期刊
ATHEROSCLEROSIS
卷 201, 期 2, 页码 345-352出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.atherosclerosis.2008.02.008
关键词
Statins; Non-HDL-cholesterol; Obesity; Metabolic syndrome; Hepatic enzymes
资金
- Non-Profit Organization for Medical Frontier, Chiba, Japan
- Ministry of Health, Labour and Welfare
Aims: To compare the efficacy and safety of pitavastatin and atorvastatin in Japanese patients with hypercholesterolemia. Methods and results: Japanese patients with total cholesterol (TC) >= 220 mg/dL were randomized to receive pitavastatin 2 mg (n = 126) or atorvastatin 10 mg (n = 125) for 12 weeks. The primary endpoint was percent change front baseline in non-HDL-C level after 12 weeks of treatment. Reduction of non-HDL-C by pitavastatin treatment (39.0%, P = 0.456 vs. atorvastatin) was non-inferior to that by atorvastatin (40.3%). Both pitavastatin and atorvastatin also significantly reduced LDL-C by 42.6% and 44.1%, TC by 29.7% and 31.1% and TG by 17314 and 10.7%. respectively. at 12 weeks without intergroup differences. HDL-C showed a significant increase at 12 weeks with pitavastatin treatment (3.2%, P = 0.033 vs. baseline) but not with atorvastatin treatment ( 1.7%, P = 0.221 vs. baseline). Waist circumference. body weight and BMI were significantly correlated with percent reduction of non-HDL-C in the atorvastatin group, whereas pitavastatin showed consistent reduction of non-HDL-C regardless of the body size. fit patients with metabolic syndrome, LDL-C was reduced significantly more in patients receiving pitavastatin when compared with those receiving atorvastatin. AST. ALT and gamma GTP increased significantly in patients receiving atorvastatin but not in those receiving pitavastatin. Both treatments were well tolerated. Conclusion: Pitavastatin 2 mg, and atorvastatin 10 mg are equally effective in improving the lipid profile mid were well tolerated in Japanese patients with hypercholesterolemia. (C) 2008 Published by Elsevier Ireland Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据