Review
Immunology
Ling-Zhi Hong, Qi Xue, Hong Shao
Summary: Atherosclerosis is linked to inflammation, with inflammatory biomarkers being potential tools for monitoring disease progression. CRP is a common inflammatory marker, while research also suggests other inflammatory factors and genetic polymorphisms are associated with the development of atherosclerosis.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Review
Chemistry, Medicinal
Armita Mahdavi Gorabi, Mitra Abbasifard, Danyal Imani, Saeed Aslani, Bahman Razi, Shahab Alizadeh, Zahra Bagheri-Hosseinabadi, Thozhukat Sathyapalan, Amirhossein Sahebkar
Summary: Curcumin supplementation has been shown to significantly reduce CRP and hs-CRP levels, with a stronger effect observed at doses <= 1,000 mg/day and interventions lasting <= 10 weeks. A non-linear reduction in hs-CRP was seen with curcumin consumption, especially at doses below 2,000 mg/day. Overall, curcumin appears beneficial in decreasing inflammatory markers such as hs-CRP and CRP.
PHYTOTHERAPY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Ali Rafiei, Gordon A. Ferns, Reza Ahmadi, Arsalan Khaledifar, Tina Rahimzadeh-Fallah, Mina Mohmmad-Rezaei, Shohreh Emami, Nader Bagheri
Summary: Atherosclerosis is a chronic inflammatory disease with high mortality worldwide. MiR-27a and miR-329 expression levels, as well as serum levels of hs-CRP, ox-LDL, and MDA, were significantly higher in CAD patients compared to controls, while ABCA1 and ABCG1 gene expression was lower. Levels of hs-CRP, ox-LDL, and miR-27a were inversely related to ABCA1 and ABCG1 expression in all subjects.
Article
Medicine, General & Internal
Manuel Scimeca, Manuela Montanaro, Marina Cardellini, Rita Bonfiglio, Lucia Anemona, Nicoletta Urbano, Elena Bonanno, Rossella Menghini, Viviana Casagrande, Eugenio Martelli, Francesca Servadei, Erica Giacobbi, Arnaldo Ippoliti, Roberto Bei, Vittorio Manzari, Massimo Federici, Orazio Schillaci, Alessandro Mauriello
Summary: The study found that high levels of hs-CRP significantly increase the risk of carotid plaque instability in dyslipidemic patients, particularly in those with high LDL-C. The highest risk was observed in male dyslipidemic patients and in older female patients. These findings suggest a biological relationship between hs-CRP values and lipid metabolism alterations, with potential implications for screening and prevention of atherosclerotic disease.
Article
Neurosciences
Yechuang Wang, Jialin Fu, Fang Liang, Theresa M. Oniffrey, Kai Ding, Jing Zeng, Justin B. Moore, Xianwu Luo, Rui Li
Summary: This study aimed to investigate the associations between baseline high-sensitivity C-reactive protein (Hs-CRP) and its change with subsequent cognitive decline and impairment. Data from a national community-based prospective cohort study were analyzed, including repeated measurements of Hs-CRP level and cognitive function over a 7-year follow-up. The study found that higher baseline Hs-CRP levels and an increase in Hs-CRP were associated with faster cognitive decline and an increased risk of cognitive impairment. These findings suggest that Hs-CRP may serve as a potential predictor for cognitive deterioration in middle-aged and older adults.
Review
Chemistry, Medicinal
Armita Mahdavi Gorabi, Saeed Aslani, Danyal Imani, Bahman Razi, Thozhukat Sathyapalan, Amirhossein Sahebkar
Summary: This meta-analysis demonstrates that resveratrol consumption is effective in lowering CRP and hs-CRP levels in inflammatory conditions, especially if supplementation takes place for >= 10 weeks with >= 500 mg/day.
PHYTOTHERAPY RESEARCH
(2021)
Article
Clinical Neurology
Viktoria L. K. Schaeff, Pia S. Sperber, Sophie K. Piper, Naomi K. Giesers, Karen Gertz, Peter U. Heuschmann, Matthias Endres, Thomas G. Liman
Summary: This study found that elevated levels of high-sensitivity C-reactive protein (hs-CRP) were associated with increased depressive symptoms over time in mild-to-moderate first-ever ischemic stroke patients, particularly in women.
JOURNAL OF NEUROLOGY
(2023)
Article
Nutrition & Dietetics
Claudia Vales-Villamarin, Olaya de Dios, Iris Perez-Nadador, Teresa Gavela-Perez, Leandro Soriano-Guillen, Carmen Garces
Summary: Obesity in childhood is associated with low-grade inflammation, which could be attributed to dysregulation in adipokines secretion. This study aimed to investigate the role of leptin levels in the association between body mass index (BMI) and high-sensitivity C-reactive protein (hs-CRP) in healthy schoolchildren. The study found significant correlations between hs-CRP concentrations, BMI, and leptin levels in prepubertal children and adolescents. However, after adjusting for leptin concentration, the correlation between hs-CRP and BMI was not significant in prepubertal children but remained significant in adolescents. These findings suggest that leptin may play a role in low-grade inflammation in early life, while other factors may contribute to hs-CRP levels later in life.
Article
Chemistry, Medicinal
Elaheh Honarkar Shafie, Fateme Taheri, Neda Alijani, Ahmad Reza Okhovvat, Razieh Goudarzi, Nasrin Borumandnia, Leila Aghaghazvini, Seyed Mahdi Rezayat, Saeidreza Jamalimoghadamsiahkali, Mohammad Javad Hosseinzadeh-Attar
Summary: The study showed that nanocurcumin can significantly increase oxygen saturation, reduce the severity of symptoms, and shorten hospital stay in COVID-19 patients. Nanocurcumin may be used as a complementary agent to accelerate patient recovery.
PHYTOTHERAPY RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Paul M. Haller, Alina Gossling, Christina Magnussen, Hermann Brenner, Ben Schoettker, Licia Iacoviello, Simona Costanzo, Frank Kee, Wolfgang Koenig, Allan Linneberg, Chaterina Sujana, Barbara Thorand, Veikko Salomaa, Teemu J. Niiranen, Stefan Soederberg, Henry Voelzke, Marcus Doerr, Susana Sans, Teresa Padro, Stephan B. Felix, Matthias Nauck, Astrid Petersmann, Luigi Palmieri, Chiara Donfrancesco, Roberto De Ponti, Giovanni Veronesi, Marco M. Ferrario, Kari Kuulasmaa, Tanja Zeller, Francisco M. Ojeda, Stefan Blankenberg, Dirk Westermann
Summary: This study demonstrates the role of cardiac biomarkers in predicting cardiovascular events and death in both general population and individuals with known diabetes. The findings suggest that these biomarkers can help identify individuals at highest risk for cardiovascular events and improve early identification of high-risk individuals. Therefore, they should be considered for routine risk assessment and can enhance the initiation of preventive therapies.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Nutrition & Dietetics
Qianqian Shen, Tingchao He, Ting Li, Ignatius Man-Yau Szeto, Shuai Mao, Wuxian Zhong, Pin Li, Hua Jiang, Yumei Zhang
Summary: This study evaluated the joint effect of overweight/obesity and high HbA1c levels on the risk of elevated hs-CRP levels. The results showed that the presence of overweight/obesity increased the risk of elevated hs-CRP levels in individuals with high HbA1c levels, especially in adults aged 18-44 years and females. Therefore, simultaneous prevention of high blood glucose levels and excessive body weight may play a crucial role in reducing hs-CRP-related diseases.
FRONTIERS IN NUTRITION
(2023)
Review
Immunology
Seyyed Mostafa Arabi, Mahla Chambari, Mahsa Malek-Ahmadi, Leila Sadat Bahrami, Vahid Hadi, Manfredi Rizzo, Amirhossein Sahebkar
Summary: This study conducted a systematic review and meta-analysis to evaluate the effect of statin therapy in combination with ezetimibe on CRP and hs-CRP levels. The results showed that the combination therapy significantly reduced the levels of hs-CRP and overall CRP, suggesting its potential in suppressing inflammation.
INFLAMMOPHARMACOLOGY
(2022)
Article
Pediatrics
Gihan M. Bebars, Asmaa N. Mostafa, Hend M. Moness, Reem A. Abdel Aziz
Summary: Infection is a common problem in diabetic patients, and a study has shown that NGAL and hsCRP can be used to detect early kidney injury in these patients.
Article
Oncology
Yuantian Mao, Jinlu Liu, Jiaming Li, Yue Qiu, Zhen Wang, Bopei Li, Siyu Liu, Lei Tian, Junqiang Chen
Summary: This study investigated the relationship between preoperative serum hs-CRP level and clinicopathological features and nutritional status in gastric cancer (GC) patients. The results showed that hs-CRP level was significantly correlated with age, tumor characteristics, and nutritional parameters. In addition to conventional nutritional evaluation indicators, hs-CRP level may be used as a screening and evaluation indicator for the nutritional status of GC patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Geriatrics & Gerontology
Yen-Chun Fan, Chia-Chi Chou, Bagas Suryo Bintoro, Kuo-Liong Chien, Chyi-Huey Bai
Summary: Chronic inflammation and high levels of glycated hemoglobin are associated with an increased risk of developing all-cause dementia. Future studies should focus on the clinical implementation of inflammation markers and HbA1c to monitor cognitive deficits.
Article
Nutrition & Dietetics
Fuyuko Takahashi, Yoshitaka Hashimoto, Ayumi Kaji, Ryosuke Sakai, Yuka Kawate, Takuro Okamura, Noriyuki Kitagawa, Hiroshi Okada, Naoko Nakanishi, Saori Majima, Takafumi Senmaru, Emi Ushigome, Masahide Hamaguchi, Mai Asano, Masahiro Yamazaki, Michiaki Fukui
Summary: This study revealed that habitual miso consumption was associated with the presence of sarcopenia in women with type 2 diabetes but not in men.
Article
Nutrition & Dietetics
Yoshitaka Hashimoto, Fuyuko Takahashi, Ayumi Kaji, Ryosuke Sakai, Takuro Okamura, Noriyuki Kitagawa, Hiroshi Okada, Naoko Nakanishi, Saori Majima, Takafumi Senmaru, Emi Ushigome, Mai Asano, Masahide Hamaguchi, Masahiro Yamazaki, Michiaki Fukui
Summary: This study aimed to investigate the relationship between eating speed and the presence of sarcopenia in older patients with type 2 diabetes (T2D). The results showed that patients with a slow eating speed had a higher risk of low skeletal muscle mass, low muscle strength, and sarcopenia compared to those with a fast or normal eating speed.
Article
Environmental Sciences
Yuto Saijo, Hiroshi Okada, Masahide Hamaguchi, Momoko Habu, Kazushiro Kurogi, Hiroaki Murata, Masato Ito, Michiaki Fukui
Summary: This study found significant differences in risk factors for developing type 2 diabetes between different BMI categories in a Japanese population. The risk factors were different for individuals with BMI < 22 kg/m(2) compared to those with 22 <= BMI < 25 kg/m(2) or BMI >= 25 kg/m(2).
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Keiko Iwai, Emi Ushigome, Kazufumi Okada, Isao Yokota, Saori Majima, Naoko Nakanishi, Yoshitaka Hashimoto, Hiroshi Okada, Takafumi Senmaru, Masahide Hamaguchi, Mai Asano, Masahiro Yamazaki, Michiaki Fukui
Summary: This study aimed to investigate the effects of aerobic exercise on home blood pressure in patients with diabetes. The results showed that moderate aerobic exercise was not effective in lowering nocturnal blood pressure.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Takuro Okamura, Masahide Hamaguchi, Jun Mori, Mihoko Yamaguchi, Katsura Mizushima, Aya Abe, Makoto Ozeki, Ryoichi Sasano, Yuji Naito, Michiaki Fukui
Summary: This study investigated the potential therapeutic effect of dietary supplementation with PHGG against sarcopenic obesity using Db/Db mice. The results showed that PHGG could increase grip strength and skeletal muscle weight, as well as increase the concentration of short-chain fatty acids in feces and sera. PHGG also exhibited anti-inflammatory effects in the small intestine, indicating its preventive role in sarcopenic obesity.
Article
Medicine, General & Internal
Yusuke Mineoka, Michiyo Ishii, Yoshitaka Hashimoto, Aki Yamashita, Takahiro Takemura, Sachiyo Yamaguchi, Machiko Toyoda, Michiaki Fukui
Summary: Our study found a significant relationship between nutritional status and foot risk in patients with type 2 diabetes, especially in older patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Fuyuko Takahashi, Yoshitaka Hashimoto, Yukiko Kobayashi, Ayumi Kaji, Ryosuke Sakai, Takuro Okamura, Naoko Nakanishi, Saori Majima, Hiroshi Okada, Takafumi Senmaru, Emi Ushigome, Mai Asano, Masahide Hamaguchi, Masahiro Yamazaki, Wataru Aoi, Masashi Kuwahata, Michiaki Fukui
Summary: This study showed that household income was related to dietary fiber intake and dietary acid load in men but not in women.
Article
Nutrition & Dietetics
Ayasa Nitta, Saeko Imai, Shizuo Kajiayama, Mikuko Matsuda, Takashi Miyawaki, Shinya Matsumoto, Shintaro Kajiyama, Yoshitaka Hashimoto, Neiko Ozasa, Michiaki Fukui
Summary: This study aimed to evaluate the effect of dietitian-led medical nutrition therapy on glycemic control in patients with type 2 diabetes. The results showed that patients in the intervention group had a significant improvement in glycemic control after 5 years, compared to the control group. Additionally, dietary intake in the intervention group also showed improvement.
Article
Nutrition & Dietetics
Shinnosuke Hata, Takuro Okamura, Ayaka Kobayashi, Ryo Bamba, Tomoki Miyoshi, Hanako Nakajima, Nobuko Kitagawa, Yoshitaka Hashimoto, Saori Majima, Takafumi Senmaru, Hiroshi Okada, Emi Ushigome, Naoko Nakanishi, Hiroshi Takakuwa, Ryoichi Sasano, Masahide Hamaguchi, Michiaki Fukui
Summary: This study compared the effects of luseogliflozin and a low-carbohydrate diet on sarcopenic obesity. The results showed that luseogliflozin could prevent sarcopenic obesity by improving amino acid metabolism.
Article
Nutrition & Dietetics
Hiroyuki Tominaga, Masahide Hamaguchi, Shinto Ando, Megumi Minamida, Yuriko Kondo, Kazuki Hamada, Tetsuya Nojiri, Michiaki Fukui
Summary: The study found that individuals with type 2 diabetes preferred to choose lower-carbohydrate and lower-calorie food menus at home using online diet management applications. This preference could help improve sustained self-management and quality of life.
Article
Nutrition & Dietetics
Yuriko Kondo, Yoshitaka Hashimoto, Masahide Hamaguchi, Ayumi Kaji, Ryosuke Sakai, Ryo Inoue, Saori Kashiwagi, Katsura Mizushima, Kazuhiko Uchiyama, Tomohisa Takagi, Yuji Naito, Michiaki Fukui
Summary: This study examines the association between smoking and gut microbiota, taking into account the impact of smoking on dietary intake. The results show that smoking is associated with both dietary intake and the composition of the gut microbiota.
Article
Nutrition & Dietetics
Hanako Nakajima, Hiroshi Okada, Ayaka Kobayashi, Fuyuko Takahashi, Takuro Okamura, Yoshitaka Hashimoto, Naoko Nakanishi, Takafumi Senmaru, Emi Ushigome, Masahide Hamaguchi, Michiaki Fukui
Summary: This study aimed to identify the serum metabolites associated with sarcopenic risk in Japanese patients with type 2 diabetes. The relationship between dietary protein intake and the metabolites concerning sarcopenia was analyzed, and the factors affecting sarcopenic risk were clarified. Leucine and glutamic acid were found to be useful biomarkers for sarcopenia.
Article
Nutrition & Dietetics
Saeko Imai, Shizuo Kajiyama, Kaoru Kitta, Takashi Miyawaki, Shinya Matsumoto, Neiko Ozasa, Shintaro Kajiyama, Yoshitaka Hashimoto, Michiaki Fukui
Summary: People with fast eating habits have an increased risk of diabetes and obesity. A study found that consuming vegetables first, regardless of eating speed, can improve postprandial blood glucose and insulin levels. Compared to consuming carbohydrates first, the food order of vegetables first resulted in significantly lower standard deviation, large amplitude of excursion, and incremental area under the curve for blood glucose and insulin.
Article
Medicine, General & Internal
Shinnosuke Hata, Mai Asano, Hiroyuki Tominaga, Masahide Hamaguchi, Fumiya Hongo, Takeshi Usui, Eiichi Konishi, Michiaki Fukui
Summary: Recently, there has been rapid progress in uncovering the genetic background of pheochromocytomas/paragangliomas (PPGLs). These tumors, previously known as the ten percent tumor, are now found to have a higher frequency of genetic variants than expected. This report presents a case of bilateral pheochromocytoma with a variant in the MYC-associated factor X (MAX) gene.
CLINICS AND PRACTICE
(2022)
Article
Medicine, General & Internal
Chihiro Munekawa, Yoshitaka Hashimoto, Noriyuki Kitagawa, Takafumi Osaka, Masahide Hamaguchi, Michiaki Fukui
Summary: Teriparatide was shown to have a positive effect on bone mineral density and trabecular bone score in osteoporosis patients with type 2 diabetes mellitus, compared to bisphosphonates and no medication.
MEDICINA-LITHUANIA
(2022)
