Article
Cardiac & Cardiovascular Systems
Thomas C. Gilliland, Yuxi Liu, Reza Mohebi, Hannah Miksenas, Sara Haidermota, Megan Wong, Xingdi Hu, Joaquim Rosado Cristino, Auris Browne, Jorge Plutzky, Sotirios Tsimikas, James L. Januzzi Jr, Pradeep Natarajan
Summary: This study investigated the relationships between Lp(a) and OxPLs with angiographic CAD and cardiovascular outcomes. The results showed that Lp(a) and OxPL-apoB were associated with multivessel CAD, and Lp(a), OxPL-apoB, and OxPL-apo(a) were associated with cardiovascular events.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jie Gao, Jun Lu, Wenjun Sha, Bilin Xu, Cuiping Zhang, Hongping Wang, Juan Xia, Hong Zhang, Wenjun Tang, Tao Lei
Summary: This study evaluated the association between the neutrophil to HDL-C ratio (NHR) and the degree of coronary stenosis in patients with stable coronary artery disease (CAD). The results showed that NHR was not only associated with the occurrence and seriousness of CAD, but also a better predictor of severe CAD than neutrophil, HDL-C or LDL-C/HDL-C.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
David G. Thomas, Ying Wei, Alan R. Tall
Summary: The study assessed the pleiotropic effects of lipid trait genetic variants and conducted multivariable Mendelian randomization (MR) analysis in coronary artery disease. Results indicated that 30% of lipid trait genetic variants have effects on metabolic syndrome traits, yet the associations of LDL-C, HDL-C, TGs, BMI, T2D, and SBP with CAD remained independent and robust to adjustment for directional pleiotropy. MR at loci linked to direct effects on HDL-C and TGs suggested specific causal effects of these factors on CAD.
JOURNAL OF LIPID RESEARCH
(2021)
Article
Medicine, General & Internal
Hae Won Jung, Moni Ra, Han Joon Bae, Seung-Pyo Hong
Summary: The association between Apo B, Apo B/A1 ratio, lipoprotein (a), and LDL-C/Apo B ratio with coronary artery disease (CAD) in non-diabetic patients without high LDL-C levels was unclear. A study was conducted on 487 non-diabetic patients with LDL-C < 130.0 mg/dL to evaluate the most strongly associated parameter with CAD. The LDL-C/Apo B ratio was found to be the most predictive parameter for coronary atherosclerosis in non-diabetic patients without high LDL-C levels.
Article
Biochemistry & Molecular Biology
Samar R. El Khoudary, Alexis Nasr, Karen A. Matthews, Trevor J. Orchard, Maria M. Brooks, Jeffrey Billheimer, Dan McConnell, Imke Janssen, Susan A. Everson-Rose, Sybil Crawford, Daniel J. Rader
Summary: The study found that the associations between HDL metrics and CAC may vary by menopause stage and estradiol level. Different HDL subclasses may impact the likelihood of CAC presence and the stability of coronary plaque differently over the menopause transition.
JOURNAL OF LIPID RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Parveen K. Garg, William Tressel, Robyn L. McClelland, Michael H. Criqui, James H. Stein, Laurent Yvan-Chavret, Alan R. Tall, Steven Shea
Summary: The study found no association between HDL-mediated cholesterol efflux and coronary artery calcium score or density.
JOURNAL OF CLINICAL LIPIDOLOGY
(2022)
Article
Engineering, Chemical
Sandro Cusihuaman, Jeel Moya-Salazar, Pedro Wong-Salgado, Marcia M. Moya-Salazar, Betsy Canari, Karina Chicoma-Flores, Hans Contreras-Pulache
Summary: This study aimed to determine the immediate changes of cannabis consumption by pyrolytic route in heavy users. The results showed that HDL-C cholesterol increased 30 and 120 minutes after Cannabis spp. ingestion, while LDL-C and total cholesterol showed partial reductions.
Review
Food Science & Technology
Seyedeh-Masomeh Derakhshandeh-Rishehri, Saeed Ghobadi, Masoumeh Akhlaghi, Shiva Faghih
Summary: Calcium supplement intake is associated with a significant reduction in low density lipoprotein cholesterol level, especially in individuals without dyslipidemia, higher calcium intakes, and longer period of consumption.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Cardiac & Cardiovascular Systems
Sara N. Koenig, Holly C. Sucharski, Elizabeth M. Jose, Emma K. Dudley, Francesca Madiai, Omer Cavus, Aaron D. Argall, Jordan L. Williams, Nathaniel P. Murphy, Caullin B. R. Keith, Mona El Refaey, Richard J. Gumina, Konstantinos D. Boudoulas, M. Wesley Milks, Gbemiga Sofowora, Sakima A. Smith, Thomas J. Hund, Nathan T. Wright, Elisa A. Bradley, Karolina M. Zareba, Loren E. Wold, Ernest L. Mazzaferri, Peter J. Mohler
Summary: Elevated HDL-C is associated with improved cardiovascular outcomes, but clinical trials targeting HDL-C have not been successful. Rare compound heterozygous variants in SCARB1 have been found to cause severe CAD through Mendelian inheritance. These findings support the disease-contributing capability of loss-of-function SCARB1 variants.
CIRCULATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Kohei Takata, Satoshi Imaizumi, Atsushi Iwata, Bo Zhang, Emi Kawachi, Shin-ichiro Miura, Masahiro Ogawa
Summary: This study found that HDL functionality is associated with the composition of coronary plaques, particularly the percentage lipid volume. The positive correlation between high HDL-CEC and plaque volume suggests that HDL functionality may have a protective effect on the development of coronary artery disease.
Article
Pharmacology & Pharmacy
Barak Zafrir, Razi Khoury, Walid Saliba
Summary: This study investigated the association between remnant cholesterol (RC) and the risk for myocardial infarction (MI) in patients with coronary artery disease, and compared its predictive value with non-high-density lipoprotein cholesterol (non-HDL-C). The results showed that elevated RC level was associated with a higher risk for MI, and when RC and non-HDL-C levels were discordant, RC better reflected the risk for MI.
JOURNAL OF CLINICAL LIPIDOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jiaqi Chen, Kangxiang Wu, Wanchun Cao, Jianan Shao, Mingyuan Huang
Summary: This study found that patients with multi-vessel coronary artery disease (MV-CAD) had worse clinical outcomes than those with single-vessel coronary artery disease (SV-CAD). It was also observed that monocytes and high-density lipoprotein cholesterol (HDL-C) play negative and protective roles, respectively, in coronary artery disease (CAD). However, the relationship between monocyte to high-density lipoprotein ratio (MHR) and MV-CAD had not been studied before.
LIPIDS IN HEALTH AND DISEASE
(2023)
Review
Hematology
Hong Y. Choi, Iulia Iatan, Isabelle Ruel, Leslie Brown, Lindsay Hales, Shiwon Choi, Jacques Genest
Summary: The identification of DSC1 as a negative regulator of HDL biogenesis has led to a reconsideration of the hypothesis that HDL biogenesis reduces atherosclerosis. DSC1, which can be targeted by the drug docetaxel, has shown to promote HDL biogenesis and inhibit atherogenic proliferation of vascular smooth muscle cells. Animal studies have demonstrated that docetaxel reduces dyslipidemia-induced atherosclerosis, highlighting the importance of DSC1 as a potential target for HDL biogenesis.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Chao Li, Yanli Zhang, Lerong Mei, Aoming Jin, Xueli Cai, Yuesong Pan, Jing Jing, Suying Wang, Xia Meng, Shan Li, Mengxing Wang, Tiemin Wei, Yongjun Wang, Rui Chen, Yu Tian
Summary: Discordantly high Apo B with LDL-C or Non-HDL-C is associated with an increased odds of the presence and burden of intra-/extra-cranial atherosclerotic plaques.
JOURNAL OF CLINICAL LIPIDOLOGY
(2023)
Article
Multidisciplinary Sciences
Xiaoyu Tang, Ling Mao, Jin Chen, Tianhua Zhang, Shuwei Weng, Xin Guo, Jie Kuang, Bilian Yu, Daoquan Peng
Summary: In patients with coronary artery disease (CAD), increasing levels of high-density lipoprotein (HDL) cholesterol (HDL-C) as an add-on to statins does not decrease cardiovascular risk. HDL functional metric-cholesterol efflux capacity (CEC) may be a better predictor of CAD risk than HDL-C. The study suggests that hsCRP levels, a marker of acute inflammation, may be associated with HDL dysfunction in ACS subjects.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Ebenezer Oni, Oluseye Ogunmoroti, Norrina Allen, Mouaz H. A-Mallah, Ron Blankstein, Seth S. Martin, Irfan Zeb, Mary Cushman, Parag H. Joshi, Matthew J. Budoff, Michael J. Blaha, Roger S. Blumenthal, Emir Veledar, Khurram Nasir
Summary: The study found that a more favorable cardiovascular health score was associated with a lower prevalence of NAFLD. This may suggest a potential of Life's Simple 7 in the prevention of liver disease.
AMERICAN JOURNAL OF MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Omar Dzaye, Zeina A. Dardari, Miguel Cainzos-Achirica, Ron Blankstein, Arthur S. Agatston, Matthias Duebgen, Joseph Yeboah, Moyses Szklo, Matthew J. Budoff, Joao A. C. Lima, Roger S. Blumenthal, Khurram Nasir, Michael J. Blaha
Summary: This study provides a robust estimation of the warranty period for CAC = 0, considering progression to CAC >0, CAC >10, and CAC >100 and its impact on missed versus detectable 10-year coronary heart disease events in a large population. Beyond age, sex, race/ethnicity, diabetes also has a significant impact on the warranty period. Evidence-based guidance would be to consider rescanning in 3 to 7 years depending on individual demographics and risk profile.
JACC-CARDIOVASCULAR IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
Miguel Cainzos-Achirica, Dixitha Anugula, Reed Mszar, Gowtham Grandhi, Kershaw Patel, Marcio S. Bittencourt, Ron Blankstein, Michael J. Blaha, Roger S. Blumenthal, Kausik K. Ray, Deepak L. Bhatt, Khurram Nasir
Summary: The article discusses using the CAC score to enhance prognostic enrichment in RCTs of add-on therapies, with a focus on risk stratification and cost reduction. Various approaches are suggested to maximize the advantages of a CAC-based enrichment strategy in future RCTs.
AMERICAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Mahmoud Al Rifai, Michael J. Blaha, Vijay Nambi, Steven J. C. Shea, Erin D. Michos, Roger S. Blumenthal, Christie M. Ballantyne, Moyses Szklo, Philip Greenland, Michael D. Miedema, Khurram Nasir, Jerome I. Rotter, Xiuqing Guo, Jie Yao, Wendy S. Post, Salim S. Virani
Summary: Current cigarette smoking, diabetes, and hypertension are independently associated with incident ASCVD over a 16-year follow-up among those with CAC=0.
Review
Cardiac & Cardiovascular Systems
Brent Gudenkauf, Allison G. Hays, Jacqueline Tamis-Holland, Jeffrey Trost, Daniel Ambinder, Katherine C. Wu, Armin Arbab-Zadeh, Roger S. Blumenthal, Garima Sharma
Summary: Myocardial infarction with nonobstructive coronary arteries (MINOCA) is a complex disease requiring multiple imaging techniques for diagnosis. Cardiac magnetic resonance can exclude nonischemic causes and invasive coronary imaging can evaluate plaque formation and the presence of disruption or dissection. The application of noninvasive imaging techniques is also being studied.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Letter
Cardiac & Cardiovascular Systems
Carine E. Hamo, Lucia Kwak, Dan Wang, Roberta Florido, Justin B. Echouffo-Tcheugui, Roger S. Blumenthal, Laura Loehr, Kunihiro Matsushita, Vijay Nambi, Christie M. Ballantyne, Elizabeth Selvin, Aaron R. Folsom, Gerardo Heiss, Josef Coresh, Chiadi E. Ndumele
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Public, Environmental & Occupational Health
Yaa A. Kwapong, Ellen Boakye, Olufunmilayo H. Obisesan, Lochan M. Shah, S. Michelle Ogunwole, Allison G. Hays, Roger S. Blumenthal, Andreea A. Creanga, Michael J. Blaha, Miguel Cainzos-Achirica, Khurram Nasir, Pamela S. Douglas, Xiaobin Wang, Garima Sharma
Summary: This study analyzed data from the Boston Birth Cohort on non-Hispanic Black, non-Hispanic White, and Hispanic women, and found disparities in preterm birth related to nativity and duration of U.S. residence. Foreign-born women had better cardiovascular risk profiles and lower odds of preterm birth in the non-Hispanic Black and Hispanic groups.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Oluseye Ogunmoroti, Olatokunbo Osibogun, Lena Mathews, Olumuyiwa A. Esuruoso, Chiadi E. Ndumele, Victor Okunrintemi, Gregory L. Burke, Roger S. Blumenthal, Matthew J. Budoff, Erin D. Michos
Summary: This study found that favorable cardiovascular health is associated with a lower risk of extracoronary atherosclerosis. These findings emphasize the importance of primordial prevention as an intervention to reduce the burden of cardiovascular disease.
CIRCULATION-CARDIOVASCULAR IMAGING
(2022)
Review
Pharmacology & Pharmacy
Shiavax J. Rao, Seth Shay Martin, Shari M. Lawson, Tigist Hailu, Dorothy M. Davis, Khurram Nasir, Miguel Cainzos-Achirica, Roger S. Blumenthal, Garima Sharma
Summary: Pregnant women with gestational hypertension and/or preeclampsia have abnormal lipid profiles that contribute to the development of atherosclerosis. Changes in maternal lipids can promote atherogenesis through endothelial injury, and these alterations have been associated with adverse pregnancy outcomes and maternal morbidity and mortality. Statin therapies, with their effects on endothelial dysfunction, inflammation, and plaque stabilization, may be useful in the prevention and treatment of preeclampsia.
JOURNAL OF CLINICAL LIPIDOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Rishav Adhikari, Kunal Jha, Zeina Dardari, James Heyward, Roger S. Blumenthal, Robert H. Eckel, G. Caleb Alexander, Michael J. Blaha
Summary: While the use of SGLT2is and GLP-1RAs by cardiologists in the United States has increased significantly over a 6-year period, they still account for a small proportion of overall usage, leading to underutilization in the treatment of individuals with type 2 diabetes at high cardiovascular risk.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Review
Hematology
Nadia R. Sutton, Rajeev Malhotra, Cynthia St. Hilaire, Elena Aikawa, Roger S. Blumenthal, Grace Gackenbach, Parag Goyal, Adam Johnson, Sagar U. Nigwekar, Catherine M. Shanahan, Dwight A. Towler, Brooke N. Wolford, Yabing Chen
Summary: Cardiovascular disease is the leading cause of death globally, particularly in individuals over the age of 65, with myocardial infarction and stroke being the primary contributors. The development of vascular aging and vascular calcification with aging is not fully understood, but is believed to be influenced by genetic risk, environmental factors, and the ability of vascular smooth muscle cells to acquire an osteogenic phenotype. Understanding the molecular mechanisms behind age-associated vascular pathology may lead to strategies for promoting healthy vascular aging. This article provides a summary of current knowledge on age-associated vascular disease, with a focus on vascular calcification.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Gemma A. Figtree, Philip D. Adamson, Charalambos Antoniades, Roger S. Blumenthal, Michael Blaha, Matthew Budoff, David S. Celermajer, Mark Y. Chan, Clara K. Chow, Damini Dey, Girish Dwivedi, Nicola Giannotti, Stuart M. Grieve, Christian Hamilton-Craig, Bronwyn A. Kingwell, Jason C. Kovacic, James K. Min, David E. Newby, Sanjay Patel, Karlheinz Peter, Peter J. Psaltis, Stephen T. Vernon, Dennis T. Wong, Stephen J. Nicholls
Summary: Coronary artery disease (CAD) is the leading cause of adult mortality globally. Improvements in imaging techniques have provided a better understanding of different phenotypes of coronary atherosclerosis, which are associated with different risks for acute ischemic events. Noninvasive coronary imaging techniques have the potential to accelerate cardiovascular drug development and reduce costs and timelines.
Article
Cardiac & Cardiovascular Systems
Yaa A. Kwapong, Ellen Boakye, Sadiya S. Khan, Michael C. Honigberg, Seth S. Martin, Chigolum P. Oyeka, Allison G. Hays, Pradeep Natarajan, Mamas A. Mamas, Roger S. Blumenthal, Michael J. Blaha, Garima Sharma
Summary: Depression and poor mental health are associated with increased risk of cardiovascular disease and suboptimal cardiovascular health among young adults.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Christeen Samuel, Jihwan Park, Aparna Sajja, Erin D. Michos, Roger S. Blumenthal, Steven R. Jones, Seth S. Martin
Summary: This study compared the accuracy of 23 available LDL-C equations with ultracentrifugation measurement and found that most alternatives to the Friedewald equation have lower accuracy. The Martin/Hopkins equation demonstrated the highest accuracy overall and across subgroups.
Meeting Abstract
Cardiac & Cardiovascular Systems
Oluseye Ogunmoroti, Olatokunbo Osibogun, Richard Ferraro, Olumuyiwa Esuruoso, Paul Ndunda, Nicholas Larson, Paul Decker, Suzette Bielinski, Roger Blumenthal, Matthew Budoff, Erin Michos
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)