Article
Cardiac & Cardiovascular Systems
Shuren Guo, Xiaohuan Mao, Xiaohua Li, Huan Ouyang, Yuhua Gao, Liang Ming
Summary: Serum complement C1q activity is associated with obstructive CAD, higher lipid levels, and has a low value in predicting the occurrence of CAD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Mohamed Y. Elwazir, Mohammad H. Hussein, Eman A. Toraih, Essam Al Ageeli, Safya E. Esmaeel, Manal S. Fawzy, Salwa Faisal
Summary: Variants of angiogenesis-related long non-coding RNAs (lncRNAs) may be associated with the development and severity of coronary artery disease (CAD). MIAT rs1061540 and MALAT1 rs3200401 variants are correlated with the severity of CAD and Gensini scores.
Article
Allergy
Ambika Sharma, Sargeet Kaur, Malay Sarkar, B. C. Sarin, Harish Changotra
Summary: Chronic obstructive pulmonary disease (COPD) is a heterogeneous group of lung diseases characterized by limited airflow, chronic bronchitis, and emphysema. Research has shown that the receptor for advanced glycation end products (RAGE) plays an important role in the pathology of COPD, and its truncated form, soluble RAGE (sRAGE), is considered a significant marker for COPD.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Yao Wang, Qingbo Lv, Ya Li, Songzan Chen, Liding Zhao, Guosheng Fu, Wenbin Zhang
Summary: The Gensini score is a useful tool for evaluating the severity and complexity of coronary artery diseases. This research found a correlation between the Gensini score and periprocedural myocardial infarction (PMI), with higher scores associated with a higher incidence of PMI. The study also determined the optimal cut-off values of the Gensini score for predicting PMI.
Article
Respiratory System
Marta Marin-Oto, David Sanz-Rubio, Fernando Santamaria-Martos, Ivan Benitez, Ana L. Simon, Marta Forner, Pablo Cubero, Ana Gil, Manuel Sanchez-de-laTorre, Ferran Barbe, Jose M. Marin
Summary: The study found that patients with hypoxia-related diseases (including COPD, OSA, and OSA-COPD overlap) had lower levels of sRAGE compared to healthy individuals. However, patients with OSA who received CPAP treatment, especially those with concurrent COPD, showed a significant increase in sRAGE levels.
RESPIRATORY RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Fei Ma, Jing Hao, Jing Zhao, De-ying Liu, Hui-li Cao, Bing Yang, Jin Li
Summary: This study found a negative association between serum FAM19A5 levels and the presence and severity of coronary artery disease (CAD), suggesting its potential as a diagnostic and severity indicator for CAD.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Libo Yang, Mingliang Zhang, Hui Zhang, Guanlin Zheng, Chao Xu, Guangyao Li
Summary: This study investigated the relationship between thyroid autoimmune bodies and coronary artery disease in euthyroid subjects. The results showed that positive thyroglobulin antibody might be an independent protective factor for coronary artery disease.
Article
Pharmacology & Pharmacy
A. Kirankaya, S. Tugrul, S. Ozcan, O. Ince, E. Donmez, A. Atici, E. Hancioglu, E. Okuyan, I. Sahin
Summary: This study aimed to investigate the relationship between circulating lumican levels and the severity of coronary artery disease (CAD). The results showed that lumican levels were higher in the advanced CAD group and positively correlated with the Gensini score. Diabetes mellitus, EF, and lumican were found to be predictive factors for advanced CAD. Lumican levels can be used to predict the seriousness of CAD with a sensitivity rate of 64% and specificity rate of 65%.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Mireia Pujals, Carla Mayans, Chiara Bellio, Olga Mendez, Emanuela Greco, Roberta Fasani, Merce Alemany-Chavarria, Esther Zamora, Laura Padilla, Francesc Mitjans, Paolo Nuciforo, Francesc Canals, Lara Nonell, Maria Abad, Cristina Saura, Josep Tabernero, Josep Villanueva
Summary: Epithelial/mesenchymal (E/M) plasticity is important in both embryogenesis and tumorigenesis. The role of receptor for advanced glycation end products (RAGE) in triple-negative breast cancer (TNBC) is unclear. This study shows that RAGE signaling maintains the mesenchymal phenotype of aggressive TNBC cells through the expression of SNAIL1 and its crosstalk with the TGF-β pathway. RAGE inhibition promotes epithelial features and reduces migration and invasion capacities. In vivo inhibition of RAGE reduces metastasis incidence and improves survival.
Article
Medicine, General & Internal
Lior Charach, Alex Blatt, Michael Jonas, Nick Teodorovitz, Dan Haberman, Gera Gendelman, Itamar Grosskopf, Jacob George, Gideon Charach
Summary: The Gensini score is related to the severity of coronary artery disease, multivessel disease, medication, and cardiovascular risk factors.
Article
Cardiac & Cardiovascular Systems
Aikeliyaer Ainiwaer, Wen Qing Hou, Kaisaierjiang Kadier, Rena Rehemuding, Peng Fei Liu, Halimulati Maimaiti, Lian Qin, Xiang Ma, Jian Guo Dai
Summary: This study used machine learning models to predict the presence and severity of coronary artery disease (CAD). The study included 284 retrospective participants and 116 prospectively enrolled participants, and the data was pre-processed using outlier processing and One-Hot coding. The results showed that the proposed model had good performance in predicting CAD and could provide a foundation for risk stratification and severity assessment of CAD.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Benjamin Bay, Alina Gossling, Christopher M. Blaum, Friederike Kroeger, Luise Koppe, Thiess Lorenz, Lukas Koester, Peter Clemmensen, Dirk Westermann, Paulus Kirchhof, Stefan Blankenberg, Tanja Zeller, Moritz Seiffert, Christoph Waldeyer, Fabian J. Brunner
Summary: High-sensitivity troponin T and high-sensitivity troponin I levels are independently associated with all-cause mortality in stable patients, while only high-sensitivity troponin I is associated with major adverse cardiovascular events, even after adjusting for confounders including coronary artery disease severity.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Biochemistry & Molecular Biology
Foddha Hajer, Saoud Hana, Chouchene Saoussen, Foddha Abdelhak, Bouzidi Nadia, Dhiflaoui Ameni, Gamra Habib, Ben abdennebi Hassen, Haj Khelil Amel
Summary: This study found that two SNPs in the VEGFA/VEGFR2 signaling pathway were associated with CHD, and two VEGFA SNPs were associated with high Gensini score. These findings contribute to a better understanding of the pathophysiology of CHD.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Diana Elizabeth Gonzalez-Guerrero, Maria-Luisa Lazo-de-la-Vega-Monroy, Armando Gomez-Ojeda, Claudia Luevano-Contreras, Armando Rojas-Rubio, Ma. Eugenia Garay-Sevilla
Summary: This study aimed to investigate whether the -374 T/A and -429 T/C polymorphisms were associated with metabolic syndrome (MS). The results showed that these two polymorphisms were not associated with MS in the Mexican population and had no influence on serum sRAGE levels.
Article
Cardiac & Cardiovascular Systems
Dong Lv, Yanfu Guo, Li Zhang, Xia Li, Guangping Li
Summary: This study investigated the relationship between circulating miR-183-5p levels and stable coronary artery disease (CAD). The results showed that serum miR-183-5p levels were significantly increased in CAD patients with different severities compared to non-CAD patients. Furthermore, serum miR-183-5p levels were found to predict the presence and severity of CAD independently.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Oncology
Nitin Mahajan
Article
Cardiac & Cardiovascular Systems
Kunal Mahajan, Prakash Chand Negi, Rajeev Merwaha, Nitin Mahajan, Vivek Chauhan, Sanjeev Asotra
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2017)
Article
Medicine, Research & Experimental
Nitin Mahajan, Veena Dhawan, Safrun Mahmood, Sonal Malik, Sanjay Jain
ARCHIVES OF MEDICAL RESEARCH
(2012)
Letter
Cardiac & Cardiovascular Systems
Nitin Mahajan, Veena Dhawan, Sonal Malik, Sanjay Jain
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2010)
Letter
Cardiac & Cardiovascular Systems
Nitin Mahajan, Veena Dhawan, Sonal Malik, Sanjay Jain
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2010)
Letter
Cardiac & Cardiovascular Systems
Nitin Mahajan, Veena Dhawan
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2012)
Letter
Cardiac & Cardiovascular Systems
Nitin Mahajan, Veena Dhawan
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2013)
Letter
Cardiac & Cardiovascular Systems
Nitin Mahajan, Safrun Mahmood, Sanjay Jain, Veena Dhawan
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2013)
Review
Cardiac & Cardiovascular Systems
Nitin Mahajan, Veena Dhawan
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2013)
Article
Oncology
Yamini Sabherwal, Nitin Mahajan, Donald L. Helseth, Mayumi Gassmann, Heidi Shi, Ming Zhang
INTERNATIONAL JOURNAL OF ONCOLOGY
(2012)
Article
Biochemistry & Molecular Biology
Nitin Mahajan, Heidi Y. Shi, Thomas J. Lukas, Ming Zhang
JOURNAL OF BIOLOGICAL CHEMISTRY
(2013)
Article
Oncology
Yamini Sabherwal, Nitin Mahajan, Ming Zhang
Article
Dermatology
Nitin Mahajan, Divya Kapoor, Dinesh Bisht, Surjit Singh, Ranjana W. Minz, Veena Dhawan
PEDIATRIC DERMATOLOGY
(2013)
Review
Biotechnology & Applied Microbiology
Gang Wu, Nitin Mahajan, Veena Dhawan
BIOMED RESEARCH INTERNATIONAL
(2014)
Meeting Abstract
Medicine, Research & Experimental
Ming Zhang, Nitin Mahajan, Heidi Y. Shi
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2013)