LGI Proteins in the Nervous System

Leucine-rich glioma inactivated 3 associates negatively with adiponectin

(2013) Hyun A Kim et al.   CYTOKINE

Hyperactive behavior in a family with autosomal dominant lateral temporal lobe epilepsy caused by a mutation in the LGI1/epitempin gene

(2013) B. Berghuis et al.   EPILEPSY & BEHAVIOR

Secretory Defect and Cytotoxicity

(2013) Songhua Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resetting translational homeostasis restores myelination in Charcot-Marie-Tooth disease type 1B mice

(2013) Maurizio D’Antonio et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The African coelacanth genome provides insights into tetrapod evolution

(2013) Chris T. Amemiya et al.   NATURE

Teaching NeuroImages: Basal ganglia involvement in facio-brachial dystonic seizures associated with LGI1 antibodies

(2013) D. Plantone et al.   NEUROLOGY

Leucine-rich glioma inactivated 3 regulates adipogenesis through ADAM23

(2012) Hyun A Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Leucine-rich glioma inactivated 1 (Lgi1), an epilepsy-related secreted protein, has a nuclear localization signal and localizes to both the cytoplasm and the nucleus of the caudal ganglionic eminence neurons

(2012) Sayaka Kusuzawa et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Ultraviolet B-induced LGI3 secretion protects human keratinocytes

(2012) Seung Hoon Lee et al.   EXPERIMENTAL DERMATOLOGY

Defect in the gene encoding the EAR/EPTP domain-containing protein TSPEAR causes DFNB98 profound deafness

(2012) Sedigheh Delmaghani et al.   HUMAN MOLECULAR GENETICS

A rat model for LGI1-related epilepsies

(2012) Stéphanie Baulac et al.   HUMAN MOLECULAR GENETICS

LGI1 and LGI4 bind to ADAM22, ADAM23 and ADAM11

(2012) Koji Sagane et al.   International Journal of Biological Sciences

Epilepsy Gene LGI1 Regulates Postnatal Developmental Remodeling of Retinogeniculate Synapses

(2012) Y.-D. Zhou et al.   JOURNAL OF NEUROSCIENCE

Endoplasmic reticulum dysfunction in neurological disease

(2012) Benoit D Roussel et al.   LANCET NEUROLOGY

Domain-dependent clustering and genotype-phenotype analysis of LGI1 mutations in ADPEAF

(2012) Y.-Y. Ho et al.   NEUROLOGY

Identification of a Novel Idiopathic Epilepsy Locus in Belgian Shepherd Dogs

(2012) Eija H. Seppälä et al.   PLoS One

How the vertebrates were made: selective pruning of a double-duplicated genome

(2011) Gerard Manning et al.   BMC BIOLOGY

Mechanisms of excitatory synapse maturation by trans-synaptic organizing complexes

(2011) Samuel A McMahon et al.   CURRENT OPINION IN NEUROBIOLOGY

Low penetrance and effect on protein secretion of LGI1 mutations causing autosomal dominant lateral temporal epilepsy

(2011) Carlo Di Bonaventura et al.   EPILEPSIA

Autoantibodies associated with diseases of the CNS: new developments and future challenges

(2011) Angela Vincent et al.   LANCET NEUROLOGY

Familial temporal lobe epilepsy with psychic auras associated with a novel LGI1 mutation

(2011) P. Striano et al.   NEUROLOGY

A Computational Model of the LGI1 Protein Suggests a Common Binding Site for ADAM Proteins

(2011) Emanuela Leonardi et al.   PLoS One

Loss of Zebrafish lgi1b Leads to Hydrocephalus and Sensitization to Pentylenetetrazol Induced Seizure-Like Behavior

(2011) Yong Teng et al.   PLoS One

LGI2 Truncation Causes a Remitting Focal Epilepsy in Dogs

(2011) Eija H. Seppälä et al.   PLoS Genetics

Structure and function of WD40 domain proteins

(2011) Chao Xu et al.   Protein & Cell

Faciobrachial dystonic seizures precede Lgi1 antibody limbic encephalitis

(2010) Sarosh R. Irani et al.   ANNALS OF NEUROLOGY

Similarity of molecular phenotype between known epilepsy gene LGI1 and disease candidate gene LGI2

(2010) Vachiranee Limviphuvadh et al.   BMC BIOCHEMISTRY

Electroclinical characterization of epileptic seizures in leucine-rich, glioma-inactivated 1-deficient mice

(2010) Elodie Chabrol et al.   BRAIN

Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan’s syndrome and acquired neuromyotonia

(2010) Sarosh R. Irani et al.   BRAIN

Synaptic organizing complexes

(2010) Tabrez J Siddiqui et al.   CURRENT OPINION IN NEUROBIOLOGY

Evaluation of depression risk in LGI1 mutation carriers

(2010) Gary A. Heiman et al.   EPILEPSIA

Human limbic encephalitis serum enhances hippocampal mossy fiber-CA3 pyramidal cell synaptic transmission

(2010) Tatjana Lalic et al.   EPILEPSIA

A proteome map of axoglial specializations isolated and purified from human central nervous system

(2010) Ajit S. Dhaunchak et al.   GLIA

Knockdown of zebrafish Lgi1a results in abnormal development, brain defects and a seizure-like behavioral phenotype

(2010) Y. Teng et al.   HUMAN MOLECULAR GENETICS

Lgi1 null mutant mice exhibit myoclonic seizures and CA1 neuronal hyperexcitability

(2010) Y. Eugene Yu et al.   HUMAN MOLECULAR GENETICS

Lgi4 Promotes the Proliferation and Differentiation of Glial Lineage Cells throughout the Developing Peripheral Nervous System

(2010) J. Nishino et al.   JOURNAL OF NEUROSCIENCE

LGI1 Is a Nogo Receptor 1 Ligand that Antagonizes Myelin-Based Growth Inhibition

(2010) R. Thomas et al.   JOURNAL OF NEUROSCIENCE

Adam22 Is a Major Neuronal Receptor for Lgi4-Mediated Schwann Cell Signaling

(2010) E. Ozkaynak et al.   JOURNAL OF NEUROSCIENCE

Biological characterization of ADAM22 variants reveals the importance of a disintegrin domain sequence in cell surface expression

(2010) Koji Sagane et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Neuron-glia signaling and the protection of axon function by Schwann cells

(2010) Susanne Quintes et al.   JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM

Investigation of LGI1 as the antigen in limbic encephalitis previously attributed to potassium channels: a case series

(2010) Meizan Lai et al.   LANCET NEUROLOGY

Myelination and support of axonal integrity by glia

(2010) Klaus-Armin Nave   NATURE

Leucine-Rich Glioma Inactivated 3 Induces Neurite Outgrowth Through Akt and Focal Adhesion Kinase

(2010) Woo-Jae Park et al.   NEUROCHEMICAL RESEARCH

LGI3 interacts with flotillin-1 to mediate APP trafficking and exosome formation

(2010) Sachi Okabayashi et al.   NEUROREPORT

Dual DNA Methylation Patterns in the CNS Reveal Developmentally Poised Chromatin and Monoallelic Expression of Critical Genes

(2010) Jinhui Wang et al.   PLoS One

Disruption of LGI1–linked synaptic complex causes abnormal synaptic transmission and epilepsy

(2010) Yuko Fukata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Genome of the Western Clawed Frog Xenopus tropicalis

(2010) U. Hellsten et al.   SCIENCE

Whole genome duplications and expansion of the vertebrate GATA transcription factor gene family

(2009) William Q Gillis et al.   BMC EVOLUTIONARY BIOLOGY

Role of the superior colliculus in the expression of acute and kindled audiogenic seizures in Wistar audiogenic rats

(2009) Maria C. Doretto et al.   EPILEPSIA

Mutations inLGI1gene in Japanese families with autosomal dominant lateral temporal lobe epilepsy: The first report from Asian families

(2009) Jun Kawamata et al.   EPILEPSIA

A novel three base-pair LGI1 deletion leading to loss of function in a family with autosomal dominant lateral temporal epilepsy and migraine-like episodes

(2009) Julitta de Bellescize et al.   EPILEPSY RESEARCH

Inactivation of LGI1 expression accompanies early stage hyperplasia of prostate epithelium in the TRAMP murine model of prostate cancer

(2009) John K. Cowell et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Reexpression of LGI1 in glioma cells results in dysregulation of genes implicated in the canonical axon guidance pathway

(2009) Padmaja Kunapuli et al.   GENOMICS

LGI1mutations in autosomal dominant and sporadic lateral temporal epilepsy

(2009) Carlo Nobile et al.   HUMAN MUTATION

LGI1-associated epilepsy through altered ADAM23-dependent neuronal morphology

(2009) Katherine Owuor et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Arrested maturation of excitatory synapses in autosomal dominant lateral temporal lobe epilepsy

(2009) Yu-Dong Zhou et al.   NATURE MEDICINE

The evolutionary significance of ancient genome duplications

(2009) Yves Van de Peer et al.   NATURE REVIEWS GENETICS

Leucine-rich glioma inactivated 3 is involved in amyloid β peptide uptake by astrocytes and endocytosis itself

(2009) Sachi Okabayashi et al.   NEUROREPORT

Expression Profile of Lgi1 Gene in Mouse Brain During Development

(2008) Patrícia A. O. Ribeiro et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Penetrance of LGI1 mutations in autosomal dominant partial epilepsy with auditory features

(2008) M. J. Rosanoff et al.   NEUROLOGY

Leucine-rich glioma inactivated 3 associates with syntaxin 1

(2008) Woo-Jae Park et al.   NEUROSCIENCE LETTERS

Synaptic adhesion molecules and PSD-95

(2007) Kihoon Han et al.   PROGRESS IN NEUROBIOLOGY

Evolution of the β-propeller fold

(2007) Indronil Chaudhuri et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS