Review
Biology
Cameron D. Haydinger, Liam M. Ashander, Alwin Chun Rong Tan, Justine R. Smith
Summary: Intercellular adhesion molecule 1 (ICAM-1) is a transmembrane protein that plays important roles in the immune system and is involved in various diseases. It mediates cellular adhesive interactions and is upregulated in inflammation. This review provides a comprehensive summary of the structure and regulation of ICAM1 gene and the ICAM-1 protein, discusses its functions in the immune system and diseases, and explores current therapeutics and future advancements.
Article
Oncology
Bing Zhu, Xinyan Wang, Takaya Shimura, Andrew C. Huang, Nana Kong, Yujie Dai, Jianmin Fang, Peng Guo, Jie-Er Ying
Summary: This preclinical study reports two effective targeted therapeutics for the treatment of cholangiocarcinoma. By conjugating ICAM1 antibodies with different cytotoxic payloads, tumor growth was successfully attenuated. This study paves the road for developing a promising targeted therapeutic candidate for clinical treatment of cholangiocarcinoma.
NPJ PRECISION ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Dicky L. Tahapary, Tasykuru Rizqa, Cut Vania Syarira, Lusiani Lusiani, Aulia Rizka, Syahidatul Wafa, Wismandari Wisnu, Tri Juli Edi Tarigan, Dante Saksono Harbuwono
Summary: This study aimed to determine the changes in ICAM-1 levels in patients with type 2 diabetes mellitus (T2DM) and non-DM patients during Ramadan fasting. The results showed that both T2DM and non-DM patients had a significant decrease in ICAM-1 levels after Ramadan fasting, but only non-DM patients had a significantly lower post-Ramadan ICAM-1 level.
Article
Multidisciplinary Sciences
Akira Sakamoto, Hiroyuki Inoue, Shohei Miyamoto, Shun Ito, Yasushi Soda, Kenzaburo Tani
Summary: Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related deaths globally. This study highlights the potential of oncolytic virotherapy using coxsackievirus A11 (CVA11) as a less toxic and more effective treatment for NSCLC. CVA11 infection showed extensive oncolytic activity in human NSCLC cell lines and induced immunogenic cell death. In vivo experiments also demonstrated complete tumor regression without significant weight loss. Further investigation in clinical trials, especially in combination with immunotherapy, is warranted.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Xiang Shu, Qin Zhou, Xiaohui Sun, Michelle Flesaker, Xingyi Guo, Jirong Long, Mark E. Robson, Xiao-Ou Shu, Wei Zheng, Jonine L. Bernstein
Summary: This study identified 98 proteins that may have potential causal associations with the risk of breast cancer subtypes. The associations of ICAM1, PLA2R1, and TXNDC12 varied significantly across the subtypes. These findings contribute to understanding the heterogeneity in the etiology of different subtypes of breast cancer and may aid in personalized risk assessment of the disease.
BRITISH JOURNAL OF CANCER
(2022)
Article
Endocrinology & Metabolism
Emma M. Lessieur, Haitao Liu, Aicha Saadane, Yunpeng Du, Jianying Kiser, Timothy S. Kern
Summary: This study found that the diabetes-induced upregulation of ICAM-1 on the luminal surface of vascular endothelium varies considerably among tissues and is highest in the retina. The induction of ICAM-1 on retinal vascular endothelial cells in diabetes is influenced by vision-related processes in photoreceptor cells. The unique presence of photoreceptors in the retina might contribute to the greater susceptibility of this tissue to vascular disease in diabetes.
Article
Cardiac & Cardiovascular Systems
Pedro Giro, Jonathan w. Cunningham, Laura Rasmussen-torvik, Suzette j. Bielinski, Nicholas b. Larson, Laura a. Colangelo, David r. Jacobs Jr, Myron Gross, Alex p. Reiner, Donald m. Lloyd-jones, Xiuqing Guo, Kent Taylor, Muthiah Vaduganathan, Wendy s. Post, Alain Bertoni, Christie Ballantyne, Amil Shah, Brian Claggett, Eric Boerwinkle, Bing Yu, Scott d. Solomon, Sanjiv j. Shah, Ravi b. Patel
Summary: ICAM-1 genetic variants are associated with circulating ICAM-1 levels and incident heart failure.
JOURNAL OF CARDIAC FAILURE
(2023)
Article
Immunology
Mona Singh, Mony Thakur, Manish Mishra, Manisha Yadav, Rajkamal Vibhuti, Athira M. Menon, Girima Nagda, Ved Prakash Dwivedi, Tikam Chand Dakal, Vinod Yadav
Summary: ICAM-1 is a key inducible cell adhesion molecule involved in immune functions, with its expression regulated by various inflammatory mediators such as transcription factors and signaling pathways. Transcriptional regulation and epigenetic modifications play important roles in controlling ICAM-1 expression.
IMMUNOLOGY LETTERS
(2021)
Article
Cell Biology
Eun-Ji Lim, Jae-Hyeok Kang, Yeon-Ju Kim, Seungmo Kim, Su-Jae Lee
Summary: ICAM-1 is a potential therapeutic target for colorectal cancer (CRC) that enhances treatment effectiveness by promoting the c-MET-SRC signaling axis. Treatment with antibodies targeting ICAM-1 can reduce metastasis and angiogenesis in CRC.
CELL DEATH & DISEASE
(2022)
Article
Biology
R. M. Hashem, L. A. Rashed, R. M. Abdelkader, K. S. Hashem
Summary: The study demonstrated that MSCs therapy effectively replaced neointimal SMCs and reduced adhesion molecules, oxidative stress, and inflammatory markers in atherosclerosis, as evidenced by histopathological and biochemical analyses. Resveratrol was used as a benchmark to evaluate the efficacy of stem cell therapy, showing significant improvements in the experimental model of atherosclerosis.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2021)
Article
Ophthalmology
Natalia I. Khramenko, Natalia V. Konovalova, Volodymyr Ya. Usov, Liudmyla M. Velychko, Olexandra V. Bogdanova
Summary: The parameters of the T-cell link of the immune response and the parameters of humoral immunity were different between patients with uncomplicated recurrent anterior uveitis (AU) and those with recurrent AU complicated by uveitic macular edema (UME). The patients with UME had increased T-cell immune response parameters and decreased humoral immunity parameters. The relative numbers of natural killer cells and phagocytic neutrophils were also different between the two groups. The expression levels of ICAM-1 and CD5 seem to play a role in uveitic macular edema.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Cell Biology
Shan Huang, Tinghui Shao, Hong Liu, Qianyun Wang, Tianfa Li, Qianwen Zhao
Summary: The findings of this study demonstrate that oxidized low-density lipoprotein (oxLDL) activates the transcription of adhesion molecules in endothelial cells and leads to dynamic changes in the acetylation of myocardin-related transcription factor A (MRTF-A). The acetylation status of MRTF-A appears to be sensitive to cellular redox status, as treatment with the antioxidant NAC reduces its acetylation. Silencing of the lysine deacetylase SIRT6 restores MRTF-A acetylation despite NAC treatment, suggesting that SIRT6 plays a role in modulating MRTF-A acetylation. SIRT6 interacts with MRTF-A and promotes its deacetylation, leading to its expulsion from the nucleus and reduced occupancy on the ICAM-1 promoter. Furthermore, SIRT6 expression is downregulated with oxLDL stimulation due to promoter hypermethylation mediated by DNA methyltransferase 1 (DNMT1), which is recruited to the SIRT6 promoter and represses its expression. The ability of DNMT1 to repress SIRT6 expression is partly dependent on ROS-sensitive serine 154 phosphorylation.
CELL DEATH DISCOVERY
(2022)
Article
Neurosciences
Jonathan D. Drake, Alison B. Chambers, Brian R. Ott, Lori A. Daiello
Summary: The study found that plasma-based vascular biomarkers, particularly VCAM-1 and ICAM-1, were associated with Alzheimer's disease (AD) and clinical impairment. VCAM-1 was linked with clinical dementia rating sum-of-boxes (CDR-SB) scores, with the APOE epsilon 4 genotype modifying this relationship. Additionally, combining VCAM-1 and cerebrospinal fluid (CSF) biomarkers showed independent associations with AD-related clinical impairment.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Medicine, General & Internal
Chiung-Jung Wen, Chin-Hao Chang, Chin-Ying Chen, Jen-Kuei Peng, Hsien-Liang Huang, Pei-Ni Chuang, Ching-Yu Chen, Jaw-Shiun Tsai
Summary: The study found that the mRNA levels of ICAM-1 and TLR4 in PBMCs are significantly higher in older adults compared to younger adults. TLR4 is an independent factor affecting the expression of ICAM-1 in PBMCs. This suggests that ICAM-1 and TLR4 in PBMCs could be potential biomarkers for the ageing process.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Biotechnology & Applied Microbiology
Qian Zhang, Wei Zhang, Jing Liu, Haisen Yang, Yuxia Hu, Mengdi Zhang, Tuya Bai, Fuhou Chang
Summary: The study investigated the regulatory role of LPC on endothelial cell adhesion marker expression, suggesting that the LPC-G2A-ICAM-1/VCAM-1 pathway may contribute to atherogenic activity of oxLDL, with NF-kappa B antagonists potentially serving as effective therapeutic tools for cardiovascular diseases.
Article
Endocrinology & Metabolism
Carolina G. Downie, Sofia F. Dimos, Stephanie A. Bien, Yao Hu, Burcu F. Darst, Linda M. Polfus, Yujie Wang, Genevieve L. Wojcik, Ran Tao, Laura M. Raffield, Nicole D. Armstrong, Hannah G. Polikowsky, Jennifer E. Below, Adolfo Correa, Marguerite R. Irvin, Laura J. F. Rasmussen-Torvik, Christopher S. Carlson, Lawrence S. Phillips, Simin Liu, James S. Pankow, Stephen S. Rich, Jerome Rotter, Steven Buyske, Tara C. Matise, Kari E. North, Christy L. Avery, Christopher A. Haiman, Ruth J. F. Loos, Charles Kooperberg, Mariaelisa Graff, Heather M. Highland
Summary: The study investigated the genetic basis of fasting glucose, fasting insulin, and HbA(1c) in participants from diverse backgrounds, identifying novel associations and highlighting the importance of conducting genetic studies in diverse populations.
Article
Dentistry, Oral Surgery & Medicine
Hamdi S. Adam, Kamakshi Lakshminarayan, Wendy Wang, Faye L. Norby, Thomas Mosley, Keenan A. Walker, Rebecca F. Gottesman, Katie Meyer, Timothy M. Hughes, James S. Pankow, Dean F. Wong, Clifford R. Jack, Souvik Sen, Pamela L. Lutsey, Jim Beck, Ryan T. Demmer
Summary: This study investigates the relationship between periodontal disease and cerebrovascular and neurodegenerative markers of dementia and Alzheimer's pathology. The results suggest that periodontal disease is not associated with altered brain volumes, microhaemorrhages, or beta-amyloid positivity. However, tooth loss is associated with lower odds of cerebral infarcts.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)
Article
Health Care Sciences & Services
Sungrim Moon, Luke A. Carlson, Ethan D. Moser, Bhavani Singh Agnikula Kshatriya, Carin Y. Smith, Walter A. Rocca, Liliana Gazzuola Rocca, Suzette J. Bielinski, Hongfang Liu, Nicholas B. Larson
Summary: This study compares the gynecological surgical history extracted from an EHR using natural language processing techniques with manually curated surgical history information. The study finds that missing or inaccurately reported and recorded information contributes to the misclassification of surgical status.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Pathology
Jaime L. Lopes, Kimberley Harris, Mary Beth Karow, Sandra E. Peterson, Michelle L. Kluge, Katrina E. Kotzer, Guilherme S. Lopes, Nicholas B. Larson, Suzette J. Bielinski, Steven E. Scherer, Liewei Wang, Richard M. Weinshilboum, John L. Black, Ann M. Moyer
Summary: Clinical pharmacogenomic testing typically uses targeted genotyping, but sequencing is necessary to detect rare variants that cannot be detected by targeted genotyping.
JOURNAL OF MOLECULAR DIAGNOSTICS
(2022)
Article
Geriatrics & Gerontology
Jingzhong Ding, Kurt Lohman, Anthony Molina, Osvaldo Delbono, Alain Bertoni, Steven Shea, Wendy Post, Xiuqing Guo, R. Graham Barr, Ani W. Manichaikul, James S. Pankow, Jerome Rotter, Ina Hoeschele, Stephen B. Kritchevsky, Yongmei Liu
Summary: Translating our knowledge of biological aging from animals to humans can lead to new approaches for targeting multiple aging-related diseases and increasing health span. This study used transcriptomic signatures of monocytes to identify aging pathways underlying multiple aging-related diseases in humans for the first time.
Article
Cardiac & Cardiovascular Systems
Florian Thibord, Derek Klarin, Jennifer A. Brody, Ming-Huei Chen, Michael G. Levin, Daniel Chasman, Ellen L. Goode, Kristian Hveem, Maris Teder-Laving, Angel Martinez-Perez, Dylan Aissi, Delphine Daian-Bacq, Kaoru Ito, Pradeep Natarajan, Pamela L. Lutsey, Girish N. Nadkarni, Paul S. de Vries, Gabriel Cuellar-Partida, Brooke N. Wolford, Jack W. Pattee, Charles Kooperberg, Sigrid K. Braekkan, Ruifang Li-Gao, Noemie Saut, Corriene Sept, Marine Germain, Renae L. Judy, Kerri L. Wiggins, Darae Ko, Christopher J. O'Donnell, Kent D. Taylor, Franco Giulianini, Mariza De Andrade, Therese H. Nost, Anne Boland, Jean-Philippe Empana, Satoshi Koyama, Thomas Gilliland, Ron Do, Jennifer E. Huffman, Xin Wang, Wei Zhou, Jose Manuel Soria, Juan Carlos Souto, Nathan Pankratz, Jeffery Haessler, Kristian Hindberg, Frits R. Rosendaal, Constance Turman, Robert Olaso, Rachel L. Kember, Traci M. Bartz, Julie A. Lynch, Susan R. Heckbert, Sebastian M. Armasu, Ben Brumpton, David M. Smadja, Xavier Jouven, Issei Komuro, Katharine R. Clapham, Ruth J. F. Loos, Cristen J. Willer, Maria Sabater-Lleal, James S. Pankow, Alexander P. Reiner, Vania M. Morelli, Paul M. Ridker, Astrid van Hylckama Vlieg, Jean-Francois Deleuze, Peter Kraft, Daniel J. Rader, Kyung Min Lee, Bruce M. Psaty, Anne Heidi Skogholt, Joseph Emmerich, Pierre Suchon, Stephen S. Rich, Ha My T. Vy, Weihong Tang, Rebecca D. Jackson, John-Bjarne Hansen, Pierre-Emmanuel Morange, Christopher Kabrhel, David-Alexandre Tregouet, Scott M. Damrauer, Andrew D. Johnson, Nicholas L. Smith
Summary: This study identified new genetic loci associated with VTE by using cross-ancestry genomic resources. The findings highlight new pathways to thrombosis and provide novel molecules that may be useful in the development of improved antithrombosis treatments.
Article
Endocrinology & Metabolism
Brian T. Steffen, Weihong Tang, Pamela L. Lutsey, Ryan T. Demmer, Elizabeth Selvin, Kunihiro Matsushita, Alanna C. Morrison, Weihua Guan, Mary R. Rooney, Faye L. Norby, Nathan Pankratz, David Couper, James S. Pankow
Summary: Proteomics analysis identified plasma proteins associated with the risk of type 2 diabetes. These proteins may serve as potential targets for intervention or pharmacological approaches to prevent, reverse, or slow down the progression of type 2 diabetes.
Article
Geriatrics & Gerontology
Pablo Martinez-Amezcua, Emmanuel Garcia Morales, Kelley P. Gabriel, Erin E. Dooley, Bjoern Hornikel, Josef Coresh, Frank R. Lin, James S. Pankow, A. Richey Sharrett, Jennifer A. Schrack, Kevin J. Sullivan, Nicholas Reed, Jennifer A. Deal, Priya Palta
Summary: This study examines the association between midlife leisure-time physical activity and hearing loss in older ages. Results show that meeting physical activity recommendations during midlife is associated with better hearing and reduced risk of hearing loss in older ages.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Medicine, General & Internal
Sheila M. Manemann, Alanna M. Chamberlain, Suzette J. Bielinski, Ruoxiang Jiang, Susan A. Weston, Veronique L. Roger
Summary: The predictive ability of the Framingham Heart Study Dementia Risk Score (FDRS) was evaluated in heart failure and atrial fibrillation patients, and the addition of comorbidities and risk factors to improve risk prediction for AD/ADRD was explored. The FDRS variables performed well in predicting AD/ADRD in both populations, and the addition of comorbidities and risk factors slightly improved the performance.
AMERICAN JOURNAL OF MEDICINE
(2023)
Article
Hematology
Brian T. Steffen, James S. Pankow, Faye L. Norby, Pamela L. Lutsey, Ryan T. Demmer, Weihua Guan, Nathan Pankratz, Aixin Li, Guning Liu, Kunihiro Matsushita, Adrienne Tin, Weihong Tang
Summary: This study identified proteomic signatures and pathways related to 23 gene loci associated with abdominal aortic aneurysm (AAA). The results suggest that low levels of neogenin and kit ligand may be novel risk factors for AAA development.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Endocrinology & Metabolism
Suzette J. Bielinski, Licy L. Yanes Cardozo, Paul Y. Takahashi, Nicholas B. Larson, Alexandra Castillo, Alana Podwika, Eleanna De Filippis, Valentina Hernandez, Gouri J. Mahajan, Crystal Gonzalez, Shubhangi, Paul A. Decker, Jill M. Killian, Janet E. Olson, Jennifer L. St Sauver, Pankaj Shah, Adrian Vella, Euijung Ryu, Hongfang Liu, Gailen D. Marshall, James R. Cerhan, Davinder Singh, Richard L. Summers
Summary: Demographic and clinical factors available in the electronic health record (EHR) can predict metformin failure. Baseline HbA1c is the strongest predictor, and the addition of other clinical factors improves the predictive model's performance.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Biochemical Research Methods
Bruno Bohn, Pamela L. Lutsey, Weihong Tang, James S. Pankow, Faye L. Norby, Bing Yu, Christie M. Ballantyne, Eric A. Whitsel, Kunihiro Matsushita, Ryan T. Demmer
Summary: This study compared the proteome of statin users and nonusers and found differences in proteins unrelated to lipid metabolism. Further investigation into these differences may help elucidate the pleiotropic effects of statins.
JOURNAL OF PROTEOMICS
(2023)
Article
Multidisciplinary Sciences
Konrad Teodor Sawicki, Drew R. Nannini, Suzette J. Bielinski, Nicholas B. Larson, Donald M. Lloyd-Jones, Bruce Psaty, Kent D. Taylor, Sanjiv J. Shah, Laura J. Rasmussen-Torvik, John T. Wilkins, Elizabeth M. McNally, Ravi B. Patel
Summary: Circulating protease inhibitors play a critical role in regulating inflammation and are related to the development of heart failure (HF). In this study, the researchers investigated the association between circulating secretory leukocyte protease inhibitor (SLPI) and incident HF in a multi-ethnic cohort. The results showed that higher baseline serum SLPI levels were independently associated with incident HF and HFpEF, but not HFrEF, over long-term follow-up. This suggests that serum SLPI may be a biomarker for inflammation and provides insights into the pathobiology of HFpEF.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Kathryn Recto, Priyadarshini Kachroo, Tianxiao Huan, David Van Den Berg, Gha Young Lee, Helena Bui, Dong Heon Lee, Jessica Gereige, Chen Yao, Shih-Jen Hwang, Roby Joehanes, George T. O'Cornor, Daniel Levy, Dawn L. DeMeo
Summary: By integrating eQTM and MR analyses in general and clinical asthma populations, our findings provide a deeper understanding of the multidimensional inter-relations of DNA methylation, gene expression, and IgE levels. We identified differentially methylated CpGs associated with IgE levels and replicated them in other populations. We also identified biological pathways related to IgE regulation and proposed CTSB and USP20 as potential therapeutic targets for IgE levels.
Article
Geriatrics & Gerontology
Jacob D. Negrey, Brett M. Frye, Suzanne Craft, Thomas C. Register, Mark G. Baxter, Matthew J. Jorgensen, Carol A. Shively
Summary: This study examined the age-related associations between social interactions, activity patterns, and cognitive function in female vervet monkeys. The results showed that time spent in affiliative behavior and grooming others decreased with age, while time spent alone increased. The number of social partners for grooming also decreased. Grooming patterns mirrored physical activity levels, and cognitive performance partially mediated the relationship between age and grooming time. These findings suggest that aging vervet monkeys engage less in social behavior, potentially due to cognitive deficits.
