Article
Physiology
Sebastian Castillo-Galan, Daniela Parrau, Ismael Hernandez, Sebastian Quezada, Marcela Diaz, German Ebensperger, Emilio A. Herrera, Fernando A. Moraga, Rodrigo Iturriaga, Anibal J. Llanos, Roberto V. Reyes
Summary: The study found that 2-APB treatment can partially reduce the contractile hypoxic response and revert the pulmonary vascular remodeling in newborn lambs, but it is not enough to normalize the pulmonary hemodynamics in chronically hypoxic lambs.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Physiology
S. Saxer, P. R. Bader, S. R. Schneider, M. Mademilov, U. Sheraliev, P. Appenzeller, J. Mueller, T. M. Sooronbaev, K. E. Bloch, S. Ulrich, M. Lichtblau
Summary: This study investigated the acute and subacute cardiopulmonary acclimatization in middle-aged asthmatics without comorbidities to high altitude. The results showed that exposure to hypoxia at high altitude increased pulmonary artery pressure and extravascular lung water, while the coupling of pulmonary artery and right ventricle decreased. However, during subacute exposure, extravascular lung water returned to baseline values, suggesting compensatory mechanisms during acclimatization.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Hematology
Darae Ko, Sarah R. Preis, Andrew D. Johnson, Ramachandran S. Vasan, Emelia J. Benjamin, Naomi M. Hamburg, Gary F. Mitchell
Summary: The study did not find any significant association between arterial vascular function measures and the risk of VTE after multivariable adjustment in a comprehensive examination.
THROMBOSIS RESEARCH
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wanlin Peng, Hongwei Li, Chunchao Xia, Yingkun Guo, Xu Xu, Wen Zeng, Keling Liu, Qianqiu Che, Yuexin Jiang, Kejin Xiang, Xiaoyue Zhou, Gang Li, Zhenlin Li
Summary: This study aimed to assess biventricular function and mechanics in patients with chronic high-altitude disease (CHAD) using cardiovascular MRI and explore the possible risk factors associated with ventricular remodeling. Multiple linear regression analyses revealed that HGB was related to the LV remodeling index, while BUN was associated with the RV remodeling index. These findings suggest that with the deterioration of RV function in CHAD patients, LV function is also impaired concomitantly, and hypoxia-induced erythrocytosis may contribute to LV impairment, while BUN is considered an independent risk factor for RV remodeling.
EUROPEAN RADIOLOGY
(2023)
Article
Endocrinology & Metabolism
Wenjin Liu, Zhensen Chen, Dakota Ortega, Xuebing Liu, Xiaoqin Huang, Lulu Wang, Li Chen, Jie Sun, Thomas S. Hatsukami, Chun Yuan, Haige Li, Junwei Yang
Summary: In older hypertensive males, arterial stiffness and endothelial dysfunction are associated with reduced brain perfusion and overall cerebral vascular injury.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Sport Sciences
Franck Brocherie, Sebastien Racinais, Scott Cocking, Nathan Townsend, Anthony Couderc, Julien Piscione, Olivier Girard
Summary: In world-class female rugby sevens players, four additional repeated-sprint sessions before competition can improve repeated-sprint ability and brachial endothelial function. However, adding severe hypoxic stress during sets of repeated sprints does not provide supplementary benefits.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Article
Medicine, General & Internal
Xinran Li, Rufeng Shi, Qingtao Meng, Xin Zhang, Xiaoping Chen
Summary: This study found a significant association between arterial stiffness and orthostatic hypotension (OH) and orthostatic blood pressure changes among high-altitude Tibetans. Arterial stiffness may be a potential mechanism affecting hemodynamic response to orthostatic challenges in this population.
POSTGRADUATE MEDICINE
(2021)
Review
Food Science & Technology
Banafsheh Jafari Azad, Javad Heshmati, Elnaz Daneshzad, Andriko Palmowski
Summary: Through a systematic review and meta-analysis of multiple studies, it was found that coffee intake has a beneficial short-term effect on endothelial function, while it may have an unfavorable impact on arterial stiffness. The long-term effects of coffee intake on endothelial function and arterial stiffness remain controversial.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Review
Physiology
Xin Chen, Jiexin Zhang, Yuan Lin, Yan Li, Han Wang, Zhanhao Wang, Huawei Liu, Yonghe Hu, Lei Liu
Summary: This review provides a theoretical reference for exploring and treating high altitude-induced cognitive impairment by summarizing the manifestations, mechanisms, and preventive and therapeutic methods of hypobaric hypoxia (HH) environment affecting cognitive function.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Physiology
Alejandro Gonzalez-Candia, Emilio A. Herrera
Summary: A large human population lives in high-altitude areas, where research shows that gestational high-altitude hypoxia may affect fetal development and growth significantly, as well as induce cardiovascular impairments in both the mother and fetus. Further studies are needed to understand the mechanisms and potential treatments for the pathological effects of chronic hypobaric hypoxia.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
Alejandro Gonzalez-Canadia, Alejandro A. Candia, Pamela Arias, Adolfo A. Paz, Emilio A. Herrera, Rodrigo L. Castillo
Summary: This study aimed to investigate the effects of chronic intermittent hypobaric hypoxia on cardiac and vascular response in adult rats simulating high-altitude working shifts. The results showed that chronic intermittent hypobaric hypoxia induced cardiac dysfunction and ventricular remodeling, increased collagen content in the right ventricle, and decreased antioxidant capacity in cardiac tissue. It also led to decreased contractile capacity and impaired vasodilation in carotid and femoral arteries. These findings highlight the importance of periodic cardiovascular evaluation in high-altitude workers.
Article
Pharmacology & Pharmacy
Jun Hou, Keji Lu, Peiwen Chen, Peng Wang, Jing Li, Jiali Yang, Qing Liu, Qiang Xue, Zhaobing Tang, Haifeng Pei
Summary: This review provides an overview of the relationship between high-altitude hypoxia and heart rate variability (HRV), summarizing the mechanisms of diseases caused by hypoxia and changes in HRV across various systems. The study also discusses pharmaceutical interventions and aims to provide research ideas for in-depth studies on HRV.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Review
Biochemistry & Molecular Biology
William Durante, Ghazaleh Behnammanesh, Kelly J. Peyton
Summary: SGLT2 inhibitors improve cardiovascular outcomes in patients with diabetes through various mechanisms such as increasing nitric oxide bioavailability, regulating endothelial cell function, and exerting antioxidant and anti-inflammatory effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Sophia A. Mahoney, Ravinandan Venkatasubramanian, Mary A. Darrah, Katelyn R. Ludwig, Nicholas S. Vandongen, Nathan T. Greenberg, Abigail G. Longtine, David A. Hutton, Vienna E. Brunt, Judith Campisi, Simon Melov, Douglas R. Seals, Matthew J. Rossman, Zachary S. Clayton
Summary: This study found that fisetin can improve arterial function and reduce arterial stiffness by reducing vascular cell senescence and inflammation. Fisetin enhances endothelial function by increasing the bioavailability of nitric oxide and reducing oxidative stress.
Article
Biochemistry & Molecular Biology
Yunkyung Kim, Geun-Tae Kim, Jihun Kang
Summary: The study found that FM patients had a higher risk of central obesity, high triglyceride levels, and impaired fasting glucose. FM group exhibited higher carotid artery beta-index values, possibly correlated with cardiometabolic risk factors and arterial stiffness.
Review
Cardiac & Cardiovascular Systems
Alexandre Persu, Piotr Dobrowolski, Heather L. Gornik, Jeffrey W. Olin, David Adlam, Michel Azizi, Pierre Boutouyrie, Rosa Maria Bruno, Marion Boulanger, Jean-Baptiste Demoulin, Santhi K. Ganesh, Tomasz J. Guzik, Magdalena Januszewicz, Jason C. Kovacic, Mariusz Kruk, Peter de Leeuw, Bart L. Loeys, Marco Pappaccogli, Melanie H. A. M. Perik, Emmanuel Touze, Patricia Van der Niepen, Daan J. L. Van Twist, Ewa Warchol-Celinska, Aleksander Prejbisz, Andrzej Januszewicz
Summary: Fibromuscular dysplasia (FMD) is a non-atherosclerotic vascular disease that predominantly affects women. Its exact cause is still poorly understood, but it is likely to involve a combination of genetic and environmental factors, leading to arterial fibrosis, cellular hyperplasia, and distortion of the arterial wall architecture. FMD can affect various arteries throughout the body, not just the renal and cerebrovascular arteries.
CARDIOVASCULAR RESEARCH
(2022)
Editorial Material
Peripheral Vascular Disease
Pierre Boutouyrie, Rachel E. Climie, Rosa-Maria Bruno
AMERICAN JOURNAL OF HYPERTENSION
(2022)
Article
Biology
Kristen M. Meiburger, Francesco Marzola, Guillaume Zahnd, Francesco Faita, Christos P. Loizou, Nolann Laine, Catarina Carvalho, David A. Steinman, Lorenzo Gibello, Rosa Maria Bruno, Ricarda Clarenbach, Martina Francesconi, Andrew N. Nicolaides, Herve Liebgott, Aurelio Campilho, Reza Ghotbi, Efthyvoulos Kyriacou, Nassir Navab, Maura Griffin, Andrie G. Panayiotou, Rachele Gherardini, Gianfranco Varetto, Elisabetta Bianchini, Constantinos S. Pattichis, Lorenzo Ghiadoni, Jose Rouco, Maciej Orkisz, Filippo Molinari
Summary: This study presents technical outlooks on computerized carotid intima-media thickness (CIMT) measurements and provides considerations for the development and comparison of these methods. A multi-center database of 500 images was collected and three manual segmentations and seven computerized methods were employed to measure the CIMT. The computerized methods showed comparable results with previous studies and demonstrated promising segmentation outcomes. The entire database has been made publicly available for further research and comparison.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Giulia Elena Mandoli, Chiara Borrelli, Matteo Cameli, Sergio Mondillo, Lorenzo Ghiadoni, Claudia Taddei, Claudio Passino, Michele Emdin, Alberto Giannoni
Summary: Obstructive and central apneas have negative impacts on cardiac structure and function, with obstructive apneas promoting progressive cardiac alterations leading to heart failure. Early identification of these effects and detection of initial cardiac dysfunction in patients with apneas are becoming increasingly relevant. Speckle tracking echocardiography is recognized as an effective method for early detection of cardiac dysfunction, but more research is needed on apnea-related alterations in heart failure progression.
HEART FAILURE REVIEWS
(2022)
Article
Peripheral Vascular Disease
Agnieszka Latosinska, Rosa Maria Bruno, Marco Pappaccogli, Alessandra Bacca, Christophe Beauloye, Pierre Boutouyrie, Hakim Khettab, Jan A. Staessen, Stefano Taddei, Laurent Toubiana, Miikka Vikkula, Harald Mischak, Alexandre Persu
Summary: This study investigates the use of urinary proteomics in the diagnosis of FMD and develops a classifier to distinguish FMD patients from healthy controls and other diseases. Furthermore, the study finds a positive correlation between the proteomic score and the arterial geometry and mechanics in FMD patients.
Article
Emergency Medicine
Gianni Turcato, Alessandro Cipriano, Arian Zaboli, Naria Park, Alessandro Riccardi, Massimo Santini, Roberto Lerza, Giorgio Ricci, Antonio Bonora, Lorenzo Ghiadoni
Summary: Repeat head CT in patients on DOACs with MTBI after an initial negative CT scan is a common clinical practice. In this study, researchers assessed the incidence of delayed ICH and its association with clinical and risk factors presented on patient arrival in the ED. The results showed that delayed ICH is an uncommon event at the 24-hour control CT and does not affect patient outcome.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Multidisciplinary Sciences
Elisa Ferrari, Luna Gargani, Greta Barbieri, Lorenzo Ghiadoni, Francesco Faita, Davide Bacciu
Summary: We propose a clinical data analysis workflow based on Bayesian Structure Learning (BSL). This workflow incorporates prior medical knowledge into the learning process and provides explainable results in the form of causal connections among analyzed features. Evaluation on a COVID-19 dataset shows that the proposed framework gives a schematic overview of the multi-factorial processes contributing to the outcome and rediscovers established cause-effect relationships. Furthermore, the approach yields a highly interpretable tool that accurately predicts the outcome using a small number of features.
Article
Acoustics
Federica Poli, Catherine Fortier, Hakim Khettab, Francesco Faita, Saverio Vitali, Giacomo Aringhieri, Lorenzo Ghiadoni, Stefano Taddei, Laurence Amar, Aurelien Lorthioir, Pierre Boutouyrie, Rosa Maria Bruno
Summary: Ultrahigh-frequency ultrasound is a useful tool for studying human small muscular arteries and understanding arterial aging. The Carotid Studio software is a valid and reproducible tool for analyzing UHFUS scans of digital arteries.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Nicola Riccardo Pugliese, Alessio Balletti, Silvia Armenia, Nicolo De Biase, Francesco Faita, Alessandro Mengozzi, Francesco Paneni, Frank Ruschitzka, Agostino Virdis, Lorenzo Ghiadoni, Stefano Taddei, Bryan Williams, Francesco Antonini-Canterin, Stefano Masi
Summary: This study evaluated the ventricular-arterial coupling in heart failure patients and found that abnormal ventricular-arterial coupling is directly correlated with the severity of heart failure and worse functional capacity. Furthermore, heart failure patients with preserved ejection fraction have worse ventricular-arterial coupling.
JACC-CARDIOVASCULAR IMAGING
(2022)
Article
Emergency Medicine
Gianni Turcato, Alessandro Cipriano, Naria Park, Arian Zaboli, Giorgio Ricci, Alessandro Riccardi, Greta Barbieri, Sara Gianpaoli, Grazia Guiddo, Massimo Santini, Norbert Pfeifer, Antonio Bonora, Ciro Paolillo, Roberto Lerza, Lorenzo Ghiadoni
Summary: This study showed that post-traumatic intracranial hemorrhage (ICH) risk in patients with mild traumatic brain injury (MTBI) on oral anticoagulant therapy (OAT) is associated with clinical risk factors such as post-traumatic amnesia, post-traumatic transitory loss of consciousness, greater trauma dynamic, GCS less than 15, and evidence of trauma above the clavicles. The absence of concussion and neurological alteration at admission significantly reduces the likelihood of ICH. The use of a machine-learning-based CART model can help stratify patients and guide decision-making in this population.
BMC EMERGENCY MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Jordi Alastruey, Peter H. Charlton, Vasiliki Bikia, Birute Paliakaite, Bernhard Hametner, Rosa Maria Bruno, Marijn P. Mulder, Samuel Vennin, Senol Piskin, Ashraf W. Khir, Andrea Guala, Christopher C. Mayer, Jonathan Mynard, Alun D. Hughes, Patrick Segers, Berend E. Westerhof
Summary: Arterial pulse waves (PWs), such as blood pressure and photoplethysmogram (PPG) signals, are rich sources of information for assessing vascular age and identifying individuals at elevated cardiovascular risk. This review explores the possibilities and limitations of reduced-order biophysical models and theoretical and empirical methods for analyzing PW signals and extracting clinically relevant information. Detailed mathematical derivations are provided, demonstrating the relationships between these models and methods. Suggestions for future research are also outlined to fully utilize the potential of modeling and analyzing PW signals for accurate vascular age assessment.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Review
Peripheral Vascular Disease
Keeron Stone, Dave Veerasingam, Michelle L. Meyer, Kevin S. Heffernan, Simon Higgins, Rosa Maria Bruno, Celia Alvarez Bueno, Marcus Doeerr, Arno Schmidt-Trucksass, Dimitrios Terentes-Printzios, Julija Voicehovska, Rachel E. Climie, Chloe Park, Giacomo Pucci, Martin Bahls, Lee Stoner
Summary: This review critiques the literature on the clinical assessment and management of cardiovascular disease using brachial-ankle pulse wave velocity (baPWV). It discusses the measurement of baPWV, its differences from carotid-femoral pulse wave velocity, and its value as an independent vascular biomarker. The review also identifies the evidence supporting baPWV in terms of concept validation, prospective validation, incremental value, and clinical utility, as well as the areas where evidence is limited or lacking.
Article
Environmental Sciences
Nicola Fullin, Enrico Duo, Stefano Fabbri, Mirko Francioni, Monica Ghirotti, Paolo Ciavola
Summary: The integration of multiple data sources is crucial for studying landslide processes, especially in inaccessible areas. This case study focused on cliff-top retreat in the Conero Regional Park, Italy, using aerial orthophotos, UAV photographs, and LiDAR data. The analysis revealed significant erosion over a 40-year period.
Review
Peripheral Vascular Disease
Rosa-Maria Bruno, Szabolcs Varbiro, Giacomo Pucci, Janos Nemcsik, Mai Tone Lonnebakken, Karolina Kublickiene, Helena Schluchter, Chloe Park, Ioana Mozos, Andrea Guala, Bernhard Hametner, Ute Seeland, Pierre Boutouyrie
Summary: Blood pressure and vascular ageing trajectories differ between men and women due to sex-related and gender-related factors. Endogenous 17β-estradiol plays a protective role in women's vascular aging, but gender-related factors such as psychological stress and low socioeconomic status have a greater impact on vascular aging in women. On the other hand, men are more susceptible to the adverse effects of alcohol consumption and social deprivation. Unhealthy diet habits and smoking have a disproportional negative effect on women's vascular health. Therefore, future research and prevention strategies should take into account the complex role of gender-related factors.
JOURNAL OF HUMAN HYPERTENSION
(2023)
