Article
Cardiac & Cardiovascular Systems
Jennifer J. Stuart, Lauren J. Tanz, Eric B. Rimm, Donna Spiegelman, Stacey A. Missmer, Kenneth J. Mukamal, Kathryn M. Rexrode, Janet W. Rich-Edwards
Summary: This study aimed to evaluate the association between hypertensive disorders of pregnancy (HDP) and long-term cardiovascular disease (CVD) and identify the proportion mediated by established CVD risk factors. The results showed that women with HDP during their first pregnancy had a higher risk of CVD, which was mainly mediated by established CVD risk factors.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Cecilia Hvitfeldt Fuglsang, Istvan Bakos, Kristina Laugesen, Frederikke Schonfeldt Troelsen, Erzsebet Horvath-Puho, Henrik Toft Sorensen
Summary: This population-based cohort study in Denmark investigated the association between smoking during pregnancy and the risk of appendicitis in offspring. The results showed a slightly higher hazard rate for children of smoking mothers compared to nonsmokers. The association may be mediated by later-life exposures.
Article
Multidisciplinary Sciences
Maren Goetz, Mitho Mueller, Raphael Gutsfeld, Tjeerd Dijkstra, Kathrin Hassdenteufel, Sara Yvonne Brucker, Armin Bauer, Stefanie Joos, Miriam Giovanna Colombo, Sabine Hawighorst-Knapstein, Ariane Chaudhuri, Gudula Kirtschig, Frauke Saalmann, Stephanie Wallwiener
Summary: Observational cohort study in Germany found that preterm delivery and preeclampsia are independent risk factors for chronic kidney disease in women, with a significantly increased risk for severe CKD when both conditions are present together.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Claudette Cantin, Andrea Morales, Ramon Serra, Sebastian E. Illanes, Andrea Leiva
Summary: Maternal supraphysiological hypercholesterolemia (MSPH) women present dysfunctional HDL and increased atherogenic cardiovascular risk factors.
Article
Medicine, General & Internal
Lili Yang, Huan Wang, Liu Yang, Min Zhao, Yajun Guo, Pascal Bovet, Bo Xi
Summary: This study used a large birth cohort in the USA to investigate the associations between maternal cigarette smoking and various subtypes of birth congenital anomalies. The results showed that smoking before or during pregnancy significantly increased the risk of several congenital anomalies, even with low cigarette consumption. Smoking cessation during pregnancy did not reduce the risk of birth congenital anomalies. These findings highlight the importance of implementing smoking cessation interventions before pregnancy.
Article
Medicine, General & Internal
Hein Odendaal, Kimberly A. Dukes, Amy J. Elliott, Marian Willinger, Lisa M. Sullivan, Tara Tripp, Coen Groenewald, Michael M. Myers, William P. Fifer, Jyoti Angal, Theonia K. Boyd, Larry Burd, Jacob B. Cotton, Rebecca D. Folkerth, Gary Hankins, Robin L. Haynes, Howard J. Hoffman, Perri K. Jacobs, Julie Petersen, Nicolo Pini, Bradley B. Randall, Drucilla J. Roberts, Fay Robinson, Mary A. Sens, Peter Van Eerden, Colleen Wright, Ingrid A. Holm, Hannah C. Kinney
Summary: This cohort study found that dual exposure to drinking and smoking after the first trimester of pregnancy was associated with nearly 3 times the risk of late stillbirth compared with no exposure or quitting before the end of the first trimester, suggesting a significantly increased risk.
Article
Biochemistry & Molecular Biology
Jasenka Zubcevic, Jacqueline Watkins, Cindy Lin, Byrell Bautista, Heather M. Hatch, Sergei G. Tevosian, Linda F. Hayward
Summary: Smoking during pregnancy is strongly associated with adverse outcomes, and the effects of nicotine intake apart from smoking are less explored. This study reveals that changes in the maternal gut microbiome mediate the effects of prenatal nicotine exposure, influencing gene expression and altering fetal exposure to short-chain fatty acids and leptin during in utero development.
Article
Psychology, Clinical
Edmond D. Shenassa, Michelle L. Rogers, Stephen L. Buka
Summary: The study found an independent association between maternal smoking during pregnancy and the risk of depression. By considering non-shared factors and mediating factors in sibling studies, accurate conclusions can be drawn.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Amanda M. Perak, Nicola Lancki, Alan Kuang, Darwin R. Labarthe, Norrina B. Allen, Svati H. Shah, Lynn P. Lowe, William A. Grobman, Jean M. Lawrence, Donald M. Lloyd-Jones, William L. Lowe, Denise M. Scholtens
Summary: Maternal cardiovascular health during pregnancy is significantly associated with offspring cardiovascular health during early adolescence, indicating a potential lifelong impact of maternal health status on offspring. This multinational cohort study reveals that poorer maternal cardiovascular health is correlated with higher risks of poorer cardiovascular health in offspring during early adolescence.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Endocrinology & Metabolism
Emil Kaanta, Roope Parviainen, Marjaana Tikanmaki, Suvi Alenius, Juha-Jaakko Sinikumpu, Eero Kajantie
Summary: This study found an association between maternal smoking during pregnancy and an increased risk of bone fractures in children aged 5-15 years.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Review
Immunology
Ling Yang, Yao Meng, Yuxiang Shi, Hongxu Fang, Leying Zhang
Summary: This review focuses on the anatomical and immunological adaptations of the maternal liver during pregnancy, as well as the associated diseases. It also presents the factors that regulate hepatic immunology during pregnancy. These findings are important for the prevention of embryo loss, abortion, and pregnancy-associated liver diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Neurosciences
Magdalena Kobus, Aneta Sitek, Boguslaw Antoszewski, Jacek J. Rozniecki, Jacek Pelka, Elzbieta Zadzinska
Summary: The prenatal period is crucial for human development and certain prenatal factors increase the risk of disease later in life. This study found a significant association between maternal tobacco smoking during pregnancy, traumatic events during pregnancy, and the occurrence of migraine in adulthood. These findings suggest that early life environment may influence the risk of migraine in adulthood.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Cardiac & Cardiovascular Systems
Yang Yang, Nianchun Peng, Gang Chen, Qin Wan, Li Yan, Guixia Wang, Yingfen Qin, Zuojie Luo, Xulei Tang, Yanan Huo, Ruying Hu, Zhen Ye, Guijun Qin, Zhengnan Gao, Qing Su, Yiming Mu, Jiajun Zhao, Lulu Chen, Tianshu Zeng, Xuefeng Yu, Qiang Li, Feixia Shen, Li Chen, Yinfei Zhang, Youmin Wang, Huacong Deng, Chao Liu, Shengli Wu, Tao Yang, Mian Li, Yu Xu, Min Xu, Zhiyun Zhao, Tiange Wang, Jieli Lu, Yufang Bi, Weiqing Wang, Guang Ning, Qiao Zhang, Lixin Shi
Summary: Smoking and diabetes interact with each other in relation to increased risk of cardiovascular disease events, and the beneficial effect of risk factor management on cardiovascular disease risk among participants with diabetes is attenuated by smoking.
CARDIOVASCULAR DIABETOLOGY
(2022)
Review
Medicine, General & Internal
Sylwia Slawek-Szmyt, Katarzyna Kawka-Paciorkowska, Aleksandra Cieplucha, Maciej Lesiak, Mariola Ropacka-Lesiak
Summary: Cardiovascular diseases (CVDs) are the top cause of death in women worldwide. Traditional risk factors and pregnancy-related complications both impact a woman's future CVD risk. Some pregnancy complications and CVDs may share common pathophysiological pathways.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Reproductive Biology
Kim N. Cajachagua-Torres, Hanan El Marroun, Irwin K. M. Reiss, Vincent W. V. Jaddoe
Summary: Maternal tobacco and cannabis use during pregnancy are associated with adverse perinatal outcomes. Placental adaptations caused by tobacco and cannabis use may lead to these outcomes.
REPRODUCTIVE TOXICOLOGY
(2022)
Article
Nutrition & Dietetics
Francine Silva dos Santos, Gicele Costa Mintem, Isabel Oliveira de Oliveira, Bernardo Lessa Horta, Elisabete Ramos, Carla Lopes, Denise Petrucci Gigante
Summary: This study evaluated the association between ultra-processed foods (UPF) and serum IL-6 concentration, finding that it is not explained by adiposity.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Public, Environmental & Occupational Health
Mariana Lima Correa, Bruna Goncalves Cordeiro da Silva, Fernando C. Wehrmeister, Bernardo L. Horta, Helen Goncalves, Luciana Anselmi, Fernando Barros, Ana Maria Baptista Menezes
Summary: Maternal smoking during pregnancy is associated with a decrease in offspring's IQ, and this association is partly mediated by breastfeeding and birth weight.
PREVENTIVE MEDICINE
(2022)
Article
Multidisciplinary Sciences
Michel S. Naslavsky, Marilia O. Scliar, Guilherme L. Yamamoto, Jaqueline Yu Ting Wang, Stepanka Zverinova, Tatiana Karp, Kelly Nunes, Jose Ricardo Magliocco Ceroni, Diego Lima de Carvalho, Carlos Eduardo da Silva Simoes, Daniel Bozoklian, Ricardo Nonaka, Nayane dos Santos Brito Silva, Andreia da Silva Souza, Heloisa de Souza Andrade, Marilia Rodrigues Silva Passos, Camila Ferreira Bannwart Castro, Celso T. Mendes-Junior, Rafael L. Mercuri, Thiago L. A. Miller, Jose Leonel Buzzo, Fernanda O. Rego, Nathalia M. Araujo, Wagner C. S. Magalhaes, Regina Celia Mingroni-Netto, Victor Borda, Heinner Guio, Carlos P. Rojas, Cesar Sanchez, Omar Caceres, Michael Dean, Mauricio L. Barreto, Maria Fernanda Lima-Costa, Bernardo L. Horta, Eduardo Tarazona-Santos, Diogo Meyer, Pedro A. F. Galante, Victor Guryev, Erick C. Castelli, Yeda A. O. Duarte, Maria Rita Passos-Bueno, Mayana Zatz
Summary: This study presents a high-coverage WGS dataset of elderly Brazilians from a mixed population, providing valuable data on non-European and mixed populations. The results demonstrate that WGS can identify previously undescribed variants and genomic segments, as well as alleles from HLA genes. The study also shows the clinical usefulness of reclassifying and validating variants associated with dominantly-inherited Mendelian disorders. Furthermore, the findings highlight the improved potential of whole-genome and HLA imputation using WGS data.
NATURE COMMUNICATIONS
(2022)
Review
Pediatrics
Bernardo Lessa Horta, Nigel Rollins, Mariane S. Dias, Valquiria Garcez, Rafael Perez-Escamilla
Summary: Breastfeeding reduces the odds of overweight or obesity in children. Even after considering the effects of publication bias and residual confounding, breastfeeding remains beneficial. The benefits of breastfeeding are also observed in studies that are susceptible to positive confounding by socioeconomic status.
Article
Dentistry, Oral Surgery & Medicine
L. A. Chisini, F. D. S. Costa, B. L. Horta, L. Tovo-Rodrigues, F. F. Demarco, M. B. Correa
Summary: This research investigates the association between dental caries trajectory and rs307355 (TAS1R3) and rs35874116 (TAS1R2), as well as the epistatic association between rs307355 (TAS1R3) and rs35874116 (TAS1R2). A representative sample of 5,914 individuals from the 1982 Pelotas birth cohort was prospectively studied. Group-based trajectory modeling identified different groups with similar dental caries trajectories throughout life. Genetic material was collected for genotyping rs307355 (TAS1R3) and rs35874116 (TAS1R2). The study found that the genotype and allele of rs307355 (TAS1R3) were positively associated with the trajectory of decayed and missing dental components. Epistatic interaction between rs307355 and rs35874116 may increase the decayed caries trajectory.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Tatiana Pereira Cenci, Mariana Gonzalez Cademartori, Laylla Galdino dos Santos, Marcos Britto Correa, Bas Loomans, Bernardo Lessa Horta, Flavio Fernando Demarco
Summary: This study investigated the prevalence of tooth wear and its associated factors in adults from the 1982 Pelotas Birth Cohort. The results showed that 61.6% of the individuals had tooth wear, with females having a lower prevalence compared to males. Additionally, the consumption of acid and alcoholic beverages was positively associated with tooth wear.
JOURNAL OF DENTISTRY
(2023)
Article
Public, Environmental & Occupational Health
Franciney Anselmo Ferreira, Fernando Jose Herkrath, Bernardo Lessa Horta, Luiza Garnelo
Summary: This study analyzed the work processes of institutional supporters in delivering care services through a mobile river clinic. The findings highlight the lack of institutionalization in the work of supporters, the importance of immersion in rural mobile activities, and the centrality of daily living work. The study also reveals that the lack of administrative support and underfunding for infrastructure and logistics weaken the interventions of supporters and multiprofessional teams.
INTERFACE-COMUNICACAO SAUDE EDUCACAO
(2023)
Article
Dentistry, Oral Surgery & Medicine
Luiz Alexandre Chisini, Francine da costa Santos, Rodrigo Varella de Carvalho, Bernardo Lessa Horta, Luciana Tovo-Rodrigues, Flavio Fernando Demarco, Marcos Britto Correa
Summary: This study aimed to investigate the influence of Single Nucleotide Polymorphisms (SNPs) in tooth mineral tissue genes on dental caries trajectory and the potential gene-gene interaction. A representative sample of 5,914 births from the 1982 Pelotas birth cohort study was prospectively investigated. The findings suggest that certain SNPs in tooth mineral tissue genes are associated with dental caries trajectory and epistatic interactions, expanding the understanding of individual caries experience. The results highlight the clinical significance of SNPs in the pathway of tooth mineral tissue genes in the development of dental caries throughout the lifespan.
JOURNAL OF DENTISTRY
(2023)
Article
Medicine, General & Internal
Natalia E. Poveda, Linda S. Adair, Reynaldo Martorell, Shivani A. Patel, Manuel Ramirez-Zea, Santosh K. Bhargava, Sonny A. Bechayda, Delia B. Carba, Maria F. Kroker-Lobos, Bernardo Lessa Horta, Natalia Peixoto Lima, Monica Mazariegos, Ana Maria Baptista Menezes, Shane A. Norris, Lukhanyo H. Nyati, Linda M. Richter, Harshpal Sachdev, Fernando C. Wehrmeister, Aryeh D. Stein
Summary: This study found that higher birth weight and relative weight gains in infancy, childhood, and adolescence were positively associated with adult body composition. Relative weight gains in childhood and adolescence were the strongest predictors of adult body composition, while a faster linear growth in infancy weakly predicted higher adult adiposity.
Article
Public, Environmental & Occupational Health
Charles Phillipe de Lucena Alves, Inacio Crochemore-Silva, Natalia P. Lima, Pieter Coenen, Bernardo Lessa Horta
Summary: This study found that there was no association or limited clinical relevance between occupational and leisure-time physical activity and cardiovascular risk factors in early adulthood.
JOURNAL OF PHYSICAL ACTIVITY & HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Oscar J. Mujica, Antonio Sanhueza, Liliana Carvajal-Velez, Luis Paulo Vidaletti, Janaina C. Costa, Aluisio J. D. Barros, Cesar G. Victora
Summary: This study aims to document the progress in maternal and child health indicators in Latin American and Caribbean countries from 2011 to 2020. It also assesses the evolution of socioeconomic inequalities within each country over time.
INTERNATIONAL JOURNAL FOR EQUITY IN HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Vania Pereira Oliveira, Mariane da Silva Dias, Natalia Peixoto Lima, Bernardo Lessa Horta
Summary: This study aimed to investigate the association between birth conditions, nutritional status, childhood growth, and cardiometabolic risk factors at 30 years of age. The researchers also examined whether body mass index (BMI) at 30 years old mediated the relationship between childhood weight gain and cardiometabolic risk factors. The findings suggest that rapid relative weight gain after 2 years of age may have long-term consequences on the risk of metabolic and cardiovascular disorders.
CADERNOS DE SAUDE PUBLICA
(2023)
Meeting Abstract
Obstetrics & Gynecology
Michael Ross, Manasa Kavasery, MacKenzie Cervantes, Kelly Coca, Bernardo Horta, Mina Desai
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Pediatrics
Elma Izze da Silva Magalhaes, Natalia Peixoto Lima, Ana Maria Baptista Menezes, Helen Goncalves, Fernando C. Wehrmeister, Maria Cecilia Formoso Assuncao, Bernardo Lessa Horta
Summary: The purpose of this study was to investigate the impact of grandmother's smoking during pregnancy on the birthweight of grandchildren, as well as whether maternal smoking during pregnancy modified this association. The study found that although grandmother's smoking was not associated with grandchild's birthweight, it had an effect when the mother also smoked during pregnancy.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Psychiatry
Dominique P. Behague, Helen Goncalves, Suelen Henriques da Cruz, Larissa de Cruz, Bernardo L. Horta, Natalia P. Lima
Summary: This paper explores how Brazilian socially sensitive therapy can respond to care-users' desire to change the social and political forces shaping their lives. The study shows that the use of socially sensitive therapy is associated with increased political participation and reporting of discrimination, with greater empowering effects observed in individuals with lower education and family income.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2023)