Article
Cardiac & Cardiovascular Systems
Xiao-Hong Chen, Yu Tan, ShuQin Yu, Lijun Lu, Youqing Deng
Summary: This study found that pinitol has the potential to reduce endothelial dysfunction caused by oxidized low-density lipoprotein (ox-LDL). Pinitol can decrease the production of reactive oxygen species, reduce the expression of IL-6 and monocyte chemoattractant protein-1, and decrease the attachment of monocytes to endothelial cells. Additionally, pinitol decreases the expression of LOX-1 and rescues the expression of KLF2.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2022)
Article
Cell Biology
Almudena Gomez-Hernandez, Natalia de las Heras, Andrea R. Lopez-Pastor, Gema Garcia-Gomez, Jorge Infante-Menendez, Paula Gonzalez-Lopez, Tamara Gonzalez-Illanes, Vicente Lahera, Manuel Benito, Oscar Escribano
Summary: The study demonstrates that severe hepatic insulin resistance can lead to cardiovascular insulin resistance and dysfunction, affecting not only the liver but also vascular tissues. Long-term hepatic expression of IRA can restore the vascular damage observed in iLIRKO mice.
Review
Biochemistry & Molecular Biology
Nadezhda Barvitenko, Elisaveta Skverchinskaya, Alfons Lawen, Elena Matteucci, Carlota Saldanha, Giuseppe Uras, Alessia Manca, Muhammad Aslam, Antonella Pantaleo
Summary: ROS are recognized as important signaling messengers in endothelial cells, with potential positive effects on pro-survival pathways downstream of G(i)-protein-coupled receptors. However, the role of ROS in stabilizing the endothelial barrier remains uncertain.
Article
Cardiac & Cardiovascular Systems
Min Ji Cho, Dong Gwang Lee, Jeong Woong Lee, Byungtae Hwang, Sung-Jin Yoon, Seon-Jin Lee, Young-Jun Park, Seung-Ho Park, Hee Gu Lee, Yong-Hoon Kim, Chul-Ho Lee, Jangwook Lee, Nam-Kyung Lee, Tae-Su Han, Hyun-Soo Cho, Jeong Hee Moon, Ga Seul Lee, Kwang-Hee Bae, Geum-Sook Hwang, Sang-Hak Lee, Sang J. Chung, Sungbo Shim, Jaehyung Cho, Goo Taeg Oh, Young-Guen Kwon, Jong-Gil Park, Jeong-Ki Min
Summary: This study investigates the role of protein tyrosine phosphatase type IVA1 (PTP4A1) in the negative regulation of the NF-kappa B signalling pathway in endothelial cells (ECs). The findings suggest that PTP4A1 regulates NF-kappa B inactivation through the USF1/A20 axis, and its expression or activation in ECs may be useful for the treatment of vascular inflammatory diseases.
CARDIOVASCULAR RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Song Xue, Hanfei Tang, Gefei Zhao, Chao Fang, Yang Shen, Dong Yan, Ye Yuan, Weiguo Fu, Zhenyu Shi, Xiao Tang, Daqiao Guo
Summary: The study revealed that CCL8 may promote atherosclerosis by inducing endothelial permeability increase. The NOX2/ROS signaling pathway may be the underlying mechanism for this effect. This research contributes to a deeper understanding of the connection between chemokines and atherosclerosis.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Immunology
Linfang Zhang, Xiujuan Xia, Hao Wu, Xuanyou Liu, Qiang Zhu, Meifang Wang, Hong Hao, Yuqi Cui, De-Pei Li, Shi-You Chen, Luis A. Martinez-Lemus, Michael A. Hill, Canxia Xu, Zhenguo Liu
Summary: H. pylori infection impairs endothelial function in male mice through exosome-mediated ROS formation, while female mice show no change in endothelial function. This effect is achieved by increasing ROS production in the blood vessels.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Marcela Kreslova, Olga Kirchnerova, Daniel Rajdl, Vendula Sudova, Jiri Blazek, Aneta Sykorova, Petr Jehlicka, Ladislav Trefil, Jan Schwarz, Renata Pomahacova, Josef Sykora
Summary: This study assessed the association between the severity of asthma, eosinophilic inflammation, lung function, and asthma control with endothelial dysfunction (ED). The results showed that ED worsened with the severity of asthma and was associated with inflammatory severity.
Article
Multidisciplinary Sciences
Pedro Martinez-Ayala, Guillermo Adrian Alanis-Sanchez, Monserrat Alvarez-Zavala, Karina Sanchez-Reyes, Vida Veronica Ruiz-Herrera, Rodolfo Ismael Cabrera-Silva, Luz Alicia Gonzalez-Hernandez, Carlos Ramos-Becerra, Ernesto Cardona-Munoz, Jaime Federico Andrade-Villanueva
Summary: This study investigated the effect of one year of ART on arterial stiffness, inflammatory, and vascular cytokines in treatment-naive HIV(+) individuals. The results showed that ART treatment reduced inflammation and vascular cytokines and improved arterial stiffness.
Article
Medicine, Research & Experimental
Xiong Piao, Lie Ma, Qinqi Xu, Xiaomin Zhang, Chengzhu Jin
Summary: Noncoding RNAs play versatile roles in the regulation of endothelial dysfunction in atherosclerosis, including inflammation, migration, proliferation, and apoptosis. Understanding these regulatory roles may lead to the development of novel therapeutic strategies.
Article
Cardiac & Cardiovascular Systems
Xiujuan Xia, Linfang Zhang, Hao Wu, Feng Chen, Xuanyou Liu, Huifang Xu, Yuqi Cui, Qiang Zhu, Meifang Wang, Hong Hao, De-Pei Li, William P. Fay, Luis A. Martinez-Lemus, Michael A. Hill, Canxia Xu, Zhenguo Liu
Summary: This study found that CagA(+) H. pylori effectively colonizes gastric mucosa and impairs endothelial function, leading to increased atherosclerosis through exosomes-mediated ROS formation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Pediatrics
Jennifer J. Y. Lee, Brian M. Feldman, Brian W. McCrindle, Ping Li, Rae S. M. Yeung, Jessica Widdifield
Summary: This study evaluated the risk of hypertension and major adverse cardiac events in Kawasaki disease (KD) patients up to young adulthood. The results showed that KD patients had favorable cardiac prognosis with low events of hypertension and excellent survival. However, they had an increased risk of hypertension, which was highest around the time of KD diagnosis.
PEDIATRIC RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Nadia Di Pietrantonio, Carola Palmerini, Caterina Pipino, Maria Pompea Antonia Baldassarre, Giuseppina Bologna, Angelika Mohn, Cosimo Giannini, Paola Lanuti, Francesco Chiarelli, Assunta Pandolfi, Natalia Di Pietro
Summary: Childhood obesity is associated with impaired vascular insulin sensitivity, altered oxidant-antioxidant state, and chronic inflammation leading to endothelial dysfunction. In vitro study shows that inhibiting the mTORC1-S6K1 pathway can restore insulin receptor signaling and provide insights into the mechanisms underlying endothelial dysfunction in childhood obesity.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Dermatology
G. Holzer, M. Hoke, S. Sabeti-Sandor, T. Perkmann, A. Rauscher, B. Strassegger, S. Radakovic, A. Tanew
Summary: This study compared the effects of adalimumab and fumaric acid esters on cardiovascular disease markers in psoriasis patients. The results showed that adalimumab significantly improved FMD, while fumaric acid esters reduced total cholesterol levels.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zhuqing Li, Qi Li, Li Wang, Chao Li, Mengping Xu, Yajun Duan, Likun Ma, Tingting Li, Qiao Chen, Yilin Wang, Yanxin Wang, Jiaxin Feng, Xuemei Yin, Xiaolin Wang, Jihong Han, Chengzhi Lu
Summary: Chronic sympathetic hyperactivity can lead to oxidative stress and inflammation in endothelial cells, contributing to atherosclerosis development. Renal denervation (RDN) may protect endothelial cells by reducing oxidative stress-induced inflammation, thus reducing atherosclerosis.
Article
Public, Environmental & Occupational Health
Hend Alqaderi, Fahad Hegazi, Fahd Al-Mulla, Chung-Jung Chiu, Alpdogan Kantarci, Ebaa Al-Ozairi, Mohamed Abu-Farha, Saadoun Bin-Hasan, Aishah Alsumait, Jehad Abubaker, Sriraman Devarajan, J. Max Goodson, Hatice Hasturk, Mary Tavares
Summary: This study evaluated the relationship between specific salivary biomarkers, obesity, and intermediate hyperglycemia in children. Longitudinal analyses showed that higher salivary CRP and insulin levels were predictive of hyperglycemia and obesity.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Peripheral Vascular Disease
Khalid A. Al Faraidy, Lukman Thalib, Owayed Al Shammeri, Fayez Bokhari, Ahmad Hersi, Hussam Alfaleh, Tarek Kashour
Article
Computer Science, Artificial Intelligence
Syed Asif Raza, Lukman Thalib, Jassim Al Suwaidi, Kadhim Sulaiman, Wael Almahmeed, Haitham Amin, Khalid F. AlHabib
Review
Nursing
Zhaoyu Li, Frances Lin, Lukman Thalib, Wendy Chaboyer
INTERNATIONAL JOURNAL OF NURSING STUDIES
(2020)
Review
Respiratory System
Mohamed Sherbash, Luis Furuya-Kanamori, Joanne Daghfal Nader, Lukman Thalib
BMC PULMONARY MEDICINE
(2020)
Review
Pediatrics
Amer Alsaied, Nazmul Islam, Lukman Thalib
Review
Obstetrics & Gynecology
N. Islam, L. Furuya-Kanamori, S. Mahmood, L. Thalib
Summary: Prophylactic antibiotics are effective in reducing post-abortion GTI among women undergoing surgical procedures for incomplete abortion, especially in high-income countries. However, the effect is not significant in low- and middle-income countries, and more studies are needed for confirmation.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Obstetrics & Gynecology
Wendy Chaboyer, David Ellwood, Lukman Thalib, Sailesh Kumar, Kassam Mahomed, Evelyn Kang, Brigid M. Gillespie
Summary: This study aimed to identify the cumulative incidence and predictors of surgical site infection in women with a pre-pregnancy BMI >= 30 kg/m(2) who gave birth by elective CS. The results showed that higher BMI, multiple previous pregnancies, and lack of pre-CS vaginal cleansing were associated with increased risk of SSI. These findings could help in counseling and decision-making for planned elective CS in women with higher pre-pregnancy BMI.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2022)
Article
Nutrition & Dietetics
Emily Burch, Lauren T. Williams, Lukman Thalib, Lauren Ball
Summary: The study shows that the diet quality of individuals newly diagnosed with T2DM remained stable over a 12-month period, with very few participants consistently improving their diet quality. No associations were found between changes in DASH, energy, fruit, or vegetable intake over time and specific characteristics.
JOURNAL OF HUMAN NUTRITION AND DIETETICS
(2022)
Letter
Pharmacology & Pharmacy
Lukman Thalib
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Letter
Health Care Sciences & Services
Lukman Thalib
JOURNAL OF EVALUATION IN CLINICAL PRACTICE
(2022)
Letter
Obstetrics & Gynecology
Lukman Thalib
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2022)
Article
Dermatology
Madeline A. Bone, Brigid M. Gillespie, Sharon Latimer, Rachel M. Walker, Lukman Thalib
Summary: This study observed the variations in sacral subepidermal oedema levels over a continuous period of 60-degree head of bed elevation positioning. In a sample of healthy individuals, 120 min of continuous loading with a 60-degree head of bed elevation did not lead to a significant change in sacral subepidermal oedema levels. Further research on the response of healthy adult tissue under external forces associated with different angles of head of bed positioning may further contribute to our understanding pressure injury prevention.
JOURNAL OF TISSUE VIABILITY
(2023)
Article
Dermatology
Annette McLaren-Kennedy, Wendy Chaboyer, Lukman Thalib, Sharon Latimer
Summary: This study examined the effect of head of bed elevation (HOBE) on subepidermal moisture (SEM) in the sacrum and heels, and found that HOBE did not significantly affect SEM.
JOURNAL OF TISSUE VIABILITY
(2023)
Article
Obstetrics & Gynecology
Jennifer A. Whitty, Adam P. Wagner, Evelyn Kang, David Ellwood, Wendy Chaboyer, Sailesh Kumar, Vicki L. Clifton, Lukman Thalib, Brigid M. Gillespie
Summary: This study assessed the cost-effectiveness of closed incision negative pressure wound therapy (ci-NPWT) compared to standard dressings for preventing surgical site infections (SSIs) in obese women undergoing caesarean section (CS). The results showed that although ci-NPWT can reduce the occurrence of SSIs in obese women, it is associated with higher costs and does not improve quality of life. Therefore, routine use of ci-NPWT for preventing SSIs in obese women undergoing CS is currently not recommended.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2023)
Review
Nursing
R. D. Udeshika Priyadarshani Sugathapala, Sharon Latimer, Aindralal Balasuriya, Wendy Chaboyer, Lukman Thalib, Brigid M. Gillespie
Summary: Pressure injuries are a significant concern for older people living in nursing homes. This study aimed to quantify the prevalence and incidence of pressure injuries in this population and identify the most common stages and locations of pressure injuries. The results showed a high prevalence and incidence of pressure injuries, highlighting the need for targeted prevention measures.
INTERNATIONAL JOURNAL OF NURSING STUDIES
(2023)