Article
Medicine, Research & Experimental
Mauro G. Silva, Gerardo R. Corradi, Juan Perez Duhalde, Myriam Nunez, Eliana M. Cela, Daniel H. Gonzales Maglio, Ana Brizzio, Martin R. Salazar, Walter G. Espeche, Mariela M. Gironacci
Summary: This study found that COVID-19 patients have higher levels of ACE2 expression and enzymatic activity in their blood compared to healthy individuals, while levels of AngII and Ang-(1-7) are lower. Even when excluding COVID-19 patients under RAS blockade treatment, ACE2 expression and enzymatic activity remain higher in COVID-19 patients, suggesting the involvement of RAS in COVID-19.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Medicine, Research & Experimental
Yannick Marc, Reda Hmazzou, Nadia De Mota, Fabrice Balavoine, Catherine Llorens-Cortes
Summary: The study found that the tritherapy of firibastat, enalapril, and HCTZ significantly improved the blood pressure control and arginine-vasopressin release in deoxycorticosterone acetate-salt rats, compared to bitherapy with enalapril and HCTZ.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Mingfei Li, Ying Wang, Ndindam Ndiwane, Michelle B. Orner, Natalia Palacios, Brant Mittler, Dan Berlowitz, Lewis E. Kazis, Weiming Xia
Summary: The study aimed to investigate the association between ACEI and ARB medication use and COVID-19 occurrence and severity in US Veterans with hypertension. Results showed that ACEI significantly decreased the odds of testing positive for COVID-19 and was associated with a slight increase in the odds of using mechanical ventilators.
Article
Cardiac & Cardiovascular Systems
Rohan Khera, Callahan Clark, Yuan Lu, Yinglong Guo, Sheng Ren, Brandon Truax, Erica S. Spatz, Karthik Murugiah, Zhenqiu Lin, Saad B. Omer, Deneen Vojta, Harlan M. Krumholz
Summary: The study found that ACE inhibitors and ARBs were not significantly associated with the risk of COVID-19 hospitalization or mortality. Despite some tendency to lower hospitalization risk in older individuals, recent data consistency supports this conclusion.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Jaejin An, Rong Wei, Hui Zhou, Tiffany Q. Luong, Michael K. Gould, Matthew T. Mefford, Teresa N. Harrison, Beth Creekmur, Ming-Sum Lee, John J. Sim, Jeffrey W. Brettler, John P. Martin, Angeline L. Ong-Su, Kristi Reynolds
Summary: The study found that the use of ACEIs or ARBs was not significantly associated with COVID-19 infection among patients with hypertension. However, there was a lower odds of COVID-19 infection among adults over 85 years old using ACEIs, suggesting that further investigation is warranted.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Endocrinology & Metabolism
Nicole M. Fischer, Tim O. Nieuwenhuis, Bhuchitra Singh, Gayane Yenokyan, James H. Segars
Summary: The study found that adult hypertensive women who used ACE inhibitors had a reduced odds of developing clinically recognized leiomyoma compared to non-users by approximately 31.8%. This association was significant across all age groups (30-39 years, 40-49 years, 50-59 years, 60-65 years). Specifically, lisinopril, quinapril, and ramipril were significantly associated with reduced leiomyoma incidence.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Peripheral Vascular Disease
Zhen-Yu Zhang, Yu-Ling Yu, Kei Asayama, Tine W. Hansen, Gladys E. Maestre, Jan A. Staessen
Summary: Additional digital content is available in the text.
Review
Pharmacology & Pharmacy
Saeed Alshahrani
Summary: Chronic kidney disease is a complex condition with various underlying causes. Current pharmacotherapeutic treatment options aim to slow disease progression and improve quality of life but cannot achieve complete cure. The first-line treatment for controlling blood pressure in chronic kidney disease is the use of renin-angiotensin-aldosterone system modulators. These modulators, including direct renin inhibitors, angiotensin-converting enzyme inhibitors, and angiotensin II receptor blockers, have different structures and mechanisms of action, leading to varying treatment outcomes. The choice of modulator depends on patient presentation, comorbidities, treatment availability and affordability, and healthcare provider expertise. Comparative studies between these modulators are currently lacking, which could provide valuable information for healthcare providers and researchers. This review compares the direct renin inhibitor (aliskiren) with angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers, aiming to identify specific areas of interest for intervention and the best possible treatment option.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Amy H. Stanford, Melanie Reyes, Danielle R. Rios, Regan E. Giesinger, Jennifer G. Jetton, Adrianne R. Bischoff, Patrick J. McNamara
Summary: Neonatal hypertension, often accompanied by impaired left ventricular diastolic function, can be effectively treated with ACE inhibitor enalapril in premature infants. This treatment leads to improvements in blood pressure and LV diastolic function, potentially benefiting cardiovascular health in the long term.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Yao Lin, Yaxi Cui, Yue Yuan, Lu Gao, Qirui Li, Xiaolan Huang, Yanyan Liu, Lin Shi
Summary: This study aimed to investigate the predictive value of plasma FGF23 levels for fosinopril therapy in pediatric primary hypertension. The study found a significant association between plasma FGF23 levels and the effectiveness of fosinopril treatment, suggesting that plasma FGF23 might be a valuable biomarker for guiding fosinopril therapy in children with primary hypertension.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Nutrition & Dietetics
Francisca Isabel Bravo, Enrique Calvo, Rafael A. Lopez-Villalba, Cristina Torres-Fuentes, Begona Muguerza, Almudena Garcia-Ruiz, Diego Morales
Summary: Hypertension is a major contributor to premature deaths worldwide and can be prevented by managing cardiovascular diseases. Protein hydrolysates containing antihypertensive peptides derived from agri-food industry byproducts, such as chicken slaughterhouse byproducts, have shown potential in lowering blood pressure. These byproducts, including blood, bones, skins, and chicken feet, have been used to produce protein hydrolysates with angiotensin-converting enzyme (ACE) inhibitory activity. Mechanisms underlying their effects include increased levels of antioxidant compounds, reduced ACE activity, and improved endothelial dysfunction associated with hypertension. However, further clinical studies are needed to confirm these antihypertensive properties and enhance the value of these byproducts in the circular economy model of slaughterhouses.
Review
Multidisciplinary Sciences
Nancy Xurui Huang, Qi Yuan, Fang Fang, Bryan P. Yan, John E. Sanderson
Summary: This meta-analysis found that the use of ACEI/ARB was associated with reduced mortality and shorter duration of hospital stay in East-Asian Covid-19 patients. There was no significant difference in disease severity between individuals receiving ACEI/ARB or not. Therefore, it is recommended to continue the use of ACEI/ARB in patients infected by Covid-19.
Review
Cardiac & Cardiovascular Systems
Xiao-Ce Dai, Zhuo-Yu An, Zi-Yang Wang, Zi-Zhen Wang, Yi-Ren Wang
Summary: The use of ACEIs/ARBs does not appear to have a significant impact on mortality, disease severity, or duration of hospitalization in COVID-19 patients. Based on the findings of this meta-analysis, there is no support for discontinuing treatment with ACEIs or ARBs in patients with COVID-19.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Michael A. Puskarich, Nicholas E. Ingraham, Lisa H. Merck, Brian E. Driver, David A. Wacker, Lauren Page Black, Alan E. Jones, Courtney Fletcher, Andrew M. South, Thomas A. Murray, Christopher Lewandowski, Joseph Farhat, Justin L. Benoit, Michelle H. Biros, Kartik Cherabuddi, Jeffrey G. Chipman, Timothy W. Schacker, Faheem W. Guirgis, Helen T. Voelker, Joseph S. Koopmeiners, Christopher J. Tignanelli
Summary: This study found that oral administration of losartan did not improve the PaO2:FiO(2) ratio at 7 days in hospitalized patients with COVID-19 and acute lung injury. The use of losartan also did not improve secondary clinical outcomes and resulted in fewer vasopressor-free days compared to placebo.
Article
Peripheral Vascular Disease
Jessica R. Wilson, Erica M. Garner, Mona Mashayekhi, Scott A. Hubers, Claudia E. Ramirez Bustamante, Scott Jafarian Kerman, Hui Nian, Cyndya A. Shibao, Nancy J. Brown
Summary: DPP4 inhibition may increase catecholamine levels, but does not increase blood pressure. Increased catecholamines during concurrent use of ACE and DPP4 inhibitors may contribute to cardiovascular complications in patients predisposed to heart failure.
Article
Peripheral Vascular Disease
Deborah de Farias Lelis, Roberto S. Cunha, Raul D. Santos, Andrei C. Sposito, Rosane Harter Griep, Sandhi Maria Barreto, Maria del Carmen B. Molina, Maria Ines Schmidt, Bruce B. Duncan, Isabela Bensenor, Paulo Andrade Lotufo, Jose Geraldo Mill, Marcelo Perim Baldo
Summary: Atherogenic dyslipidemia is associated with carotid-femoral pulse wave velocity (cf-PWV), and there is a linear association between triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and the triglycerides to high-density lipoprotein (TG/HDL-C) ratio with arterial stiffness. HDL-C has a stronger association with arterial stiffness, while the association of TG/HDL-C with arterial stiffness is dependent on HDL-C levels.
Article
Cardiac & Cardiovascular Systems
Matheus C. Barbosa, Willian Cirillo, Fernando Piza, Marcio J. O. Figueiredo, Odilson M. Silvestre, Miguel M. Fernandes-Silva, Roberto Schreiber, Matheus F. R. A. Oliveira, Pedro P. M. Oliveira, Lindemberg M. Silveira-Filho, Orlando Petrucci Jr, Otavio R. Coelho-Filho, Jose R. Matos-Souza, Andrei C. Sposito, Wilson Nadruz Jr
Summary: This study investigated the predictors and prognostic impact of in-hospital infection among patients waiting for permanent cardiac pacemaker implantation. It found that urinary catheter use, complete atrioventricular block, implantation of temporary pacemaker and diabetes mellitus were independent predictors of infection. Patients who developed infection had a higher risk of early mortality after pacemaker implantation. The use of a clinical score can help prioritize high-risk patients and reduce this adverse event.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Peripheral Vascular Disease
Marco A. M. Alves, Audes D. M. Feitosa, Marco A. Mota-Gomes, Annelise M. G. Paiva, Weimar S. Barroso, Roberto D. Miranda, Eduardo C. D. Barbosa, Andrea A. Brandao, Paulo G. S. Diniz, Otavio Berwanger, Jose L. Lima-Filho, Andrei C. Sposito, Antonio Coca, Wilson Nadruz
Summary: This study found that the accuracy of guideline-proposed office blood pressure screening thresholds in identifying individuals at high risk of having masked hypertension in an office setting is limited and is inferior to that yielded by scores derived from simple clinical variables.
HYPERTENSION RESEARCH
(2023)
Review
Endocrinology & Metabolism
Isabella Bonilha, Beatriz Luchiari, Wilson Nadruz, Andrei C. Sposito
Summary: Individuals with very low HDL-C levels, such as Tangier disease, LCAT deficiency, and familial hypoalphalipoproteinemia, have an increased risk of premature atherosclerosis. However, comparing populations with small variations in HDL-C due to polygenic alterations does not confirm these findings, suggesting an indirect association or heterogeneity in the pathophysiological mechanisms related to HDL-C reduction. Trials evaluating HDL functions show a stronger association between the HDL system and atherosclerotic risk, but the causal relationship is still unclear. Current randomized clinical trials aim to increase HDL-C concentration but have not shown independent reduction in cardiovascular risk. Therefore, there is a need to understand the molecular action and cellular interaction of HDL beyond plasma HDL-C concentration to mitigate atherosclerotic risk.
ARCHIVES OF ENDOCRINOLOGY METABOLISM
(2023)
Letter
Cardiac & Cardiovascular Systems
Ana Beatrice Magalhaes de Oliveira, Beatriz Luchiari, Isabella Bonilha, Joaquim Barreto, Ana Claudia Cavalcante Nogueira, Guilherme Duprat Ceniccola, Carisi Anne Polanczyk, Andrei Carvalho Sposito, Luiz Sergio Fernandes de Carvalho
Article
Endocrinology & Metabolism
Kelcia R. S. Quadros, Noemi A. V. Roza, Renata A. Franca, Andre B. A. Esteves, Joaquim Barreto, Wagner V. Dominguez, Luzia N. S. Furukawa, Jacqueline Teixeira Caramori, Andrei C. Sposito, Rodrigo Bueno de Oliveira
Summary: Advanced glycation end products (AGEs) accumulation is associated with the progression of CKD-bone disorders. This study investigated the relationship between AGEs measured in blood, skin, and bone with bone histomorphometry parameters, protein, gene expression, and serum biomarkers in CKD patients. The results showed that bone AGEs accumulation was inversely correlated with serum receptor activator of NF-KB ligand/PTH ratio, and RAGE expression was negatively correlated with serum tartrate-resistant acid phosphatase-5b/PTH.
Article
Urology & Nephrology
Joaquim Barreto, Cynthia Borges, Tais Betoni Rodrigues, Daniel C. Jesus, Alessandra M. Campos-Staffico, Wilson Nadruz, Jose Luiz da Costa, Rodrigo Bueno de Oliveira, Andrei C. Sposito
Summary: The study aimed to evaluate the effects of SGLT2 inhibitors on cardiovascular outcomes in patients with conservatively managed CKD. It was found that dapagliflozin was well tolerated and had nonaccumulating pharmacokinetic properties in patients with kidney failure on dialysis.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Endocrinology & Metabolism
Helison Rafael P. Carmo, Marcos Y. Yoshinaga, Alejandro Rosell Castillo, Adriano Britto Chaves-Filho, Isabella Bonilha, Joaquim Barreto, Stefanie Primon Muraro, Gabriela Fabiano de Souza, Gustavo Gastao Davanzo, Mauricio W. Perroud Jr, Kishal Lukhna, Mpiko Ntsekhe, Sean Davidson, Licio A. Velloso, Wilson Nadruz, Luiz Sergio F. Carvalho, Miguel Sainz-Jaspeado, Alessandro S. Farias, Jose Luiz Proenca-Modena, Pedro M. Moraes-Vieira, Sotirios K. Karathanasis, Derek Yellon, Sayuri Miyamoto, Alan T. Remaley, Andrei C. Sposito
Summary: Phenotypic changes in LDL particles are associated with disease progression and adverse clinical outcomes in COVID-19 patients and could serve as a potential prognostic biomarker.
MOLECULAR GENETICS AND METABOLISM
(2023)
Article
Multidisciplinary Sciences
Cinthia E. M. Carbonara, Noemi A. V. Roza, Kelcia R. S. Quadros, Renata A. Franca, Andre B. A. Esteves, Celia R. Pavan, Joaquim Barreto, Luciane M. dos Reis, Vanda Jorgetti, Andrei C. Sposito, Rodrigo Bueno Oliveira
Summary: The prevalence of aluminum (Al) intoxication has declined, but bone accumulation of Al is still reported. This study found that bone Al accumulation is related to bone pain, tendon rupture, and pruritus, as well as being an independent predictor for cardiovascular events.
Article
Cardiac & Cardiovascular Systems
Carlos Collet, Nils P. Johnson, Takuya Mizukami, William F. Fearon, Colin Berry, Jeroen Sonck, Damien Collison, Bon-Kwon Koo, Nicolas Meneveau, Shiv Kumar Agarwal, Barry Uretsky, Abdul Hakeem, Joon-Hyung Doh, Bruno R. Da Costa, Keith G. Oldroyd, Jonathon A. Leipsic, Umberto Morbiducci, Charles Taylor, Brian Ko, Pim A. L. Tonino, Divaka Perera, Toshiro Shinke, Claudio Chiastra, Andrei C. Sposito, Antonio Maria Leone, Olivier Muller, Stephane Fournier, Hitoshi Matsuo, Julien Adjedj, Nicolas Amabile, Zsolt Piroth, Fernando Alfonso, Fernando Rivero, Jung-Min Ahn, Gabor G. Toth, Abdul Ihdayhid, Nick E. J. West, Tetsuya Amano, Eric Wyffels, Daniel Munhoz, Marta Belmonte, Hirofumi Ohashi, Koshiro Sakai, Emanuele Gallinoro, Emanuele Barbato, Thomas Engstrom, Javier Escaned, Ziad A. Ali, Morton J. Kern, Nico H. J. Pijls, Peter Jueni, Bernard De Bruyne
Summary: This study found that the post-PCI FFR of the left anterior descending (LAD) artery was lower than that of non-LAD arteries, highlighting the importance of interpreting post-PCI FFR on a vessel-specific basis. Although a higher post-PCI FFR was associated with improved prognosis, its predictive capacity for events differed between the LAD and non-LAD arteries, being poor in the LAD and moderate in the non-LAD vessels.
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Nestor S. Martins, Joaquim Barreto, Sheila Tatsumi Kimura-Medorima, Sofia Helena Vitte, Thiago Quinaglia, Barbara Assato, Otavio Rizzi Coelho-Filho, Jose Roberto Matos-Souza, Wilson Nadruz, Andrei C. Sposito
Summary: This study found that in individuals with type 2 diabetes, carotid intimal thickness (cIT) is a better predictor of coronary artery calcification (CAC) than carotid intima-media thickness (cIMT), and carotid media thickness (cM) is not associated with CAC.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Economics
Ana Claudia Cavalcante Nogueira, Joaquim Barreto, Filipe A. Moura, Beatriz Luchiari, Abrao Abuhab, Isabella Bonilha, Wilson Nadruz, J. Michael Gaziano, Thomas Gaziano, Luiz Sergio F. de Carvalho, Andrei C. Sposito, Brazilian Heart Study Grp
Summary: This study compared the effectiveness and cost-effectiveness of glucose-lowering therapies (GLT) in individuals with type 2 diabetes in Brazil. The findings showed that SGLT2 inhibitors, GLP-1 agonists, and pioglitazone can reduce the relative risks of non-fatal cardiovascular events. Pioglitazone was found to be the most cost-effective treatment in both primary and secondary prevention scenarios.
HEALTH ECONOMICS REVIEW
(2023)
Letter
Urology & Nephrology
Joaquim Barreto, Rafael Y. Sano, Cynthia Borges, Wilson Nadruz, Kelcia Quadros, Andrei C. Sposito, Rodrigo Bueno de Oliveira
JOURNAL OF NEPHROLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Mariana Rodrigues Pioli, Renata Muller Couto, Jose de Arimateia Francisco, Diego Quilles Antoniassi, Celia Regina de Souza, Matheus Ynada de Olivio, Gabriel Forato Anhe, Silvio Giopatto, Andrei C. Sposito, Wilson Nadruz, Otavio Rizzi Coelho-Filho, Rodrigo Modolo
Summary: This retrospective observational study compared the efficacy of intravenous hydration and outpatient oral hydration in preventing contrast-induced nephropathy in patients undergoing coronary procedures. The results showed no significant difference in the incidence of contrast-induced nephropathy between the two groups. The outpatient oral hydration protocol appears to be as effective as in-hospital intravenous hydration for renal protection.
ARQUIVOS BRASILEIROS DE CARDIOLOGIA
(2023)
Article
Cardiac & Cardiovascular Systems
Patricia O. Guimaraes, Marcelo Franken, Caio A. M. Tavares, Fabio S. Silveira, Murillo O. Antunes, Ricardo R. Bergo, Rodrigo M. Joaquim, Jessica C. S. Hirai, Pedro B. Andrade, Fabio G. Pitta, Jose Mariani, Bruno R. Nascimento, Marcos S. Silveira, Tiberio A. O. Costa, Frederico T. C. Dall'Orto, Renato G. Serpa, Fernanda B. A. Sampaio, Louis N. Ohe, Fernanda M. Mangione, Remo H. M. Furtado, Rogerio Sarmento-Leite, Frederico Monfardini, Silvia R. L. Assis, Jose C. Nicolau, Andrei C. Sposito, Renato D. Lopes, Yoshinobu Onuma, Marco Valgimigli, Dominick J. Angiolillo, Patrick W. Serruys, Otavio Berwanger, Fernando Bacal, Pedro A. Lemos
Summary: This study aims to compare the efficacy and safety of immediate aspirin-free single antiplatelet therapy (SAPT) with dual antiplatelet therapy (DAPT) in patients with acute coronary syndromes (ACS) following percutaneous coronary intervention (PCI). It will provide important insights on the efficacy and safety of withdrawing aspirin in the early phase of ACS.