Article
Biochemistry & Molecular Biology
Shinya Yokomizo, Malte Roessing, Atsuyo Morita, Timo Kopp, Emiyu Ogawa, Wataru Katagiri, Susanne Feil, Paul L. Huang, Dmitriy N. Atochin, Satoshi Kashiwagi
Summary: This study provides evidence that NIR-II laser enhances bioavailable NO in endothelial cells, suggesting its potential use in restoring endothelial NO and treating or preventing cardiovascular diseases.
Article
Pharmacology & Pharmacy
Tatsiana Suvorava, Sara Metry, Stephanie Pick, Georg Kojda
Summary: Vascular tone regulation by nitric oxide is a crucial physiological function, with endothelial dysfunction potentially being an underlying cause of hypertension. Increasing eNOS activity reduces blood pressure, while decreasing activity has the opposite effect. These findings have important implications for pre-hypertensive treatment.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Michal Kluknavsky, Andrea Micurova, Martin Skratek, Peter Balis, Monika Okuliarova, Jan Manka, Iveta Bernatova
Summary: This study investigated the differences in biodistribution of superparamagnetic magnetite nanoparticles (IONs) in the heart and liver of normotensive Wistar Kyoto (WKY) and spontaneously hypertensive (SHR) rats. It also examined the effects of IONs on the expression of selected genes involved in iron metabolism regulation. The results showed that SHR had less ION incorporation in tissues compared to WKY, and hearts had less ION distribution compared to livers.
Article
Food Science & Technology
Francineide Fernandes-Costa, Rayanelle Tissiane Gomes da Silva, Atalia Ferreira de Lima Flor, Maria Claudia R. Brandao, Petronio F. Athayde-Filho, Maria do Socorro Franca-Falcao, Valdir de Andrade Braga, Gustavo Jorge dos Santos, Mattias Carlstrom, Josiane de Campos Cruz
Summary: Our study investigated the cardiometabolic effect of NDBP treatment in a mouse model of type 1 diabetes (T1DM). The results showed that NDBP treatment reduced hyperglycemia, improved glucose tolerance, and decreased oxidative stress in the liver and pancreas. Additionally, NDBP treatment improved vascular function but had no effect on hypertension.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Medicine, General & Internal
Tina Tomic Mahecic, Branko Malojcic, Dinko Tonkovic, Mirabel Mazar, Robert Baronica, Snjezana Juren Measki, Andrea Crkvenac Gregorek, Jens Meier, Martin W. W. Duenser
Summary: This single-center trial examined the impact of near-infrared spectroscopy (NIRS)-guided blood pressure management on neurocognitive function and perioperative complications in patients undergoing carotid endarterectomy (CEA). The results showed that the intervention group, guided by NIRS, had lower systolic blood pressure and norepinephrine doses during carotid cross-clamping, as well as a lower rate of perioperative complications.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Emily Margaret Jakubcik, Kay Rutherfurd-Markwick, Marsanne Chabert, Marie Wong, Ajmol Ali
Summary: This study found that the ingestion of inorganic nitrate in beetroot juice is a critical factor in elevating plasma nitrate and nitrite levels. Both nitrate and nitrite have potential to reduce mean arterial pressure, with high nitrate concentration leading to significant reductions in mean arterial pressure in a shorter period of time. However, it is currently unclear whether nitrite contributes to the reduction in blood pressure.
Article
Biochemistry & Molecular Biology
Andrea Micurova, Michal Kluknavsky, Silvia Liskova, Peter Balis, Martin Skratek, Ludmila Okruhlicova, Jan Manka, Iveta Bernatova
Summary: The study investigated the effects of Fe3O4@PEG nanoparticles in hypertensive rats, noting alterations in blood pressure, nitric oxide synthase activity, and gene expression in the aorta and liver. Results suggest that caution should be taken when using iron oxide nanoparticles in hypertensive subjects due to potential differences in tissue distribution and biological effects.
Article
Nutrition & Dietetics
Ji Soo Baik, Ji Hong Min, Sung Min Ju, Jae Hyun Ahn, Sung Hwa Ko, Hyun Soo Chon, Min Sun Kim, Yong Il Shin
Summary: The study found that FGE containing NO2- can improve vascular function, increase blood flow, and enhance regional cerebral blood flow, resulting in an increase in body temperature. No significant side effects were observed in healthy participants during the study, suggesting potential benefits of NO2- containing FGE in regulating circulation.
Article
Peripheral Vascular Disease
Fulye Argunhan, Dibesh Thapa, Aisah Aniisah Aubdool, Emanuele Carlini, Kate Arkless, Erica Ruth Hendrikse, Joao de Sousa Valente, Xenia Kodji, Brentton Barrett, Carlo Alberto Ricciardi, Luigi Gnudi, Debbie Lucy Hay, Susan Diana Brain
Summary: CGRP plays a protective role in cardiovascular function by restoring blood pressure and preventing cardiovascular remodeling when nitric oxide production is diminished. Endogenous CGRP acts to protect cardiovascular function, while exogenous CGRP can rescue affected mice.
Article
Peripheral Vascular Disease
Kelly A. Stockelman, Anthony R. Bain, Anabel Goulding, Noah M. DeSouza, Clay Rahaman, Lukas Maly, Jared J. Greiner, Brian L. Stauffer, Christopher A. DeSouza
Summary: Insufficient nightly sleep is associated with reduced nitric oxide-mediated endothelium-dependent vasodilation and endothelial tPA release in hypertensive adults, likely due to increased oxidative stress.
Article
Peripheral Vascular Disease
Kristen J. Bubb, Owen Tang, Carmine Gentile, Seyed M. Moosavi, Thomas Hansen, Chia-Chi Liu, Belinda A. Di Bartolo, Gemma A. Figtree
Summary: FXYD1 plays a crucial role in protecting eNOS from oxidative stress and contributes to cardiovascular health; FXYD1 regulates oxidative dysregulation within caveolae where it is colocalized; In addition to impacting eNOS function, FXYD1 is closely associated with hypertension and diabetic vascular oxidative stress.
Article
Multidisciplinary Sciences
Daniel L. D. Freitas, Ana F. S. Peres, Lidiane G. Silva, Joao V. M. Mariz, Marcos G. Santos, Rayanne S. P. Morais, Camilo L. M. Morais, Francis L. Martin, Daniel A. Pascoal, Juliana D. de A. S. Camargo, Janaina C. O. Crispim, Kassio M. G. Lima
Summary: The prevention of mother-to-child transmission programs in Brazil have seen success, as access to antiretroviral therapy during pregnancy has led to a reduction in new infections among children. By utilizing near-infrared spectroscopy, pregnant women with and without HIV infection can be quickly and accurately differentiated, offering a new perspective on investigating vertical transmission and providing a potential low-cost screening tool for fast HIV detection.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Francesca Leo, Tatsiana Suvorava, Sophia K. Heuser, Junjie Li, Anthea LoBue, Frederik Barbarino, Eugenia Piragine, Rebekka Schneckmann, Beate Hutzler, Miranda E. Good, Bernadette O. Fernandez, Lukas Vornholz, Stephen Rogers, Allan Doctor, Maria Grandoch, Johannes Stegbauer, Eddie Weitzberg, Martin Feelisch, Jon O. Lundberg, Brant E. Isakson, Malte Kelm, Miriam M. Cortese-Krott
Summary: This study demonstrates that eNOS in ECs and RBCs independently contribute to blood pressure homeostasis. EC eNOS KO mice exhibited significantly impaired aortic dilatory responses to acetylcholine, loss of flow-mediated dilation, and increased blood pressure. On the other hand, RBC eNOS KO mice showed no alterations in acetylcholine-mediated dilation or flow-mediated dilation but were hypertensive.
Article
Engineering, Environmental
Aliya Tiemuer, Hui Yu, Chao Zhao, Wanlu Sun, Yuanyuan Zhang, Yiming Jiang, Yueqing Gu, Yi Liu
Summary: Gas therapy, particularly utilizing NO gas transmitter, has shown promise for effective cancer treatment. This study focused on addressing the drawbacks of current NO prodrugs, developing NIR light-triggered NO-releasing donors with superb spatiotemporal controllability for efficient NO delivery and real-time drug monitoring. The use of frequency upconversion luminescence (FUCL) readout for imaging provides high sensitivity and resolution, making it a potential breakthrough in deep-seated tumor therapy.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Multidisciplinary Sciences
Giorgio Manferdelli, Benjamin J. Narang, Vincent Pialoux, Guido Giardini, Tadej Debevec, Gregoire P. Millet
Summary: Premature birth is associated with impaired physiological responses to acute altitude exposure due to endothelial and mitochondrial dysfunction, and chronic oxidative stress. The study found that preterm adults exhibited a lower microvascular reperfusion rate and higher skeletal muscle oxidative capacity compared to term born controls after acute high-altitude exposure.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Anni Vanhatalo, Joanna E. L'Heureux, James Kelly, Jamie R. Blackwell, Lee J. Wylie, Jonathan Fulford, Paul G. Winyard, David W. Williams, Mark van der Giezen, Andrew M. Jones
Summary: The study found that after nitrate supplementation, there were changes in the relative abundance of oral bacteria, which had stable effects on cardiovascular health and cognitive function. The nitrate-sensitive oral microbiome modules may serve as potential targets for improving cardiovascular and cognitive health in older people.
Article
Biochemistry & Molecular Biology
Mohammed Abu-Alghayth, Anni Vanhatalo, Lee J. Wylie, Sinead TJ. McDonagh, Christopher Thompson, Stefan Kadach, Paul Kerr, Miranda J. Smallwood, Andrew M. Jones, Paul G. Winyard
Summary: Ingestion of beetroot juice rich in nitrate increases the concentration of RSNO in red blood cells and plasma, potentially playing a role in nitrate metabolism and actions.
Article
Food Science & Technology
Andrea M. McGrattan, Blossom C. M. Stephan, Oliver M. Shannon, Mohsen Mazidi, Mark Gilchrist, Miranda Smallwood, Paul Winyard, Nicholas McMahon, Lauren C. Blekkenhorst, Devi Mohan, Stefania Bandinelli, Louise Robinson, Luigi Ferrucci, Mario Siervo
Summary: This study investigated the associations between dietary sodium and nitrate intakes with cognitive function and blood pressure. The results showed that urinary nitrate excretion was associated with lower blood pressure, while sodium intake did not significantly correlate with cognitive performance. Further longitudinal studies are needed to confirm these findings.
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
(2022)
Article
Chemistry, Medicinal
Sotiris Kyriakou, Venetia Tragkola, Heba Alghol, Ioannis Anestopoulos, Tom Amery, Kyle Stewart, Paul G. Winyard, Dimitrios T. Trafalis, Rodrigo Franco, Aglaia Pappa, Mihalis I. Panayiotidis
Summary: This study chemically characterized and biologically evaluated watercress, finding that the edible part contained higher amounts of nutrients and phytochemicals compared to the non-edible part. The edible watercress showed higher cytotoxic potential against malignant melanoma cells, indicating its potential as an anti-cancer agent.
Article
Endocrinology & Metabolism
Rocky Strollo, Chiara Vinci, Y. K. Stella Man, Sara Bruzzaniti, Erica Piemonte, Ghadeer Alhamar, Silvia Irina Briganti, Ilaria Malandrucco, Flavia Tramontana, Chiara Fanali, James Garnett, Roberto Buccafusca, Perrin Guyer, Mark Mamula, Eddie A. James, Paolo Pozzilli, Johnny Ludvigsson, Paul G. Winyard, Mario Galgani, Ahuva Nissim
Summary: The study found that patients with type 1 diabetes had stronger antibody and T cell responses to insulin with oxidative post-translational modifications. Specific peptide segments induced stronger stimulation of CD4(+) and CD8(+) T cells in type 1 diabetes patients, leading to more antibody responses.
Article
Nutrition & Dietetics
Stuart P. P. Cocksedge, Adam J. J. Causer, Paul G. G. Winyard, Andrew M. M. Jones, Stephen J. J. Bailey
Summary: This study investigated the effects of oral temperature and pH on the increases in salivary and plasma [NO2-] after dietary NO3- supplementation. The results showed that salivary [NO2-] increased when oral pH was elevated, regardless of oral temperature, while plasma [NO2-] increased to a greater extent at a higher oral pH.
Article
Plant Sciences
Sotiris Kyriakou, Kyriaki Michailidou, Tom Amery, Kyle Stewart, Paul G. Winyard, Dimitrios T. Trafalis, Rodrigo Franco, Aglaia Pappa, Mihalis I. Panayiotidis
Summary: Watercress, a rich source of secondary metabolites, contains various active compounds with disease-preventing and health-promoting properties. The content of these compounds differs in watercress flowers, leaves, and stems. The level of isothiocyanates is not only influenced by the bioconversion of individual glucosinolates, but also by other glucosinolates of the same group.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Samantha N. Rowland, Mariasole Da Boit, Rachel Tan, George P. Robinson, Emma O'Donnell, Lewis J. James, Stephen J. Bailey
Summary: Short-term dietary nitrate supplementation can enhance performance in submaximal endurance and short-duration, maximal-intensity exercise. A study found that participants who ingested NO3--rich beetroot powder had higher plasma [NO3-] and [NO2-] levels, and showed improved mean power output and faster muscle oxygenation kinetics during an end-sprint. These findings suggest that NO3- supplementation can improve end-sprint performance in endurance events when taken before and during exercise.
Article
Engineering, Biomedical
Emily J. Owen, Rachel A. Heylen, Kyle Stewart, Paul G. Winyard, A. Toby A. Jenkins
Summary: This review discusses the current understanding of the prevention and treatment of Incontinence Associated Dermatitis (IAD). It emphasizes the need for specific preventative measures targeting faecal/urinary irritants, including the use of urease inhibitors. The lack of internationally accepted diagnostic methods for IAD severity is identified, with current diagnosis relying on visual inspection. Non-invasive techniques, such as impedance spectroscopy, could potentially provide objective assessments of skin barrier function and aid in early detection and intervention.
PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE
(2023)
Review
Nutrition & Dietetics
Rachel Tan, Adam Pennell, Sean T. Karl, Jordan K. Cass, Katherine Go, Tom Clifford, Stephen J. Bailey, Cooker Perkins Storm
Summary: This systematic review and meta-analysis examined the impact of dietary nitrate supplementation on resistance exercise performance. Six studies were analyzed and showed that nitrate supplementation improved repetitions-to-failure, mean power, and mean velocity but had no effect on peak power or peak velocity. Subgroup analyses suggested that back squats were more likely to be enhanced and dosing regimens may influence the efficacy of nitrate supplementation. Additional studies are needed to further understand the effects of dietary nitrate supplementation on resistance exercise performance.
Review
Biochemistry & Molecular Biology
Nehal S. Alsharif, Tom Clifford, Abrar Alhebshi, Samantha N. Rowland, Stephen J. Bailey
Summary: Inorganic nitrate (NO3-) has shown potential as an ergogenic aid in enhancing performance during high-intensity exercise. This review analyzed 27 studies and conducted a meta-analysis, which found that NO3- supplementation improved time to reach peak power, mean power output, and total distance covered in the Yo-Yo intermittent recovery level 1 test. These findings suggest that athletes participating in high-intensity exercise may benefit from NO3- supplementation.
Article
Biochemistry & Molecular Biology
Chenguang Wei, Anni Vanhatalo, Stefan Kadach, Zdravko Stoyanov, Mohammed Abu-Alghayth, Matthew I. Black, Miranda J. Smallwood, Raghini Rajaram, Paul G. Winyard, Andrew M. Jones
Summary: Dietary nitrate supplementation can increase nitric oxide bioavailability and lower blood pressure in humans. This study investigated the correlations between changes in NO biomarkers in different blood compartments and changes in blood pressure following acute nitrate ingestion.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Samantha N. N. Rowland, Liam M. M. Heaney, Mariasole Da Boit, Stephen J. J. Bailey
Summary: This study suggests that there was no difference in TMAO concentration between eumenorrheic women, contraceptive users, and men. Additionally, blood pressure remained consistent across menstrual cycle and pill days, although brachial systolic blood pressure was higher in males compared to females.
Meeting Abstract
Gastroenterology & Hepatology
R. Nice, J. R. Goodhand, N. Kennedy, T. Ahmad, P. Winyard, T. J. McDonald
JOURNAL OF CROHNS & COLITIS
(2022)