton, Nicholas A. Keks
Summary: The usefulness of esketamine for treating treatment-resistant depression was reviewed in this article. Results showed that esketamine, in combination with an antidepressant, had a higher remission rate compared to a placebo. However, relapse was observed when esketamine was withdrawn in stable remitters. Adverse effects such as dissociation, dizziness, and nausea were reported, while the risk of abuse was low. The cost of treatment may be a limiting factor.
AUSTRALASIAN PSYCHIATRY
(2023)
