Review
Endocrinology & Metabolism
Haiyan Zhu, Xin Wang, Shihao Lu, Kongbo Ou
Summary: Clear cell renal cell carcinoma (ccRCC) is a malignancy characterized by metabolic reprogramming, which provides potential targets for therapeutic interventions. This review summarizes recent discoveries of metabolic alterations in ccRCC, including changes in glucose, lipid, and amino acid metabolism. It also discusses the development of metabolic drugs targeting these pathways and proposes future trends in drug development. Overall, this review highlights the potential for developing new treatments for ccRCC based on metabolic alterations.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Food Science & Technology
Xiao-Feng Zhang, Yue Qi, Yong-Ping Zhang, Jin-Lan Deng, Xiao-Li Chen, Ruo-Nan Li, Qi-Lun Zhou, Jian-Ming Fan
Summary: This systematic review and meta-analysis evaluated the effects of fermented foods on metabolic outcomes in patients with diabetes and prediabetes. The results showed a significant reduction in fasting blood glucose, insulin resistance, total cholesterol, low density lipid cholesterol, and diastolic blood pressure in the intervention group. Fermented foods have the potential to improve metabolic outcomes in patients with diabetes and prediabetes.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Nutrition & Dietetics
Oliver J. Perkin, Yung-Chih Chen, Drusus A. Johnson, Joel E. Thomas, Greg Atkinson, James A. Betts, Javier T. Gonzalez
Summary: Ingesting polymerized polyphenols (PP) alone at doses <150 mg does not significantly alter early-phase postprandial triacylglycerol concentrations in healthy adults. However, the addition of caffeine and catechins to PP lowers postprandial glucose and insulin concentrations. Therefore, the effects of PP on postprandial lipemia are limited, but the addition of caffeine and catechins may have a regulatory effect on postprandial blood glucose and insulin.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Review
Nutrition & Dietetics
Emanuele D'Amico, Giuseppe Grosso, Jeri W. Nieves, Aurora Zanghi, Pam Factor-Litvak, Hiroshi Mitsumoto
Summary: ALS is a devastating neurodegenerative disease that affects motor neurons and leads to muscle paralysis and respiratory failure. Metabolic abnormalities and nutritional factors may play a role in disease progression. Nutritional assessment and maintenance of weight are important for ALS patients, potentially influencing disease progression.
Review
Clinical Neurology
Andrew T. Nelson, Davide Trotti
Summary: ALS is a devastating neurodegenerative disease that affects motor neurons, causing muscle atrophy, paralysis, and death. Despite progress in research, there are currently no effective treatments available. Alterations to bioenergetic and metabolic homeostasis have been identified as potential therapeutic targets for ALS.
Article
Nutrition & Dietetics
Haijing Wang, Yanxiang Wang, Zumin Shi, Lei Zhao, Wenxiu Jian, Ke Li, Ruihua Xu, Yan Wu, Fei Xu, Youfa Wang, Wen Peng
Summary: This study aimed to investigate the longitudinal association between dietary patterns and metabolic disorders in Tibetans living at high altitude areas. The results showed that participants in the third tertile of the urban dietary pattern had a 3.42-fold higher risk of metabolic syndrome compared to those in the first tertile. Moreover, the modern dietary pattern was associated with elevated blood pressure and triglycerides, but inversely associated with high-density lipoprotein cholesterol. The urban dietary pattern was associated with a higher risk of low-density lipoprotein cholesterol, but a lower risk of impaired fasting blood glucose. On the other hand, the pastoral dietary pattern was a risk factor for impaired fasting blood glucose, but protective for central obesity and elevated blood pressure. Altitude was found to modify the associations of the modern and pastoral dietary patterns with metabolic disorders.
Review
Oncology
Ahmad Ali, Ugo Chianese, Chiara Papulino, Antonella Toraldo, Mawada Elmagboul Abdalla Abakar, Eugenia Passaro, Rosario Cennamo, Nunzio Del Gaudio, Lucia Altucci, Rosaria Benedetti
Summary: This article describes the metabolic features of pancreatic ductal adenocarcinoma and discusses how this could be exploited as a weakness for clinical interventions. Metabolism plays a crucial role in the development of PDAC, and interventions on bioenergetic circuits could potentially reduce its aggressiveness.
Article
Surgery
Shahriar Shahrokhi, Marc G. Jeschke
Summary: Nutrition and metabolic treatment are crucial for burn patients and directly impact their outcomes. Early and sufficient nutrition is essential. Other interventions such as warm patient rooms, early mobilization and exercise, and early excision and grafting also affect metabolism. Adjunctive therapies including oxandrolone, insulin, metformin, and propranolol, particularly in intensive care units, are recommended. Anabolic agents should be used, if tolerated, throughout the hospitalization period and there is evidence for long-term treatment with propranolol and oxandrolone for up to 2 to 3 years postburn.
SURGICAL CLINICS OF NORTH AMERICA
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Pier Mannuccio Mannucci, Carla Ancona
Summary: The study found that exposure to road traffic noise above 65 dB(A) was associated with small but adverse changes in blood pressure and cardiovascular biochemistry, especially with significant positive associations even after adjusting for BMI.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Zuzana Kupcikova, Daniela Fecht, Rema Ramakrishnan, Charlotte Clark, Yutong Samuel Cai
Summary: The aim of this study was to investigate the associations between modelled residential road traffic noise and cardiovascular disease risk factors in UK Biobank. Exposure to road traffic noise >65 dB[A] was associated with small but adverse changes in blood pressure and cardiovascular biochemistry, independent of nitrogen dioxide.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Zuzana Kupcikova, Daniela Fecht, Rema Ramakrishnan, Charlotte Clark, Yutong Samuel Cai
Summary: The study aimed to investigate the associations between modeled residential road traffic noise and cardiovascular disease risk factors, finding that higher levels of road traffic noise were associated with adverse changes in blood pressure and cardiovascular biochemistry.
EUROPEAN HEART JOURNAL
(2021)
Article
Nutrition & Dietetics
Tiago Rodrigues de Lima, David Alejandro Gonzalez-Chica, Eleonora D'Orsi, Xuemei Sui, Diego Augusto Santos Silva
Summary: This study aimed to determine the cut-points for muscle strength based on metabolic syndrome diagnosis. The findings suggest that cut-points derived from ROC analysis have good discriminatory power for metabolic syndrome among adults aged 25 to <50 years but not for adults aged 50+ years. Additionally, the cut-points for muscle strength may assist in the identification of adults at risk for cardiometabolic disease.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Yang Xu, Yan Wang, Yongwei Shi, Miao Yu, Wenhui Xu, Yixia Wu, Kun Xu, Yajuan Liu, Lin Xie
Summary: This study found that the fermented beverage (FB) is a medium GI food and plays a protective role against oxidative stress in diabetic rats.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Biochemical Research Methods
Lin Wang, Xi Xing, Xianfeng Zengl, S. RaElle Jackson, Tara TeSlaa, Osama Al-Dalahmah, Laith Z. Samarah, Katharine Goodwin, Lifeng Yang, Melanie R. McReynolds, Xiaoxuan Li, Jeremy J. Wolff, Joshua D. Rabinowitz, Shawn M. Davidson
Summary: Isotope imaging enables quantification of metabolic activity in mammalian tissues with spatial resolution, revealing metabolic heterogeneity in the kidney and brain and spatial gradients in metabolic processes.
Article
Biochemistry & Molecular Biology
Yohei Hayashi, Yukiko Tando, Yumi Ito-Matsuoka, Kaho Ikuta, Asuka Takehara, Katsutaro Morino, Hiroshi Maegawa, Yasuhisa Matsui
Summary: This study reveals that the hexosamine biosynthetic pathway controls the fate determination of primordial germ cells (PGCs) through O-GlcNAc modification. A maternal ketogenic diet that reduces carbohydrate metabolism represses PGC formation and affects the number of ovarian germ cells in newborn pups. These findings suggest the importance of nutritional and metabolic mechanisms in PGC fate determination.