期刊
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
卷 49, 期 2, 页码 130-136出版社
WILEY-BLACKWELL PUBLISHING, INC
DOI: 10.1111/j.1479-828X.2009.00953.x
关键词
perinatal mortality; periodontal disease; preterm birth; stillbirth
资金
- RANZCOG Research Foundation
- NHMRC [353577]
- Channel 7 Telethon and the Forrest Fellowship
- Women and Infants Research Foundation
Periodontal disease has been associated with increased perinatal mortality. To examine the association between maternal periodontal disease and perinatal mortality. We performed a retrospective and prospective matched case-control study of women with unexplained perinatal mortality at more than 20 weeks gestational age. Women were matched for socioeconomic status, smoking status and time since delivery. All women underwent a detailed periodontal examination and completed a questionnaire describing oral health symptoms. No intervention took place. Fifty-three women who had experienced a perinatal death and 111 controls completed the study. Thirty-two women were recruited retrospectively and 21 women were recruited prospectively. Twenty-three (43.4%) women who had experienced a perinatal death and 27 (24.3%) controls had periodontal disease. There were no differences in oral health behaviours or symptoms between cases and controls. Perinatal death was associated with periodontal disease (odds ratio (OR) 2.34, 95% confidence interval (CI) 1.05, 5.47). Periodontal disease was more strongly associated with perinatal mortality due to extreme prematurity (OR 3.60, 95% CI 1.20, 12.04). Multivariate analysis showed this relationship to be consistent after inclusion of higher parity, country of birth, advanced maternal age and maternal obesity in the model (OR 4.56, 95% CI 1.25, 21.27). Maternal periodontal disease may contribute to perinatal mortality, especially that caused by extreme prematurity.
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