Article
Medicine, General & Internal
Maria Chondrogianni, Vaia Lambadiari, Aristeidis H. Katsanos, Maria Ioanna Stefanou, Lina Palaiodimou, Alexandros Stavros Triantafyllou, Georgios Karagiannis, Vasileios Konstantakos, Michael Ioakeimidis, Sokratis Triantafyllou, Christina Zompola, Chryssa Liantinioti, Alexandra Pappa, Ioannis Rizos, Konstantinos Voumvourakis, Georgios Tsivgoulis, Eleni Boutati
Summary: Mounting evidence suggests an association between adipokines and inflammation-related atherosclerosis. Omentin, but not vaspin, was found to be correlated with stroke severity and ipsilateral carotid stenosis, potentially serving as a biomarker linked to atherosclerotic plaque presence in patients with acute cerebral ischemia.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Nutrition & Dietetics
Hamdan Z. Hamdan, Tasneem Ali, Ishag Adam
Summary: This systematic review and meta-analysis found a significant association between higher levels of retinol-binding protein 4 (RBP4) and the risk of preeclampsia. More longitudinal studies are needed to further understand the association and dynamics of RBP4 in preeclampsia cases.
Article
Peripheral Vascular Disease
Mustafa Celik, Rukiye Nar, Gokay Nar, Erdogan Sokmen, Guven Gunver
Summary: Omentin-1, a glucoprotein with anti-inflammatory effects, is associated with various diseases. Research shows that circulating Omentin-1 levels are significantly lower in patients with hypertension compared to healthy normotensive controls.
JOURNAL OF HUMAN HYPERTENSION
(2021)
Review
Oncology
Pawel Dec, Agata Poniewierska-Baran, Andrzej Modrzejewski, Andrzej Pawlik
Summary: Adipocytes in visceral adipose tissue release omentin-1, which is associated with type 2 diabetes and plays a role in the development and progression of various cancers. Omentin-1 functions as an anti-inflammatory and pro-apoptotic adipokine, regulating glucose and fat metabolism. Understanding the effects of omentin-1 on carcinogenesis is important in exploring new therapeutic strategies.
Article
Chemistry, Medicinal
Noheul Kim, Ronny Priefer
Summary: RBP4 is associated with various diseases and metabolic syndromes, and the development of RBP4 antagonists and protein synthesis inhibitors may have therapeutic potential.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Clinical Neurology
Russell Yanofsky, Carina Sancho, Karina Gasbarrino, Huaien Zheng, Robert J. Doonan, Fanny Jaunet, Samantha Steinmetz-Wood, John P. Veinot, Chi Lai, Stella S. Daskalopoulou
Summary: The study found that mRNA expression of resistin and chemerin was lower in unstable plaques compared to stable plaques, while protein expression of resistin and chemerin was higher in unstable plaques. There was no difference in ChemR23 mRNA expression. The results suggest that these adipokines may play different roles in the pathogenesis of carotid atherosclerotic plaques.
Article
Geriatrics & Gerontology
Chen-Lu Chang, Yan-Ru Li, Zhi-Yue Wang, Mei-Lin Li, Kai-Yue Jia, Hui-Xian Sun, Quan Wang, Can Zhao, Xiang Lu, Wei Gao
Summary: This study evaluated the association between serum RBP4 level and sarcopenia in older adults. The results showed a positive correlation between serum RBP4 level and the risk and severity of sarcopenia, indicating its potential as a biomarker for screening and evaluation of sarcopenia.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jae Chul Lee, Sung Hoon Kim, Young Sang Oh, Ju Hee Kim, Sa Ra Lee, Hee Dong Chae
Summary: RBP4 plays a crucial role in the pathogenesis of endometriosis by increasing the viability, proliferation, and invasion of endometrial cells. High levels of RBP4 in peritoneal fluid and ovarian endometriomas of women with endometriosis suggest its potential as a biomarker for the disease. In vitro studies show that RBP4 enhances the aggressive behavior of endometrial stromal cells, indicating its involvement in the progression of endometriosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Daniela Dadej, Ewelina Szczepanek-Parulska, Marek Ruchala
Summary: Signalling between different tissues plays a significant role in the development of metabolic disorders, particularly the interaction between liver-derived hepatokines and adipokines. The thyroid hormone is crucial for basal metabolic rate and lipid metabolism, and its dysfunction contributes to metabolic disorders. This review discusses the interplay between adipokines and thyroid hormones, shedding light on the mechanisms underlying atherosclerosis, cardiovascular complications, obesity, insulin resistance, and diabetes associated with thyroid dysfunction. Clinical findings on these cytokines in thyroid disorders are also summarized.
Article
Nutrition & Dietetics
Courtney P. Victor, Juan S. Leon, Anne M. Williams
Summary: This study aimed to evaluate the ratio of retinol to RBP in individuals with and without norovirus infection, and investigate the impact of inflammation on retinol, RBP, and the ratio between the two. The findings indicate that the ratio was the same among infected and uninfected individuals, and inflammation had an effect on both retinol and RBP. However, adjusting for inflammation did not result in the expected equivalence between retinol and RBP.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Nikolaos P. E. Kadoglou, George Kassimis, Nikolaos Patsourakos, Ioannis Kanonidis, Georgia Valsami
Summary: The study found that low levels of omentin-1 and vaspin in serum are associated with preclinical carotid atherosclerosis, and atorvastatin treatment significantly increases the levels of these adipokines. Further investigation is needed to understand the underlying mechanisms and clinical impact of these changes.
Review
Biochemistry & Molecular Biology
Yilin Wang, Tao Wang, Yumin Luo, Liqun Jiao
Summary: Vulnerable plaques are a hot topic in the field of stroke and carotid atherosclerosis. Risk stratification and intervention for carotid plaques are currently guided by the degree of luminal stenosis. However, it has been recognized that the vulnerability of plaques may contribute to the risk of stroke. This review summarizes the identification of vulnerable plaques at both macroscopic and microscopic levels.
Article
Endocrinology & Metabolism
Guo-bao Hong, Xiao-fei Shao, Jia-min Li, Qin Zhou, Xiao-Su Ke, Pei-Chun Gao, Xiao-Lin Li, Jing Ning, Hai-Shan Chen, Hua Xiao, Chong-Xiang Xiong, Hequn Zou
Summary: This study found that RBP4 is strongly associated with hyperuricemia, and its predictive value was higher than that of traditional predictors. The optimum predictive model for hyperuricemia in the general population included RBP4, sex, body mass index, serum creatinine, high-sensitivity C-reactive protein, fasting blood glucose, insulin, and alcohol consumption.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Medicine, General & Internal
Guangcheng Gao, Yuli Cui, Haiyan Cheng
Summary: This study comprehensively evaluated the association between plasma retinol binding protein-4 (RBP-4) and psoriasis vulgaris. The results showed that RBP-4 levels were significantly elevated in patients with psoriasis vulgaris, and systematic treatment could lower these levels. Therefore, RBP-4 may serve as an important indicator for the diagnosis, efficacy assessment, and comorbidity monitoring of this disease.
FRONTIERS IN MEDICINE
(2023)
Review
Medicine, General & Internal
Hangkai Huang, Chengfu Xu
Summary: Nonalcoholic fatty liver disease (NAFLD) is becoming more common as the global economy grows. Retinol-binding protein-4 (RBP4) has been found to be related to various metabolic diseases. However, observational studies on the association between serum RBP4 level and NAFLD prevalence have shown contradictory results. Further research should focus on the predictive value of RBP4 in NAFLD development and its potential as a therapeutic target.
CHINESE MEDICAL JOURNAL
(2022)
Article
Chemistry, Medicinal
Ignatios Ikonomidis, George Pavlidis, Nikolaos Kadoglou, George Makavos, Konstantinos Katogiannis, Aikaterini Kountouri, John Thymis, Gavriella Kostelli, Irini Kapniari, Konstantinos Theodoropoulos, John Parissis, Pelagia Katsimbri, Evangelia Papadavid, Vaia Lambadiari
Summary: The phosphodiesterase 4 inhibitor apremilast has significant effects on endothelial glycocalyx, vascular, and myocardial function in the treatment of psoriasis. It restores glycocalyx integrity and confers greater improvement in vascular and myocardial function compared to anti-tumor necrosis factor-alpha or cyclosporine.
Article
Medicine, General & Internal
Emmanouil Korakas, Theodoros Argyropoulos, Georgia-Angeliki Koliou, Aristofanis Gikas, Aikaterini Kountouri, Stavroula Kostaridou Nikolopoulou, Panagiotis Plotas, Konstantinos Kontoangelos, Ignatios Ikonomidis, Nikolaos P. E. Kadoglou, Athanasios Raptis, Vaia Lambadiari
Summary: This is the first report on the prevalence of stress hyperglycemia in pediatric patients in Greece. Asthma, corticosteroids, and beta 2-agonists significantly increase the risk of stress hyperglycemia.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Chemistry, Medicinal
Nikolaos P. E. Kadoglou, Chrystalla Panayiotou, Michail Vardas, Nikolaos Balaskas, Nikolaos G. Kostomitsopoulos, Alexandra K. Tsaroucha, Georgia Valsami
Summary: Silibinin/silymarin has various pharmacological properties including antioxidant, hypolipidemic, hypoglycemic, anti-hypertensive, and cardioprotective effects. Clinical trials have shown significant improvements in glycemic and lipid profiles in patients with diabetes mellitus and hyperlipidemia, but the anti-hypertensive effects are modest. However, the current clinical trial data are insufficient to draw conclusive results.
Review
Chemistry, Medicinal
Anastasia Stella Perpinia, Nikolaos Kadoglou, Maria Vardaka, Georgios Gkortzolidis, Apostolos Karavidas, Theodoros Marinakis, Chrysostomi Papachrysostomou, Panagiotis Makaronis, Charikleia Vlachou, Marina Mantzourani, Dimitrios Farmakis, Konstantinos Konstantopoulos
Summary: Modern treatment modalities in hematology have improved clinical outcomes of patients with hematological malignancies, but some anticancer drugs may have adverse effects on the cardiovascular system, leading to various cardiac disorders. Therefore, it is crucial to understand all aspects of cardiotoxicity and provide appropriate care promptly to patients.
Editorial Material
Engineering, Electrical & Electronic
Konstantina S. Nikita
Summary: The author is delighted and privileged to present the January 2023 issue of IEEE Transactions on Antennas and Propagation (TAP). Since taking over as the Editor-in-Chief in October 2022, the author has worked with the Editorial Board and the IEEE staff to ensure a smooth transition, with gratitude to predecessor Prof. Danilo Erricolo for his advice and support.
IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION
(2023)
Article
Health Care Sciences & Services
Maria Athanasiou, Georgios Fragkozidis, Konstantia Zarkogianni, Konstantina S. Nikita
Summary: This study combines ILI surveillance data, weather data, and Twitter data with deep learning techniques to develop models that can predict ILI cases. By considering both traditional and alternative data sources, this study provides a novel approach to enhance accuracy and reliability in infectious disease surveillance. The TL-based model, which incorporates Twitter data, weather data, and ILI surveillance data, achieves the best performance.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Review
Biology
Elina Khattab, Nikolaos Velidakis, Evaggelia Gkougkoudi, Nikolaos P. E. Kadoglou
Summary: Exercise-induced pulmonary hypertension (EIPH) is characterized by an increase in pulmonary arterial pressure during exercise in otherwise healthy individuals. It may precede the development of manifest pulmonary hypertension and is associated with decreased life expectancy in patients with heart failure or left ventricle valvular diseases. The gold standard for EIPH assessment is right heart catheterization, but non-invasive methods like exercise stress echocardiography and cardiopulmonary exercise testing are also used. However, further research is needed to determine the role of EIPH diagnosis in clinical practice.
Editorial Material
Engineering, Electrical & Electronic
Konstantina S. Nikita, Zoya Popovic
IEEE ANTENNAS AND PROPAGATION MAGAZINE
(2023)
Review
Biochemistry & Molecular Biology
Konstantinos Parperis, Nikolaos Velidakis, Elina Khattab, Evangelia Gkougkoudi, Nikolaos P. E. Kadoglou
Summary: Pulmonary hypertension is commonly seen in patients with systemic lupus erythematosus, presenting with non-specific symptoms and negatively affecting survival. It can result from immune system dysregulation, as well as various other conditions. Early diagnosis and identification of underlying pathogenetic mechanisms are crucial for introducing targeted therapy and preventing irreversible pulmonary vascular damage. The management of pulmonary hypertension in SLE patients is similar to that of idiopathic PAH, but specific diagnostic tools for early diagnosis seem to be unavailable yet.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Ekaterina-Michaela Tomou, Paraskevi Papakyriakopoulou, Helen Skaltsa, Georgia Valsami, Nikolaos P. E. Kadoglou
Summary: Cardiovascular diseases are the leading cause of morbidity and mortality worldwide, making it a top priority for scientific research to find interventions that modify risk factors. Herbal supplements, such as apigenin, quercetin, and silibinin, have shown potential as beneficial supplements for preventing CVDs. This comprehensive review focuses on the cardioprotective effects and mechanisms of these compounds, as well as their extraction and identification methods. However, uncertainties remain due to limited clinical studies, inconsistent doses, diverse constituents, and the lack of pharmacodynamic/pharmacokinetic analyses.
Article
Oncology
Shefali Setia Verma, Lindsay Guare, Sarah Ehsan, Aimilia Gastounioti, Gabrielle D. Scales, Marylyn D. Ritchie, Despina Kontos, Anne Marie McCarthy
Summary: Black women in the US have higher breast cancer mortality rates and later-stage tumor diagnoses compared to White women. Previous studies have identified breast density as an important risk factor for breast cancer, but little is known about its influence on African ancestry populations. This study aimed to determine genetic factors associated with breast density in African ancestry populations using a Genome-Wide Association Study (GWAS) and post-GWAS analyses.
Article
Chemistry, Medicinal
Nikolaos P. E. Kadoglou, Marianna Stasinopoulou, Evangelia Gkougkoudi, Eirini Christodoulou, Nikolaos Kostomitsopoulos, Georgia Valsami
Summary: Dabigatran etexilate and exercise training have complementary effects on the development and stability of atherosclerotic lesions in diabetic mice, mediated by anti-inflammatory modulation.
Review
Chemistry, Medicinal
Kyriakos Goulas, Dimitrios Farmakis, Anastasia Constantinidou, Nikolaos P. E. Kadoglou
Summary: This systematic review and meta-analysis found that the use of beta-blockers, angiotensin receptor blockers, or angiotensin converting enzyme inhibitors did not significantly reduce the occurrence of cardiotoxicity in breast cancer patients receiving trastuzumab therapy.
Article
Computer Science, Information Systems
Nektarios Moraitis, Konstantina S. Nikita
Summary: This paper introduces a study on propagation at sub-THz frequencies in an urban environment. Simulation and digital mapping are used to explore different scenarios and antenna configurations, as well as describe propagation mechanisms. The findings show that high data rate links are possible even at non-line-of-sight locations, within a distance limit of 100-150 m.
Review
Biology
Nikolaos Velidakis, Elina Khattab, Evangelia Gkougkoudi, Nikolaos P. E. Kadoglou
Summary: Left ventricular valvular diseases are common causes of pulmonary hypertension. The pathophysiology involves increased left ventricular filling pressure and left atrial pressure, leading to elevated pulmonary artery pressure and increased pulmonary vascular resistance. Early intervention in patients with severe LV valvular diseases can improve prognosis, but post-operative cardiac and all-cause mortality rates remain relatively high.
