Article
Medicine, General & Internal
Rithvik Swamynathan, Vinithra Varadarajan, Hieu Nguyen, Colin O. Wu, Kiang Liu, David A. Bluemke, Nadjia Kachenoura, Alban Redheuil, Joao A. C. Lima, Bharath Ambale-Venkatesh
Summary: This study investigates the association between chronic inflammation and subclinical vascular dysfunction. The results show that higher levels of CRP at baseline are independently associated with a 10-year increase in aortic stiffness, as measured by decreased aortic distensibility.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Caifeng Shi, Aiqin He, Xiaomei Wu, Lulu Wang, Xueting Zhu, Lei Jiang, Junwei Yang, Yang Zhou
Summary: The urinary levels of IL-18 appear to be associated with greater pulse wave velocity (PWV) in patients with T2D, indicating a link between urinary IL-18 and arterial stiffness.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zheng-Wei Chen, Chien-Ting Pan, Cheng-Hsuan Tsai, Yi-Yao Chang, Chin-Chen Chang, Bo-Ching Lee, Yu-Wei Chiu, Wei-Chieh Huang, Yu-Li Lin, Vin-Cent Wu, Chi-Sheng Hung, Che-Wei Liao, Yen-Hung Lin
Summary: In this study involving 1006 PA patients and 983 EH patients, it was found that haPWV is more sensitive than baPWV in detecting aldosterone-induced arterial stiffness. Results indicated that PA patients had significantly higher baPWV compared to EH patients.
Article
Computer Science, Interdisciplinary Applications
Yang Yao, Shuran Zhou, Jordi Alastruey, Liling Hao, Stephen E. Greenwald, Yuelan Zhang, Lin Xu, Lisheng Xu, Yudong Yao
Summary: This study aims to identify pulse wave features for a more accurate estimation of carotid-femoral pulse wave velocity (cfPWV) from a single radial pulse wave measurement. The results show that the amplitude ratio of the diastolic peak to the notch of the radial pulse waveform is correlated with cfPWV and this correlation may not be dependent on wave reflection.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Medicine, General & Internal
Crina Claudia Rusu, Ina Kacso, Diana Moldovan, Alina Potra, Dacian Tirinescu, Maria Ticala, Ancuta M. M. Rotar, Remus Orasan, Cristian Budurea, Andrada Barar, Florin Anton, Ana Valea, Cosmina Ioana Bondor, Madalina Ticolea
Summary: Cardiovascular diseases are the leading cause of mortality in patients with chronic kidney disease. This study evaluated the impact of nutritional, hormonal, and inflammatory markers on brachial-ankle Pulse Wave Velocity in pre-dialysis CKD patients. The results showed that reduced muscle mass, low levels of total cholesterol, triglycerides, triiodothyronine, and prolactin were associated with high Pulse Wave Velocity, as well as advanced age.
Article
Medicine, General & Internal
Mariana P. de Souza, Paulo Cesar Lopes, Gabriel Bazo, Paulo Ricardo H. Rocha, Daniela Aparecida Lorencini, Heloisa Bettiol, Marco Antonio Barbieri, Eduardo B. Coelho
Summary: The study aimed to determine the most accurate diagnostic criteria of arterial hypertension (AH) for detecting early vascular aging (EVA). The results of the cross-sectional study on 1775 participants showed that the 2017 ACC/AHA criteria had higher accuracy in diagnosing EVA.
Article
Biochemistry & Molecular Biology
Simin Feng, Minghui Sui, Dan Wang, Christos Ritzoulis, Mohamed A. Farag, Ping Shao
Summary: The study showed that nano-embedded stigmasterol based on zein and pectin could alleviate colitis in mice by reducing adverse physiological symptoms, preventing colon shortening, and inhibiting the NF-kappa B signaling pathway. The addition of pectin increased the stability of the nanoparticles and improved the therapeutic effect. Future research is needed to investigate the efficacy of nano-embedded stigmasterol in humans.
Article
Pharmacology & Pharmacy
Chun-mei Chen, Chun-feng Lu, Wang-shu Liu, Zhen-hua Gong, Xue-qin Wang, Feng Xu, Jian-feng Ji, Xing-xing Fang
Summary: This study aimed to examine the relationship between fibrinogen albumin ratio (FAR) and arterial stiffness in patients with type 2 diabetes (T2D). The results showed a significant positive correlation between FAR and brachial-ankle pulse wave velocity (baPWV) as well as arterial stiffness, but only in male patients.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tomasz Powrozek, Dominika Pigon-Zajac, Marcin Mazurek, Michael Ochieng Otieno, Mansur Rahnama-Hezavah, Teresa Malecka-Massalska
Summary: This study aimed to evaluate the impact of inflammatory conditions on the expression of long non-coding RNAs (lncRNAs) in a mouse skeletal muscle cell line. Three lncRNAs (Gm4117, Ccdc41os1, and 5830418P13Rik) were found to be significant in inflammatory-related myotube atrophy. The expression of lncRNAs varied depending on the concentration of the inflammatory factor and the treatment time. Bioinformatics analysis identified potential target genes and miRNAs for these lncRNAs, further implicating their involvement in molecular processes related to muscle atrophy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Irina Lousa, Flavio Reis, Alice Santos-Silva, Luis Belo
Summary: Chronic kidney disease is a global public health problem with high morbidity and mortality. Inflammation and inflammatory mediators, such as tumor necrosis factor-related biomarkers, play a role in the development and progression of CKD. Tumor necrosis factor receptors 1 and 2 have been associated with changes in kidney function and injury, and could potentially serve as biomarkers for CKD prognosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Carmen Hannemann, Johannes H. Schecker, Alica Brettschneider, Jana Grune, Nicole Roesener, Andrea Weller, Verena Stangl, Edward A. Fisher, Karl Stangl, Antje Ludwig, Bernd Hewing
Summary: The study demonstrated that deficiency of iRhom2 can reduce the development of atherosclerosis, particularly in early stages. Additionally, iRhom2 deficiency was found to lower serum levels of TNF-alpha, as well as circulating and hepatic levels of cholesterol and triglycerides.
CARDIOVASCULAR RESEARCH
(2022)
Article
Engineering, Biomedical
Tadeusz Sondej, Iwona Jannasz, Krzysztof Sieczkowski, Andrzej Dobrowolski, Karolina Obia, Tomasz Targowski, Robert Olszewski
Summary: The study validated a new device for multi-site arterial PWV measurement using PPG sensors, with the reference device being SphygmoCor XCEL, according to ASG recommendations. Through experiments on 108 subjects, it was found that there was a high correlation between multi-site PWV and cfPWV, with the best results obtained when the proximal PPG sensor was placed on the head.
BIOCYBERNETICS AND BIOMEDICAL ENGINEERING
(2021)
Article
Chemistry, Analytical
Xue Wang, Zhiping Feng, Gaoqiang Zhang, Luna Wang, Liang Chen, Jin Yang, Zhonglin Wang
Summary: Recent advances in flexible pressure sensors have made them promising technologies for human epidermal pulse wave monitoring. A 3 x 1 flexible pressure sensor array was developed using three single-electrode sensors with small area to measure pulse waves at different local positions of the radial artery. The designed single sensor has a small area of 6 x 6 mm² and demonstrates high pressure sensitivity, fast response time, wide frequency range, and stability.
Article
Biochemistry & Molecular Biology
Marco Gasparella, Carola Cenzi, Monica Piccione, Valentina Noemi Madia, Roberto Di Santo, Valeria Tudino, Marco Artico, Samanta Taurone, Chiara De Ponte, Roberta Costi, Rosa Di Liddo
Summary: This study investigated the effects of a derivative of glucosamine called DCF001 on the proliferation and chondrogenic induction of stem cells under inflammatory stimuli. The results showed that DCF001 could regulate the expression of CD39, CD73, and TNF receptors, modulate the release of growth factors, and enhance the chondrogenic potential of stem cells. These findings suggest that DCF001 could be a valuable supplement for improving the outcome of cartilage repair using stem cells under inflammatory conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yue Wang, Ruiwei Ye, Liming Fan, Xin Zhao, Linxue Li, Hao Zheng, Yan Qiu, Xiuxia He, Yiming Lu
Summary: The study demonstrates that an anti-tumor necrosis factor-alpha (TNF-α) peptide, SN1-13, has anti-inflammatory activity by inhibiting TNF-α-induced cytotoxicity and blocking TNF-α-triggered signaling pathways. Molecular docking analysis also suggests that SN1-13 can disrupt the binding between TNF-α and its receptors, TNFR1 and TNFR2. These findings indicate that SN1-13 has potential as a therapeutic peptide for TNF-α-mediated inflammatory diseases.
BIOORGANIC & MEDICINAL CHEMISTRY
(2023)
Review
Cardiac & Cardiovascular Systems
Alexandre Persu, Piotr Dobrowolski, Heather L. Gornik, Jeffrey W. Olin, David Adlam, Michel Azizi, Pierre Boutouyrie, Rosa Maria Bruno, Marion Boulanger, Jean-Baptiste Demoulin, Santhi K. Ganesh, Tomasz J. Guzik, Magdalena Januszewicz, Jason C. Kovacic, Mariusz Kruk, Peter de Leeuw, Bart L. Loeys, Marco Pappaccogli, Melanie H. A. M. Perik, Emmanuel Touze, Patricia Van der Niepen, Daan J. L. Van Twist, Ewa Warchol-Celinska, Aleksander Prejbisz, Andrzej Januszewicz
Summary: Fibromuscular dysplasia (FMD) is a non-atherosclerotic vascular disease that predominantly affects women. Its exact cause is still poorly understood, but it is likely to involve a combination of genetic and environmental factors, leading to arterial fibrosis, cellular hyperplasia, and distortion of the arterial wall architecture. FMD can affect various arteries throughout the body, not just the renal and cerebrovascular arteries.
CARDIOVASCULAR RESEARCH
(2022)
Article
Peripheral Vascular Disease
Benjamin Kably, Eliane M. Billaud, Audrey Derobertmasure, Anne Blanchard, Pierre Boutouyrie, Michel Azizi
Summary: Urinary measurement of AcSDKP can serve as a reliable method for assessing adherence to ACEI treatment, showing good consistency and correlation with ACEI metabolite concentrations.
JOURNAL OF HYPERTENSION
(2022)
Article
Nutrition & Dietetics
Jeremy Bellien, Erwan Bozec, Frederic Bounoure, Hakim Khettab, Julie Malloizel-Delaunay, Mohamed Skiba, Michele Iacob, Nathalie Donnadieu, Aude Coquard, Beatrice Morio, Brigitte Laillet, Jean-Paul Rigaudiere, Jean-Michel Chardigny, Christelle Monteil, Cathy Vendeville, Alain Mercier, Anne-Francoise Cailleux, Anne Blanchard, Jacques Amar, Leopold K. Fezeu, Bruno Pannier, Alessandra Bura-Riviere, Pierre Boutouyrie, Robinson Joannides
Summary: This study assessed the cardiovascular and metabolic effects of camelina oil in hypertensive patients with metabolic syndrome. The results showed that camelina oil supplementation did not improve vascular function but adversely affected glucose metabolism.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Ophthalmology
Niccolo Castellino, Salvatore Scuto, Luca Zanoli, Mario Damiano Toro, Teresio Avitabile, Pietro Castellino, Andrea Russo
Summary: This case report describes a patient with relapsing granulomatosis with polyangiitis who presented with bilateral orbital inflammation as the only sign of disease recurrence, and achieved complete regression of inflammatory signs through treatment with anti-CD20 antibodies.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Paolo Lentini, Luca Zanoli, Claudio Ronco, Claudia Benedetti, Antonino Previti, Giorgio Laudadio, Federica Vienna, Sofia Andrighetto, Valeria Fuso, Giovanni Gambaro
Summary: The incidence of cardiovascular disease is higher in patients with diabetic kidney disease. Aortic stiffness is a well-accepted biomarker for cardiovascular events in chronic kidney disease. The metabolic abnormalities of diabetes, combined with worsening renal function and the rise of uraemic toxins, amplify the impact on cardiac and vascular function.
CARDIORENAL MEDICINE
(2022)
Article
Medicine, General & Internal
Sebastiano Cicco, Marco D'Abbondanza, Marco Proietti, Vincenzo Zaccone, Chiara Pes, Federica Caradio, Massimo Mattioli, Salvatore Piano, Alberto Maria Marra, Alessandro Nobili, Pier Mannuccio Mannucci, Antonello Pietrangelo, Giorgio Sesti, Elena Buzzetti, Andrea Salzano, Antonio Cimellaro
Summary: This study investigated the determinants and outcomes of antihypertensive drug prescription in older hospitalized patients. The findings suggest that adherence to guideline-recommended antihypertensive treatment is associated with a lower risk of adverse clinical outcomes.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Review
Urology & Nephrology
Marlies Noordzij, Bjorn Meijers, Ron T. Gansevoort, Adrian Covic, Raphael Duivenvoorden, Luuk B. Hilbrands, Marc H. Hemmelder, Kitty J. Jager, Geir Mjoen, Ionut Nistor, Ekaterina Parshina, Giuseppina Pessolano, Serhan Tuglular, Priya Vart, Luca Zanoli, Casper F. M. Franssen, ERACODA collaborators
Summary: This study analyzed the infection prevention and control strategies implemented by dialysis centers in Europe during the first wave of the COVID-19 pandemic. The results showed that most centers implemented measures such as fever screening, hand disinfection, and mask-wearing to prevent the spread of the virus. There were variations between centers and national guidelines in terms of recommended distances between dialysis chairs and isolation practices.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Medicine, General & Internal
Elena Succurro, Alessio Novella, Alessandro Nobili, Federica Giofre, Franco Arturi, Angela Sciacqua, Francesco Andreozzi, Antonello Pietrangelo, Giorgio Sesti
Summary: Diabetes is a growing health burden globally, especially among elderly individuals with the highest prevalence. This study aimed to evaluate the appropriateness and adherence to safety recommendations in glucose-lowering drug prescriptions for hospitalized elderly patients with diabetes. The findings revealed a high prevalence of inappropriate use of sulfonylureas in the prescription of anti-diabetes drugs.
INTERNAL AND EMERGENCY MEDICINE
(2023)
Article
Urology & Nephrology
Tae Won Yi, Brendan Smyth, Gian Luca Di Tanna, Clare Arnott, Kathryn Cardoza, Amy Kang, Carol Pollock, Rajiv Agarwal, George Bakris, David M. Charytan, Dick de Zeeuw, Hiddo J. L. Heerspink, Bruce Neal, David C. Wheeler, Christopher P. Cannon, Hong Zhang, Bernard Zinman, Vlado Perkovic, Adeera Levin, Kenneth W. Mahaffey, Meg Jardine
Summary: This study found that the effect of canagliflozin on adverse kidney and cardiovascular events in individuals with diabetic kidney disease does not vary by age and sex. Canagliflozin consistently reduces the risk of kidney events in both sexes and across different age groups.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Editorial Material
Peripheral Vascular Disease
Luca Zanoli, Agostino Gaudio, Lorenzo Lo Cicero
Article
Cardiac & Cardiovascular Systems
Aboubakari Nambiema, Quentin Lisan, Julien Vaucher, Marie-Cecile Perier, Pierre Boutouyrie, Nicolas Danchin, Frederique Thomas, Catherine Guibout, Geoffroy Solelhac, Raphael Heinzer, Xavier Jouven, Pedro Marques-Vidal, Jean-Philippe Empana
Summary: The study found that higher healthy sleep scores and improvement over time were associated with a lower risk of coronary heart disease and stroke in the community.
EUROPEAN HEART JOURNAL
(2023)
Article
Medicine, General & Internal
Maurizio Di Marco, Nicoletta Miano, Simona Marchisello, Giuseppe Coppolino, Giuseppe L'Episcopo, Sabrina Scilletta, Concetta Spichetti, Serena Torre, Roberto Scicali, Luca Zanoli, Agostino Gaudio, Pietro Castellino, Salvatore Piro, Francesco Purrello, Antonino Di Pino
Summary: The COVID-19 pandemic had a significant impact on internal medicine departments not directly managing COVID-19 patients, leading to increased mortality and length of hospital stay for non-COVID-19 patients. Factors such as being bedridden, respiratory failure, glomerular filtration rate, and hospitalization during the COVID-19 outbreak era were associated with higher mortality.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Rheumatology
M. Colaci, L. Zanoli, L. La Malfa, R. Caruso, M. I. De Andres, D. Sambataro, G. Sambataro, P. Castellino, L. Malatino
Summary: The study found that BRS was significantly reduced in SSc patients compared to healthy controls, which may represent a SSc-related alteration involving the autonomic system, rather than just the consequence of sclerodermic vasculopathy.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Roberto Catanzaro, Federica Selvaggio, Morena Sciuto, Luca Zanoli, Azam Yazdani, Fang He, Francesco Marotta
Summary: This study aimed to determine the association between TG/HDL-C ratio and NAFLD and MetS. The results demonstrated that a higher TG/HDL-C ratio is significantly associated with NAFLD and MetS. Although TG/HDL-C ratio is not currently a criteria for NAFLD diagnosis, the researchers believe that it could be used as a reliable non-invasive marker in routine diagnostics of NAFLD in the future.
MINERVA GASTROENTEROLOGY
(2022)
Letter
Gastroenterology & Hepatology
Luca Zanoli, Paolo Lentini, Agostino Gaudio, Pietro Castellino
TURKISH JOURNAL OF GASTROENTEROLOGY
(2022)