Review
Oncology
Minhong Wu, Yan Zhou, Qingsheng Chen, Zhiling Yu, Hongyong Gu, Pengxiu Lin, Yanling Li, Cailing Liu
Summary: This study suggests that C-reactive protein to albumin ratio (CAR) has a potential prognostic role in patients with urinary cancers. High pretreated CAR is associated with inferior overall survival and progression-free survival. CAR can act as a predictor in renal cell carcinoma, bladder cancer, and prostate cancer subgroups. The results of this study are reliable and robust.
FRONTIERS IN ONCOLOGY
(2022)
Review
Endocrinology & Metabolism
Kechong Zhou, Chao Li, Tao Chen, Xuejun Zhang, Baoluo Ma
Summary: In this meta-analysis of 16 studies, elevated levels of C-reactive protein (CRP) were found to be associated with worse overall survival, cancer-specific survival, and progression-free survival in patients with prostate cancer. Subgroup analysis based on disease staging yielded consistent results. However, further studies are needed to confirm these findings.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Oncology
Sheng Yang, Zongxin Zhang, Linglong Shen
Summary: The meta-analysis finds that increased C-reactive protein levels are significantly associated with poor overall survival and shortened progression-free survival in patients with cervical cancer.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Xinglong He, Ade Su, Yongcheng Xu, Diaolong Ma, Guoyuan Yang, Yiyun Peng, Jin Guo, Ming Hu, Yuntao Ma
Summary: The lymphocyte-C-reactive protein ratio (LCR) is associated with the prognosis of colorectal cancer patients, with lower levels of LCR indicating poorer prognosis. More high-quality studies are needed to validate these findings.
FRONTIERS IN ONCOLOGY
(2022)
Review
Immunology
Cheng-Long Han, Guang-Xiao Meng, Zi-Niu Ding, Zhao-Ru Dong, Zhi-Qiang Chen, Jian-Guo Hong, Lun-Jie Yan, Hui Liu, Bao-Wen Tian, Long-Shan Yang, Jun-Shuai Xue, Tao Li
Summary: This meta-analysis suggests that a high baseline C-reactive protein (CRP) level may indicate worse overall survival (OS) and progression-free survival (PFS) in cancer patients receiving immune checkpoint inhibitor (ICI) treatment. However, more high-quality prospective studies are needed to further evaluate the predictive value of CRP for ICI treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Yongjuan Ye, Guozhi Wu, Hao Yuan, Ya Zheng, Yuping Wang, Qinghong Guo
Summary: The lymphocyte/C-reactive protein (LCR) level is associated with the clinical outcomes in patients with upper gastrointestinal cancers, with lower LCR levels indicating worse prognosis. More high-quality studies are needed to validate these findings.
FRONTIERS IN ONCOLOGY
(2023)
Review
Medicine, General & Internal
Yan Pan, Yinmei Lou, Lin Wang
Summary: The C-reactive protein to albumin ratio (CAR) has been investigated in association with the prognosis of metastatic colorectal cancer (mCRC) in several studies, showing that higher CAR is significantly correlated with poorer overall survival and decreased progression-free survival/disease-free survival/recurrence-free survival. More large-sample clinical trials are needed to confirm the prognostic significance of CAR in mCRC.
Review
Medicine, General & Internal
Masashi Utsumi, Masaru Inagaki, Koji Kitada, Naoyuki Tokunaga, Midori Kondo, Kosuke Yunoki, Yuya Sakurai, Ryosuke Hamano, Hideaki Miyasou, Yousuke Tsunemitsu, Shinya Otsuka
Summary: This systematic review and meta-analysis found that an elevated preoperative C-reactive protein-to-albumin ratio is significantly associated with poor prognosis in patients with biliary tract cancer. The C-reactive protein-to-albumin ratio may serve as an independent prognostic biomarker for overall survival and recurrence-free survival in these patients.
Article
Cell Biology
Jiahui Zhou, Wene Wei, Hu Hou, Shufang Ning, Jilin Li, Baoyue Huang, Kaisheng Liu, Litu Zhang
Summary: The study found that CRP, GPS, and CAR have independent prognostic values in patients with CRC. Survival nomograms based on these markers can provide more valuable clinical significance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Kelechi Njoku, Neal C. Ramchander, Y. Louise Wan, Chloe E. Barr, Emma J. Crosbie
Summary: This study found that pretreatment systemic inflammation markers, such as CRP levels, are associated with survival outcomes in endometrial cancer patients. CRP may serve as a simple, low-cost predictive biomarker to guide personalized care in endometrial cancer. Further studies are needed to confirm the utility of CRP in other populations as most participants in this study were of White British ethnicity.
GYNECOLOGIC ONCOLOGY
(2022)
Review
Oncology
Jianhui Du, Jianhua Lan, Jingjing Xiong, Hai Yang, Xiaohan Xu, Chaolai Tang, Guohua Huang, Qiao Ying, Jian Mu, Qiyi Hu
Summary: This meta-analysis focused on the value of C-reactive protein (CRP) in predicting survival rate in patients with prostate cancer (PCa). Results from 12 included studies showed a significant correlation between increased CRP levels and survival rate among PCa patients.
TRANSLATIONAL CANCER RESEARCH
(2021)
Article
Medicine, General & Internal
Samantha N. Neumann, Jun-Juan Li, Xiao-Dong Yuan, Shuo-Hua Chen, Chao-Ran Ma, Laura E. Murray-Kolb, Yun Shen, Shou-Ling Wu, Xiang Gao
Summary: The study demonstrated a significant association between anemia and insomnia in adults, even after adjusting for chronic inflammation. Meta-analysis results also confirmed a positive correlation between anemia and insomnia in adult populations.
CHINESE MEDICAL JOURNAL
(2021)
Review
Oncology
Daniel C. McFarland, Meredith Doherty, Thomas M. Atkinson, Robin O'Hanlon, William Breitbart, Christian J. Nelson, Andrew H. Miller
Summary: This study conducted a systematic review and meta-analysis to examine the relationship between inflammation and depression in cancer patients. The findings suggest that peripheral inflammatory markers, such as IL-6, TNF, and CRP, are associated with depressive symptoms in various cancer settings. These results have implications for the identification and management of depression in cancer patients.
Article
Clinical Neurology
Liuting Chen, Min Wang, Chanrui Yang, Yefei Wang, Bonan Hou
Summary: This study evaluated the prognostic value of high-sensitivity C-reactive protein (hs-CRP) levels in stroke patients and found that high hs-CRP levels were associated with increased mortality, risk of stroke recurrence, and poor prognosis in ischemic stroke patients. For hemorrhagic stroke patients, high hs-CRP levels were associated with all-cause mortality. Thus, hs-CRP levels may contribute to the prognosis prediction of stroke patients.
FRONTIERS IN NEUROLOGY
(2023)
Review
Medical Laboratory Technology
Marta Kramer Mikkelsen, Nana Aviaja Frederikke Lindblom, Anne Dyhl-Polk, Carsten Bogh Juhl, Julia Sidenius Johansen, Dorte Nielsen
Summary: Inflammation is an important characteristic of cancer, and circulating inflammatory biomarkers, such as C-reactive protein (CRP), have been explored for their clinical value in prognosis, prediction, and monitoring of therapeutic response in breast cancer patients. However, the results regarding the use of serum CRP as a biomarker in breast cancer appear inconsistent, particularly in non-metastatic and general breast cancer populations. Meta-analyses suggest limited value in these settings, but consistent findings support an association between high serum CRP and poor prognosis in metastatic breast cancer patients. Further research is needed to assess the role of serum CRP in prediction and monitoring of treatment response.
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
(2022)