Article
Nanoscience & Nanotechnology
Zhiwei Zhang, Jiawei Zhuang, Daohan Sun, Qingwei Ding, Hui Zheng, Haixiang Li, Xiaoyu Zhang, Yaming Du, Teng Ma, Qingyou Meng
Summary: A study developed a netrin-1-responsive AAA-targeted nanoparticle loaded with metformin for the treatment of abdominal aortic aneurysms. The results showed that metformin can prevent AAA progression by inhibiting the phenotypic transformation of vascular smooth muscle cells.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Medical Laboratory Technology
Likun Sun, Xin Li, Zhongchen Luo, Maohua Li, Hongyu Liu, Zhaowei Zhu, Junwei Wang, Peng Lu, Lunchang Wang, Chenzi Yang, Tun Wang, Hao He, Ming Li, Chang Shu, Jiehua Li
Summary: The purinergic receptor P2X7 plays a crucial role in abdominal aortic aneurysm (AAA) development by modulating macrophage pyroptosis and inflammation. P2X7 is highly expressed in human AAA specimens and experimental murine AAA lesions. Inhibition or deficiency of P2X7 attenuates aneurysm formation in experimental murine models, while its activation promotes AAA development. Mechanistically, macrophage P2X7 activates the NLRP3 inflammasome and its downstream caspase-1 to initiate the pyroptosis pathway.
TRANSLATIONAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Jianan Huang, Yunlong Jiang, Ruiyuan Ji, Yutian Jia, Saiya Wang, Zhongqiu Zhou, Siying Wang, Jie Wang, Qing Yang, Hui Bai, Xudong Zhu, Bin Jiang, Jingjing Ben, Hanwen Zhang, Xiaoyu Li, Qi Chen
Summary: This study aims to investigate the role of scavenger receptor A1 (SR-A1) in the pathogenesis of abdominal aortic aneurysm (AAA) and found that its deficiency aggravates AAA development by suppressing immunoresponsive gene 1 (IRG1) and increasing inflammatory response. Restoration of macrophage SR-A1 can relieve AAA.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Dunpeng Cai, Chenming Sun, Takashi Murashita, Xingyi Que, Shi-You Chen
Summary: This study reveals the crucial role of macrophage activation in abdominal aortic aneurysm (AAA) development. It identifies adenosine deaminase acting on RNA (ADAR1) as a novel mechanism underlying macrophage activation and AAA formation.
CIRCULATION RESEARCH
(2023)
Article
Peripheral Vascular Disease
Kayo Takahashi, Jun Aono, Yasuhisa Nakao, Mika Hamaguchi, Chika Suehiro, Mie Kurata, Tomohisa Sakaue, Akemi Kakino, Tatsuya Sawamura, Katsuji Inoue, Shuntaro Ikeda, Jun Suzuki, Osamu Yamaguchi
Summary: This study found that deficiency of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) may not mitigate the development of abdominal aortic aneurysm (AAA), but rather increases the vulnerability of rupture by suppressing adventitial fibroblast proliferation and collagen synthesis.
HYPERTENSION RESEARCH
(2023)
Article
Chemistry, Analytical
Yajiao Huang, Hongping Deng, Jintao Zhang, Hengwei Sun, Wei Li, Chunya Li, Yijia Zhang, Dong Sun
Summary: A 3-butyl-1-dodecyl-imidazolium bromide ionic liquid was synthesized to aid in the exfoliation of ReS2 bulk crystal to produce nanosheets, which were then used to construct a photoelectrochemical immunosensor for detecting collagen III. The use of the ionic liquid improved the photocurrent response of the nanosheets and accelerated the separation of electron-hole pairs, enhancing the sensor's characteristics. This ReS2-based immunosensor showed promising results in clinical serum samples.
MICROCHEMICAL JOURNAL
(2021)
Article
Genetics & Heredity
Linlin Meng, Yue Lu, Xinlu Wang, Wenhai Sui, Xiao Ge, Ming Zhong, Xiao Meng, Yun Zhang
Summary: In this study, it was found that simvastatin therapy can prevent the development of AAA, partly through inducing Treg accumulation, and it can also regulate gut microbial dysbiosis.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Hematology
Blain Jones, Anna Debski, Chetan P. Hans, Michael R. Go, Gunjan Agarwal
Summary: The study utilized multimodal microscopy techniques to investigate the impact of collagen fibril structure on platelet adhesion in abdominal aortic aneurysm tissues. The findings revealed that abnormal collagen fibrils inhibit platelet adhesion, providing insights into thrombosis or bleeding disorders.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Immunology
Xiaoying Ma, Jinfang Xu, Qingsheng Lu, Xiang Feng, Jiajun Liu, Chaoyi Cui, Chao Song
Summary: This study investigates the role of circRNA in abdominal aortic aneurysms (AAA) and macrophages. The researchers found that hsa_circ_0087352, a circRNA, is up-regulated in human AAA specimens and is related to the inflammatory response in THP-1 macrophages. Further experiments revealed that hsa_circ_0087352 promotes IL-6 transcription and the secretion of inflammatory cytokines by sponging endogenous hsa-miR-149-5p in macrophages, potentially through the ERK/NF-kappa B pathway. Additionally, hsa_circ_0087352 overexpression induces apoptosis in human vascular smooth muscle cells. These findings suggest the potential of hsa_circ_0087352 as a biomarker and therapeutic target for AAA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rena Fujishima, Hirona Kugo, Kenichi Yanagimoto, Hirofumi Enomoto, Tatsuya Moriyama, Nobuhiro Zaima
Summary: The research suggests that eicosapentaenoic acid (EPA) may suppress the development of abdominal aortic aneurysm (AAA) by enhancing the anti-inflammatory properties of M2 macrophages.
Article
Cardiac & Cardiovascular Systems
Bartosz Pilecki, Paulo V. S. D. de Carvalho, Katrine L. Kirketerp-Moller, Anders Schlosser, Karin Kejling, Magdalena Dubik, Nicklas P. Madsen, Jane Stubbe, Pernille B. L. Hansen, Thomas L. Andersen, Jesper B. Moeller, Niels Marcussen, Vasco Azevedo, Svend Hvidsten, Christina Baun, Guo-Ping Shi, Jes S. Lindholt, Grith L. Sorensen
Summary: MFAP4 plays a crucial role in promoting the development of AAA by inducing macrophage-rich inflammation and MMP activity within the vessel wall. Its deficiency leads to reduced AAA incidence and ameliorates pathological changes in AAA, implicating regulation of monocyte influx and MMP production as key mechanisms.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Hengyuan Zhang, Na Geng, Lingyue Sun, Xinyu Che, Qingqing Xiao, Zhenyu Tao, Long Chen, Yuyan Lyu, Qin Shao, Jun Pu
Summary: The study showed that decreased expression of Nur77 is associated with accelerated development of AAA in mice. Activation of Nur77 by celastrol had beneficial effects against AAA. The detrimental effects of Nur77 deficiency were linked to increased macrophage infiltration and expression of pro-inflammatory cytokines and MMP-9 in AAA lesions.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Yubin Chen, Tianyu Ouyang, Cheng Fang, Can-e Tang, Kaibo Lei, Longtan Jiang, Fanyan Luo
Summary: Weakening of the aortic wall and immune response contribute to the development of AAA, and the inflammatory response is closely associated with aortic rupture. Infiltration of immune cells differs significantly between different samples. NFKB1 may be an important transcription factor in AAA and aortic rupture. CD19, SELL, and CCR7 have potential diagnostic value for AAA, while OAS3, IFIT1, and IFI44L may be predictive factors for aortic rupture.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Weilai Fu, Haole Liu, Panpan Wei, Congcong Xia, Qingqing Yu, Kangli Tian, Yankui Li, Enqi Liu, Baohui Xu, Masaaki Miyata, Rong Wang, Sihai Zhao
Summary: PIAS3 deficiency can alleviate the development of abdominal aortic aneurysms by reducing elastin degradation, smooth muscle cell loss, leukocyte accumulation, and angiogenesis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Medicine, General & Internal
Petroula Nana, Konstantinos Dakis, Alexandros Brodis, Konstantinos Spanos, George Kouvelos
Summary: A systematic review examined the correlation of abdominal aortic aneurysm expansion rates with serum circulating biomarkers, identifying specific biomarkers potentially useful for individualized surveillance of patients with increased AAA growth rates. Various biomarkers, including D-dimers, LDL-C, HDL-C, and genetic factors, were found to be significantly associated with AAA growth rates, suggesting a potential role for serum biomarkers in patient monitoring.
JOURNAL OF CLINICAL MEDICINE
(2021)
