Article
Materials Science, Multidisciplinary
Chao -ping He, Wen-juan Quan, Ya-ling Zeng, Hong-yan Zhou, Pei-dong You, Zhen-xian Li, Ya-mei Li, Li-mei Lin, Bin Liu, Duan-fang Liao, Qin-hui Tuo
Summary: In this study, a compound of curcumin nicotinate (CN) was synthesized and loaded onto biomimetic nanosystem constructed by Prussian blue nanoparticles (PB NPs) to improve its solubility. Hyaluronic acid (HA) modification was adopted to prolong circulation time and improve the accumulation of drugs in the plaque region. The designed nano-platform showed potential for prevention and targeted therapy of atherosclerosis through specific pathways.
MATERIALS & DESIGN
(2023)
Article
Cardiac & Cardiovascular Systems
Juan Francisco Aranda, Ana Perez-Garcia, Marta Torrecilla-Parra, Mario Fernandez-de Frutos, Yolanda Martin-Martin, Pedro A. Mateos-Gomez, Virginia Pardo-Marques, Rebeca Busto, Cristina M. Ramirez
Summary: Hypoxia plays a crucial role in the maintenance of atherosclerotic lesions. miR-199a-5p and ABCA1 are inversely regulated by hypoxia and Ac-LDL, and their interaction can control macrophage cholesterol efflux during the onset of atherosclerosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cell Biology
Heon-Su Kim, Jung-Soo Suh, Yoon-Kwan Jang, Sang-Hyun Ahn, Gyu-Ho Choi, Jin-Young Yang, Gah-Hyun Lim, Youngmi Jung, Jie Jiang, Jie Sun, Myungeun Suk, Yingxiao Wang, Tae-Jin Kim
Summary: This study reveals the relationship between Piezo1-mediated Ca2+ influx and cellular behavior using innovative biosensors and imaging analysis. The results demonstrate that Piezo1 induces extracellular Ca2+ influx, which requires the support of caveolin, cholesterol, and the cytoskeleton. Increased cytoplasmic Ca2+ levels enhance the activity of PKA, ERK, Rac1, and ROCK, promoting cancer cell survival and migration. Furthermore, Piezo1-mediated Ca2+ influx upregulates membrane ruffling, a characteristic feature of cancer cell metastasis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Li Zhu, Hongjiao Li, Jiyu Li, Yuan Zhong, Shuai Wu, Meng Yan, Sheng Ni, Kun Zhang, Guixue Wang, Kai Qu, Deqin Yang, Xian Qin, Wei Wu
Summary: A disorder of cholesterol homeostasis initiates atherosclerosis progression. Macrophage membrane-camouflaged methotrexate nanoparticles (MM@MTX NPs) showed improved therapeutic efficacy by promoting cholesterol efflux and inhibiting foam cell formation. The NPs significantly reduced plaque area, aortic plaque, and cholesterol crystal deposition in ApoE-/- mice, and exhibited good biocompatibility.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xiao Li, Tengfei Zheng, Yu Zhang, Yachao Zhao, Fengming Liu, Shen Dai, Xiaolin Liu, Mei Zhang
Summary: This study found that DKK1 promotes smooth muscle cell foam cell formation during atherosclerosis by reducing CYP4A11-20-HETE/SREBP2-mediated ABCA1 expression.
Article
Physics, Multidisciplinary
Matthew Pittman, Ernest Iu, Keva Li, Mingjiu Wang, Junjie Chen, Nilay Taneja, Myung Hyun Jo, Seungman Park, Wei-Hung Jung, Le Liang, Ishan Barman, Taekjip Ha, Stavros Gaitanaros, Jian Liu, Dylan Burnette, Sergey Plotnikov, Yun Chen
Summary: Cell behaviour is influenced by the physical forces and mechanical properties of both cells and their microenvironment. This study explores the effect of viscosity, an important component of the cellular microenvironment, on cell behaviour. The results show that cells respond in a similar manner to elevated viscosity, with increased spread area, focal adhesion formation and turnover, traction forces, and migration speed. Cells utilize membrane ruffling to sense changes in extracellular fluid viscosity and trigger adaptive responses.
Article
Multidisciplinary Sciences
Daria Zdzalik-Bielecka, Agata Poswiata, Kamila Kozik, Kamil Jastrzebski, Kay Oliver Schink, Marta Brewinska-Olchowik, Katarzyna Piwocka, Harald Stenmark, Marta Miaczynska
Summary: The study identified an interactome of AXL and its associations with proteins regulating actin dynamics. GAS6-mediated AXL activation triggered actin remodeling and macropinocytosis, promoting the survival of cancer cells under glutamine-deprived conditions. AXL activation by GAS6 drove invasion of cancer cells through actin-driven cytoskeletal rearrangements.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Physical
Guanghao Wu, Changwen Mu, Qianru Zhao, Yao Lei, Ran Cheng, Weidong Nie, Jiamin Qu, Yuping Dong, Ruili Yang, Haiyan Xie
Summary: A hybrid cell is constructed for the sonodynamic effect promoted cell therapy of early atherosclerosis. The study shows that the hybrid cell accumulates in atherosclerotic plaques, reducing cholesterol accumulation and inflammation, and inducing foam cell apoptosis under ultrasound activation. The cooperation of M2 macrophages and TK membranes leads to significant elimination of atherosclerotic plaques without obvious side-effects.
Review
Biochemistry & Molecular Biology
Liwen Yu, Yujie Zhang, Changhao Liu, Xiao Wu, Shasha Wang, Wenhai Sui, Yun Zhang, Cheng Zhang, Meng Zhang
Summary: Technology at the single-cell level has advanced dramatically in characterizing molecular heterogeneity, including cell subtype diversity in atherosclerotic plaques. Recent progress in single-cell technologies enables the comprehensive mapping of macrophage subsets and phenotypes within plaques, providing potential therapeutic targets for cardiovascular diseases.
Article
Biochemistry & Molecular Biology
Sara Franceschelli, Federica De Cecco, Mirko Pesce, Patrizio Ripari, Maria Teresa Guagnano, Arturo Bravo Nuevo, Alfredo Grilli, Silvia Sancilio, Lorenza Speranza
Summary: This study aimed to investigate whether hydroxytyrosol (HT), a phenolic compound with anti-inflammatory and antioxidant properties, can reduce cholesterol accumulation in foam cells derived from THP-1 macrophages, and to explore the underlying mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Ke Wang, Qi Cao, Qiong Yang, Qiang Wei, Jiarui Zhao, Yuan Wang, Junfeng Hou, Shuliang Song
Summary: HE-D can inhibit the migration of macrophages by inhibiting IKK alpha and IKK gamma in the NF-Kappa B signaling pathway, and promote the transformation of macrophages from M1 to M2 subtypes. Therefore, HE-D can potentially be used as a drug for the treatment of atherosclerosis.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiao Li, Tengfei Zheng, Yu Zhang, Yachao Zhao, Fengming Liu, Shen Dai, Xiaolin Liu, Mei Zhang
Summary: This study reveals that DKK1 promotes foam cell formation in smooth muscle cells (SMCs) during atherosclerosis by reducing CYP4A11-20-HETE/SREBP2-mediated ABCA1 expression. This finding is important for understanding the pathogenesis of atherosclerosis and developing related therapeutic strategies.
Article
Cell Biology
Antonino Schepis, Sudhir Kumar, Stefan H. I. Kappe
Summary: Plasmodium sporozoites, the mobile forms of malaria parasites, actively drive the invasion of hepatocytes with the assistance of host cell processes. The initial interactions between sporozoites and hepatocytes induce plasma membrane ruffles and filopodia extensions, which are critical for successful infection. Rho GTPase signaling plays a crucial role in regulating these processes and increasing hepatocyte susceptibility to malaria parasite infection. This study highlights the importance of host cell signaling events in plasma membrane dynamics during malaria parasite invasion of hepatocytes.
Article
Biotechnology & Applied Microbiology
Xuan Sha, Yue Dai, Lijuan Chong, Min Wei, Mengyuan Xing, Chun Zhang, Jingjing Li
Summary: The design of macrophage membrane biomimetic nanoparticles can effectively treat atherosclerosis by reducing lipid uptake by macrophages, decreasing foam cell formation, and inhibiting the expression of inflammatory cytokines.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Nataliya V. Mushenkova, Nikita G. Nikiforov, Alexandra A. Melnichenko, Vladislav Kalmykov, Nikolay K. Shakhpazyan, Varvara A. Orekhova, Alexander N. Orekhov
Summary: This review discusses the functional phenotypes of intraplaque macrophages and their distinct contribution to atherosclerosis inflammation.
Review
Cardiac & Cardiovascular Systems
Mario Bo, Alberto Corsini, Enrico Brunetti, Gianluca Isaia, Maddalena Gibello, Nicola Ferri, Daniela Poli, Niccolo Marchionni, Gaetano Maria De Ferrari
Summary: Underdosing of oral factor Xa inhibitors in clinical practice is often intentional, but studies do not show significant net clinical benefit.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2021)
Article
Hematology
Marco Busnelli, Stefano Manzini, Matteo Chiara, Alice Colombo, Fabrizio Fontana, Roberto Oleari, Francesco Poti, David Horner, Stefano Bellosta, Giulia Chiesa
Summary: The study found that overexpression of ApoA-I in EKO mice aorta modulates the development of atherosclerosis, affecting pathways beyond those associated with inflammation and immune response.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
S. Bellosta, C. Rossi, A. S. Alieva, A. L. Catapano, A. Corsini, A. Baragetti
Summary: In recent years, advances in genetic research and technology have led to the discovery of new therapeutic approaches for dyslipidemias. These approaches include targeting proteins, transcripts, and genomic sequences. These pharmacological advances have been particularly successful in treating previously untreatable genetic conditions in the cardiovascular field.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Review
Cardiac & Cardiovascular Systems
Massimiliano Ruscica, Nicola Ferri, Maciej Banach, Cesare R. Sirtori, Alberto Corsini
Summary: Treatment with statins has proven effective in preventing cardiovascular events, but discontinuation due to intolerance and non-adherence remains a major issue. Muscle side effects, such as myalgia, are the most commonly reported, but whether they are a result of the drug's effect is still debated.
CARDIOVASCULAR RESEARCH
(2022)
Review
Medicine, General & Internal
Lorenzo Arnaboldi, Alberto Corsini, Stefano Bellosta
Summary: There is a relationship between low-density lipoprotein cholesterol (LDL-C) and the risk of developing cardiovascular disease. In addition to conventional pharmacological treatments, nutraceuticals and functional foods are increasingly being considered as effective support for reducing LDL-C. This review summarizes the effects of artichoke and bergamot on lipid and inflammatory parameters.
Article
Hematology
Anna E. Bortnick, Petra Buzkova, James Otvos, Majken Jensen, Michael Y. Tsai, Matthew Budoff, Rachel Mackey, Samar R. El Khoudary, Elda Favari, Ryung S. Kim, Carlos J. Rodriguez, George Thanassoulis, Jorge R. Kizer
Summary: This study found that high-density lipoprotein (HDL) cholesterol, HDL particle number and size, apoC3-defined HDL subtypes were inversely associated with the long-term incidence and progression of aortic valve calcification (AVC). Further investigation of HDL composition and mechanisms could be useful in understanding pathways that slow AVC.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Stefano Bellosta, Francesca Selmin, Giulia Magri, Silvia Castiglioni, Patrizia Procacci, Patrizia Sartori, Edoardo Scarpa, Valerio Tolva, Clara Rossi, Francesco Puoci, Loris Rizzello, Francesco Cilurzo
Summary: This study demonstrates the use of grafting caffeic acid or resveratrol on a poly(lactide-co-glycolide) backbone (g-CA-PLGA or g-RV-PLGA) and fluvastatin as a drug for drug-eluting nanoparticles, which can effectively prevent restenosis after angioplasty.
MOLECULAR PHARMACEUTICS
(2022)
Review
Biochemistry & Molecular Biology
Erika Paolini, Miriam Longo, Alberto Corsini, Paola Dongiovanni
Summary: Nonalcoholic fatty liver disease (NAFLD) is a common liver disease worldwide. Currently, there are no approved therapeutic strategies for NAFLD, and hepatic biopsy is still the gold standard for diagnosis. NAFLD is a multifactorial disease with a spectrum of conditions ranging from simple steatosis to more severe stages. Studies have highlighted the need for an NAFLD risk prediction model based on genetics, biomarkers, and metabolic disorders. Mitochondrial dysfunction plays a key role in the progression of NAFLD. Alterations in the displacement loop (D-loop) region and cell-free circulating mitochondrial DNA (mt-ccf) have been proposed as potential non-invasive biomarkers for NAFLD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Annalisa Ronca, Nicoletta Pellegrini, Giuditta Pagliai, Monica Dinu, Matteo Manfredini, Matteo Incerti, Elda Favari, Francesco Sofi
Summary: This study aimed to evaluate the effect of Mediterranean diet (MD) and lacto-ovo-vegetarian diet (VD) on HDL function in healthy subjects at low-to-moderate cardiovascular disease (CVD) risk. The results showed that MD was more effective than VD in promoting cholesterol efflux and reducing the concentration of pro-atherogenic lipoproteins, suggesting that MD may be a better therapeutic strategy for cardiovascular prevention.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Laura Bianchi, Isabella Damiani, Silvia Castiglioni, Alfonso Carleo, Rossana De Salvo, Clara Rossi, Alberto Corsini, Stefano Bellosta
Summary: Cigarette smoke affects the smooth muscle cells in the aorta, leading to inflammation and reduced contraction. Mass spectrometry analysis revealed significant changes in protein abundance in human smooth muscle cells exposed to cigarette smoke, involving pathways related to inflammatory cytokines and interferon. Gene expression and protein abundance data identified KLF4 and PKR as the most relevant factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
F. M. Accattatis, S. Mazza, F. Bordonaro, A. Granata, E. Vergani, M. Rodolfo, L. Bianchi, F. Francomano, A. Carleo, S. Bellosta, A. Corsini, L. Arnaboldi
Meeting Abstract
Cardiac & Cardiovascular Systems
I. Damiani, C. Rossi, S. Castiglioni, V. Rusconi, A. Corsini, S. Bellosta
Meeting Abstract
Cardiac & Cardiovascular Systems
S. Mazza, F. M. Accattatis, F. Bordonaro, A. Granata, L. Bianchi, F. Francomano, A. Carleo, E. Vergani, M. Rodolfo, S. Bellosta, A. Corsini, L. Arnaboldi
Meeting Abstract
Cardiac & Cardiovascular Systems
M. Busnelli, S. Manzini, A. Colombo, F. Fontana, R. Oleari, F. Poti, S. Castiglioni, S. Bellosta, G. Chiesa
