Article
Cardiac & Cardiovascular Systems
Ming Dong, Dishen Chen, Yanxia Zhu, Shu Yang, Santosh Kumar, Rui Zhang, Yin Zhou, Ziyi Yang, Na Zheng, Ting Zhu, Jiaqing Xiang, Yun Liu, Lin Kang, Jie Liu
Summary: This study found that aging increases the size of myocardial infarction and impairs cardiac contractile function. The expression of MLCK3 and the activity of MLC2 do not increase in the aging hearts after myocardial infarction. miR-146a-5p down-regulates MMP2/16 expression, which in turn increases MLCK3 expression and MLC2 activity. However, this regulatory mechanism is compromised in senescent cardiomyocytes or in hearts lacking miR-146a.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Jeppe K. Petersen, Abdulrahman N. Shams-Eldin, Emil L. Fosbol, Rasmus Rorth, Rikke Sorensen, Reza Jabbari, Thomas Engstrom, Lene Holmvang, Frants Pedersen, Amna Alhakak, Johanna Kroll, Christian Torp-Pedersen, Lars Kober, Jawad H. Butt
Summary: Employment status prior to acute myocardial infarction is associated with long-term risk of mortality and recurrent MI. Patients who were not part of the workforce had a higher risk of death and new heart attacks following discharge compared to those who were part of the workforce.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Geriatrics & Gerontology
Pedro Luis Cepas-Guillen, Julio Echarte-Morales, Guillem Caldentey, Eduardo Martinez Gomez, Eduardo Flores-Umanzor, Javier Borrego-Rodriguez, Marc Llagostera, Ana Viana Tejedor, Pablo Vidal, Tomas Benito-Gonzalez, Xavier Quiroga, Antonio Fernandez Ortiz, Xavier Freixa, Armando Perez de Prado, Francisco Noriega Sanz, Felipe Fernandez-Vazquez, Manel Sabate
Summary: This study aimed to analyze characteristics of nonagenarian patients with ACS and found that PCI treatment was associated with a decreased risk of 1-year all-cause death.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Review
Medicine, General & Internal
Caelan Taggart, Ryan Wereski, Nicholas L. Mills, Andrew R. Chapman
Summary: The increased use of high-sensitivity cardiac troponins in clinical practice has raised awareness of non-ischaemic myocardial injury. While such injuries can be caused by various diseases, evidence suggests that patients' clinical outcomes are poor.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Nutrition & Dietetics
Carla Barbosa Nonino, Natalia Yumi Noronha, Maysa de Araujo Ferreira-Julio, Ligia Moriguchi Watanabe, Karen Francislaine Cassia, Carolina Ferreira Nicoletti, Caroline Rossi Welendorf, Wilson Salgado Junior, Doroteia Rossi Silva Souza, Marcela Augusta de Souza Pinhel
Summary: This study investigated the gene expression of metalloproteinases before and after Roux-en-Y gastric bypass (RYBG) in obese individuals. The results showed that RYGB significantly contributes to weight loss, improved BMI, reduced fat mass, and decreased TIMP2 expression, which might play a role in extracellular matrix remodeling in obesity and could serve as a potential circulating biomarker.
FRONTIERS IN NUTRITION
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
David A. Morrow
Summary: This paragraph highlights the complexity and overlapping nature of current diagnostic and prognostic algorithms for high-sensitivity cardiac troponin measurement. It also explains the different zones that indicate varying levels of confidence in diagnosing myocardial injury or myocardial infarction.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Yader Sandoval, Bradley R. Lewis, Ramila A. Mehta, Olatunde Ola, Jonathan D. Knott, Laura De Michieli, Ashok Akula, Ronstan Lobo, Eric H. Yang, S. Michael Gharacholou, Marshall Dworak, Erika Crockford, Nicholas Rastas, Eric Grube, Swetha Karturi, Scott Wohlrab, David O. Hodge, Tahir Tak, Charles Cagin, Rajiv Gulati, Allan S. Jaffe
Summary: Using a single hs-cTnT below the limit of quantitation of 6 ng/L is a safe and rapid method to identify a substantial number of patients at very low risk for acute myocardial injury and infarction.
Article
Biochemistry & Molecular Biology
Yixuan Ma, Yixin Kuang, Wenyan Bo, Qiaoqin Liang, Wenfei Zhu, Mengxin Cai, Zhenjun Tian
Summary: Exercise training can increase FGF21 protein expression, regulate the TGF-beta 1-Smad2/3-MMP2/9 signaling pathway, alleviate cardiac fibrosis, oxidative stress, and cell apoptosis, and ultimately improve cardiac function in mice with MI. FGF21 plays a crucial role in the anti-fibrosis effect of exercise training.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Carolin Torregroza, Birce Yueksel, Raphael Ruske, Martin Stroethoff, Annika Raupach, Andre Heinen, Markus W. Hollmann, Ragnar Huhn, Katharina Feige
Summary: The study found that under hyperglycemic conditions, the infarct size reducing effects of Levosimendan-induced postconditioning are blocked, but can be restored by combining with the mitochondrial permeability transition pore (mPTP) blocker cyclosporine A (CsA).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Biomedical
Panke Cheng, Hukui Han, Fuli Chen, Lianying Cheng, Cui Ma, Hui Huang, Chi Chen, Hua Li, Hao Cai, Hao Huang, Gang Li, Jianhong Tao
Summary: This study elucidated the roles of m(6)A RNA methylation and mitochondrial metabolism in acute myocardial infarction (AMI) and proposed a potential strategy for AMI treatment using a surface-modified bioengineered ferritin nanocage. The findings provide valuable insights for future research and treatment of AMI.
ACTA BIOMATERIALIA
(2022)
Article
Geriatrics & Gerontology
Yu Kang, Xiang-Yang Fang, Dong Wang, Xiao-Juan Wang
Summary: The incidence of AMI during CAP hospitalization in geriatric patients is notable and has an impact on in-hospital mortality. Respiratory failure, preexisting coronary artery disease, diabetes, and BUN are associated with the occurrence of AMI in older patients after hospitalization with CAP. Special attention should be paid to older patients with risk factors for AMI.
Review
Cardiac & Cardiovascular Systems
Abdulmajeed Alharbi, Allison Franz, Halah Alfatlawi, Mohaamed Wazzan, Anas Alsugher, Ehab Eltahawy, Ragheb Assaly
Summary: The COVID-19 pandemic has had a significant impact on the clinical course of patients with acute coronary syndrome, leading to higher in-hospital mortality, longer lengths of stay, and increased hospital costs. Patients with COVID-19 infection also experienced delays in receiving percutaneous coronary intervention compared to those without.
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Thuy Mi Nguyen, Daniela Melichova, Eivind W. Aabel, Oyvind H. Lie, Lars Gunnar Klaeboe, Bjornar Grenne, Benthe Sjoli, Harald Brunvand, Kristina Haugaa, Thor Edvardsen
Summary: This study aimed to compare long-term outcomes between NSTEMI and STEMI patients in Southern Norway. The results showed that mortality remained high and unchanged in NSTEMI patients, while mortality decreased in STEMI patients over a decade of treatment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Mina Ghobrial, Bilal Bawamia, Timothy Cartlidge, Ioakim Spyridopoulos, Vijay Kunadian, Azfar Zaman, Mohaned Egred, Adam Mcdiarmid, Matthew Williams, Mohamed Farag, Mohammad Alkhalil
Summary: This review focuses on the phenomenon of microvascular obstruction (MVO) following mechanical reperfusion in patients with ST-segment elevation myocardial infarction (STEMI). The accuracy of invasive and non-invasive methods to detect and measure MVO varies, and the presence of MVO increases the risk and leads to adverse cardiac remodeling and worse prognosis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
David Peeney, Yueqin Liu, Carolyn Lazaroff, Sadeechya Gurung, William G. Stetler-Stevenson
Summary: TIMPs are a crucial family of proteins that regulate ECM structure and composition. TIMP2 plays a complex role in cancer progression, with both tumor suppressor and potential tumor-promoting functions.
Article
Cardiac & Cardiovascular Systems
Mitja Lainscak, Ivan Milinkovic, Marija Polovina, Marisa G. Crespo-Leiro, Lars H. Lund, Stefan D. Anker, Cecile Laroche, Roberto Ferrari, Andrew J. S. Coats, Theresa McDonagh, Gerasimos Filippatos, Aldo R. Maggioni, Massimo F. Piepoli, Giuseppe M. C. Rosano, Frank Ruschitzka, Dragan Simic, Milika Asanin, Jean-Christophe Eicher, Mehmet B. Yilmaz, Petar M. Seferovic
EUROPEAN JOURNAL OF HEART FAILURE
(2020)
Review
Biochemistry & Molecular Biology
Mauro Vaccarezza, Veronica Papa, Daniela Milani, Arianna Gonelli, Paola Secchiero, Giorgio Zauli, Donato Gemmati, Veronica Tisato
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Letter
Cardiac & Cardiovascular Systems
Patrick Rossignol, Mitja Lainscak, Maria G. Crespo-Leiro, Cecile Laroche, Massimo F. Piepoli, Gerasimos Filippatos, Giuseppe M. C. Rosano, Gianluigi Savarese, Stefan D. Anker, Petar M. Seferovic, Frank Ruschitzka, Andrew J. S. Coats, Alexandre Mebazaa, Theresa McDonagh, Ana Sahuquillo, Maria Penco, Aldo P. Maggioni, Lars H. Lund
EUROPEAN JOURNAL OF HEART FAILURE
(2020)
Article
Cardiac & Cardiovascular Systems
Chris J. Kapelios, Cecile Laroche, Maria G. Crespo-Leiro, Stefan D. Anker, Andrew J. S. Coats, Beatria Diaz-Molina, Gerasimos Filippatos, Mitja Lainscak, Aldo P. Maggioni, Theresa McDonagh, Alexandre Mebazaa, Marco Metra, Brenda Moura, Wilfried Mullens, Massimo F. Piepoli, Giuseppe M. C. Rosano, Frank Ruschitzka, Petar M. Seferovic, Lars H. Lund
EUROPEAN JOURNAL OF HEART FAILURE
(2020)
Article
Biochemistry & Molecular Biology
Francesco Vieceli Dalla Sega, Francesca Fortini, Paolo Cimaglia, Luisa Marracino, Elisabetta Tonet, Antonio Antonucci, Marco Moscarelli, Gianluca Campo, Paola Rizzo, Roberto Ferrari
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Cardiac & Cardiovascular Systems
Maria Lukacs Krogager, Kristian Kragholm, Jesper Qvist Thomassen, Peter Sogaard, Basil S. Lewis, Sven Wassmann, Iris Baumgartner, Claudio Ceconi, Thomas Andersen Schmidt, Juan Carlos Kaski, Heinz Drexel, Anne Grete Semb, Stefan Agewall, Alexander Niessner, Gianluigi Savarese, Keld Per Kjeldsen, Claudio Borghi, Juan Tamargo, Christian Torp-Pedersen
Summary: This review highlights the importance of tight potassium regulation in patients with cardiovascular disease, explaining the mechanisms of potassium homeostasis maintenance, common causes of hypokalaemia, and strategies for management. It suggests raising potassium levels in asymptomatic patients with lower normal concentrations and concurrent cardiovascular disease, providing assistance to clinicians in the absence of more evidence.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2021)
Article
Medicine, General & Internal
Matteo Bertini, Emanuele D'Aniello, Alberto Cereda, Marco Toselli, Filippo Maria Verardi, Luca Rossi, Daniela Aschieri, Alberto Monello, Marco Manfrini, Davide Vignale, Anna Palmisano, Antonio Esposito, Roberto Ferrari, Claudio Rapezzi, Francesco Giannini
Summary: The study discovered that combining chest CT scan and ECG data can improve risk stratification in COVID-19 pneumonia by identifying a distinctive phenotype with both parenchymal and vascular damage of the lung. Patients with severe pneumonia at chest CT scan plus ECG signs of acute RV strain have an extremely poor short-term prognosis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Alessandro Fucili, Paolo Cimaglia, Paolo Severi, Francesco Giannini, Alberto Boccadoro, Marco Micillo, Claudio Rapezzi, Luigi Tavazzi, Roberto Ferrari
Summary: After a decade of stagnation in clinical research for HF treatment, five large randomized trials have recently supported the use of four new classes of drugs, which have proven beneficial for long-term outcomes and quality of life. Beyond their clinical relevance, these novel treatments have different mechanisms of action compared to traditional neuro-hormonal blocking agents. The diverse pathways and solid clinical evidence urge a re-evaluation of HF treatment and personalized drug selection based on patient characteristics.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Francesca Fortini, Francesco Vieceli Dalla Sega, Luisa Marracino, Paolo Severi, Claudio Rapezzi, Paola Rizzo, Roberto Ferrari
Summary: Endothelial dysfunction is a central feature of the cardiovascular continuum, influencing the prognosis and treatment outcomes of cardiovascular diseases. COVID-19-related endothelial dysfunction leads to severe complications, particularly in high-risk individuals with existing endothelial dysfunction.
Article
Chemistry, Medicinal
Annalisa Marcuzzi, Erika Rimondi, Elisabetta Melloni, Arianna Gonelli, Antonio Giacomo Grasso, Egidio Barbi, Natalia Maximova
Summary: Janus kinases (JAKs), as a family of tyrosine kinases, play important roles in immune cell regulation by transducing cytokine-mediated signals through the JAK-STAT pathway. In recent years, JAK inhibitors have shown promise in the treatment of various inflammatory conditions, including acute steroid-refractory graft-versus-host disease (SR-aGVHD). Ruxolitinib, a JAK1/2 inhibitor, has been approved by the FDA for the treatment of SR-aGVHD and has demonstrated rapid and effective response.
Article
Biology
Francesco Vieceli Dalla Sega, Francesca Fortini, Paolo Severi, Paola Rizzo, Iija Gardi, Paolo Cimaglia, Claudio Rapezzi, Luigi Tavazzi, Roberto Ferrari
Summary: This review discusses the pathogenesis and therapeutic approaches of vascular and heart calcifications in different conditions. Calcifications are complex disorders that have significant implications for cardiovascular and kidney diseases.
Article
Cardiac & Cardiovascular Systems
Eva Gerdts, Isabella Sudano, Sofie Brouwers, Claudio Borghi, Rosa Maria Bruno, Claudio Ceconi, Veronique Cornelissen, Francois Dievart, Marc Ferrini, Thomas Kahan, Maja Lisa Lochen, Angela H. E. M. Maas, Felix Mahfoud, Anastasia S. Mihailidou, Trine Moholdt, Gianfranco Parati, Giovanni de Simone
Summary: Sex chromosomes and sex hormones play differential roles in blood pressure regulation and cardiovascular risk factors between females and males with essential arterial hypertension. The risk for cardiovascular disease is higher in females at lower blood pressure levels, suggesting the need for sex-specific thresholds in hypertension diagnosis. It is currently unknown if hypertension should be managed differently in females and males, highlighting the need for focused research on sex-specific prevention and management.
EUROPEAN HEART JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Matteo Fields, Annalisa Marcuzzi, Arianna Gonelli, Claudio Celeghini, Natalia Maximova, Erika Rimondi
Summary: Neurodegenerative diseases are characterized by progressive loss of neuronal functions and structures. Mitochondrial dysfunction and oxidative stress have been identified as common mechanisms leading to neurodegeneration. Antioxidant therapies, specifically targeting mitochondria, have become increasingly important in reverting neuronal damage. Novel mitochondria-targeted antioxidant compounds, such as MitoQ, SkQ1, MitoVitE and MitoTEMPO, have been developed and studied to address the need for effective treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Meeting Abstract
Oncology
P. Franco, A. Porreca, M. Di Nicola, G. Mantello, F. Valvo, N. Slim, S. Manfrida, M. A. Gambacorta, F. De Felice, S. Vagge, M. Krengli, E. Palazzari, M. F. Osti, A. Gonelli, G. Catalano, P. Pittoni, M. Lupattelli, M. R. Niespolo, M. E. Rosetto, G. Macchia, O. Durante, F. Munoz, R. M. D'Angelillo, D. Genovesi, L. Caravatta
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Immunology
Alessandra Bortoluzzi, Cecilia Beatrice Chighizola, Micaela Fredi, Elena Raschi, Caterina Bodio, Daniela Privitera, Arianna Gonelli, Ettore Silvagni, Marcello Govoni, Ilaria Cavazzana, Paolo Airo, Pier Luigi Meroni, Angela Tincani, Franco Franceschini, Silvia Piantoni, Fabio Casciano
FRONTIERS IN IMMUNOLOGY
(2020)
