期刊
ATHEROSCLEROSIS
卷 210, 期 1, 页码 274-277出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.atherosclerosis.2009.11.005
关键词
TRAIL; OPG; Acute myocardial infarction; Heart failure
资金
- Programma di Ricerca Regione-Universita
Background: This study was designed to evaluate the biological significance of simultaneous changes in the circulating levels of osteoprotegerin (OPG) and TNF-related apoptosis inducing ligand (TRAIL) in patients with coronary artery disease (CAD), and, in particular, with acute myocardial infarction (AMI). Methods: Total levels of OPG and TRAIL were measured by ELISA in patients with AMI (n = 113), unstable angina (UA, n = 21) and healthy controls (n = 120). Results: Since OPG was elevated during the acute phase (first 12-24-48 h) after AMI and in patients with UA with respect to healthy controls, while TRAIL was decreased in acute AMI patients, CAD patients were characterized by an increased OPG/TRAIL ratio. Moreover, the OPG/TRAIL ratio was significantly (p < 0.05) higher in the acute AMI patients who developed heart failure (HF) than in those who did not develop HF in the follow-up. Conclusions: An impaired OPG/TRAIL ratio after AMI is related to a higher risk of HF. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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