Article
Medicine, Research & Experimental
Samar A. Antar, Walied Abdo, Reda S. Taha, Amira E. Farage, Laila E. El-Moselhy, Mohamed E. Amer, Ahmed S. Abdel Monsef, Amer M. Abdel Hamid, Emadeldin M. Kamel, Ahmad F. Ahmeda, Ayman M. Mahmoud
Summary: This study found that telmisartan has a protective effect on renal damage in diabetic rats, reducing hyperglycemia, oxidative stress, inflammation, apoptosis, and angiogenesis. It achieves this protective effect by upregulating the Nrf2/HO-1 signaling pathway.
Article
Cardiac & Cardiovascular Systems
Yahya M. Naguib, Rehab M. Samaka, Mohamed S. Rizk, Omnia Ameen, Shaimaa M. Motawea
Summary: The prevalence of hypertension and obesity has been increasing in recent decades, and they are associated with increased cardiovascular mortality. Telmisartan not only has an anti-hypertensive effect, but also shows profound actions on visceral adipose tissue structure and function in obesity-related hypertension. Targeting polymodal molecules that focus on adipose tissue-related disorders should receive more attention.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Environmental Sciences
Hassan Ahmed, Karima A. Bakry, Ahmed Abdeen, Halla E. K. El Bahgy, Mohamed Abdo, Florin Imbrea, Liana Fericean, Mona A. Elshemy, Samah F. Ibrahim, Mustafa Shukry, Samar H. Baloza, Walaa F. A. Emeish
Summary: This study investigates the molecular mechanisms underlying the response to salinity stress in common carp. The results demonstrate that high salinity adversely affects biochemical markers and modulates the expression of immune, endocrine, and neural-related genes in different organs.
FRONTIERS IN MARINE SCIENCE
(2023)
Article
Clinical Neurology
Pengyue Zhang, Yuan Hou, Wanzhu Tu, Noll Campbell, Andrew A. Pieper, James B. Leverenz, Sujuan Gao, Jeffrey Cummings, Feixiong Cheng
Summary: The study found that moderate to high exposure to telmisartan was significantly associated with a reduced incidence of Alzheimer's disease in African Americans, but not in non-Hispanic European Americans. The medication possession ratio and average hypertension daily dosage of telmisartan were significantly associated with a stronger reduction in the incidence of both Alzheimer's disease and dementia in African Americans.
ALZHEIMERS & DEMENTIA
(2023)
Article
Cell Biology
Meenakshi Tiwary, Robert J. Rooney, Swantje Liedmann, Kim S. LeMessurier, Amali E. Samarasinghe
Summary: Eosinophils play an important role in providing immediate protection during early phase of influenza infection by neutralizing virus and promoting barrier responses to improve antiviral defenses in airway epithelial cells.
Article
Cell Biology
Maciej Gagat, Wioletta Zielinska, Klaudia Mikolajczyk, Jan Zabrzynski, Adrian Krajewski, Anna Klimaszewska-Wisniewska, Dariusz Grzanka, Alina Grzanka
Summary: TNF alpha plays a role in activating endothelial cells and reorganizing the actin cytoskeleton to facilitate cell migration. The activation of TPM1 gene can stabilize the actin cytoskeleton, inhibit inflammatory response, and maintain stable cell-cell junctions in endothelial cells. This approach may serve as a potential therapeutic target for treating proinflammatory vascular disorders.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Xiangwen Liang, Ping Li, Wenchao Xie, Zhihai Lin, Zhengdong Wang, Shuyi Zeng, Ming Liu
Summary: This study demonstrates that febuxostat has a protective effect on endothelial dysfunction by reducing oxidative stress, inflammation, and monocyte attachment induced by ox-LDL stimulation.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Cristhianne Molinero Ratkevicius Andrade, Aline Caroline de Lima Marques, Rodolfo Pessato Timoteo, Ana Carolina de Morais Oliveira-Scussel, Fernanda Bernadelli De Vito, Marcos Vinicius da Silva, Jose Roberto Mineo, Reginaldo Botelho Teodoro, Denise Bertulucci Rocha Rodrigues, Virmondes Rodrigues Junior
Summary: This study found that the use of TNF-a blockers does not increase the risk of toxoplasmosis reactivation.
Article
Biochemistry & Molecular Biology
Jamel Corredores, Brice Vofo, Radgonde Amer
Summary: This retrospective study evaluated the medium and long-term effects of TNF-alpha inhibitors on pediatric uveitis. The results showed that TNF-alpha inhibitors effectively controlled the disease progression and reduced the need for steroids in children with chronic uveitis. Furthermore, the initial visual acuity was found to be a significant predictor for moderate to severe visual loss.
Article
Environmental Sciences
Mine Kokturk
Summary: Dyes have adverse effects on the aquatic environment and aquatic life, but limited research has been done on their toxic properties. This study found that the textile dye RG-GR has sublethal toxicity on zebrafish embryos and larvae, affecting their morphological development and biochemical parameters.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Pharmacology & Pharmacy
Georgi Tchernev, Ani Bitolska, James W. Patterson
Summary: The known connections between sartans and melanoma are growing in clinical field, with evidence suggesting a significant relationship between these concepts. Experimental studies and clinical cases have shown the influence and potential carcinogenic effects of sartans on melanoma development. The multifactorial pathogenesis of melanoma requires further research and investigation.
EXPERT REVIEW OF CLINICAL PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Sophie F. F. Ellermann, Rianne M. M. Jongman, Matthijs Luxen, Timara Kuiper, Josee Plantinga, Jill Moser, Thomas W. L. Scheeren, Gregor Theilmeier, Grietje Molema, Matijs Van Meurs
Summary: Major surgery induces systemic inflammation and pro-inflammatory activation of endothelial cells, leading to postoperative organ damage. This study identifies activated kinases as potential therapeutic targets to interfere with excessive endothelial inflammation. Pharmacological inhibition of Axl and Fyn, two selected kinases, reduces TNF-alpha-induced endothelial inflammation in vitro.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Xiuying Zhang, Yanfeng Dong, Hanyu Dong, Yanhui Cui, Qing Du, Xiaoli Wang, Lanlan Li, Hongju Zhang
Summary: The study showed that Telmisartan attenuated oxidative stress induced by TNF-α and inhibited the expression and secretion of proinflammatory mediators. It also rescued the reduction of type II collagen levels caused by TNF-α, making it a potential agent for the treatment of OA.
Article
Biochemistry & Molecular Biology
Michael Birk, Ewa Baum, Jenia Kouchek Zadeh, Caroline Manicam, Norbert Pfeiffer, Andreas Patzak, Johanna Helmstaedter, Sebastian Steven, Marin Kuntic, Andreas Daiber, Adrian Gericke
Summary: The study found that Ang II may induce endothelial dysfunction in mouse ophthalmic arteries via AT1R activation and NOX2-dependent ROS formation. Blocking AT1R signaling and/or NOX2 may be helpful in maintaining or restoring endothelial function in ocular blood vessels in certain ocular diseases.
Article
Biochemistry & Molecular Biology
Taiki Tojo, Minako Yamaoka-Tojo
Summary: This study investigated the molecular and cellular mechanisms underlying stenotic calcification of the aortic valve. Gene expression analysis of human aortic stenosis and normal aortic valve tissue identified differentially expressed genes (DEGs) associated with valve calcification and disease progression. Protein-protein interaction analysis revealed hub genes that could serve as potential biomarkers and therapeutic targets for aortic stenosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemical Research Methods
Denise Biagini, Jonathan Fusi, Annasilvia Vezzosi, Paolo Oliveri, Silvia Ghimenti, Alessio Lenzi, Pietro Salvo, Simona Daniele, Giorgia Scarfo, Federico Vivaldi, Andrea Bonini, Claudia Martini, Ferdinando Franzoni, Fabio Di Francesco, Tommaso Lomonaco
Summary: The composition of exhaled breath is influenced by various factors and it is difficult to identify specific biomarkers or differentiate between healthy and pathological subjects. This study compared the breath composition of individuals following vegan and Mediterranean omnivorous diets, and found that differences in compound profiles can distinguish between different dietary groups.
JOURNAL OF BREATH RESEARCH
(2022)
Article
Geriatrics & Gerontology
Maria Giulia Bacalini, Flavia Palombo, Paolo Garagnani, Cristina Giuliani, Claudio Fiorini, Leonardo Caporali, Michelangelo Stanzani Maserati, Sabina Capellari, Martina Romagnoli, Sara De Fanti, Luisa Benussi, Giuliano Binetti, Roberta Ghidoni, Daniela Galimberti, Elio Scarpini, Marina Arcaro, Enrica Bonanni, Gabriele Siciliano, Michelangelo Maestri, Biancamaria Guarnieri, Morena Martucci, Daniela Monti, Valerio Carelli, Claudio Franceschi, Chiara La Morgia, Aurelia Santoro
Summary: Many physiological processes in the human body follow a 24-hour circadian rhythm controlled by the circadian clock system. Light is a predominant zeitgeber that synchronizes circadian rhythms to light-dark cycles. This study found a significant association between the rs3027178 polymorphism in the PER1 circadian gene and Alzheimer's disease, with the G allele being protective, highlighting the relevance of circadian dysfunction in predisposition to AD and contributing to the discussion on the genetics of age-related diseases and longevity.
Meeting Abstract
Cardiac & Cardiovascular Systems
D. Acierno, G. Scarfo, F. Franzoni, M. Miniati, G. Perugi
EUROPEAN HEART JOURNAL SUPPLEMENTS
(2022)
Article
Medicine, General & Internal
Vito Cela, Simona Daniele, Maria Elena Rosa Obino, Maria Ruggiero, Elisa Zappelli, Lorenzo Ceccarelli, Francesca Papini, Ilaria Marzi, Giorgia Scarfo, Fulvia Tosi, Ferdinando Franzoni, Claudia Martini, Paolo Giovanni Artini
Summary: This cohort study outlines the relationship between endometrial microbiota, inflammation, and in vitro fertilization (IVF) outcomes. Endometrial dysbiosis was found to be associated with inflammation-related changes in the endometrium, which may impair the process of embryo implantation. Assessing uterine microbiota is crucial for patients undergoing IVF treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Giorgia Scarfo, Simona Daniele, Jonathan Fusi, Marco Gesi, Claudia Martini, Ferdinando Franzoni, Vito Cela, Paolo Giovanni Artini
Summary: Polycystic ovary syndrome (PCOS) is an endocrine systemic disorder characterized by hormonal and metabolic imbalances, leading to ovulation disorders, increased androgen levels, and the formation of ovarian cysts. The molecular mechanisms and signaling pathways underlying the pathogenesis of PCOS are still not well understood. Recent research has suggested that epigenetic modifications, influenced by factors like age, environment, lifestyle, and disease state, can alter the clinical presentation of PCOS. Genetic variants in genes involved in steroid synthesis and glucose homeostasis play a crucial role in PCOS development. Epigenetic control may also affect inflammation- and cell proliferation-related genes. Lifestyle factors, such as diet and physical activity, are important in reducing oxidative stress, inflammation, and improving metabolic and hormonal parameters in PCOS management.
Review
Biology
Davide Maria Cammisuli, Ferdinando Franzoni, Giorgia Scarfo, Jonathan Fusi, Marco Gesi, Ubaldo Bonuccelli, Simona Daniele, Claudia Martini, Gianluca Castelnuovo
Summary: Alzheimer's disease is a major challenge in terms of social and medical costs. Neuroprotective effects and antioxidants play a crucial role in countering cognitive deterioration in elderly individuals. Higher cognitive reserve reduces the impact of disease-related brain changes on cognition. Mild Cognitive Impairment (MCI) could be a potential target for intervention, where antioxidants can contribute to delaying cognitive decline and crossing the threshold for clinical dementia at a later stage.
Article
Biochemistry & Molecular Biology
Vittore Verratti, Simona Mrakic-Sposta, Jonathan Fusi, Iva Sabovic, Ferdinando Franzoni, Tiziana Pietrangelo, Danilo Bondi, Stefano Dall'Acqua, Simona Daniele, Giorgia Scarfo, Camillo Di Giulio, Andrea Garolla
Summary: This study evaluated the effects of high-altitude exposure on sperm parameters and health status in travellers. The results showed that high-altitude trekking led to a decrease in sperm concentration and seminal volume, and an increase in oxidative stress. The study also suggested that uncontrolled ROS production may be the cause of impaired sperm quality.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Frank L. Dini, Ferdinando Franzoni, Giorgia Scarfo, Nicola Riccardo Pugliese, Massimo Imazio
Summary: This study retrospectively included 28 patients diagnosed with acute pericarditis following COVID-19 vaccination. The incidence of acute pericarditis post-vaccination may be higher than previously estimated, possibly due to a more comprehensive assessment of clinical and echocardiographic parameters.
JOURNAL OF CARDIOVASCULAR MEDICINE
(2022)
Review
Cell Biology
Davide Maria Cammisuli, Jonathan Fusi, Giorgia Scarfo, Simona Daniele, Gianluca Castelnuovo, Ferdinando Franzoni
Summary: Connecting clinical neuroscience with microbiology and exercise science can have several benefits. The muscle-gut-brain axis influences mental health, with the gut microbiota playing a crucial role. Psychobiotics and physical exercise have been shown to improve mental health.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Review
Biochemistry & Molecular Biology
Giorgia Scarfo, Rebecca Piccarducci, Simona Daniele, Ferdinando Franzoni, Claudia Martini
Summary: The human brain consists mainly of lipids, and dysfunctions in lipid-binding proteins can disrupt normal neuronal functions and increase the risk of neurodegenerative diseases. Nutraceutical supplementation and regular physical activity have been shown to improve cognitive functions and protect against neurodegeneration.
Article
Biochemistry & Molecular Biology
Paolo Giovanni Artini, Giorgia Scarfo, Ilaria Marzi, Jonathan Fusi, Maria Elena Obino, Ferdinando Franzoni, Elisa Zappelli, Elisa Chelucci, Claudia Martini, Vito Cela, Simona Daniele
Summary: The molecular/metabolic composition of follicular fluid (FF) has a significant impact on oocyte development and fertilization. The antioxidant potential of FF is correlated with the number of retrieved/mature oocytes and fertilized ones. FF from normal fertilized oocytes exhibits elevated antioxidant capability, lower levels of pro-inflammatory molecules, and higher IL-10 concentration. Samples giving rise to top-quality embryos display a unique antioxidant capability and further decrease in pro-inflammatory molecules compared to FF from poor-quality embryos. Successful embryo implantation is associated with lower pro-inflammatory molecules and high antioxidant capability. Antioxidant capability and IL-10 show good predictive ability for fertilization and embryo quality.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Biology
Ferdinando Franzoni, Davide Maria Cammisuli, Giorgia Scarfo, Gianluca Castelnuovo
Article
Medicine, General & Internal
Martina Pappalardo, Laura Gori, Emioli Randazzo, Riccardo Morganti, Michelangelo Scaglione, Margherita Valiani, Alessandra Beni, Maria Di Cicco, Diego G. Peroni, Ferdinando Franzoni, Pasquale Comberiati
Summary: This study found an association between body weight and structural changes in the foot in children and adolescents, which may be related to weight gain rather than diabetes pathology. Ultrasound is a valuable tool for assessing early structural changes in the foot in young individuals.
Review
Cardiac & Cardiovascular Systems
Nicola R. Pugliese, Nicola de Biase, Alessio Balletti, Francesco Filidei, Alessandra Pieroni, Gennaro D'Angelo, Silvia Armenia, Matteo Mazzola, Luna Gargani, Lavinia del Punta, Muzaffar Asomov, Eugenio Cerri, Ferdinando Franzoni, Lorenzo Nesti, Alessandro Mengozzi
Summary: Heart failure is a complex clinical syndrome characterized by different etiologies and a broad spectrum of cardiac structural and functional abnormalities. Current guidelines classify heart failure based on left ventricular ejection fraction, distinguishing between reduced and preserved ejection fraction. Heart failure can progress from asymptomatic stages to clinically manifest syndrome, and the progression is associated with prognosis. However, the understanding of the steps and risk factors leading to heart failure progression is still lacking, especially in preserved ejection fraction heart failure. Precise hemodynamic and metabolic characterization may help identify different disease trajectories and risk factors, leading to specific treatment targets.
MINERVA CARDIOLOGY AND ANGIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
A. Del Chiaro, B. Ciampi, F. Franzoni, M. Miccoli, S. Galletti, S. M. Stella
Summary: CTJs are small arthrodial joints articulating with the costal tuberosity on the transverse process of thoracic vertebrae, explaining the different rib movements. Our study showed that ultrasound imaging is effective in detecting joint effusion and capsular ligament thickening in patients with CTJ pathology.
JOURNAL OF ULTRASOUND
(2022)