Article
Immunology
Rohit Bazaz, Helen M. Marriott, Carl Wright, Janet Chamberlain, Laura E. West, Catherine Gelsthorpe, Paul R. Heath, Afsaneh Maleki-Dizaji, Sheila E. Francis, David H. Dockrell
Summary: This study investigated the effects of different pneumococcal infections on atherosclerotic plaques and found that pneumonia led to an increase in plaque macrophages, but had no significant impact on plaque burden or vulnerability markers.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Andrea Starsichova
Summary: Cardiovascular diseases are the leading cause of death worldwide, with atherosclerosis being the main underlying pathology. The SR-B1-/-ApoE-R61h/h mouse model mimics clinical coronary heart disease and provides a valuable tool for studying vulnerable plaques, testing treatment options, and exploring new technologies in cardiovascular medicine.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Article
Immunology
Kobkaew Bumroongthai, Dean P. J. Kavanagh, Paul Genever, Neena Kalia
Summary: This study demonstrates that 3D culture of specific bone marrow-derived MSC sub-populations improves their homing and protective effects on coronary blood vessels in the injured heart. Compared to conventional 2D culture, 3D culture enhances the adhesive behavior of MSCs and reduces neutrophil events in the coronary capillaries. Additionally, the combination of dual therapy with heparin further enhances the vasculoprotective efficacy. The findings highlight the importance of 3D culture and specific MSC sub-populations in improving therapeutic outcomes for reperfusion injury.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Xiuying Zhang, Qilei Chen, Jia Zhao, Wei Zhao, Ni Fan, Yu Wang, Hubiao Chen, Jianhui Rong
Summary: This study aimed to investigate the cardioprotective activity of the herbal medicine formula Baoyuan Decoction (BYD), identify the active compounds and molecular targets. The results showed that BYD effectively reduced infarct size and preserved cardiac functions. Network pharmacology analysis revealed that BYD might control cardiac inflammation through targeting the TNF-alpha/NF-kappa B pathway and other related pathways.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cell Biology
Xiaoyan Tang, Huilin Jiang, Peiyi Lin, Zhenhui Zhang, Meiting Chen, Yi Zhang, Junrong Mo, Yongcheng Zhu, Ningning Liu, Xiaohui Chen
Summary: This study demonstrated that hypoxia up-regulates IGFBP-1 and HIF-1 alpha expression in cardiomyocytes. Additionally, IGFBP-1 regulates HIF-1 alpha stabilization through interacting with VHL. Therefore, IGFBP-1-HIF-1 alpha could be targeted for treating ischemic heart disease.
CELL DEATH DISCOVERY
(2021)
Article
Pharmacology & Pharmacy
Alexandre Paccalet, Claire Crola Da Silva, Laura Mechtouff, Camille Amaz, Yvonne Varillon, Charles de Bourguignon, Regine Cartier, Cyril Prieur, Danka Tomasevic, Nathalie Genot, Simon Leboube, Francois Derimay, Gilles Rioufol, Eric Bonnefoy-Cudraz, Nathan Mewton, Michel Ovize, Gabriel Bidaux, Thomas Bochaton
Summary: The circulating concentrations of sTNFR1 and sTNFR2 are inflammatory markers of morphological and functional injury after STEMI, and can predict clinical outcomes in patients. Patients with higher levels of sTNFR1 or sTNFR2 are more likely to experience adverse events within 24 months after suffering from STEMI. Soluble TNFR1 is an independent predictor of major adverse cardiovascular events and outperforms troponin I in predicting outcomes.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
James Nadel, Andrew Jabbour, Roland Stocker
Summary: Intracellular myeloperoxidase (MPO) plays a role in innate immunity, but when released extracellularly during inflammation, it causes oxidative tissue damage. Recent research has found that extracellular MPO is abundant in unstable atheroma and is causally linked to plaque destabilization. By separating the protective and harmful effects of MPO, it can be selectively detected and targeted using non-invasive molecular imaging and pharmacotherapies. MPO is a potentially superior inflammatory target compared to other therapies and imaging biomarkers, making it useful in the management of patients with vulnerable atherosclerotic plaques.
CARDIOVASCULAR RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Junteng Zhou, Zhichao Zhou, Xiaojing Liu, Hai-Yan Yin, Yong Tang, Xin Cao
Summary: Activation of the P2X7 receptor mediates inflammatory responses and pyroptosis in cardiovascular diseases, leading to the release of pro-inflammatory cytokines and worsening cardiac phenotypes. Inhibition of the P2X7 receptor has shown promise in attenuating these pathological mechanisms and improving cardiovascular outcomes.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Carmen Hannemann, Johannes H. Schecker, Alica Brettschneider, Jana Grune, Nicole Roesener, Andrea Weller, Verena Stangl, Edward A. Fisher, Karl Stangl, Antje Ludwig, Bernd Hewing
Summary: The study demonstrated that deficiency of iRhom2 can reduce the development of atherosclerosis, particularly in early stages. Additionally, iRhom2 deficiency was found to lower serum levels of TNF-alpha, as well as circulating and hepatic levels of cholesterol and triglycerides.
CARDIOVASCULAR RESEARCH
(2022)
Review
Cardiac & Cardiovascular Systems
Sreejit Gopalkrishna, Jillian Johnson, Robert M. Jaggers, Albert Dahdah, Andrew J. Murphy, Nordin M. J. Hanssen, Prabhakara R. Nagareddy
Summary: Neutrophils play a dual role in inflammation and wound healing, causing tissue damage while also facilitating healing. Recent studies have revealed their transcriptional activity and ability to influence other cells through cargo release. They have emerged as important regulators in cardiovascular diseases and could be potential targets for therapeutic strategies.
CARDIOVASCULAR RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Hui Li, Shiyu Du, Panpan Niu, Xiaosong Gu, Jun Wang, Ying Zhao
Summary: VAP-1 plays a role in atherosclerosis, sVAP-1 has potential value for the diagnosis and prognosis of cardiovascular diseases, and VAP-1 inhibitors show promise in slowing the progression of atherosclerosis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Samuel S. Gidding, Laura A. Colangelo, Chike C. Nwabuo, Cora E. Lewis, David R. Jacobs, Pamela J. Schreiner, Joao A. C. Lima, Norrina B. Allen
Summary: The PDAY risk score based on post-mortem measurements was found to be highly predictive of future ASCVD events in young adults. The presence of coronary artery calcium improved risk prediction only if the score was 0. Cumulative risk exposure and PDAY score at age 18-30 were also significant factors for predicting ASCVD.
EUROPEAN HEART JOURNAL
(2022)
Article
Rheumatology
Olivier Fakih, Maxime Desmarets, Berenger Martin, Clement Prati, Daniel Wendling, Elisabeth Monnet, Frank Verhoeven
Summary: This study aimed to investigate the incidence of major adverse cardiovascular events (MACEs) in French patients benefiting from the Long-term Illness scheme (LTI) for ankylosing spondylitis (AS) and the effect of different treatments on MACE occurrence. The results showed that NSAIDs and anti-TNF treatment were associated with a lower risk of MACE occurrence, while anti-IL17 treatment was not.
Article
Cardiac & Cardiovascular Systems
Alberto Aimo, Domingo A. Pascual-Figal, Andrea Barison, German Cediel, Alvaro Hernandez Vicente, Luigi F. Saccaro, Michele Emdin, Antoni Bayes-Genis
Summary: Inflammation plays a crucial role in atherosclerosis and coronary artery disease, with anti-inflammatory therapies showing potential benefits for patients.
TRENDS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biochemical Research Methods
Ahmad Shirazi, Tayebeh Sahraeibelverdi, Miki Lee, Haijun Li, Joonyoung Yu, Sangeeta Jaiswal, Kenn R. Oldham, Thomas D. Wang
Summary: We demonstrate a side-view dual axes confocal endomicroscope that can be repetitively inserted in hollow organs of genetically engineered mice for in vivo real-time imaging in both horizontal and vertical planes. Near infrared (NIR) excitation at λex = 785 nm was used, and a monolithic 3-axis parametric resonance scan mirror fabricated using micro-electromechanical systems (MEMS) technology enabled post-objective scanning in the distal end of a 4.19 mm diameter instrument. Torsional and serpentine springs were designed to switch the mode of imaging between vertical and horizontal planes by tuning the actuation frequency. This system achieved real-time in-vivo images with a depth of 310 μm and lateral and axial resolution of 1.75 and 7.5 μm, respectively, in both horizontal and vertical planes, allowing identification of individual cells and discrete mucosal structures.
BIOMEDICAL OPTICS EXPRESS
(2023)
Article
Cardiac & Cardiovascular Systems
Richard H. Barnes, Takeshi Akama, Miina K. Ohman, Moon-Sook Woo, Julian Bahr, Stephen J. Weiss, Daniel T. Eitzman, Tae-Hwa Chun
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2017)
Article
Biochemistry & Molecular Biology
Kristmundur Sigmundsson, Juha R. M. Ojala, Miina K. Ohman, Anne-May Osterholm, Aida Moreno-Moral, Anna Domogatskaya, Li Yen Chong, Yang Sun, Xiaoran Chai, Joseph A. M. Steele, Benjamin George, Manuel Patarroyo, Ann-Sofie Nilsson, Sergey Rodin, Sujoy Ghosh, Molly M. Stevens, Enrico Petretto, Karl Tryggvason
Article
Hematology
Miina K. Oehman, Andrew P. Wright, Kevin J. Wickenheiser, Wei Luo, Hana M. Russo, Daniel T. Eitzman
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2010)
Article
Hematology
Taina Vuorio, Harri Nurmi, Karen Moulton, Jere Kurkipuro, Marius R. Robciuc, Miina Ohman, Suvi E. Heinonen, Haritha Samaranayake, Tommi Heikura, Kari Alitalo, Seppo Yla-Herttuala
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2014)
Article
Cardiac & Cardiovascular Systems
Wei Luo, Peter F. Bodary, Yuechun Shen, Kevin J. Wickenheiser, Miina K. Oehman, Chiao Guo, Kristina L. Bahrou, Martin G. Myers, Daniel T. Eitzman
Article
Cardiac & Cardiovascular Systems
M. K. Oehman, W. Luo, H. Wang, C. Guo, W. Abdallah, H. M. Russo, D. T. Eitzman
Article
Cardiac & Cardiovascular Systems
Wei Luo, Hui Wang, Miina K. Oehman, Chiao Guo, Kate Shi, Julia Wang, Daniel T. Eitzman
Article
Cell Biology
Suryaprakash Raichur, Siew Tein Wang, Puck Wee Chan, Ying Li, Jianhong Ching, Bhagirath Chaurasia, Shaillay Dogra, Miina K. Oehman, Kosuke Takeda, Shigeki Sugii, Yael Pewzner-Jung, Anthony H. Futerman, Scott A. Summers
Correction
Cell Biology
Suryaprakash Raichur, Siew Tein Wang, Puck Wee Chan, Ying Li, Jianhong Ching, Bhagirath Chaurasia, Shaillay Dogra, Miina K. Oehman, Kosuke Takeda, Shigeki Sugii, Yael Pewzner-Jung, Anthony H. Futerman, Scott A. Summers
Article
Cardiac & Cardiovascular Systems
Hana M. Russo, Kevin J. Wickenheiser, Wei Luo, Miina K. Oehman, Luigi Franchi, Andrew P. Wright, Peter F. Bodary, Nunez Gabriel, Daniel T. Eitzman
CIRCULATION RESEARCH
(2010)
Correction
Cardiac & Cardiovascular Systems
Hana M. Russo, Kevin J. Wickenheiser, Wei Luo, Miina K. Oehman, Luigi Franchi, Andrew P. Wright, Peter F. Bodary, Gabriel Nunez, Daniel T. Eitzman
CIRCULATION RESEARCH
(2010)
Letter
Hematology
W. Luo, M. Oehman, A. Wright, S. Kamrudin, H. Wang, C. Guo, D. Eitzman
THROMBOSIS RESEARCH
(2012)
Meeting Abstract
Cardiac & Cardiovascular Systems
Richard H. Barnes, Miina K. Ohman, Stephen J. Weiss, Daniel T. Eitzman, Tae-Hwa Chun
Meeting Abstract
Cardiac & Cardiovascular Systems
Tae-Hwa Chun, Miina Ohman, Daniel Eitzman, Jiang Yibin, Mayumi Inoue
Meeting Abstract
Endocrinology & Metabolism
Miina K. Oehman, Wei Luo, Wissam Abdallah, Chiao Guo, Hana M. Russo, Daniel T. Eitzman
