Article
Pharmacology & Pharmacy
Xiaomei Yang, Xiaona An, Cheng Wang, Feng Gao, Yicheng Lin, Wenjing Chen, Qiming Deng, Dongsheng Xu, Shengqiang Li, Peng Zhang, Baozhu Sun, Yuedong Hou, Jianbo Wu
Summary: This study aimed to investigate whether oxytocin (OT) can attenuate ventilator-induced lung injury (VILI) and explore the underlying mechanism. The results showed that OT treatment reduced pathological injury, lung wet/dry ratio, and myeloperoxidase (MPO) activity in VILI mice. OT administration also downregulated TLR4/My-D88 expression and NF-kappa B, NLRP3, and caspase-1 activation in lung tissues, as well as decreased inflammatory cytokine levels in bronchoalveolar lavage fluid.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hajera Amatullah, Tatiana Maron-Gutierrez, Yuexin Shan, Sahil Gupta, James N. Tsoporis, Amir K. Varkouhi, Ana Paula Teixeira Monteiro, Xiaolin He, Jun Yin, John C. Marshall, Patricia R. M. Rocco, Haibo Zhang, Wolfgang M. Kuebler, Claudia C. dos Santos
Summary: The research highlights the role of DJ-1 as a negative regulator of ROS and inflammation in sterile LPS-induced acute lung injury and ventilator-induced lung injury, protecting against the effects of oxidative stress.
Article
Multidisciplinary Sciences
Chin-Kuo Lin, Tzu-Hsiung Huang, Cheng-Ta Yang, Chung-Sheng Shi
Summary: The study found that lung-recruited monocytes post-VILI are predominantly Ly6C(+low), and pulmonary VEGF decreases initially but increases significantly on days 7 and 14 after injury. There is a strong positive correlation between VEGF expression and alveolar epithelial cell proliferation, and the restoration of pulmonary VEGF by monocytes may play a crucial role in post-VILI lung repair.
Review
Physiology
Neel Shah, Bhushan H. Katira
Summary: Adverse cardiopulmonary interaction during mechanical ventilation plays a significant role in the development of ventilator-induced lung injury (VILI). High transpulmonary pressure increases afterload on the right heart, while high pleural pressure reduces the right ventricular preload, resulting in swings of pulmonary vascular flow and pressure. These alterations in vascular flow and pressure lead to microvascular injury and increased permeability, which can be reduced by targeting cardiovascular stressors in the pulmonary circulation.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Critical Care Medicine
Gary Nieman, Michaela Kollisch-Singule, Harry Ramcharran, Joshua Satalin, Sarah Blair, Louis A. Gatto, Penny Andrews, Auyon Ghosh, David W. Kaczka, Donald Gaver, Jason Bates, Nader M. Habashi
Summary: Time-controlled adaptive ventilation (TCAV) is a novel ventilator approach that considers the temporal aspects of dynamic lung mechanics. It aims to reduce the risk of ventilator-induced lung injury (VILI) by adjusting the duration of expiration and inspiration, leading to improved survival rate of patients.
Article
Physiology
Harry Ramcharran, Jason H. T. Bates, Joshua Satalin, Sarah Blair, Penny L. Andrews, Donald P. Gaver, Louis A. Gatto, Guirong Wang, Auyon J. Ghosh, Benjamin Robedee, James Vossler, Nader M. Habashi, Nirav Daphtary, Michaela Kollisch-Singule, Gary F. Nieman
Summary: Ventilator-induced lung injury is a significant risk for patients with ARDS. Avoiding cyclic recruitment and derecruitment may be more important than overdistension in managing ARDS patients.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Physiology
Martin Scharffenberg, Jakob Wittenstein, Xi Ran, Yingying Zhang, Anja Braune, Raphael Theilen, Lorenzo Maiello, Giulia Benzi, Thomas Bluth, Thomas Kiss, Paolo Pelosi, Patricia R. M. Rocco, Marcus J. Schultz, Joerg Kotzerke, Marcelo Gama de Abreu, Robert Huhle
Summary: In this study, pulmonary neutrophilic inflammation evaluated by PET/CT increased after 24 hours of mechanical ventilation, and correlated with mechanical power.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Critical Care Medicine
Faizan Anwar, Nicklaus A. Sparrow, Mohammad Harun Rashid, Gena Guidry, Michael M. Gezalian, Eric J. Ley, Maya Koronyo-Hamaoui, Itai Danovitch, E. Wesley Ely, S. Ananth Karumanchi, Shouri Lahiri
Summary: This study demonstrates the pathogenic role of systemic IL-6 in mediating structural and functional acute neuropsychiatric symptoms in VILI. The researchers found that inhibiting IL-6 can reduce neural injury and improve acute neuropsychiatric behaviors in mice with VILI.
Article
Critical Care Medicine
Susumu Nakahashi, Hiroshi Imai, Nobutake Shimojo, Yasuhiro Magata, Takahiro Einama, Mineji Hayakawa, Takeshi Wada, Yuji Morimoto, Satoshi Gando
Summary: This study assessed the role of prone position in the development of VILI-associated lung inflammation. Using an experimental rabbit lung injury model, it was found that the prone position reduced lung inflammation and slowed down the progression of VILI through the homogenization of lung tissue and mechanical forces.
Article
Physiology
Almos Schranc, Gergely H. Fodor, Roberta Suedy, Jozsef Tolnai, Barna Babik, Ferenc Petak
Summary: This study investigates the impact of type 2 diabetes on ventilator-induced lung injury and finds that untreated diabetes exacerbates the injury while controlling blood sugar levels with metformin can alleviate respiratory defects during mechanical ventilation.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Respiratory System
Vlasios Karageorgos, Athanasia Proklou, Katerina Vaporidi
Summary: In order to adhere to the Hippocratic Oath, efforts must be made to minimize the adverse effects of mechanical ventilation. Recent research has increased our understanding of ventilator-induced lung injury (VILI) and ventilator-induced diaphragm dysfunction (VIDD). Focus is now on monitoring lung stress and inhomogeneity and setting appropriate ventilator targets. Early assisted ventilation also presents new challenges, such as adjusting inspiratory effort and synchronizing patient-ventilator interaction.
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2022)
Review
Respiratory System
Allan J. G. Bruinooge, Ruochen Mao, Tania H. Gottschalk, Sadeesh K. Srinathan, Gordon Buduhan, Lawrence Tan, Andrew J. Halayko, Biniam Kidane
Summary: In this scoping review, IL-6 and TNF-alpha were identified as the most reliable biomarkers for ventilator-induced lung injury (VILI) after one-lung ventilation (OLV). However, studies on this topic are limited in sample size and the use of human participants.
JOURNAL OF THORACIC DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Athanassios Fragoulis, Kristina Biller, Stephanie Fragoulis, Dennis Lex, Stefan Uhlig, Lucy Kathleen Reiss
Summary: Selecting suitable reference genes is crucial in qRT-PCR data analysis. The stability of reference genes varies in acute lung injury models, and inappropriate normalization can lead to significant misinterpretation of gene expression data.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Nicklaus A. Sparrow, Faizan Anwar, Ambart E. Covarrubias, Padmesh S. Rajput, Mohammad Harun Rashid, Peyton L. Nisson, Michael M. Gezalian, Shahed Toossi, Maranatha O. Ayodele, S. Ananth Karumanchi, E. Wesley Ely, Shouri Lahiri
Summary: Mechanical ventilation is a risk factor for cognitive impairment, with upregulation of IL-6 potentially playing a role. Inhibiting systemic IL-6 could mitigate neuropathological effects associated with cognitive impairment, providing a potential novel neuroprotective strategy worth further investigation.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Frank Silva Bezerra, Manuella Lanzetti, Renata Tiscoski Nesi, Akinori Cardozo Nagato, Cyntia Pecli e Silva, Emanuel Kennedy-Feitosa, Adriana Correa Melo, Isabella Cattani-Cavalieri, Luis Cristovao Porto, Samuel Santos Valenca
Summary: Acute and chronic lung injuries are major causes of global mortality. Current therapies primarily focus on symptom relief rather than reversing or preventing lung pathology. Supportive interventions, such as oxygen and mechanical ventilation, can worsen lung function and lead to permanent injuries. Sepsis, originating from extrapulmonary or respiratory sources, contributes to lung-related deaths. This article aims to summarize the molecular and cellular mechanisms of acute and chronic lung injuries, focusing on airway inflammation and oxidative stress. It also explores new antioxidant-based drug options for managing these conditions.