期刊
ATHEROSCLEROSIS
卷 219, 期 2, 页码 596-602出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.atherosclerosis.2011.08.001
关键词
Atherogenic lipoproteins; Anti-atherogenic lipoproteins; Plaque burden; Lipid-rich necrotic core
资金
- National Heart, Lung, and Blood Institute [HH5N268201100005C, HH5N268201100006C, HH5N268201100007C, HH5N268201100008C, HH5N2682011 00009C, HH5N268201100010C, HH5N268201100011C, HH5N268201100012C]
- ARIC carotid MRI [U01HL075572-01]
- Department of Veterans Affairs Health Services Research and Development Service [HSR82D, CDA-09-028]
- Merck and Co, Inc.
- National Football League Charities
- Abbott
- AstraZeneca
- Bristol-Myers Squibb
- diaDexus
- GlaxoSmithKline
- Kowa
- Merck
- Novartis
- Roche
- Sanofi-Synthelabo
- Takeda
- NIH
- American Diabetes Association
- American Heart Association
Objective: There is a paucity of data regarding relations of apolipoproteins (apolipoprotein B [ApoB] and apolipoprotein A-1 [Apo A-1]), lipoprotein particle measures (low-density lipoprotein particle concentration [LDLp] and high-density lipoprotein particle concentration [HDLp]), and lipoprotein cholesterol measures (low-density lipoprotein cholesterol [LDL-C], non-high-density lipoprotein cholesterol [non-HDL-C], and high-density lipoprotein cholesterol [HDL-C]) with atherosclerotic plaque burden, plaque eccentricity, and lipid-rich core presence as a marker of high-risk plaques. Methods: Carotid artery magnetic resonance imaging was performed in 1670 Atherosclerosis Risk in Communities study participants. Vessel wall and lipid cores were measured; normalized wall index (NWI), standard deviation (SD) of wall thickness (measure of plaque eccentricity) were calculated; and lipid cores were detected in vessels with >= 1.5 mm thickness. Fasting concentrations of cholesterol, ApoB and Apo A-1, and LDLp and HDLp were measured. Results: Measures of plaque burden (carotid wall volume, wall thickness, and NWI) were positively associated with atherogenic cholesterol and lipoproteins (p < 0.05 for total cholesterol, LDL-C, non-HDL-C, ApoB, and LDLp), but not with HDL-C, Apo A-1, or HDLp. SD of wall thickness was associated with total cholesterol (p0.01) and non-HDL-C (p 0.02). Although measures of atherogenic or anti-atherogenic cholesterol or lipoprotein were not individually associated with detection of a lipid-rich core, their ratios (total cholesterol/HDL-C, non-HDL-C/HDL-C, and LDLp/HDLp) were associated with lipid-rich core presence (p < 0.05). Conclusion: Extent of carotid atherosclerosis is associated with atherogenic cholesterol and lipoproteins. Atherogenic/anti-atherogenic cholesterol or particle ratios were associated with presence of a detectable lipid-rich core. (C)2011 Published by Elsevier Ireland Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据