Article
Engineering, Environmental
Weizhuo Yi, Feng Zhao, Rubing Pan, Yi Zhang, Zhiwei Xu, Jian Song, Qinghua Sun, Peng Du, Jianlong Fang, Jian Cheng, Yingchun Liu, Chen Chen, Yifu Lu, Tiantian Li, Hong Su, Xiaoming Shi
Summary: This study investigated the relationship between fine particulate matter (PM2.5) constituents and metabolic syndrome (MetS), and found that certain PM2.5 constituents were significantly associated with the prevalence of MetS. Furthermore, the study revealed that apolipoprotein B (ApoB) partially mediated the associations between PM2.5 constituents and MetS.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Iva Klobucar, Lucija Klobucar, Margarete Lechleitner, Matias Trbusic, Gudrun Pregartner, Andrea Berghold, Hansjoerg Habisch, Tobias Madl, Sasa Frank, Vesna Degoricija
Summary: This study found that the serum levels of endothelial lipase (EL) were associated with the serum levels and composition of apolipoprotein B (apoB)-containing lipoproteins, and these associations were different between metabolic syndrome (MS) patients and healthy volunteers (HVs). In MS patients, EL levels were negatively correlated with cholesterol levels in large very low-density lipoprotein (VLDL) particles, as well as with total-cholesterol, free-cholesterol, triglyceride, and phospholipid contents of VLDL and intermediate-density lipoprotein particles. In HVs, EL levels were positively correlated with the serum levels of apoB, triglycerides, and phospholipids in large low-density lipoprotein particles. These findings suggest that EL levels are influenced by MS and may play a role in lipid metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Shih-Jung Jang, Wei-Lun Tuan, Lung-An Hsu, Leay-Kiaw Er, Ming-Sheng Teng, Semon Wu, Yu-Lin Ko
Summary: This study found that APOB locus variants are independently associated with lipid levels and metabolic syndrome in Taiwanese individuals. Mendelian randomization analyses supported the association of APOB variants with the risk of diabetes mellitus through their associations with LDL cholesterol levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Peripheral Vascular Disease
Tsutomu Hirano, Rieko Kodera, Takeshi Hirashima, Natsuko Suzuki, Ema Aoki, Mitsuru Hosoya, Taito Oshima, Toshiyuki Hayashi, Shinji Koba, Motoko Ohta, Noriyuki Satoh, Yasuki Ito
Summary: Abnormal compositional changes in low-density lipoprotein (LDL) particles, such as triglyceride (TG) enrichment and size reduction, are common in diabetes patients. LDL-TG and sdLDL-C are sensitive biomarkers for predicting cardiovascular diseases beyond LDL-C. LDL-TG is significantly correlated with TG, LDL-C, sdLDL-C, and apoB, with apoB being the primary determinant. LDL-TG is associated with low-grade systemic inflammation independently of other lipids. LDL-TG levels are regulated by the number of LDL particles, while sdLDL-C is associated with metabolic syndrome-related factors.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2022)
Article
Nutrition & Dietetics
Salma Fourati, Annick Hamon, Rita Daclat, Joe-Elie Salem, Katell Peoc'h, Johanne Le Beyec, Francisca Joly, Jean-Marc Lacorte
Summary: This study found that ApoB-48 protein could be used as a marker to assess intestinal function in patients with short bowel syndrome. There was a positive correlation between ApoB-48 and residual small bowel length, and lower levels of ApoB-48 were observed in patients dependent on parenteral nutrition.
Review
Biochemistry & Molecular Biology
Laurie Frances, Genevieve Tavernier, Nathalie Viguerie
Summary: Adipose tissue releases a variety of bioactive factors known as adipokines, which play roles in inflammation, glucose homeostasis, and lipid metabolism. Six adipose-derived lipid-binding proteins have been identified as key factors in the development of obesity and diabetes, exhibiting diverse effects on glucose and lipid metabolism. Recent findings have also discussed the detrimental or protective roles of these lipid-binding proteins in human and murine metabolism and their involvement in metabolic diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Hui He, Jiaxing Feng, Shike Zhang, Yu Wang, Jian Li, Jingshu Gao, Jing Cong, Yi Gong, Xiaoke Wu
Summary: The study found that there is a positive association between the ApoB/ApoA1 ratio and metabolic and endocrine parameters in women with PCOS. Higher ratios were also associated with increased risk of MetS and IR. The ratio could be a useful tool for screening MetS and IR in PCOS patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Wenwang Rao, Yunshu Zhang, Keqing Li, Xiang Yang Zhang
Summary: The ApoE gene polymorphism may impact changes in blood lipid levels and cognitive impairment in the general population, but its effects in schizophrenia have not been extensively studied. This research investigated the association of ApoE rs429358 with schizophrenia using the RBANS test and SNPStats analysis. The study found that levels of ApoA1 and ApoB were predictors for various cognitive domains in schizophrenia, with the association being regulated by the ApoE rs429358 genotype.
Article
Nutrition & Dietetics
Soo Lim, Yoon Ji Kim, Ah Reum Khang, Robert H. Eckel
Summary: This study found that abdominal visceral obesity and low HDL-cholesterol concentrations were associated with increased postprandial triglycerides (TG) and apolipoprotein B (ApoB), and these elevated concentrations were linked with subclinical atherosclerosis.
CLINICAL NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Patricia Recio-Lopez, Ismael Valladolid-Acebes, Philipp Hadwiger, Markus Hossbach, Monika Krampert, Carla Prata, Per-Olof Berggren, Lisa Juntti-Berggren
Summary: In this study, siRNAs were developed to silence apoCIII in vivo and it was found that this approach can result in metabolic improvements. Reduction of apoCIII expression led to increased LPL activity, lower triglyceride levels, reduced liver fat, ceased weight gain, enhanced insulin sensitivity, and improved glucose homeostasis.
Article
Medical Laboratory Technology
Qing Liu, Li Wu, Lulin Wang, Kai Chen, Yuntao Wu, Jianhong Xia, Youjie Wang
Summary: Elevated maternal levels of ApoB and ApoB/ApoA-1 ratio during mid-pregnancy are associated with increased risk of preterm birth.
CLINICA CHIMICA ACTA
(2022)
Article
Chemistry, Multidisciplinary
Huige Lin, Lin Wang, Zhuohao Liu, Kekao Long, Mengjie Kong, Dewei Ye, Xi Chen, Kai Wang, Kelvin K. L. Wu, Mengqi Fan, Erfei Song, Cunchuan Wang, Ruby L. C. Hoo, Xiaoyan Hui, Philip Hallenborg, Hailong Piao, Aimin Xu, Kenneth K. Y. Cheng
Summary: The E3 ubiquitin ligase MDM2 controls MAFLD by blocking TG-VLDL secretion and targeting ApoB for proteasomal degradation. Inhibition of the MDM2-ApoB interaction may represent a potential therapeutic approach for MAFLD treatment.
Article
Endocrinology & Metabolism
Marja-Riitta Taskinen, Niina Matikainen, Elias Bjornson, Sanni Soderlund, Jussi Inkeri, Antti Hakkarainen, Helka Parviainen, Carina Sihlbom, Annika Thorsell, Linda Andersson, Martin Adiels, Chris J. Packard, Jan Boren
Summary: This study investigated the hypothesis that individuals with type 2 diabetes on statin therapy may have significant abnormalities in the metabolism of intestinally derived lipoproteins. The findings suggest that in these individuals, there are increased production and longer circulation time of ApoB-48-containing lipoproteins, which may contribute to residual cardiovascular disease risk.
Review
Nutrition & Dietetics
Gregory S. Nacarelli, Tracy Fasolino, Stephanie Davis
Summary: Genetic predisposition and dietary factors play a role in cardiovascular disease (CVD) risk. Evaluating the levels of apolipoprotein B and apolipoprotein A1 in plasma helps assess CVD risk. Different dietary and lifestyle interventions can impact CVD risk markers, such as these apolipoproteins. Additionally, genetic variations may affect the response to dietary interventions on these markers.
Article
Oncology
Yangxun Pan, Zhiwei Ye, Yihong Ling, Lingheng Kong, Chenwei Wang, Gong Chen, Desen Wan, Minshan Chen, Dandan Hu
Summary: This study investigated the characteristics of lipid metabolism parameters in patients with colorectal cancer (CRC) and identified the independent prognostic factors for long-term prognosis. The results showed that blood circulating apolipoprotein A-I (apoA1), apolipoprotein B (apoB), and the apoB/A ratio were independent prognostic factors for overall survival (OS) in CRC patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Sung Keun Park, Chang-Mo Oh, Ju Young Jung
Summary: A study of 379,310 Koreans found that consuming nuts at least once a month was associated with lower risk of elevated insulin resistance, particularly in women, individuals with normal blood sugar levels, and those under 40 years old.
PUBLIC HEALTH NUTRITION
(2022)
Article
Medicine, General & Internal
Sang Min Lee, Eunhee Ha, Jae-Hong Ryoo
Summary: This study aimed to assess the relationship between proteinuria and cerebral infarction. The findings from a follow-up study of 208,854 Koreans showed that an increase in urine protein levels was significantly associated with an increased risk of developing cerebral infarction. Thus, proteinuria might be a potential risk factor for cerebral infarction.
YONSEI MEDICAL JOURNAL
(2022)
Article
Oncology
Sung Keun Park, Ju Young Jung, Chang-Mo Oh, Min-Ho Kim, Eunhee Ha, Yeji Kim, Do Jin Nam, Jae-Hong Ryoo
Summary: This nationwide cohort study found that near daily vigorous intensity physical activity is associated with a decreased risk of pancreatic cancer.
CANCER RESEARCH AND TREATMENT
(2022)
Article
Public, Environmental & Occupational Health
Do Jin Nam, Chang-Mo Oh, Eunhee Ha, Min-Ho Kim, Eun Hye Yang, Hyo Choon Lee, Soon Su Shin, Woo Yeon Hwang, Ann Hee You, Jae-Hong Ryoo
Summary: This study examined the dose-response relationship between smoking amounts (pack-years) and the risk of developing pancreatic cancer in Korean men. The results showed that the risk of developing pancreatic cancer was higher in current smokers compared to former smokers, indicating that smoking cessation may have a protective effect.
EPIDEMIOLOGY AND HEALTH
(2022)
Article
Nutrition & Dietetics
Sung Keun Park, Chang-Mo Oh, Jae-Hong Ryoo, Ju Young Jung
Summary: There are reports suggesting that consuming nuts may provide potential benefits for gastric pathologies, but there are no studies specifically investigating the effect on gastric intestinal metaplasia (GIM). This Korean study analyzed a cohort of men and found that increased nut consumption was associated with a decreased risk of GIM, especially in non-obese men.
NUTRITION BULLETIN
(2022)
Article
Public, Environmental & Occupational Health
Sung Keun Park, Min-Ho Kim, Chang-Mo Oh, Eunhee Ha, Eun Hye Yang, Woo Yeon Hwang, Ann Hee You, Jae-Hong Ryoo
Summary: Smoking is a risk factor for gastric cancer, and the risk can be influenced by smoking status and smoking amount. However, there is limited research on the impact of changes in smoking status over time on the risk of gastric cancer.
EPIDEMIOLOGY AND HEALTH
(2022)
Article
Multidisciplinary Sciences
Sung Keun Park, Chang-Mo Oh, Jae-Hong Ryoo, Ju Young Jung
Summary: This study found that consuming mushrooms can reduce the risk of depressive symptoms, with similar effects observed in different genders and age groups.
SCIENTIFIC REPORTS
(2022)
Article
Public, Environmental & Occupational Health
Soonsu Shin, Eun Hye Yang, Hyo Choon Lee, Seong Ho Moon, Jae-Hong Ryoo
Summary: This study examined the relationship between the usage of visual display terminal (VDT) and symptoms related to computer vision syndrome (CVS) in a large population including both white-collar and blue-collar workers. Results showed that the risk of headache/eyestrain and suspected CVS significantly increased in the group with the highest VDT usage at work. Regardless of occupational classification, the use of VDT in the workplace was found to increase the risk of headache/eyestrain, highlighting the importance of paying attention to the health of VDT workers and improving their working conditions.
ANNALS OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Hong Jun Yang, Yeon Pyo Hong, Tai-Young Yoon, Jae-Hong Ryoo, Joong-Myung Choi, Chang-Mo Oh
Summary: This study examined the independent and synergistic associations of aerobic physical activity and resistance exercise with NAFLD. The results showed that both highly active aerobic physical activity and resistance exercise were significantly associated with a decreased risk of NAFLD. Furthermore, combining both exercises had a synergistic preventive effect on NAFLD.
Article
Endocrinology & Metabolism
Sung Keun Park, Min-Ho Kim, Ju Young Jung, Chang-Mo Oh, Eunhee Ha, Do Jin Nam, Eun Hye Yang, Woo Yeon Hwang, Sangho Lee, Jae-Hong Ryoo
Summary: Long-term and heavy smoking increases the risk of microvascular complications, including nephropathy and neuropathy, in patients with diabetes mellitus. Quitting smoking and reducing smoking amount are crucial in preventing microvascular complications in diabetic patients.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Public, Environmental & Occupational Health
Hyo Choon Lee, Eun Hye Yang, Soonsu Shin, Seoung Ho Moon, Nan Song, Jae-Hong Ryoo
Summary: There is insufficient research on the link between commute time and mental health among Koreans. Using the 6th Korean Working Conditions Survey (KWCS), this study aimed to identify the relationship between commute time and subjective mental health. The results showed that long commute times were associated with increased risk of depression, anxiety, and fatigue.
ANNALS OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Soonsu Shin, Min-Ho Kim, Dong-Young Lee, Hyejin Chun, Eunhee Ha, Hyo Choon Lee, Seong-Ho Moon, Sangho Lee, Jae-Hong Ryoo
Summary: Decreased eGFR was significantly associated with an increased risk of pancreatic cancer in the Korean population, indicating the need for further studies to explore this relationship in other ethnic groups.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Environmental Sciences
Soonsu Shin, Jae-Hong Ryoo
Summary: This study aimed to identify modifiable factors related to urinary BPA levels in Korean children. Through an environment-wide association study and machine learning-based regression analysis, two factors, urinary cotinine levels and the use of slime or clay toys, were found to be positively associated with urinary BPA levels in preschoolers.
ENVIRONMENTAL RESEARCH
(2023)