Nitroheterocyclic drug resistance mechanisms inTrypanosoma brucei

Nitroimidazo-oxazole compound DNDI-VL-2098: an orally effective preclinical drug candidate for the treatment of visceral leishmaniasis

(2014) Suman Gupta et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Nitro drugs for the treatment of trypanosomatid diseases: past, present, and future prospects

(2014) Stephen Patterson et al.   TRENDS IN PARASITOLOGY

Benznidazole Biotransformation and Multiple Targets in Trypanosoma cruzi Revealed by Metabolomics

(2014) Andrea Trochine et al.   PLoS Neglected Tropical Diseases

Assessing the Essentiality of Leishmania donovani Nitroreductase and Its Role in Nitro Drug Activation

(2012) S. Wyllie et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Benznidazole-Resistance in Trypanosoma cruzi Is a Readily Acquired Trait That Can Arise Independently in a Single Population

(2012) Ana Maria Mejia et al.   JOURNAL OF INFECTIOUS DISEASES

High-throughput decoding of antitrypanosomal drug efficacy and resistance

(2012) Sam Alsford et al.   NATURE

The Anti-Trypanosome Drug Fexinidazole Shows Potential for Treating Visceral Leishmaniasis

(2012) S. Wyllie et al.   Science Translational Medicine

Activation of Benznidazole by Trypanosomal Type I Nitroreductases Results in Glyoxal Formation

(2011) Belinda S. Hall et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Nifurtimox Activation by Trypanosomal Type I Nitroreductases Generates Cytotoxic Nitrile Metabolites

(2011) Belinda S. Hall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trypanosoma bruceiMitochondrial Respiratome: Composition and Organization in Procyclic Form

(2011) Nathalie Acestor et al.   MOLECULAR & CELLULAR PROTEOMICS

Cross-Resistance to Nitro Drugs and Implications for Treatment of Human African Trypanosomiasis

(2010) A. Y. Sokolova et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis

(2010) Deuan C. Jones et al.   BIOCHEMICAL PHARMACOLOGY

A Molecular Mechanism for Eflornithine Resistance in African Trypanosomes

(2010) Isabel M. Vincent et al.   PLoS Pathogens

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

Four histone variants mark the boundaries of polycistronic transcription units in Trypanosoma brucei

(2009) T. N. Siegel et al.   GENES & DEVELOPMENT

Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial

(2009) Gerardo Priotto et al.   LANCET

Amplification-free Illumina sequencing-library preparation facilitates improved mapping and assembly of (G+C)-biased genomes

(2009) Iwanka Kozarewa et al.   NATURE METHODS

A comparative study of methylglyoxal metabolism in trypanosomatids

(2008) Neil Greig et al.   FEBS Journal

A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes

(2008) Shane R. Wilkinson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA