Article
Oncology
Yanqing Fang, Xiaoting Cheng, Wenhui Peng, Xueying Chen, Chunping Tang, Qiusheng Huang, Sihai Wu, Yibo Huang, Fanglu Chi, Matthew R. Naunheim, Huawei Li, Bing Chen, Yilai Shu
Summary: This study aimed to analyze the clinical characteristics and misdiagnosis rate of acute coronary syndrome manifested primarily as throat discomfort. The results showed that chest tightness, dyspnea, perspiring, and exertional throat symptoms were significantly associated with acute coronary syndrome. The otorhinolaryngology department had a high misdiagnosis rate for these patients.
FRONTIERS OF MEDICINE
(2022)
Article
Geriatrics & Gerontology
James Samir Diaz-Betancur, Juan Manuel Martinez, Juan Gabriel Zapata, Isabel Marin-Orozco
Summary: Among patients aged 80 years and older admitted to the ED with chest pain, a high prevalence of ACS was found and the ACS type acted as an independent predictor of mortality. Patients diagnosed with UA had a similar prognosis to those with non-ACS chest pain, but further evidence from a prospective study is needed.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Mifetika Lukitasari, Sony Apriliyawan, Halidah Manistamara, Yurike Olivia Sella, Mohammad Saifur Rohman, Jitendra Jonnagaddala
Summary: This study aims to identify and differentiate the chest pain characteristics associated with ACS. The results show that focused questions on left/middle chest pain, retrosternal chest pain, exertional chest pain relieved by rest, and chest pain from food ingestion, positional changes, or breathing triggering can be used to accurately rule out ACS.
Article
Cardiac & Cardiovascular Systems
Gowtham R. Grandhi, Reed Mszar, Miguel Cainzos-Achirica, Tanuja Rajan, Muhammad A. Latif, Marcio S. Bittencourt, Leslee J. Shaw, Juan C. Batlle, Ron Blankstein, Michael J. Blaha, Ricardo C. Cury, Khurram Nasir
Summary: This study evaluated the effectiveness of coronary artery calcium (CAC) as an initial diagnostic tool to rule out obstructive coronary artery disease (CAD) in patients with acute chest pain (CP) who were at low to intermediate risk for acute coronary syndrome (ACS).
JACC-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Na Yan, Ling Wei, Zhiwei Li, Yu Song
Summary: This study aimed to establish a clinical prediction model for risk stratification of acute chest pain patients based on rapid cardiac troponin testing and other clinical variables. The model, which included variables such as ECG results, troponin levels, hypotension, chest pain symptoms, Killip class, and gender, showed superior diagnostic accuracy compared to the GRACE score.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Cecilia Vitali, Archna Bajaj, Christina Nguyen, Jill Schnall, Jinbo Chen, Kostas Stylianou, Daniel J. Rader, Marina Cuchel
Summary: This article systematically reviews the natural history and biomarkers of LCAT deficiency in order to guide the development of novel therapeutics. The study found that fish-eye disease and familial LCAT deficiency are characterized by early corneal opacity and markedly reduced HDL-C levels. In familial LCAT deficiency, proteinuria/hematuria are the first signs of renal impairment, followed by rapid decline of renal function. LCAT activity and the percentage of circulating esterified cholesterol (EC%) are the best discriminators between these two syndromes.
JOURNAL OF LIPID RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Gard Mikael Saele Myrmel, Ole-Thomas Steiro, Hilde Lunde Tjora, Jorund Langorgen, Rune Oskar Bjorneklett, Oyvind Skadberg, Vernon Vijay Singha Bonarjee, oistein Ronneberg Mjelva, Eva Ringdal Pedersen, Kjell Vikenes, Torbjorn Omland, Kristin Moberg Aakre
Summary: Measuring GDF-15 concentrations 3 months after admission for suspected NSTE-ACS can predict long-term mortality and cardiovascular events, providing prognostic information independent of traditional risk factors and troponin T.
Review
Biology
Daniela Maria Tanase, Evelina Maria Gosav, Anca Ouatu, Minerva Codruta Badescu, Nicoleta Dima, Ana Roxana Ganceanu-Rusu, Diana Popescu, Mariana Floria, Elena Rezus, Ciprian Rezus
Summary: Despite advancements in diagnosis and treatment, coronary artery disease (CAD) and especially ST-elevation myocardial infarction (STEMI) remain major causes of morbidity and mortality worldwide. Early and accurate diagnosis of cardiac dysfunction is crucial for improving prognosis and outcomes in STEMI patients. Recently, microRNAs (miRNAs) have gained attention as potential biomarkers for myocardial infarction (MI) and acute coronary syndromes (ACS), due to their involvement in heart development, various cardiac processes, and as indicators of cardiac damage. This review discusses the current knowledge on cardiac miRNAs and their functions, with a focus on their potential use as novel circulating diagnostic and prognostic biomarkers in STEMI.
Article
Emergency Medicine
Jason P. Stopyra, Anna C. Snavely, Nicklaus P. Ashburn, R. Darrell. Nelson, Evan L. McMurray, Meagan R. Hunt, Chadwick D. Miller, Simon A. Mahler
Summary: Utilizing EMS blood collection for troponin measurement can significantly reduce Emergency Department (ED) length of stay (LOS) for patients with acute chest pain in the United States, while proving to be safe when integrated into the HEART Pathway.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Geriatrics & Gerontology
Yu-Chang Liu, Chung-Han Ho, Yi-Chen Chen, Chien-Chin Hsu, Hung-Jung Lin, Chia-Ti Wang, Chien-Cheng Huang
Summary: This study found that older patients with CP had a higher risk of ACS compared to those without CP in the older population. The risk of ACS increased with longer follow-up periods.
Article
Chemistry, Analytical
Cyrus Jalili, Vali Akbari, Reza Khodarahmi, Hector C. Goicoechea, Ali R. Jalalvand
Summary: This paper reports the results of a project which investigated the binding and inhibition of MO by BV using electrochemical and spectroscopic techniques assisted by chemometric methods. The analyses confirmed strong binding of BV with MO and proposed a quantitative concept for electrochemical determination of MO based on its binding with BV. The EIS results were suggested as more effective than DPV for analyzing serum samples in evaluating patients with acute coronary syndrome.
MICROCHEMICAL JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Jesse Demandt, Arjan Koks, Dennis Sagel, Veerle A. E. van Hattem, Rutger J. Haest, Eric Heijmen, H. Thijssen, Luuk C. Otterspoor, Dennis van Veghel, Rob Eerdekens, Mohamed el Farissi, Koen Teeuwen, Inge Wijnbergen, Pim van der Harst, Nico H. J. Pijls, Marcel vant Veer, Pim A. L. Tonino, Lukas R. C. Dekker, Pieter J. Vlaar
Summary: Prehospital risk stratification and direct transfer to a PCI center based on the preHEART score reduces time to final invasive diagnostics and revascularization, shortens duration of hospital admission, and decreases healthcare costs in patients with NSTE-ACS.
Article
Medicine, General & Internal
June-sung Kim, Youn-jung Kim, Yo Sep Shin, Shin Ahn, Won Young Kim
Summary: This retrospective observational cohort study aimed to develop a prediction model for rapidly determining the occurrence of significant stenosis in coronary computed tomography angiography (CCTA) among chest pain patients without troponin elevation and ST-segment changes. A new prediction model was developed with independent associated factors for significant stenosis, and a score of >= 5 was chosen as cut-off values with 86.6% sensitivity and 56.4% specificity.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Hematology
Geoffrey Cheminet, Antoine Brunetti, Djamal Khimoud, Brigitte Ranque, Adrien Michon, Edouard Flamarion, Jacques Pouchot, Anne-Sophie Jannot, Jean-Benoit Arlet
Summary: This study describes 105 cases of acute chest syndrome (ACS) in 81 adult patients with sickle cell disease over a 32-month period. The characteristics of ACS episodes were compared based on time to onset after hospital admission for vaso-occlusive crisis (VOC). The early-onset episodes (<= 24h) accounted for 42% and secondary episodes (>24h) accounted for 58%. Fever and chest pain were the main symptoms, and crackles and bronchial breathing were the main abnormal findings. Disease-modifying treatments should be reevaluated after each ACS episode due to the high recurrence rate.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Minying Wan, Yi Lu, Bin Mao, Shikai Yu, Peinan Ju, Kun Hu, Yawei Xu, Xiankai Li, Jianhui Zhuang
Summary: High neutrophil to lymphocyte ratio is a predictor of poor prognosis in acute coronary syndrome (ACS). This study explores the association between neutrophil subpopulation and plaque vulnerability as well as the incidence of ACS. CD10- immature neutrophils were found to be positively correlated with plaque vulnerability and the occurrence of ACS.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)