Article
Biochemistry & Molecular Biology
Anna E. Engell, Henrik L. Jorgensen, Bent S. Lind, Anton Pottegard, Christen L. Andersen, John S. Andersen, Margit Kriegbaum, Mia K. Grand, Lise Bathum
Summary: Lipid levels in blood have decreased significantly in the general population due to the use of statins. This trend was observed in primary health care patients who were not using statins from 2001 to 2018, with substantial decreases in total cholesterol and low-density lipoprotein cholesterol levels, especially in the elderly population.
LIPIDS IN HEALTH AND DISEASE
(2021)
Review
Biology
Carlo Maria Barbagallo, Angelo Baldassare Cefalu, Antonina Giammanco, Davide Noto, Rosalia Caldarella, Marcello Ciaccio, Maurizio Rocco Averna, Emilio Nardi
Summary: Chronic kidney disease is an important risk factor for cardiovascular disease, with dyslipidemia often present in patients with CKD. Various lipoprotein abnormalities occur due to impaired enzymes pathways and proteins involved in lipoprotein metabolism in CKD patients. Hypolipidemic treatments may alter the progression of CVD in CKD patients.
Review
Urology & Nephrology
Carinna Hockham, Lexia Bao, Anushree Tiku, Sunil Badve, Aminu K. Bello, Meg J. Jardine, Vivekanand Jha, Tadashi Toyama, Mark Woodward, Min Jun
Summary: Studies have shown that there are important sex disparities in the prevalence of chronic kidney disease (CKD) in Asia. However, the nature of these disparities has been inconsistent. This study aimed to synthesize available sex-disaggregated CKD prevalence data in Asia and found that there is considerable between-country and -region heterogeneity in the female:male prevalence ratio of CKD. Further research and country-level assessment are needed to better understand and address these disparities.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Multidisciplinary Sciences
Hyungjong Park, Yoonkyung Chang, Heajung Lee, Iksun Hong, Tae-Jin Song
Summary: The study investigates the association between total cholesterol (TC) variability and the occurrence of venous thromboembolism (VTE) using a Korean database. The results show a positive correlation between higher TC variability and the occurrence of VTE, emphasizing the importance of maintaining stable TC levels to prevent VTE.
Article
Clinical Neurology
Siang Ing Lee, Jennifer Cooper, Anthony Fenton, Anuradhaa Subramanian, Tom Taverner, Krishna M. Gokhale, Katherine Phillips, Mitesh Patel, Lorraine Harper, G. Neil Thomas, Krishnarajah Nirantharakumar
Summary: Decreased renal function is associated with an increased risk of dementia, which has significant implications for the care of patients with kidney disease.
ALZHEIMERS & DEMENTIA
(2022)
Article
Urology & Nephrology
Alberto Ortiz
Summary: Iceland has a low incidence of kidney replacement therapy (KRT) and chronic kidney disease (CKD), suggesting a low need for KRT. The country also provides a well-characterized population for studying the influence of genetics, environment, and lifestyle on CKD. Risk factors such as obesity and sleep apnea are associated with increased CKD incidence, highlighting the importance of early diagnosis.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Nutrition & Dietetics
Massimo Cirillo, Pierpaolo Cavallo, Enrico Zulli, Rachele Villa, Rosangela Veneziano, Simona Costanzo, Sara Magnacca, Augusto Di Castelnuovo, Licia Iacoviello
Summary: The study found independent positive associations of an index of sodium intake with proteinuria and albuminuria in the population.
Article
Medicine, Research & Experimental
Maria Lucia Souza Siqueira, Sara Michelli Vieira Andrade, Jose Luiz Fernandes Vieira, Marta Chagas Monteiro
Summary: The long-term use of tamoxifen in breast cancer patients can affect lipid metabolism, but the relationship between blood lipids and the plasma concentrations of tamoxifen and its active metabolites is not significant. Weak associations were found between the plasma concentrations of tamoxifen and the active metabolites with HDL-c, LDL-c, and VLDL-c.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Medicine, General & Internal
Arnaud D. Kaze, Bernard G. Jaar, Gregg C. Fonarow, Justin B. Echouffo-Tcheugui
Summary: The study found that increasing albuminuria and worsening stages of early CKD were independently associated with a higher risk of incident stroke in adults with type 2 diabetes.
Article
Cardiac & Cardiovascular Systems
Bethan L. Clifford, Kelsey E. Jarrett, Joan Cheng, Angela Cheng, Marcus Seldin, Pauline Morand, Richard Lee, Mary Chen, Angel Baldan, Thomas Q. de Aguiar Vallim, Elizabeth J. Tarling
Summary: This study reveals a novel role of RNF130 in regulating LDL-C levels by modulating the availability of LDLR.
CIRCULATION RESEARCH
(2023)
Article
Nutrition & Dietetics
Kate M. Bermingham, Mohsen Mazidi, Paul W. Franks, Tyler Maher, Ana M. Valdes, Inbar Linenberg, Jonathan Wolf, George Hadjigeorgiou, Tim D. Spector, Cristina Menni, Jose M. Ordovas, Sarah E. Berry, Wendy L. Hall
Summary: This study characterized the variability and correlations of postprandial metabolite changes in a large cohort. The majority of metabolites showed significant changes after a meal, particularly in very large lipoprotein particles and ketone bodies. Strong correlations were observed between fasting and postprandial metabolites, although some metabolites showed weak correlations.
Article
Urology & Nephrology
Reka Szentimrei, Hajnalka Lorincz, Anita Szentpeteri, Viktoria E. Varga, Mariann Harangi, Ildiko Seres, Reka P. Szabo, Balazs Nemes, Gyorgy Paragh
Summary: The study found that renal transplant patients had significantly higher PEDF levels before transplantation, which decreased to the level of healthy controls after 1 month post-transplant and remained low during the 6-month follow-up period. Additionally, there were significant correlations between PEDF and lipid parameters, indicating that PEDF may play an important role in oxidative stress and atherogenesis in renal transplant patients.
Review
Endocrinology & Metabolism
Jose Ignacio Martinez-Montoro, Enrique Morales, Isabel Cornejo-Pareja, Francisco J. Tinahones, Jose Carlos Fernandez-Garcia
Summary: Obesity-related glomerulopathy (ORG) is a silent comorbidity associated with serious health consequences. Despite the pathogenic mechanisms not fully understood, factors such as glomerular hemodynamic changes and RAAS overactivation are believed to play a major role. Early diagnosis and intervention are crucial for improving the prognosis of ORG.
Review
Hematology
Christian M. Madsen, Anette Varbo, Borge G. Nordestgaard
Summary: Recent studies have suggested that extremely high levels of HDL cholesterol are associated with increased mortality, indicating that HDL may have harmful effects in some instances. Furthermore, observational and genetic studies have shown that HDL might be linked to the development of major noncardiovascular diseases.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Moneeza K. Siddiqui, Gillian Smith, Pamela St Jean, Adem Y. Dawed, Samira Bell, Enrique Soto-Pedre, Gwen Kennedy, Fiona Carr, Lars Wallentin, Harvey White, Colin H. Macphee, Dawn Waterworth, Colin N. A. Palmer
Summary: The study found that diabetes status modifies the association between Lp-PLA2 activity and MCE, especially in patients with type 2 diabetes, particularly those with worse glycemic control. In the high-risk group, the use of Lp-PLA2 inhibitor was associated with a 33% reduction in MCE risk compared to placebo.
Article
Psychiatry
Nicholas Hui, Margaret J. Morris, Matthew A. Allison, Michael Y. Tsai, Kerry-Anne Rye, Fatiha Tabet, Kwok Leung Ong
Summary: The study found a potential association between high ln-transformed Lp(a) levels and new elevated depressive symptoms since baseline, but this association was not robust in sensitivity analyses.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Peripheral Vascular Disease
Aelia Akbar, Kiang Liu, Erin D. Michos, Michael P. Bancks, Linda Brubaker, Talar Markossian, Ramon Durazo-Arvizu, Holly Kramer
Summary: The study found that overactive bladder (OAB) may lead to higher blood pressure and have negative effects on blood pressure control in men.
AMERICAN JOURNAL OF HYPERTENSION
(2022)
Article
Cardiac & Cardiovascular Systems
Jing Cao, Alan T. Remaley, Weihua Guan, Sridevi Devaraj, Michael Y. Tsai
Summary: In a multi-ethnic USA population, LDLMartin and LDLSampson did not over- or under-estimate ASCVD risk compared to LDLFriedewald in primary prevention according to AHA/ACC guidelines, while LDLFriedewald under-estimated subclinical ASCVD risk in the low-risk population. These findings support the replacement of LDLFriedewald by LDLMartin or LDLSampson for lipid screen in the general population.
Article
Cardiac & Cardiovascular Systems
Andrew P. DeFilippis, Patrick J. Trainor, George Thanassoulis, Lyndia C. Brumback, Wendy S. Post, Michael Y. Tsai, Sotirios Tsimikas
Summary: This study identified two new atherothrombotic factors that are significantly associated with incident ASCVD events, one representing thrombotic propensity and the other representing fibrinolytic propensity. These factors remained significantly associated with ASCVD events even after controlling for traditional risk factors.
EUROPEAN HEART JOURNAL
(2022)
Article
Nutrition & Dietetics
Ellen C. Francis, Mengying Li, Stefanie N. Hinkle, Jinbo Chen, Jing Wu, Yeyi Zhu, Haiming Cao, Michael Y. Tsai, Liwei Chen, Cuilin Zhang
Summary: Higher concentrations of maternal IL-6 during pregnancy were associated with lower neonatal birthweight, thigh and crown-heel length, and skinfolds, starting as early as 15 weeks of gestation. These findings provide insights into the relevance of maternal inflammatory markers with neonatal anthropometry.
CURRENT DEVELOPMENTS IN NUTRITION
(2021)
Article
Cardiac & Cardiovascular Systems
Rupal Mehta, Hongyan Ning, Nisha Bansal, Jordana Cohen, Anand Srivastava, Mirela Dobre, Erin D. Michos, Mahboob Rahman, Raymond Townsend, Stephen Seliger, James P. Lash, Tamara Isakova, Donald M. Lloyd-Jones, Sadiya S. Khan
Summary: Reliably identifying individuals at risk of heart failure hospitalizations in CKD patients is possible by using routinely available clinical data that include UACR.
JOURNAL OF CARDIAC FAILURE
(2022)
Article
Peripheral Vascular Disease
Leo Gozdecki, Holly Kramer, Matthew Thomas, Karam Gardezi, Elizabeth Tarlov, Ashley Hughes, Kevin Stroupe, Meghan O'Halloran
Summary: This 20-week quality improvement study examines the implementation of a hypertension identification and management program using a standardized oscillometric blood pressure measurement protocol. The study found that the implementation of the protocol reduced digit preference and improved hypertension treatment.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Editorial Material
Urology & Nephrology
Emily Janak, Holly Kramer
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Nutrition & Dietetics
Parveen K. Garg, Weihua Guan, Sarah Nomura, Natalie L. Weir, Amy B. Karger, Daniel Duprez, Michael Y. Tsai
Summary: This study found an association between circulating omega-3 and omega-6 polyunsaturated fatty acids and large artery elasticity, but not small artery elasticity. Further research is needed to understand the differential associations of omega-6 polyunsaturated fatty acids with large and small artery elasticity.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Hematology
Anna E. Bortnick, Petra Buzkova, James Otvos, Majken Jensen, Michael Y. Tsai, Matthew Budoff, Rachel Mackey, Samar R. El Khoudary, Elda Favari, Ryung S. Kim, Carlos J. Rodriguez, George Thanassoulis, Jorge R. Kizer
Summary: This study found that high-density lipoprotein (HDL) cholesterol, HDL particle number and size, apoC3-defined HDL subtypes were inversely associated with the long-term incidence and progression of aortic valve calcification (AVC). Further investigation of HDL composition and mechanisms could be useful in understanding pathways that slow AVC.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Yuni Choi, David R. Jacobs, Gautam R. Shroff, Holly Kramer, Alexander R. Chang, Daniel A. Duprez
Summary: This study found that progression to higher CKD risk categories was common among young to middle-aged adults, and it was associated with cardiovascular disease and mortality.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Peripheral Vascular Disease
Rishi Rikhi, Harpreet S. Bhatia, Christopher L. Schaich, Nicklaus Ashburn, Michael Y. Tsai, Erin D. Michos, Parag A. Chevli, David M. Herrington, Sotirios Tsimikas, Michael D. Shapiro
Summary: This study examined the relationship between Lp(a) and hypertension with cardiovascular outcomes in a large multiethnic cohort. The results showed that individuals with elevated Lp(a) and hypertension had a significantly increased risk for cardiovascular disease.
Article
Peripheral Vascular Disease
Meghan O'Halloran, Ashley M. Hughes, Zhiping Huo, Frances Weaver, Kevin Stroupe, Elizabeth Tarlov, Holly Kramer
Summary: This study examines the accuracy of blood pressure measurement in Veterans Affairs (VA) medical centers and the perceptions of clinicians regarding blood pressure measurement. The results show that terminal digit preference (TDP) exists in VA medical centers, indicating a bias in BP measurement. The study also finds that the level of TDP varies among different centers and is associated with higher blood pressure control rates. Clinicians reported using semi-automated oscillometric devices for BP measurement, but still relied on auscultatory methods for confirmation. This highlights the importance of addressing TDP and improving the accuracy of BP measurement in VA medical centers.
JOURNAL OF CLINICAL HYPERTENSION
(2023)
Article
Urology & Nephrology
Christine K. Liu, Shiyuan Miao, Jamie Giffuni, Leslie I. Katzel, Roger A. Fielding, Stephen L. Seliger, Daniel E. Weiner
Summary: Geriatric syndromes are common in older adults with CKD and are associated with reduced quality of life. Addressing geriatric syndromes could potentially improve quality of life for older adults with CKD.
Article
Urology & Nephrology
Elise Hoover, Ronald D. Perrone, Chris Rusconi, Beverly Benson, Neera K. Dahl, Berenice Gitomer, Amy Manelli, Michal Mrug, Meyeon Park, Stephen L. Seliger, Milind A. Phadnis, Nadeesha Thewarapperuma, Terry J. Watnick
Summary: This study presents a unique web-based ADPKD registry, which serves as a valuable longitudinal research tool covering all stages of ADPKD. As of now, 1563 ADPKD patients from the United States have registered and completed the core questionnaire. The registry provides important data on patient-reported diagnosis, creatinine values, and comorbidities, which are crucial for disease management and clinical trial recruitment.
