Article
Multidisciplinary Sciences
Hiroki Watanabe, Ko Yamamoto, Hiroki Shiomi, Takeshi Morimoto, Eri Kato, Yukiko Matsumura, Kenji Nakatsuma, Yasuaki Takeji, Hidenori Yaku, Erika Yamamoto, Yugo Yamashita, Yusuke Yoshikawa, Masayuki Fuki, Kyohei Yamaji, Natsuhiko Ehara, Hiroki Sakamoto, Kazuaki Imada, Takeshi Tada, Ryoji Taniguchi, Ryusuke Nishikawa, Tomohisa Tada, Takashi Uegaito, Tatsuya Ogawa, Miho Yamada, Teruki Takeda, Hiroshi Eizawa, Nobushige Tamura, Keiichi Tambara, Satoru Suwa, Manabu Shirotani, Toshihiro Tamura, Moriaki Inoko, Junichiro Nishizawa, Masahiro Natsuaki, Hiroshi Sakai, Takashi Yamamoto, Naoki Kanemitsu, Nobuhisa Ohno, Katsuhisa Ishii, Akira Marui, Hiroshi Tsuneyoshi, Yasuhiko Terai, Shogo Nakayama, Kazuhiro Yamazaki, Mamoru Takahashi, Takashi Tamura, Jiro Esaki, Shinji Miki, Tomoya Onodera, Hiroshi Mabuchi, Yutaka Furukawa, Masaru Tanaka, Tatsuhiko Komiya, Yoshiharu Soga, Michiya Hanyu, Kenji Ando, Kazushige Kadota, Kenji Minatoya, Yoshihisa Nakagawa, Takeshi Kimura
Summary: This study compared the effectiveness of percutaneous coronary intervention (PCI) using new-generation drug-eluting stents (DES) with coronary artery bypass grafting (CABG) in patients with multi-vessel coronary artery disease. The results showed that, compared to CABG, PCI for coronary revascularization was associated with an increased long-term risk of major cardiovascular events.
Article
Surgery
Ryaan EL-Andari, Jeevan Nagendran, Yongzhe Hong, Imtiaz Ali, Jayan Nagendran
Summary: Comparison of referral patterns and outcomes between two centers in the same jurisdiction showed that more patients in Center A underwent PCI and fewer underwent CABG compared to Center B, even among patients with TVD. Regression analysis showed that Center B had a protective effect on mortality for TVD patients and those undergoing PCI, but not for CABG. Center A had increased 1-year mortality for all patients and those with TVD. The differences in outcomes can be attributed to contrasting referral practices and the discrepant rates of PCI and CABG between the centers.
Article
Cardiac & Cardiovascular Systems
Yu-Ying Lu, Chen-Hung Lee, Chun-Chi Chen, Dong-Yi Chen, Ming-Yun Ho, Jih-Kai Yeh, Yu-Chang Huang, Chieh-Yu Chang, Chao-Yung Wang, Shang-Hung Chang, I-Chang Hsieh, Ming-Jer Hsieh
Summary: This study evaluated the revascularization strategy for elderly ACS patients with MVD. The patients were divided into CR and IR groups based on angiography. The three-year follow-up results showed that CR was associated with lower MACE risk compared to IR, especially in STE-ACS patients. Therefore, CR can achieve better long-term outcomes in elderly ACS patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Multidisciplinary Sciences
Hristo Kirov, Tulio Caldonazo, Mohamed Rahouma, N. Bryce Robinson, Michelle Demetres, Patrick W. Serruys, Giuseppe Biondi-Zoccai, Mario Gaudino, Torsten Doenst
Summary: For the treatment of NSTE-ACS, CABG and PCI are associated with similar rates of long-term mortality and myocardial infarction. CABG is associated with lower rates of long-term MACE and re-revascularization.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Rahele A. Farahani, Mohsen Afarideh, Xiang-Yang Zhu, Hui Tang, Kyra L. Jordan, Ishran M. Saadiq, Christopher M. Ferguson, Amir Lerman, Stephen C. Textor, Lilach O. Lerman, Alfonso Eirin
Summary: Percutaneous transluminal renal angioplasty (PTRA) may alleviate mitochondrial damage caused by renal artery stenosis and metabolic syndrome, improving renal function and reducing injury in the poststenotic kidney.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Yanyan Li, Chuang Li, Dejing Feng, Qian Zhang, Kuibao Li, Yu Liu, Xinchun Yang, Lefeng Wang
Summary: The updated ACEF II score is a more convenient and validated prediction tool for MACCE in patients with MVCAD undergoing one-stop HCR comparing to other risk models. The ACEF II score was found to be an independent prognostic indicator for MACCE with hazards ratio 2.24, and the ROC curve analysis showed a higher AUC for MACCE compared to other risk scores.
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Cardiac & Cardiovascular Systems
Valentino Bianco, Suresh Mulukutla, Edgar Aranda-Michel, Danny Chu, David Kaczorowski, Johannes Bonatti, Pyongsoo Yoon, Dustin Kliner, Catalin Toma, Yisi Wang, Steve Koscumb, Floyd Thoma, Forozan Navid, Derek Serna-Gallegos, Ibrahim Sultan
Summary: This study compares the outcomes of multiarterial grafting and percutaneous coronary intervention (PCI) in patients with multivessel coronary disease. It found that multiarterial grafting is associated with fewer adverse events, improved survival, and reduced hospital readmissions for appropriate patients.
ANNALS OF THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Jinying Zhou, Chen Liu, Peng Zhou, Jiannan Li, Runzhen Chen, Ying Wang, Xiaoxiao Zhao, Hanjun Zhao, Li Song, Hongbing Yan
Summary: This study aimed to investigate the prevalence and impact of Metabolic Syndrome (MetS) in patients with multivessel coronary artery disease (MVD) and acute coronary syndrome (ACS). The results showed that MetS was frequently observed in these patients, with young females more likely to have MetS. However, after primary PCI, MetS was not found to be an independent predictor for major adverse cardiovascular events (MACE) in these patients.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Endocrinology & Metabolism
Ziwei Jing, Liwei Liu, Yingying Shi, Qiuzheng Du, Dingding Zhang, Lihua Zuo, Shuzhang Du, Zhi Sun, Xiaojian Zhang
Summary: This study investigated common metabolic perturbations between coronary artery disease (CAD) and metabolic syndrome (MetS) using serum metabolomics analysis. A total of 30 metabolites were identified for CAD and 26 metabolites for MetS, with logistic regression showing significant associations even after adjustments for clinical risk factors. A common metabolic signature analysis revealed 11 significant serum metabolites shared between CAD and MetS outcomes, with nine showing similar trends and improving risk prediction values for both diseases.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Kuniaki Takahashi, Patrick W. Serruys, Chao Gao, Masafumi Ono, Rutao Wang, Daniel J. F. M. Thuijs, Michael J. Mack, Nick Curzen, Friedrich-Wilhelm Mohr, Piroze Davierwala, Milan Milojevic, Joanna J. Wykrzykowska, Robbert J. de Winter, Faisal Sharif, Yoshinobu Onuma, Stuart J. Head, Arie Pieter Kappetein, Marie-Claude Morice, David R. Holmes
Summary: Incomplete revascularization is common after PCI and its degree of incompleteness is associated with 10-year mortality. In patients with 3-vessel disease where complete revascularization is unlikely to be achieved with PCI, CABG should be considered.
Review
Cardiac & Cardiovascular Systems
Danilo Neglia, Natallia Maroz-Vadalazhskaya, Nazario Carrabba, Riccardo Liga
Summary: In recent decades, effective management of cardiovascular risk factors has led to a decrease in coronary artery disease prevalence. However, coronary heart disease remains a leading cause of death globally, and chronic coronary syndromes continue to be targets of cardiac imaging and invasive procedures. Current guidelines recommend non-invasive imaging for CCS patients to identify high-risk individuals for referral to invasive procedures, but recent studies have raised questions about the efficacy of coronary revascularization. The role of imaging in these patients, including those with ischemic cardiomyopathy, remains debated.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Fernando Alfonso, Cristina Fernandez-Perez, Nayade del Prado, Marcos Garcia-Guimaraes, Jose Luis Bernal, Teresa Bastante, David del Val, Nicolas Rosillo, Javier Elola
Summary: This study compared in-hospital mortality and 30-day readmission rates between patients with spontaneous coronary artery dissection (SCAD) and ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PPCI) and patients with STEMI without SCAD undergoing PPCI. The results showed that PPCI, when indicated in patients with STEMI and SCAD, has similar in-hospital mortality and 30-day readmission rates compared with PPCI for atherothrombotic STEMI. These findings support the value of PPCI in selected patients with SCAD.
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Guyu Zeng, Deshan Yuan, Peizhi Wang, Tianyu Li, Lin Jiang, Lianjun Xu, Jian Tian, Xueyan Zhao, Xinxing Feng, Dong Wang, Yin Zhang, Kai Sun, Jingjing Xu, Ru Liu, Bo Xu, Wei Zhao, Rutai Hui, Runlin Gao, Lei Song, Jinqing Yuan
Summary: This study found that even mild renal dysfunction in patients with three-vessel coronary disease is significantly associated with a higher risk of all-cause death. The superiority of coronary artery bypass grafting over percutaneous coronary intervention diminishes in patients with moderate renal dysfunction.
CARDIORENAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Vanessa Nader, Anthony Matta, Ryeonshi Kang, Antoine Deney, Rania Azar, Charlotte Rouzaud-Laborde, Oxana Kunduzova, Romain Itier, Pauline Fournier, Michel Galinier, Didier Carrie, Jerome Roncalli
Summary: This study evaluates the effect of revascularization strategy on all-cause mortality in patients with ischaemic heart failure. The findings show that coronary revascularization does not modify short-term survival outcomes in HF patients compared with optimal medical therapy alone.
Article
Radiology, Nuclear Medicine & Medical Imaging
Toshimitsu Tsugu, Kaoru Tanaka, Dries Belsack, Yuji Nagatomo, Mayuko Tsugu, Jean-Francois Argacha, Bernard Cosyns, Nico Buls, Michel De Maeseneer, Johan De Mey
Summary: In non-obstructive coronary artery disease, the decline of CT-derived fractional flow reserve (FFRCT) depends not only on vessel length but also on the lumen volume. A new marker, the ratio of lumen volume to vessel length (V/L ratio), was found to be the strongest predictor of distal FFRCT.
EUROPEAN RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Carmen Hannemann, Johannes H. Schecker, Alica Brettschneider, Jana Grune, Nicole Roesener, Andrea Weller, Verena Stangl, Edward A. Fisher, Karl Stangl, Antje Ludwig, Bernd Hewing
Summary: The study demonstrated that deficiency of iRhom2 can reduce the development of atherosclerosis, particularly in early stages. Additionally, iRhom2 deficiency was found to lower serum levels of TNF-alpha, as well as circulating and hepatic levels of cholesterol and triglycerides.
CARDIOVASCULAR RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Marie-Pierre St-Onge, Brooke Aggarwal, Matthew A. Allison, Jeffrey S. Berger, Sheila F. Castaneda, Janet Catov, Judith S. Hochman, Carl A. Hubel, Sanja Jelic, David A. Kass, Nour Makarem, Erin D. Michos, Lori Mosca, Pamela Ouyang, Chorong Park, Wendy S. Post, Robert W. Powers, Harmony R. Reynolds, Dorothy D. Sears, Sanjiv J. Shah, Kavita Sharma, Tanya Spruill, Gregory A. Talavera, Dhananjay Vaidya
Summary: The report summarizes the findings of 5 research centers funded by the American Heart Association, highlighting the increased risk of cardiovascular disease in women due to insufficient sleep, sedentariness, and pregnancy-related complications. Collaborative ancillary studies further examined the relationships between various lifestyle behaviors and CVD risk, as well as metabolomic profiling of heart failure with preserved ejection fraction in women.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Letter
Cardiac & Cardiovascular Systems
Sripal Bangalore, David J. Maron, Gregg W. Stone, Judith S. Hochman
Letter
Cardiac & Cardiovascular Systems
Renato D. Lopes, Karen P. Alexander, Judith S. Hochman, David J. Maron
Article
Cell Biology
Jasper A. F. Demandt, Kim van Kuijk, Thomas L. Theelen, Elke Marsch, Sean P. Heffron, Edward A. Fisher, Peter Carmeliet, Erik A. L. Biessen, Judith C. Sluimer
Summary: The study found that whole-body PHD3 knockout led to an unfavorable lipid profile and increased hematocrit compared to other PHD isoforms, yet did not alter the development of atherosclerotic plaques.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biology
Maud Voisin, Elina Shrestha, Claire Rollet, Cyrus A. Nikain, Tatjana Josefs, Melanie Mahe, Tessa J. Barrett, Hye Rim Chang, Rachel Ruoff, Jeffrey A. Schneider, Michela L. Garabedian, Chris Zoumadakis, Chi Yun, Bara Badwan, Emily J. Brown, Adam C. Mar, Robert J. Schneider, Ira J. Goldberg, Ines Pineda-Torra, Edward A. Fisher, Michael J. Garabedian
Summary: The study demonstrates that reducing phosphorylation at serine 196 of LXR alpha in hematopoietic cells can attenuate atherosclerosis and obesity induced by a high-fat diet in mice by reprogramming the transcriptional activity of LXR alpha in macrophages and T cells to promote an anti-inflammatory phenotype.
COMMUNICATIONS BIOLOGY
(2021)
Article
Chemistry, Analytical
Shiyu Chen, Beyza Vurusaner, Stephanie Pena, Chu T. Thu, Lara K. Mahal, Edward A. Fisher, James W. Canary
Summary: A fluorescent probe that selectively reacts with peroxynitrite, yielding over 200-fold change, effectively visualized fluctuations in peroxynitrite generation by arginase 1 in vivo and in vitro. This provides evidence that arginase 1 is a critical regulator of peroxynitrite.
ANALYTICAL CHEMISTRY
(2021)
Article
Cardiac & Cardiovascular Systems
Kevin R. Bainey, Jerome L. Fleg, Judith S. Hochman, Dennis F. Kunichoff, Rebecca Anthopolos, Alexander M. Chernyavskiy, Marcin Demkow, Juan-Manuel Lopez-Quijano, Jorge Escobedo, Kian Keong Poh, Ruben B. Ramos, Eduardo G. Lima, Herwig Schuchlenz, Ziad A. Ali, Gregg W. Stone, David J. Maron, Sean M. O'Brien, John A. Spertus, Sripal Bangalore
Summary: In patients with advanced chronic kidney disease, the extent of coronary artery disease is a better predictor of all-cause death or myocardial infarction than the severity of myocardial ischemia.
AMERICAN HEART JOURNAL
(2022)
Letter
Dermatology
Michael S. Garshick, Kamelia Drenkova, Tessa J. Barrett, Florencia Schlamp, Edward A. Fisher, Stuart Katz, Sanja Jelic, Andrea L. Neimann, Jose U. Scher, James Krueger, Jeffrey S. Berger
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Claes Held, Nermin Hadziosmanovic, Philip E. Aylward, Emil Hagstrom, Judith S. Hochman, Ralph A. H. Stewart, Harvey D. White, Lars Wallentin
Summary: In patients with stable coronary heart disease, both high and low BMI are associated with risk factors and prognosis. The lowest all-cause and cardiovascular mortality is observed at a BMI of 25 to 35 kg/m².
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Review
Hematology
Ashish Misra, Rajan Rehan, Alexander Lin, Sanjay Patel, Edward A. Fisher
Summary: Clonal expansion plays a crucial role in atherosclerosis, particularly in smooth muscle cells and macrophages. Recent studies have revealed the contribution of clonal expansion to disease pathology and provided innovative directions for future therapies of atherosclerosis and associated cardiovascular diseases.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Patrick R. Lawler, Judith S. Hochman, Ryan Zarychanski
Editorial Material
Cardiac & Cardiovascular Systems
Ajar Kochar, Nathaniel R. Smilowitz, Judith S. Hochman
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Judith S. Hochman, Rebecca Anthopolos, Harmony. R. Reynolds, Sripal Bangalore, Yifan Xu, Sean M. O'Brien, Stavroula Mavromichalis, Michelle Chang, Aira Contreras, Yves Rosenberg, Ruth Kirby, Balram Bhargava, Roxy Senior, Ann Banfield, Shaun G. Goodman, Renato D. Lopes, Radoslaw Pracon, Jose Lopez-Sendon, Aldo Pietro Maggioni, Jonathan D. Newman, Jeffrey S. Berger, Mandeep S. Sidhu, Harvey D. White, Andrea B. Troxel, Robert A. Harrington, William E. Boden, Gregg W. Stone, Daniel B. Mark, John A. Spertus, David J. Maron
Summary: The ISCHEMIA trial compared the outcomes of initial invasive strategy versus initial conservative strategy in patients with chronic coronary disease and moderate or severe ischemia. The trial found no major difference in most outcomes, but there was lower risk of cardiovascular mortality and higher risk of noncardiovascular mortality with the invasive strategy.
Editorial Material
Cardiac & Cardiovascular Systems
Sunil V. Rao, Harmony R. Reynolds, Judith S. Hochman